Hprt1 (hypoxanthine phosphoribosyltransferase 1) - Rat Genome Database

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Gene: Hprt1 (hypoxanthine phosphoribosyltransferase 1) Rattus norvegicus
Analyze
Symbol: Hprt1
Name: hypoxanthine phosphoribosyltransferase 1
RGD ID: 2826
Description: Enables hypoxanthine phosphoribosyltransferase activity. Involved in cellular response to insulin stimulus; hypoxanthine metabolic process; and spermatogenesis. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Biomarker of hepatocellular carcinoma. Human ortholog(s) of this gene implicated in HRPT-related hyperuricemia and Lesch-Nyhan syndrome. Orthologous to human HPRT1 (hypoxanthine phosphoribosyltransferase 1); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: HGPRT; Hgprtase; Hprt; hypoxanthine guanine phosphoribosyl transferase; hypoxanthine guanine phosphoribosyl transferase 1; Hypoxanthine phosphoribosyl transferase; hypoxanthine-guanine phosphoribosyltransferase; LOC103689983; MGC112554
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X137,655,744 - 137,687,718 (+)NCBIGRCr8
mRatBN7.2X132,736,175 - 132,768,149 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX132,736,096 - 132,768,154 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX134,896,246 - 134,928,216 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X138,479,092 - 138,511,062 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X136,044,802 - 136,076,774 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X158,196,640 - 158,228,815 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX158,623,240 - 158,655,198 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 EnsemblX158,197,149 - 158,228,749 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X152,821,947 - 152,854,198 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0X153,249,874 - 153,281,841 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X139,929,647 - 139,961,616 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X140,003,079 - 140,035,048 (+)NCBI
Cytogenetic MapXq36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,1,1-trichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-Methylpyrene  (ISO)
1-nitropyrene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,5-tetrachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-Amino-9H-pyrido[2,3-b]indole  (ISO)
2-hydroxypropanoic acid  (ISO)
2-naphthylamine  (ISO)
3-Amino-1-methyl-5H-pyrido[4,3-b]indole  (ISO)
3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-methyl-3H-imidazo[4,5-f]quinolin-2-amine  (EXP)
3-Nitrobenzanthrone  (ISO)
3-phenylprop-2-enal  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-hydroxynon-2-enal  (ISO)
4-nitroquinoline N-oxide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP,ISO)
acrylonitrile  (EXP,ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP,ISO)
amiodarone  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atrazine  (EXP,ISO)
azathioprine  (ISO)
benzbromarone  (EXP)
benzene  (ISO)
benzidine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[a]pyrene-7,8-diol  (ISO)
beta-carotene  (EXP)
biphenyl-4-amine  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
Brodifacoum  (EXP)
buspirone  (EXP)
buta-1,3-diene  (EXP,ISO)
cadmium dichloride  (ISO)
caffeine  (EXP)
calcitriol  (ISO)
calyculin a  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
chromium(6+)  (ISO)
clofibrate  (EXP,ISO)
clofibric acid  (EXP)
cobalt dichloride  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
curcumin  (ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (ISO)
cyhalothrin  (EXP)
cyproconazole  (ISO)
D-glucose  (ISO)
D-mannitol  (ISO)
deguelin  (ISO)
dibutyl phthalate  (ISO)
dichlorine  (EXP)
diepoxybutane  (ISO)
Diisodecyl phthalate  (ISO)
dimethyl sulfoxide  (EXP)
dioxygen  (ISO)
dorsomorphin  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (EXP)
fenthion  (ISO)
fipronil  (EXP)
folic acid  (ISO)
fructose  (ISO)
fumonisin B1  (ISO)
gamma-hexachlorocyclohexane  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glucose  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
hexaconazole  (ISO)
hydrogen peroxide  (ISO)
hypochlorous acid  (ISO)
inulin  (ISO)
isoniazide  (EXP)
ivermectin  (ISO)
