Cyp1a2 (cytochrome P450, family 1, subfamily a, polypeptide 2) - Rat Genome Database

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Gene: Cyp1a2 (cytochrome P450, family 1, subfamily a, polypeptide 2) Rattus norvegicus
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Symbol: Cyp1a2
Name: cytochrome P450, family 1, subfamily a, polypeptide 2
RGD ID: 2459
Description: Enables nitrite reductase (NO-forming) activity and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen. Involved in several processes, including cellular response to copper ion; nitroglycerin metabolic process; and response to vitamin E. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in intracellular membrane-bounded organelle. Biomarker of congestive heart failure and depressive disorder. Human ortholog(s) of this gene implicated in breast cancer; chronic obstructive pulmonary disease; endometrial cancer; and porphyria cutanea tarda. Orthologous to human CYP1A2 (cytochrome P450 family 1 subfamily A member 2); PARTICIPATES IN phase I biotransformation pathway via cytochrome P450; axitinib pharmacokinetics pathway; caffeine pharmacokinetics pathway; INTERACTS WITH (+)-artemisinin; (+)-schisandrin B; (-)-epigallocatechin 3-gallate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cholesterol 25-hydroxylase; CYPD45; CYPIA2; cytochrome P-448; cytochrome P-450d; cytochrome P450 1A2; Cytochrome P450 subfamily I (aromatic compound-inducible) member A2 (Q42 form d); cytochrome P450, 1a2; Cytochrome P450, subfamily I (aromatic compound-inducible), member A2 (Q42, form d); cytochrome P450-D; hydroperoxy icosatetraenoate dehydratase; P-448; P-450d; P450-D; RATCYPD45
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Candidate Gene For: Mcs4 Hcar3
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8866,971,261 - 66,978,149 (-)NCBIGRCr8
mRatBN7.2858,075,367 - 58,082,255 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl858,075,367 - 58,082,312 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx863,608,316 - 63,615,227 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0861,885,882 - 61,892,795 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0859,750,429 - 59,757,344 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0862,451,360 - 62,458,244 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl862,451,329 - 62,458,301 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0862,228,271 - 62,235,203 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4861,439,062 - 61,447,861 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1861,458,143 - 61,464,586 (-)NCBI
Celera857,541,217 - 57,547,956 (-)NCBICelera
Cytogenetic Map8q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-artemisinin  (EXP,ISO)
(+)-catechin  (ISO)
(+)-epicatechin-3-O-gallate  (ISO)
(+)-schisandrin B  (EXP)
(+/-)-Aegeline  (ISO)
(-)-cotinine  (ISO)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(-)-selegiline  (ISO)
(-)-trans-epsilon-viniferin  (ISO)
(1->4)-beta-D-glucan  (ISO)
(1E,4E,8E)-alpha-humulene  (EXP)
(2-hydroxyphenyl)acetic acid  (ISO)
(E,E)-germacrone  (ISO)
(R)-lipoic acid  (ISO)
(R,R,R)-alpha-tocopherol  (EXP,ISO)
(RS)-coclaurine  (ISO)
(RS)-norcoclaurine  (ISO)
(S)-coclaurine  (ISO)
(S)-duloxetine hydrochloride  (EXP)
(S)-naringenin  (ISO)
(S)-nicotine  (EXP,ISO)
1,1,1-Trichloro-2-(4-hydroxyphenyl)-2-(4-methoxyphenyl)ethane  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,1-bis(2-aminoethyl)-2-hydroxy-3-oxotriazane  (EXP)
1,2,3,7,8-Pentachlorodibenzodioxin  (ISO)
1,2,3,7,8-Pentachlorodibenzofuran  (ISO)
1,2,4,5-tetrachlorobenzene  (EXP)
1,2,4-trichlorobenzene  (ISO)
1,2-dichlorobenzene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dichloroethene  (EXP)
1,2-dimethylhydrazine  (EXP)
1,2-dimethylnaphthalene  (ISO)
1,3,7-trimethyluric acid  (ISO)
1,3-Dinitropyrene  (EXP,ISO)
1,4-dichlorobenzene  (ISO)
1,4-dimethylnaphthalene  (ISO)
1,4-naphthoquinone  (ISO)
1,6-dimethylnaphthalene  (ISO)
1,6-Dinitropyrene  (EXP)
1,7-dimethylxanthine  (ISO)
1,7-phenanthroline  (EXP)
1,8-Dinitropyrene  (EXP)
1-(1,3-benzodioxol-5-yl)-4,4-dimethyl-1-penten-3-ol  (ISO)
1-Aminopyrene  (ISO)
1-benzofuran  (ISO)
1-hydroxyanthraquinone  (ISO)
1-methyl-7H-xanthine  (ISO)
1-methylnaphthalene  (ISO)
1-Methylpyrene  (ISO)
1-naphthol  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
1-nitropyrene  (EXP,ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2'-deoxyguanosine  (ISO)
2,2',3,3',6,6'-hexachlorobiphenyl  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (EXP,ISO)
2,3,3',4,4',5,5'-Heptachlorobiphenyl  (ISO)
2,3,3',4,4',5-Hexachlorobiphenyl  (EXP,ISO)
2,3,4,3',4'-Pentachlorobiphenyl  (EXP,ISO)
2,3,4,7,8-Pentachlorodibenzofuran  (EXP,ISO)
2,3,7,8-tetrabromodibenzodioxine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP,ISO)
2,3-dihydrobenzofuran  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4,6-Triphenyl-1-hexene  (ISO)
2,4-D  (EXP)
2,4-diaminotoluene  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP,ISO)
2,4-dinitrophenol  (EXP,ISO)
2,6-dimethylnaphthalene  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-[cyclohexyl(oxo)methyl]-3,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one  (ISO)
2-acetamidofluorene  (EXP,ISO)
2-amino-2-deoxy-D-galactopyranose  (EXP)
2-Amino-3-methyl-9H-pyrido[2,3-b]indole  (EXP,ISO)
2-amino-4,6-dinitrotoluene  (EXP)
2-Amino-9H-pyrido[2,3-b]indole  (EXP,ISO)
2-benzoxazolinone  (ISO)
2-chlorobiphenyl  (ISO)
2-hydroxy-17beta-estradiol  (ISO)
2-hydroxychrysophanol  (ISO)
2-Methoxynaphthalene  (ISO)
2-methyl-1H-indole  (ISO)
2-methyl-6-(phenylethynyl)pyridine  (ISO)
2-methylnaphthalene  (ISO)
2-naphthol  (ISO)
2-naphthylamine  (ISO)
2-nitroanisole  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',4,4'-tetrachlorobiphenyl  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3,3'-diindolylmethane  (EXP,ISO)
3,4,5,3',4',5'-Hexachlorobiphenyl  (EXP,ISO)
3,4,8-Trimethyl-1H,2H,3H-imidazo[4,5-F]quinoxalin-2-imine  (ISO)
3,4-dichloroaniline  (ISO)
3,4-dihydroxybenzoic acid  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3,5-xylenol  (ISO)
3-(Methylthio)-1-propene  (EXP)
3-Amino-1-methyl-5H-pyrido[4,3-b]indole  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methyl-3H-imidazo[4,5-f]quinolin-2-amine  (EXP,ISO)
3-methylcholanthrene  (EXP,ISO)
3-Methylchrysene  (ISO)
3-methylquinoline  (ISO)
3-Nitrofluoranthene  (ISO)
3-phenoxybenzoic acid  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4',5,7-trihydroxy-3'-methoxyflavone  (ISO)
4'-tert-Butyl-2',6'-dimethyl-3',5'-dinitroacetophenone  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(methylsulfinyl)phenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-[(1E)-1,2-diphenylbut-1-en-1-yl]phenol  (ISO)
4-chlorobiphenyl  (ISO)
4-Hydroxy-N-desmethyltamoxifen  (ISO)
4-Hydroxybenzyl isothiocyanate  (EXP)
4-hydroxychalcone  (EXP)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-Ipomeanol  (ISO)
4-Methylchrysene  (ISO)
4-nitroaniline  (EXP)
4-nitrophenol  (EXP)
4-phenoxyphenol  (ISO)
5,7-dihydroxy-4'-methoxyflavone  (EXP,ISO)
5-(2-chloroethyl)-4-methylthiazole  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
5-Hydroxyflavone  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP,ISO)
5-methoxyindole  (ISO)
5-Methylchrysene  (ISO)
5-methyltryptamine  (ISO)
6-bromoindirubin-3'-oxime  (ISO)
6-chrysenamine  (ISO)
6-Methylchrysene  (ISO)
6-Nitrobenzo[a]pyrene  (ISO)
6-Nitrochrysene  (ISO)
7,12-dimethyltetraphene  (EXP,ISO)
7-hydroxyflavone  (ISO)
7-Nitrobenz[a]anthracene  (ISO)
7H-Dibenzo[c,g]carbazole  (ISO)
9-phenanthrol  (ISO)
acenaphthene  (ISO)
acenaphthylene  (ISO)
acenocoumarol  (ISO)
acephate  (ISO)
acetamide  (EXP)
acetone  (EXP)
Acetyl tributyl citrate  (ISO)
aconitine  (ISO)
acridines  (ISO)
actinomycin D  (ISO)
Aescin  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
aflatoxin B1 exo-8,9-epoxide  (ISO)
Aflatoxin G1  (ISO)
aflatoxin M1  (ISO)
alachlor  (EXP)
albendazole  (ISO)
aldehydo-D-glucose  (ISO)
alizarin  (ISO)
all-trans-retinoic acid  (ISO)
allocryptopine  (ISO)
almotriptan  (ISO)
Aloe emodin  (ISO)
alpha-linolenic acid  (ISO)
alpha-methyltryptamine  (ISO)
alpha-naphthoflavone  (EXP,ISO)
ametryn  (ISO)
amiodarone  (ISO)
amitraz  (EXP)
amitriptyline  (ISO)
amitriptylinoxide  (ISO)
amodiaquine  (ISO)
amphetamine  (ISO)
ampicillin  (EXP)
andrographolide  (EXP,ISO)
angelicin  (ISO)
aniline  (EXP,ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
anthracen-2-amine  (ISO)
anthracene  (ISO)
anthracene-1,8,9-triol  (ISO)
apigenin  (ISO)
arachidonic acid  (ISO)
Aranidipine  (ISO)
arecoline  (EXP)
aristolochic acid A  (EXP,ISO)
Aroclor 1254  (EXP,ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (ISO)
Artemisin  (ISO)
asenapine  (ISO)
aspartame  (EXP)
atazanavir sulfate  (ISO)
atovaquone  (ISO)
atrazine  (EXP,ISO)
Avasimibe  (ISO)
azoxystrobin  (ISO)
baicalein  (ISO)
baicalin  (ISO)
benidipine  (ISO)
benoxaprofen  (EXP)
benzene  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP,ISO)
Benzo[b]fluorene  (ISO)
benzo[c]phenanthrene  (ISO)
Benzo[k]fluoranthene  (ISO)
benzofurans  (EXP,ISO)
benzyl isothiocyanate  (EXP)
benzylideneacetone  (EXP)
berberine  (ISO)
bergomottin  (ISO)
Besigomsin  (ISO)