L-ascorbic acid  (EXP)
L-ethionine  (EXP)
lead diacetate  (EXP,ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
MeIQ  (EXP)
MeIQx  (EXP)
methapyrilene  (EXP)
methidathion  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
methoxychlor  (EXP)
microcystin-LR  (ISO)
N-ethyl-N-nitrosourea  (EXP,ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-methyl-N-nitrosourea  (EXP,ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (ISO)
nefazodone  (EXP)
neoglucobrassicin  (ISO)
nickel sulfate  (ISO)
nimesulide  (EXP)
nitric oxide  (ISO)
okadaic acid  (ISO)
omeprazole  (EXP)
oxirane  (ISO)
ozone  (EXP,ISO)
p-toluidine  (EXP)
paracetamol  (EXP,ISO)
paraquat  (ISO)
pent-4-enoic acid  (EXP)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP)
PhIP  (EXP,ISO)
phorbol 13-acetate 12-myristate  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (EXP,ISO)
potassium bromate  (ISO)
potassium dichromate  (ISO)
propiconazole  (ISO)
pyrogallol  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
retinyl acetate  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
styrene  (ISO)
sulfadimethoxine  (EXP)
tamoxifen  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
Thiotepa  (EXP)
tioguanine  (ISO)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP)
troglitazone  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vanillin  (ISO)
vitamin E  (EXP)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (ISO)
cytosol  (IBA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Activities of amidophosphoribosyltransferase (EC2.4.2.14) and the purine phosphoribosyltransferases (EC2.4.2.7 and 2.4.2.8), and the phosphoribosylpyrophosphate content of rat central nervous system at different stages of development--their possible relationship to the neurological dysfunction in the Lesch-Nyhan syndrome. Allsop J and Watts RW, J Neurol Sci. 1980 May;46(2):221-32.
2. Pediatric neurological syndromes and inborn errors of purine metabolism. Camici M, etal., Neurochem Int. 2010 Feb;56(3):367-78. Epub 2009 Dec 11.
3. DNA sequence flanking the protein coding regions of the rat Hprt gene. Chen T, etal., Mutat Res 1998 May;382(3-4):79-80.
4. Rat hypoxanthine phosphoribosyltransferase cDNA cloning and sequence analysis. Chiaverotti TA, etal., Adv Exp Med Biol 1991;309B:117-20.
5. Rat hypoxanthine phosphoribosyltransferase cDNA cloning and sequence analysis. Chiaverotti TA, etal., Genomics 1991 Dec;11(4):1158-60.
6. Analysis of the HPRT1 gene in 35 Italian Lesch-Nyhan families: 45 patients and 77 potential female carriers. de Gemmis P, etal., Mutat Res. 2010 Oct 13;692(1-2):1-5. doi: 10.1016/j.mrfmmm.2010.07.003. Epub 2010 Jul 16.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. The gene encoding hypoxanthine-guanine phosphoribosyltransferase as target for mutational analysis: PCR cloning and sequencing of the cDNA from the rat. Jansen JG, etal., Mutat Res 1992 Apr;266(2):105-16.
10. The gene encoding hypoxanthine-guanine phosphoribosyltransferase as target for mutational analysis: PCR cloning and sequencing of the cDNA from the rat. Jansen JG, etal., Mutat Res 1992 Apr;266(2):105-16.
11. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Enzymic capacities of purine de Novo and salvage pathways for nucleotide synthesis in normal and neoplastic tissues. Natsumeda Y, etal., Cancer Res. 1984 Jun;44(6):2475-9.
14. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
16. Insulin regulatory effects on purine- and pyrimidine metabolism in alloxan diabetic rat liver. Pillwein K, etal., Padiatr Padol. 1988;23(2):135-44.
17. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
18. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
19. GOA pipeline RGD automated data pipeline
20. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
21. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
22. Stage-specific expression of genes associated with rat spermatogenesis: characterization by laser-capture microdissection and real-time polymerase chain reaction. Sluka P, etal., Biol Reprod. 2002 Sep;67(3):820-8.
23. Increased de novo purine synthesis by insulin through selective enzyme induction in primary cultured rat hepatocytes. Tsuchiya M, etal., Am J Physiol. 1990 May;258(5 Pt 1):C841-8.