beta-carboline  (ISO)
beta-carotene  (ISO)
beta-naphthoflavone  (EXP,ISO)
bexarotene  (EXP)
bicalutamide  (ISO)
bilirubin IXalpha  (ISO)
bilobalide  (EXP)
binimetinib  (ISO)
biochanin A  (EXP,ISO)
biphenyl  (ISO)
biphenyl-2-ol  (ISO)
biphenyl-4-amine  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
bromfenac  (ISO)
bromodichloromethane  (EXP,ISO)
brucine  (EXP)
bucladesine  (ISO)
Bufuralol  (ISO)
buta-1,3-diene  (ISO)
butylated hydroxyanisole  (ISO)
Butylbenzyl phthalate  (EXP)
Butylparaben  (EXP)
butyric acid  (ISO)
C.I. Natural Red 20  (EXP,ISO)
C60 fullerene  (EXP)
cadmium dichloride  (ISO)
caffeine  (EXP,ISO)
canadine  (ISO)
cannabidiol  (ISO)
canthaxanthin  (EXP,ISO)
capsaicin  (ISO)
carbamazepine  (EXP,ISO)
carbaryl  (EXP,ISO)
carbendazim  (ISO)
carbofuran  (ISO)
carbon nanotube  (ISO)
Carnosol  (ISO)
carotenoid  (ISO)
caryophyllene oxide  (EXP,ISO)
catechols  (ISO)
celecoxib  (ISO)
CGP 52608  (ISO)
chalcone  (EXP)
chelidonine  (ISO)
chenodeoxycholic acid  (ISO)
CHIR 99021  (ISO)
chlorohydrocarbon  (EXP)
chloroquine  (ISO)
chlorotoluron  (ISO)
chlorpromazine  (EXP,ISO)
chlorpyrifos  (ISO)
chlorzoxazone  (EXP,ISO)
choline  (EXP,ISO)
chromium(6+)  (ISO)
chrysazin  (ISO)
chrysene  (EXP,ISO)
chrysin  (ISO)
chrysophanol  (ISO)
ciglitazone  (ISO)
cimetidine  (ISO)
ciprofibrate  (EXP,ISO)
ciprofloxacin  (ISO)
cisplatin  (EXP,ISO)
clarithromycin  (ISO)
clenbuterol  (EXP)
clodronic acid  (ISO)
clofibrate  (EXP,ISO)
clofibric acid  (EXP)
clopidogrel  (ISO)
clothianidin  (ISO)
clotrimazole  (EXP)
clozapine  (EXP,ISO)
Clozapine N-oxide  (ISO)
cobalt dichloride  (EXP)
colforsin daropate hydrochloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
corticosterone  (EXP,ISO)
coumarin  (EXP,ISO)
Cryptotanshinone  (ISO)
curcumin  (EXP,ISO)
cyclobarbital  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
cyhalothrin  (EXP,ISO)
cylindrospermopsin  (ISO)
cypermethrin  (EXP,ISO)
cyproconazole  (EXP,ISO)
D-glucose  (ISO)
dabrafenib  (ISO)
dacarbazine  (ISO)
daidzein  (ISO)
dantrolene  (ISO)
DDT  (EXP)
decabromodiphenyl ether  (EXP,ISO)
dehydroepiandrosterone  (ISO)
deoxycholic acid  (ISO)
Deoxyschizandrin  (ISO)
desogestrel  (ISO)
dexamethasone  (EXP,ISO)
dexmedetomidine  (EXP)
dextran sulfate  (EXP)
dextromethorphan  (ISO)
diallyl disulfide  (EXP)
Diallyl sulfide  (EXP)
diallyl trisulfide  (EXP)
diarsenic trioxide  (ISO)
diarylheptanoid  (ISO)
diazinon  (EXP,ISO)
Dibenz[a,c]anthracene  (ISO)
dibenz[a,h]anthracene  (EXP,ISO)
dibenziodolium  (EXP)
dibenzo[a,l]pyrene  (EXP,ISO)
dibenzofuran  (ISO)
dibenzofurans  (ISO)
dibutyl phthalate  (EXP)
dichloroacetic acid  (ISO)
dichloromethane  (ISO)
diclofenac  (ISO)
dicofol  (EXP)
dicrotophos  (ISO)
Dicyclohexyl phthalate  (EXP)
dieldrin  (EXP)
diethyl phthalate  (EXP)
diethyldithiocarbamic acid  (EXP,ISO)
diethylstilbestrol  (ISO)
difenoconazole  (ISO)
diflubenzuron  (ISO)
dihydroartemisinin  (ISO)
dihydrocapsaicin  (ISO)
Dihydrotanshinone I  (ISO)
dimethocaine  (ISO)
Dimethyl phthalate  (EXP)
dimethyl sulfoxide  (ISO)
dimethylarsinic acid  (EXP)
dimethylmercury  (EXP)
diosmetin  (ISO)
dioxygen  (EXP,ISO)
dipropyl phthalate  (EXP)
diuron  (ISO)
domperidone  (ISO)
dopamine  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (EXP)
Elemicin  (ISO)
ellipticine  (EXP,ISO)
emodin  (ISO)
endosulfan  (ISO)
enfuvirtide  (ISO)
enilconazole  (ISO)
enoxacin  (EXP,ISO)
epoxiconazole  (ISO)
Erucin  (EXP)
estragole  (ISO)
estrone  (ISO)
ethambutol  (ISO)
ethanol  (EXP,ISO)
ethoxyquin  (EXP)
ethylisopropylamiloride  (ISO)
ethylparaben  (EXP)
etodolac  (ISO)
etoposide  (ISO)
etoricoxib  (ISO)
eugenol  (ISO)
farnesol  (EXP,ISO)
farrerol  (ISO)
felbamate  (EXP)
felodipine  (ISO)
fenarimol  (ISO)
fenbendazole  (ISO)
fenitrothion  (EXP,ISO)
fenofibrate  (EXP)
fenproporex  (ISO)
fenvalerate  (ISO)
ferulic acid  (ISO)
finasteride  (EXP)
fipronil  (ISO)
flavanone  (ISO)
flavone  (ISO)
flavonol  (ISO)
fluconazole  (ISO)
fludioxonil  (ISO)
flumequine  (ISO)
fluoranthene  (EXP,ISO)
fluorene  (ISO)
flutamide  (EXP,ISO)
fluvoxamine  (EXP,ISO)
folic acid  (ISO)
fonofos  (ISO)
formononetin  (EXP,ISO)
Frangulin A  (ISO)
Frangulin B  (ISO)
fructose  (ISO)
Furafylline  (EXP,ISO)
furan  (EXP)
gadolinium trichloride  (EXP)
galangin  (ISO)
gallocatechin  (ISO)
gamma-decalactone  (ISO)
gamma-hexachlorocyclohexane  (EXP)
gamma-valerolactone  (ISO)
gemfibrozil  (ISO)
genistein  (EXP,ISO)
genkwanin  (ISO)
gentamycin  (EXP)
gestodene  (ISO)
Ginkgolide A  (EXP)
ginkgolide B  (EXP)
Glu-P-1  (ISO)
Glu-P-2  (ISO)
glucoerucin  (EXP)
glucoerucin(1-)  (EXP)
glucoraphanin  (EXP)
glucose  (ISO)