24. Metabolism of hypoxanthine in isolated rat hepatocytes. Vincent MF, etal., Biochem J. 1984 Aug 15;222(1):145-55.
25. Hypoxanthine guanine phosphoribosyltransferase (HPRT) deficiencies: HPRT1 mutations in new Japanese families and PRPP concentration. Yamada Y, etal., Nucleosides Nucleotides Nucleic Acids. 2014;33(4-6):218-22. doi: 10.1080/15257770.2013.865743.
Additional References at PubMed
PMID:198184   PMID:204065   PMID:291939   PMID:540025   PMID:659426   PMID:943046   PMID:1235912   PMID:1432691   PMID:1777100   PMID:2890215   PMID:2906327   PMID:3029599  
PMID:3243423   PMID:3821905   PMID:6251472   PMID:6300847   PMID:6326107   PMID:6852525   PMID:7509865   PMID:7526167   PMID:8044844   PMID:8193672   PMID:8485579   PMID:8492116  
PMID:8575415   PMID:8643611   PMID:8878108   PMID:8894695   PMID:9521733   PMID:9824441   PMID:9886073   PMID:10037486   PMID:10360366   PMID:11297820   PMID:11591653   PMID:12477932  
PMID:12812988   PMID:12944494   PMID:15013694   PMID:15990111   PMID:19527031   PMID:20458337   PMID:23376485   PMID:25047350   PMID:25187167   PMID:25416956   PMID:25502805   PMID:26316108  
PMID:31515488   PMID:32875725  


Genomics

Comparative Map Data
Hprt1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X137,655,744 - 137,687,718 (+)NCBIGRCr8
mRatBN7.2X132,736,175 - 132,768,149 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX132,736,096 - 132,768,154 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX134,896,246 - 134,928,216 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X138,479,092 - 138,511,062 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X136,044,802 - 136,076,774 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X158,196,640 - 158,228,815 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX158,623,240 - 158,655,198 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 EnsemblX158,197,149 - 158,228,749 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X152,821,947 - 152,854,198 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0X153,249,874 - 153,281,841 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X139,929,647 - 139,961,616 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X140,003,079 - 140,035,048 (+)NCBI
Cytogenetic MapXq36NCBI
HPRT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X134,460,165 - 134,500,668 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX134,460,165 - 134,520,513 (+)EnsemblGRCh38hg38GRCh38
GRCh37X133,594,195 - 133,634,698 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X133,421,923 - 133,462,362 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X133,319,776 - 133,360,216NCBI
CeleraX133,981,004 - 134,021,522 (+)NCBICelera
Cytogenetic MapXq26.2-q26.3NCBI
HuRefX122,992,617 - 123,032,595 (+)NCBIHuRef
CHM1_1X133,505,941 - 133,546,459 (+)NCBICHM1_1
T2T-CHM13v2.0X132,785,328 - 132,825,827 (+)NCBIT2T-CHM13v2.0
Hprt1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X52,076,955 - 52,110,537 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX52,077,014 - 52,110,536 (+)EnsemblGRCm39 Ensembl
GRCm38X52,988,078 - 53,021,660 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX52,988,137 - 53,021,659 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X50,341,255 - 50,374,837 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X49,232,764 - 49,266,286 (+)NCBIMGSCv36mm8
CeleraX40,414,095 - 40,447,630 (+)NCBICelera
Cytogenetic MapXA5NCBI
cM MapX29.31NCBI
Hprt1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955473462,940 - 510,006 (-)NCBIChiLan1.0ChiLan1.0
HPRT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X133,895,335 - 133,936,164 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X133,898,929 - 133,939,766 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X123,609,248 - 123,650,102 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X133,908,233 - 133,948,197 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX133,916,681 - 133,948,197 (+)Ensemblpanpan1.1panPan2
HPRT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X105,115,732 - 105,153,702 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX105,115,732 - 105,153,702 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX91,226,153 - 91,264,410 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X106,975,655 - 107,013,438 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX106,975,628 - 107,013,469 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X104,388,675 - 104,426,954 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X106,254,668 - 106,292,939 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X106,046,035 - 106,084,329 (+)NCBIUU_Cfam_GSD_1.0
Hprt1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X103,263,023 - 103,304,555 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936691652,769 - 694,463 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936691650,753 - 694,362 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HPRT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX110,321,204 - 110,357,894 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X110,321,144 - 110,357,902 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
HPRT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X109,629,674 - 109,671,409 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366606547,224,456 - 47,265,741 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hprt1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462479714,148,580 - 14,184,471 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hprt1
16 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:115
Count of miRNA genes:98
Interacting mature miRNAs:104
Transcripts:ENSRNOT00000045153
Prediction methods:Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat
1598872Memor14Memory QTL 144.5exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X93956491138956491Rat
738025Stresp3Stress response QTL 34.610.0066stress-related behavior trait (VT:0010451)defensive burying - approachX100567703150256146Rat
1598809Memor15Memory QTL 154.4exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X103312877148312877Rat
1598856Memor1Memory QTL 11.9exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)X103312877148312877Rat
738029Stresp2Stress response QTL 23.40.0004stress-related behavior trait (VT:0010451)defensive burying - approachX112934952138400867Rat
10059603Bw174Body weight QTL 1743.40.025body mass (VT:0001259)body weight (CMO:0000012)X113937816152453651Rat
634346Insul4Insulin level QTL 40blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)X126975089152453651Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 10 68 35 37 11 8
Low 1 6 4
Below cutoff 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_012583 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039099447 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AH005530 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC098629 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474185 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212770 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212939 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213155 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215291 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215779 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216318 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219798 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219974 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220248 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229135 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229708 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230307 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234297 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L31545 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M63983 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M86443 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S79292 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U06049 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X62085 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000045153   ⟹   ENSRNOP00000043388
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX132,736,103 - 132,768,147 (+)Ensembl
Rnor_6.0 EnsemblX158,623,240 - 158,655,198 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000065935   ⟹   ENSRNOP00000062740
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX132,736,491 - 132,768,062 (+)Ensembl
Rnor_6.0 EnsemblX158,197,149 - 158,228,749 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000103150   ⟹   ENSRNOP00000083078
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX132,745,305 - 132,768,149 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000103414   ⟹   ENSRNOP00000083489
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX132,745,254 - 132,768,154 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000109953   ⟹   ENSRNOP00000082017
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX132,736,096 - 132,768,149 (+)Ensembl
RefSeq Acc Id: NM_012583   ⟹   NP_036715
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X137,655,744 - 137,687,714 (+)NCBI
mRatBN7.2X132,736,175 - 132,768,149 (+)NCBI
Rnor_6.0X158,196,640 - 158,228,815 (-)NCBI
Rnor_5.0X153,249,874 - 153,281,841 (-)NCBI
RGSC_v3.4X139,929,647 - 139,961,616 (+)RGD
Sequence:
RefSeq Acc Id: XM_039099447   ⟹   XP_038955375
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X137,655,934 - 137,687,718 (+)NCBI
mRatBN7.2X132,736,365 - 132,768,149 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_036715   ⟸   NM_012583