glutathione  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glycyrrhetinate  (EXP)
glycyrrhetinic acid  (EXP)
griseofulvin  (ISO)
guanethidine  (EXP)
GW 3965  (ISO)
halocarban  (ISO)
hemin  (EXP)
heroin  (ISO)
hesperetin  (ISO)
hexachlorobenzene  (EXP)
hexane  (EXP)
huperzine A  (EXP)
hydralazine  (EXP,ISO)
hydrocortisone succinate  (ISO)
hydrogen peroxide  (ISO)
Hypaconitine  (ISO)
iberin  (EXP)
ibuprofen  (ISO)
Icaritin  (ISO)
ifosfamide  (ISO)
imipramine  (ISO)
imipramine oxide  (ISO)
imiprothrin  (EXP)
imiquimod  (ISO)
imperatorin  (ISO)
indane  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indirubin  (ISO)
indole-3-methanol  (EXP,ISO)
indolin-2-one  (ISO)
indometacin  (EXP,ISO)
indoxyl sulfate  (ISO)
inulin  (ISO)
irilone  (ISO)
iron dextran  (ISO)
isocarbophos  (ISO)
isoimperatorin  (ISO)
isoliquiritigenin  (ISO)
isopimpinellin  (ISO)
isoprenaline  (EXP,ISO)
isoproturon  (ISO)
Isosafrole  (EXP,ISO)
Isoxanthohumol  (ISO)
Isradipine  (ISO)
ivermectin  (ISO)
kaempferol  (EXP,ISO)
ketoconazole  (EXP,ISO)
L-ascorbic acid  (EXP)
L-methionine  (ISO)
lansoprazole  (EXP,ISO)
laquinimod  (EXP)
lead nitrate  (EXP,ISO)
lead(0)  (EXP)
lefetamine  (ISO)
leflunomide  (EXP,ISO)
lentinan  (ISO)
Licochalcone A  (ISO)
lidocaine  (ISO)
linoleic acid  (ISO)
linuron  (ISO)
lipoic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
lithocholic acid  (EXP,ISO)
loxapine  (ISO)
luteolin  (ISO)
Luteolin 7-methyl ether  (EXP,ISO)
lycopene  (ISO)
m-xylene  (EXP,ISO)
Magnolol  (ISO)
malathion  (ISO)
maneb  (EXP)
mangiferin  (EXP,ISO)
mebendazole  (EXP,ISO)
Meclizine  (ISO)
mefenamic acid  (ISO)
MeIQ  (EXP,ISO)
MeIQx  (EXP,ISO)
melatonin  (EXP,ISO)
meloxicam  (ISO)
melphalan  (EXP,ISO)
menadione  (EXP,ISO)
mercury atom  (ISO)
mercury dichloride  (ISO)
mercury(0)  (ISO)
metformin  (EXP,ISO)
methamphetamine  (ISO)
methidathion  (ISO)
methotrexate  (EXP,ISO)
methoxsalen  (EXP,ISO)
methoxychlor  (EXP,ISO)
methyl 2-methylpropyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate  (ISO)
methylarsonic acid  (EXP)
methylglyoxal  (ISO)
methylmercury chloride  (EXP,ISO)
metolachlor  (ISO)
metronidazole  (EXP)
miconazole  (EXP)
microcystin-LR  (ISO)
mifepristone  (EXP,ISO)
mitomycin C  (EXP)
Mitragynine  (ISO)
Monobutylphthalate  (EXP)
monocrotophos  (EXP)
monosodium L-glutamate  (ISO)
morphine  (ISO)
musk xylene  (EXP,ISO)
mycophenolic acid  (ISO)
myricetin  (ISO)
myristicin  (ISO)
N'-(2,4-dimethylphenyl)-N-methylformamidine  (EXP)
N,N-diethyl-m-toluamide  (ISO)
N,N-diisopropyltryptamine  (ISO)
N,N-dimethyltryptamine  (ISO)
N-[3-(aminomethyl)benzyl]acetamidine  (EXP)
N-acetyl-1,4-benzoquinone imine  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-desmethylclozapine  (ISO)
N-Desmethyltamoxifen  (ISO)
N-hydroxy-PhIP  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
NADP zwitterion  (ISO)
NADP(+)  (ISO)
naphthalene  (ISO)
naringin  (ISO)
nefazodone  (EXP,ISO)
neomycin  (EXP)
nicardipine  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
niclosamide  (ISO)
nicotine  (EXP,ISO)
nifedipine  (EXP,ISO)
nimesulide  (EXP,ISO)
nisoldipine  (ISO)
nitroaniline  (EXP)
nitrofurantoin  (ISO)
nitroglycerin  (EXP)
nobiletin  (ISO)
Nonylphenol  (ISO)
norfloxacin  (EXP)
norgestimate  (ISO)
nortriptyline  (ISO)
notoginsenoside R1  (EXP)
Notopterol  (ISO)
o-anisidine  (EXP,ISO)
O-methyleugenol  (ISO)
obeticholic acid  (EXP,ISO)
ochratoxin A  (ISO)
Octachlorostyrene  (ISO)
octamethylcyclotetrasiloxane  (EXP)
ofloxacin  (ISO)
okadaic acid  (EXP,ISO)
okanin  (ISO)
olanzapine  (ISO)
oleanolic acid  (EXP,ISO)
oleic acid  (ISO)
Olivacine  (ISO)
oltipraz  (EXP,ISO)
omeprazole  (EXP,ISO)
Ondansetron  (ISO)
organophosphorus compound  (ISO)
organoselenium compound  (ISO)
orphenadrine  (EXP,ISO)
ortho-Aminoazotoluene  (ISO)
Oxadiazon  (ISO)
oxfendazole  (EXP)
oxolane  (ISO)
ozone  (ISO)
p-cresol  (ISO)
paclitaxel  (EXP,ISO)
pantoprazole  (EXP)
papaverine  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
parathion  (ISO)
PCB138  (ISO)
pedalitin  (ISO)
pelargonidin  (ISO)
pentachlorobenzene  (EXP)
pentachlorophenol  (ISO)
pentobarbital  (ISO)
Pentoxifylline  (ISO)
perampanel  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
perhexiline  (ISO)
permethrin  (ISO)
phenacetin  (EXP,ISO)
phenanthrene  (ISO)
phenethyl caffeate  (EXP)
phenethyl isothiocyanate  (EXP,ISO)
phenobarbital  (EXP,ISO)
phenol  (ISO)
phenthoate  (ISO)
phenylephrine  (EXP)
phenytoin  (ISO)
PhIP  (EXP,ISO)
phlorizin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phorone  (ISO)
phosphatidylcholine  (ISO)
phosphatidylethanolamine  (ISO)
physcion  (ISO)
pifithrin-?  (ISO)
pimobendan  (ISO)
pinocembrin  (ISO)
Pipermethystine  (EXP)
piperonyl butoxide  (EXP,ISO)
pirinixic acid  (EXP,ISO)
poly(styrene)  (ISO)
potassium dichromate  (ISO)
pravastatin  (EXP,ISO)
prazosin  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
primaquine  (ISO)
prochloraz  (EXP,ISO)
profenofos  (ISO)
propachlor  (ISO)
propiconazole  (EXP,ISO)
propranolol  (EXP,ISO)
propylparaben  (EXP)
protopine  (ISO)
pterostilbene  (ISO)
pyrazinecarboxamide  (EXP)
pyrene  (EXP,ISO)
pyridine  (EXP)
pyrogallol  (ISO)
pyrrolidines  (ISO)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-glucofuranoside  (EXP)
quercetin 3-O-beta-D-glucopyranoside  (EXP)
quinaldine  (ISO)
quinidine  (ISO)
quinine  (ISO)
quinizarin  (ISO)
quinoline  (ISO)
rabeprazole  (EXP,ISO)
reactive oxygen species  (ISO)
reserpine  (EXP)
resveratrol  (EXP,ISO)
Retrorsine  (EXP)
Rhein  (ISO)
rifampicin  (EXP,ISO)
ritonavir  (EXP,ISO)
rofecoxib  (ISO)
rubiadin  (ISO)
Rutecarpine  (EXP,ISO)
safrole  (ISO)
salicylamide  (ISO)
Salinomycin  (ISO)
sanguinarine  (EXP)
saracatinib  (ISO)
scutellarein  (ISO)
secobarbital  (ISO)
selenium atom  (EXP)
senecionine  (ISO)
Sesamex  (ISO)
Shikonin  (EXP,ISO)
silicon dioxide  (ISO)
simazine  (EXP,ISO)
sinensetin  (ISO)
skatole  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sodium fluoride  (ISO)
sophoraflavanone B  (ISO)
sporidesmin A  (ISO)
sterigmatocystin  (ISO)
steviol  (ISO)
stevioside  (ISO)
streptozocin  (EXP,ISO)
styrene  (EXP)
Sudan I  (EXP,ISO)
Sudan III  (EXP)
sulfaphenazole  (ISO)
sulforaphane  (EXP,ISO)
sulfur dioxide  (EXP)
sulindac  (EXP,ISO)
sulindac sulfide  (ISO)
sulpiride  (EXP)
sunitinib  (EXP,ISO)
Sunset Yellow FCF  (ISO)
suramin  (ISO)
tacrine  (EXP,ISO)
tamarixetin  (ISO)
tamoxifen  (EXP,ISO)
tangeretin  (ISO)
Tanshinone I  (ISO)
tauroursodeoxycholic acid  (EXP)
tebuconazole  (EXP,ISO)
tegaserod  (ISO)
terbutryn  (ISO)
Tesaglitazar  (EXP)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
tetrahydrocurcumin  (ISO)
tetrahydropalmatine  (ISO)
tetraphene  (EXP,ISO)
Theaflavin 3,3'-digallate  (ISO)
theobromine  (ISO)
theophylline  (EXP,ISO)
thiabendazole  (EXP,ISO)
thiacloprid  (ISO)
thioacetamide  (EXP)
thiophanate-methyl  (EXP)
thioridazine  (ISO)
ticlopidine  (ISO)
tizanidine  (ISO)
tofacitinib  (ISO)
tolcapone  (EXP,ISO)
tolfenamic acid  (ISO)
toluene  (EXP)
toxaphene  (ISO)
trabectedin  (EXP)
trans-1,2-dichloroethene  (EXP)
trans-chalcone  (EXP)
tranylcypromine  (ISO)
triadimefon  (EXP)
triamterene  (ISO)
triazines  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triflumuron  (ISO)
trimethoprim  (ISO)
trimethylarsine oxide  (EXP,ISO)
triphenyl phosphate  (EXP)
triptonide  (ISO)
troglitazone  (ISO)
tryptamines  (ISO)
umbelliferone  (ISO)
vadimezan  (ISO)
valdecoxib  (EXP)
valproic acid  (EXP,ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vancomycin  (EXP)
veliparib  (ISO)
verapamil  (ISO)
versicolorin A  (ISO)
vinclozolin  (EXP,ISO)
vitamin E  (EXP)
warfarin  (ISO)
wortmannin  (EXP)
Wuweizisu C  (ISO)
xanthohumol  (ISO)
yohimbine  (ISO)
zafirlukast  (ISO)
zaragozic acid A  (EXP,ISO)
zearalenone  (ISO)
zerumbone  (ISO)
zileuton  (ISO)
zinc atom  (EXP)
zinc protoporphyrin  (EXP)
zinc(0)  (EXP)
zoledronic acid  (ISO)
zolmitriptan  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Ultrastructural changes, increased oxidative stress, inflammation, and altered cardiac hypertrophic gene expressions in heart tissues of rats exposed to incense smoke. Al-Attas OS, etal., Environ Sci Pollut Res Int. 2015 Jul;22(13):10083-93. doi: 10.1007/s11356-015-4212-5. Epub 2015 Feb 18.
2. A functional polymorphism of the cytochrome P450 1A2 (CYP1A2) gene: association with tardive dyskinesia in schizophrenia. Basile VS, etal., Mol Psychiatry 2000 Jul;5(4):410-7.
3. Effects of E. Coli lipopolysaccharide on the pharmacokinetics of ipriflavone and its metabolites, M1 and M5, after intravenous and oral administration of ipriflavone to rats: decreased metabolism of ipriflavone due to decreased expression of hepatic CYP1A2 and 2C11. Chung HJ, etal., J Pharm Sci. 2008 Nov;97(11):5024-36.
4. The effect of copper on the mRNA expression profile of xenobiotic-metabolizing enzymes in cultured rat H4-II-E cells. Darwish WS, etal., Biol Trace Elem Res. 2014 May;158(2):243-8. doi: 10.1007/s12011-014-9915-9. Epub 2014 Mar 6.
5. Involvement of oxidative stress in hepatocellular tumor-promoting activity of oxfendazole in rats. Dewa Y, etal., Arch Toxicol. 2008 Aug 27.
6. Applications of stable V79-derived cell lines expressing rat cytochromes P4501A1, 1A2, and 2B1. Doehmer J, etal., Xenobiotica. 1992 Sep-Oct;22(9-10):1093-9.