- UniProtKB: Q4KMC5 (UniProtKB/Swiss-Prot),   P70469 (UniProtKB/Swiss-Prot),   Q62926 (UniProtKB/Swiss-Prot),   P27605 (UniProtKB/Swiss-Prot),   A6KUK4 (UniProtKB/TrEMBL),   A0A8L2QNC2 (UniProtKB/TrEMBL),   A6KUK3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000062740   ⟸   ENSRNOT00000065935
RefSeq Acc Id: XP_038955375   ⟸   XM_039099447
- Peptide Label: isoform X1
- UniProtKB: A0A8L2QU26 (UniProtKB/TrEMBL),   A0A8I5ZZ79 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000043388   ⟸   ENSRNOT00000045153
RefSeq Acc Id: ENSRNOP00000083078   ⟸   ENSRNOT00000103150
RefSeq Acc Id: ENSRNOP00000083489   ⟸   ENSRNOT00000103414
RefSeq Acc Id: ENSRNOP00000082017   ⟸   ENSRNOT00000109953
Protein Domains
Phosphoribosyltransferase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P27605-F1-model_v2 AlphaFold P27605 1-218 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13702063
Promoter ID:EPDNEW_R12587
Type:initiation region
Name:Hprt1_1
Description:hypoxanthine phosphoribosyltransferase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X158,228,839 - 158,228,899EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2826 AgrOrtholog
BioCyc Gene G2FUF-1004 BioCyc
BioCyc Pathway PWY-6599 [guanine and guanosine salvage II] BioCyc
  PWY-6609 [adenine and adenosine salvage III] BioCyc
  PWY-6620 [guanine and guanosine salvage I] BioCyc
BioCyc Pathway Image PWY-6599 BioCyc
  PWY-6609 BioCyc
  PWY-6620 BioCyc
Ensembl Genes ENSRNOG00000031367 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00000048561 Ensembl
  ENSRNOG00055026943 UniProtKB/Swiss-Prot
  ENSRNOG00060023239 UniProtKB/Swiss-Prot
  ENSRNOG00065028933 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000045153.4 UniProtKB/TrEMBL
  ENSRNOT00000065935.4 UniProtKB/TrEMBL
  ENSRNOT00000103150.1 UniProtKB/TrEMBL
  ENSRNOT00000103414.1 UniProtKB/TrEMBL
  ENSRNOT00000109953 ENTREZGENE
  ENSRNOT00000109953.1 UniProtKB/Swiss-Prot
  ENSRNOT00055046621 UniProtKB/Swiss-Prot
  ENSRNOT00060040585 UniProtKB/Swiss-Prot
  ENSRNOT00065050123 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.2020 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Hxn_phspho_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PRibTrfase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PRTase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24465 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 24465 ENTREZGENE
PANTHER HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE UniProtKB/Swiss-Prot
  HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE UniProtKB/Swiss-Prot
  HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE UniProtKB/TrEMBL
  HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE UniProtKB/TrEMBL
Pfam Pribosyltran UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB HPRT1 RGD
PhenoGen Hprt1 PhenoGen
PROSITE PUR_PYR_PR_TRANSFER UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000031367 RatGTEx
  ENSRNOG00000048561 RatGTEx
  ENSRNOG00055026943 RatGTEx
  ENSRNOG00060023239 RatGTEx
  ENSRNOG00065028933 RatGTEx
Superfamily-SCOP SSF53271 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZX18_RAT UniProtKB/TrEMBL
  A0A8I5ZZ79 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QNC2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QU26 ENTREZGENE, UniProtKB/TrEMBL
  A6KUK3 ENTREZGENE, UniProtKB/TrEMBL
  A6KUK4 ENTREZGENE, UniProtKB/TrEMBL
  HPRT_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  P70469 ENTREZGENE
  Q4KMC5 ENTREZGENE
  Q62926 ENTREZGENE
UniProt Secondary P70469 UniProtKB/Swiss-Prot
  Q4KMC5 UniProtKB/Swiss-Prot
  Q62926 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Hprt1  hypoxanthine phosphoribosyltransferase 1  LOC103689983  hypoxanthine-guanine phosphoribosyltransferase  Data merged from RGD:9163824 737654 PROVISIONAL
2014-08-25 LOC103689983  hypoxanthine-guanine phosphoribosyltransferase      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-09-24 Hprt1  hypoxanthine phosphoribosyltransferase 1  Hprt1  hypoxanthine guanine phosphoribosyl transferase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-15 Hprt1  hypoxanthine guanine phosphoribosyl transferase 1  Hprt  hypoxanthine guanine phosphoribosyl transferase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-06-23 Hprt    HpRt  hypoxanthine guanine phosphoribosyl transferase  Symbol updated 629549 APPROVED
2003-04-09 HpRt  hypoxanthine guanine phosphoribosyl transferase  Hprt    Symbol and Name updated 629477 APPROVED
2003-03-14 Hprt  hypoxanthine guanine phosphoribosyl transferase  Hprt1    Data merged from RGD:619901 628472 PROVISIONAL
2002-08-07 Hprt1        Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Hprt  Hypoxanthine phosphoribosyl transferase      Symbol and Name status set to approved 70586 APPROVED