7. Tanshinone I protects mice from aristolochic acid I-induced kidney injury by induction of CYP1A. Feng C, etal., Environ Toxicol Pharmacol. 2013 Aug 6;36(3):850-857. doi: 10.1016/j.etap.2013.07.017.
8. Effect of biliary obstruction and internal biliary drainage on hepatic cytochrome P450 isozymes in rats. Fukushima S, etal., World J Gastroenterol. 2008 Apr 28;14(16):2556-60.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. Comparative analysis of SNP in estrogen-metabolizing enzymes for ovarian, endometrial, and breast cancers in Novosibirsk, Russia. Gulyaeva LF, etal., Adv Exp Med Biol. 2008;617:359-66.
12. Effects of aescin on cytochrome P450 enzymes in rats. Huang Y, etal., J Ethnopharmacol. 2014;151(1):583-90. doi: 10.1016/j.jep.2013.11.016. Epub 2013 Nov 16.
13. Protection by Nigella sativa against carbon tetrachloride-induced downregulation of hepatic cytochrome P450 isozymes in rats. Ibrahim ZS, etal., Jpn J Vet Res. 2008 Nov;56(3):119-28.
14. Gene Data File Integration of LocusLink data, October 12, 2001
15. MG132 alleviates liver injury induced by intestinal ischemia/reperfusion in rats: involvement of the AhR and NFκB pathways. Jing H, etal., J Surg Res. 2012 Jul;176(1):63-73. doi: 10.1016/j.jss.2011.09.001. Epub 2011 Sep 29.
16. Developmental changes in the expression of enterocytic and hepatic cytochromes P4501A in rat. Johnson TN, etal., Xenobiotica 2002 Jul;32(7):595-604.
17. Marked endogenous activation of the CYP1A1 and CYP1A2 genes in the congenitally jaundiced Gunn rat. Kapitulnik J and Gonzalez FJ, Mol Pharmacol. 1993 May;43(5):722-5.
18. Coding nucleotide sequence of 3-methylcholanthrene-inducible cytochrome P-450d cDNA from rat liver. Kawajiri K, etal., Proc Natl Acad Sci U S A 1984 Mar;81(6):1649-53.
19. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
20. Time-dependent induction of rat hepatic CYP1A1 and CYP1A2 expression after single-dose administration of the anti-angiogenic agent TSU-68. Kitamura R, etal., Drug Metab Pharmacokinet. 2008;23(6):421-7.
21. Predominant role of peripheral catecholamines in the stress-induced modulation of CYP1A2 inducibility by benzo(alpha)pyrene. Konstandi M, etal., Basic Clin Pharmacol Toxicol. 2008 Jan;102(1):35-44. Epub 2007 Oct 31.
22. Hepatic drug metabolizing profile of Flinders Sensitive Line rat model of depression. Kotsovolou O, etal., Prog Neuropsychopharmacol Biol Psychiatry. 2010 Aug 16;34(6):1075-84. Epub 2010 Jun 4.
23. Suppression of hepatic cytochrome p450-mediated drug metabolism during the late stage of sepsis in rats. Lee SH and Lee SM, Shock. 2005 Feb;23(2):144-9.
24. Global metabolic profiling for the study of Rhizoma Paridis saponins-induced hepatotoxicity in rats. Man S, etal., Environ Toxicol. 2017 Jan;32(1):99-108. doi: 10.1002/tox.22215. Epub 2015 Nov 21.
25. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
26. Vitamin E deficiency accelerates nitrate tolerance via a decrease in cardiac P450 expression and increased oxidative stress. Minamiyama Y, etal., Free Radic Biol Med. 2006 Mar 1;40(5):808-16. doi: 10.1016/j.freeradbiomed.2005.10.038. Epub 2005 Oct 28.
27. Organic nitrate tolerance is induced by degradation of some cytochrome P450 isoforms. Minamiyama Y, etal., Redox Rep. 2002;7(5):339-42. doi: 10.1179/135100002125000947.
28. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
29. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
30. Use of a quantitative real-time reverse transcription-polymerase chain reaction method to study the induction of CYP1A, CYP2B and CYP4A forms in precision-cut rat liver slices. Pan J, etal., Xenobiotica 2002 Sep;32(9):739-47.
31. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
32. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
33. Influence of acetaminophen and trichloroethylene on liver cytochrome P450-dependent monooxygenase system. Plewka A, etal., Acta Biochim Pol 2000;47(4):1129-36.
34. GOA pipeline RGD automated data pipeline
35. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
36. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
37. Hepatic microsomal cytochrome P-450 from rats treated with isosafrole. Purification and characterization of four enzymic forms. Ryan DE, etal., J Biol Chem. 1980 Aug 25;255(16):7941-55.
38. Genetic identification of multiple loci that control breast cancer susceptibility in the rat Shepel LA, etal., Genetics 1998 May;149(1):289-99
39. Estrogenic status modulates the effect of soy on hepatic responses to 7,12-dimethylbenz(a)anthracene (DMBA). Singhal R, etal., Toxicol Appl Pharmacol. 2009 Jan 1;234(1):89-97. Epub 2008 Oct 15.
40. Complete nucleotide sequence of a methylcholanthrene-inducible cytochrome P-450 (P-450d) gene in the rat. Sogawa K, etal., J Biol Chem 1985 Apr 25;260(8):5026-32.
41. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
42. CYP1A1, CYP1A2 and CYBA gene polymorphisms associated with oxidative stress in COPD. Vibhuti A, etal., Clin Chim Acta. 2010 Apr 2;411(7-8):474-80. Epub 2010 Jan 18.
43. Shengmai Yin formula exerts cardioprotective effects on rats with chronic heart failure via regulating Linoleic Acid metabolism. Wang S, etal., Prostaglandins Other Lipid Mediat. 2022 Feb;158:106608. doi: 10.1016/j.prostaglandins.2021.106608. Epub 2021 Dec 24.
44. CYP1A2*1F and GSTM1 alleles are associated with susceptibility to porphyria cutanea tarda. Wickliffe JK, etal., Mol Med. 2011 Mar-Apr;17(3-4):241-7. doi: 10.2119/molmed.2010.00130. Epub 2010 Oct 15.
45. Induction of P450 1A by 3-methylcholanthrene protects mice from aristolochic acid-I-induced acute renal injury. Xue X, etal., Nephrol Dial Transplant. 2008 Oct;23(10):3074-81. doi: 10.1093/ndt/gfn262. Epub 2008 May 21.
46. Characterization of complementary DNA clones coding for two forms of 3-methylcholanthrene-inducible rat liver cytochrome P-450. Yabusaki Y, etal., J Biochem (Tokyo) 1984 Sep;96(3):793-804.
47. The potential role of transcription factor aryl hydrocarbon receptor in downregulation of hepatic cytochrome P-450 during sepsis. Zhou M, etal., Int J Mol Med. 2008 Apr;21(4):423-8.
Additional References at PubMed
PMID:1420171   PMID:1793487   PMID:2813353   PMID:3718958   PMID:3753838   PMID:3947063   PMID:7074072   PMID:7761462   PMID:8274012   PMID:8643688   PMID:9240455   PMID:9461503  
PMID:10681376   PMID:11274970   PMID:11511187   PMID:11555828   PMID:11752233   PMID:11802804   PMID:12054491   PMID:12438513   PMID:12477932   PMID:12865317   PMID:14980704   PMID:15327587  
PMID:15680923   PMID:16183037   PMID:16401082   PMID:16636061   PMID:16758626   PMID:16820944   PMID:17101152   PMID:17166882   PMID:17276403   PMID:17311915   PMID:17366540   PMID:17881659  
PMID:17949244   PMID:18356043   PMID:18493746   PMID:18619574   PMID:18845914   PMID:19029318   PMID:19219744   PMID:19288444   PMID:19651758   PMID:20921303   PMID:20942796   PMID:21103392  
PMID:21796703   PMID:21899995   PMID:22159698   PMID:22162298   PMID:22167220   PMID:22173777   PMID:22512029   PMID:23235327   PMID:23658888   PMID:23984390   PMID:24555232   PMID:24557852  
PMID:25164943   PMID:25300103   PMID:25555259   PMID:25764964   PMID:26191268   PMID:26466350   PMID:26913515   PMID:27899252   PMID:28555194   PMID:29551500   PMID:34031539  


Genomics

Comparative Map Data
Cyp1a2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8866,971,261 - 66,978,149 (-)NCBIGRCr8
mRatBN7.2858,075,367 - 58,082,255 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl858,075,367 - 58,082,312 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx863,608,316 - 63,615,227 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0861,885,882 - 61,892,795 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0859,750,429 - 59,757,344 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0862,451,360 - 62,458,244 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl862,451,329 - 62,458,301 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0862,228,271 - 62,235,203 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4861,439,062 - 61,447,861 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1861,458,143 - 61,464,586 (-)NCBI
Celera857,541,217 - 57,547,956 (-)NCBICelera
Cytogenetic Map8q24NCBI
CYP1A2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381574,748,845 - 74,756,607 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1574,748,845 - 74,756,607 (+)EnsemblGRCh38hg38GRCh38
GRCh371575,041,186 - 75,048,948 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361572,828,237 - 72,835,994 (+)NCBINCBI36Build 36hg18NCBI36
Build 341572,828,236 - 72,835,994NCBI
Celera1551,991,217 - 51,998,975 (+)NCBICelera
Cytogenetic Map15q24.1NCBI
HuRef1551,838,984 - 51,846,743 (+)NCBIHuRef
CHM1_11575,159,686 - 75,167,443 (+)NCBICHM1_1
T2T-CHM13v2.01572,618,749 - 72,626,513 (+)NCBIT2T-CHM13v2.0
Cyp1a2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39957,584,220 - 57,590,938 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl957,584,220 - 57,590,986 (-)EnsemblGRCm39 Ensembl
GRCm38957,676,937 - 57,683,655 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl957,676,937 - 57,683,703 (-)EnsemblGRCm38mm10GRCm38
MGSCv37957,524,744 - 57,531,462 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36957,475,074 - 57,481,792 (-)NCBIMGSCv36mm8
Celera954,913,185 - 54,919,903 (-)NCBICelera
Cytogenetic Map9BNCBI
cM Map931.3NCBI
LOC102010322
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554503,165,106 - 3,171,942 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554503,165,107 - 3,171,894 (-)NCBIChiLan1.0ChiLan1.0
CYP1A2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21663,978,105 - 63,985,853 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11568,142,637 - 68,148,301 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01553,692,877 - 53,699,279 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11573,311,720 - 73,319,447 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1573,311,720 - 73,319,447 (+)Ensemblpanpan1.1panPan2
CYP1A2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13037,818,400 - 37,824,192 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3037,799,140 - 37,824,135 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3037,751,388 - 37,757,086 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03038,023,809 - 38,029,593 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3038,023,809 - 38,029,586 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13037,976,275 - 37,981,991 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03038,002,364 - 38,008,076 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03038,258,389 - 38,264,108 (+)NCBIUU_Cfam_GSD_1.0
LOC101969421
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640115,856,553 - 115,861,413 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647133,703,792 - 33,709,484 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647133,704,616 - 33,709,455 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CYP1A2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl758,779,475 - 58,786,100 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1758,779,529 - 58,786,155 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2763,468,129 - 63,474,724 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CYP1A2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1268,727,996 - 8,733,254 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666048132,898,379 - 132,904,792 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Cyp1a2
42 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:120
Count of miRNA genes:100
Interacting mature miRNAs:107
Transcripts:ENSRNOT00000021653, ENSRNOT00000058571
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
1558646Swd5Spike wave discharge measurement QTL 53.450.00036brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)81490675159906751Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)81629044461290444Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)81898416884531599Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)81933115293965294Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)82266233067662330Rat
2303564Gluco43Glucose level QTL 433blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)82613018771130187Rat
2303572Insul13Insulin level QTL 132blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)82613018771130187Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)82720571599103503Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82720571599103503Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)82720571599103503Rat
1300146Rf17Renal function QTL 172.9renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)82824291273242912Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)82824291299525068Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)82950266570386295Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)83018886794457446Rat
1331744Bp217Blood pressure QTL 2173.398arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815458482492Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83084815461290444Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83084815461290444Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83084815461290444Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83084815482460899Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83084815482460899Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83084815482460899Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83084815482460899Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)830848154101699754Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)830848154101699754Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)830848154101699754Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)830848259105647037Rat
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83085640475856404Rat
1582222Epfw2Epididymal fat weight QTL 23.20.0005epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)83173772976737729Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83555193880551938Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83558203280582032Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83646953599083736Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84071306682925667Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84071306693965294Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)84186687675097878Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)84186687686866876Rat
631216Stl9Serum triglyceride level QTL 94.710.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)84186701070386132Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84269268490165460Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)84329616998968765Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)84329616998968765Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)84329616998968765Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)84329616998968765Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)84329616998968765Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)84329616998968765Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088626Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)84653172299083736Rat
2303570Gluco48Glucose level QTL 482blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)84980583194805831Rat
2313086Bss60Bone structure and strength QTL 604.10.0001tibia length (VT:0004357)tibia length (CMO:0000450)85009524982460899Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85009524982460899Rat
5684973Bss100Bone structure and strength QTL 1004.7tibia area (VT:1000281)tibia area measurement (CMO:0001382)85009524982460899Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)851351728107062046Rat
10402857Bp380Blood pressure QTL 3800.95arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)85396876598968765Rat
2301402Bp316Blood pressure QTL 3160.005arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)85396876598968765Rat
2293697Bmd39Bone mineral density QTL 39femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)85404374498968765Rat
1582243Bw66Body weight QTL 663.40.0048body mass (VT:0001259)body weight (CMO:0000012)85423764485365202Rat
1582254Kidm31Kidney mass QTL 313kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)85423764485365202Rat
631664Hcar3Hepatocarcinoma resistance QTL 32.90.0005liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)85423764499103503Rat
1300177Cm2Cardiac mass QTL 23.65heart mass (VT:0007028)heart weight (CMO:0000017)854259986100382532Rat

Markers in Region
D8Wox5  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2858,081,909 - 58,082,156 (+)MAPPERmRatBN7.2
Rnor_6.0862,457,899 - 62,458,145NCBIRnor6.0
Rnor_5.0862,234,858 - 62,235,104UniSTSRnor5.0
Celera857,547,607 - 57,547,857UniSTS
Cytogenetic Map8q24UniSTS
Cytogenetic Map8q32UniSTS
D8Mgh13  
Rat AssemblyChrPosition (strand)SourceJBrowse
RGSC_v3.4861,443,447 - 61,443,567RGDRGSC3.4
RGSC_v3.4861,443,448 - 61,443,566UniSTSRGSC3.4
RGSC_v3.1861,462,501 - 61,462,621RGD
RH 3.4 Map8664.2UniSTS
RH 3.4 Map8664.2RGD
RH 2.0 Map8523.1RGD
Cytogenetic Map8q24UniSTS
D8Arb11  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2858,081,893 - 58,082,149 (+)MAPPERmRatBN7.2
Rnor_6.0862,457,883 - 62,458,138NCBIRnor6.0
Rnor_5.0862,234,842 - 62,235,097UniSTSRnor5.0
Celera857,547,591 - 57,547,850UniSTS
Cytogenetic Map8q24UniSTS
D8Wox33  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2858,082,664 - 58,082,802 (+)MAPPERmRatBN7.2
Rnor_6.0862,458,654 - 62,458,791NCBIRnor6.0
Rnor_5.0862,235,613 - 62,235,750UniSTSRnor5.0
RGSC_v3.4861,448,271 - 61,448,408UniSTSRGSC3.4
Celera857,548,366 - 57,548,502UniSTS
Cytogenetic Map8q24UniSTS
RH141189  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2858,075,490 - 58,075,688 (+)MAPPERmRatBN7.2
Rnor_6.0862,451,484 - 62,451,681NCBIRnor6.0
Rnor_5.0862,228,395 - 62,228,592UniSTSRnor5.0
RGSC_v3.4861,439,186 - 61,439,383UniSTSRGSC3.4
Celera857,541,341 - 57,541,538UniSTS
RH 3.4 Map8665.7UniSTS
Cytogenetic Map8q24UniSTS
PMC291882P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2858,080,400 - 58,080,594 (+)MAPPERmRatBN7.2
Rnor_6.0862,456,391 - 62,456,584NCBIRnor6.0
Rnor_5.0862,233,350 - 62,233,543UniSTSRnor5.0
RGSC_v3.4861,444,758 - 61,444,951UniSTSRGSC3.4
Celera857,546,103 - 57,546,296UniSTS
Cytogenetic Map8q24UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 1 1 1
Medium 20 20 20 1
Low 1 5 2 2 2 2 3 1 4 3 2
Below cutoff 2 2 15 2 19 2 5 5 8 7 6 7 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000021653   ⟹   ENSRNOP00000021653
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl858,075,367 - 58,082,255 (-)Ensembl
Rnor_6.0 Ensembl862,451,329 - 62,458,301 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000104692   ⟹   ENSRNOP00000090173
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl858,075,367 - 58,082,312 (-)Ensembl
RefSeq Acc Id: NM_012541   ⟹   NP_036673
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8866,971,261 - 66,978,149 (-)NCBI
mRatBN7.2858,075,367 - 58,082,255 (-)NCBI
Rnor_6.0862,451,360 - 62,458,244 (-)NCBI
Rnor_5.0862,228,271 - 62,235,203 (-)NCBI
RGSC_v3.4861,439,062 - 61,447,861 (-)RGD
Celera857,541,217 - 57,547,956 (-)RGD
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_036673   ⟸   NM_012541
- UniProtKB: A1L120 (UniProtKB/Swiss-Prot),   Q64588 (UniProtKB/Swiss-Prot),   P04799 (UniProtKB/Swiss-Prot),   A0A8I6AD25 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000021653   ⟸   ENSRNOT00000021653
RefSeq Acc Id: ENSRNOP00000090173   ⟸   ENSRNOT00000104692

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P04799-F1-model_v2 AlphaFold P04799 1-513 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696017
Promoter ID:EPDNEW_R6542
Type:multiple initiation site
Name:Cyp1a2_1
Description:cytochrome P450, family 1, subfamily a, polypeptide 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0862,458,251 - 62,458,311EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2459 AgrOrtholog
BioCyc Gene G2FUF-30299 BioCyc
Ensembl Genes ENSRNOG00000016173 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000021653 ENTREZGENE
  ENSRNOT00000021653.8 UniProtKB/Swiss-Prot
  ENSRNOT00000104692.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7373253 IMAGE-MGC_LOAD
InterPro Cyt_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_E_grp-I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_E_grp-I_CYP1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24297 UniProtKB/Swiss-Prot
MGC_CLONE MGC:156566 IMAGE-MGC_LOAD
NCBI Gene 24297 ENTREZGENE
PANTHER CYTOCHROME P450 1A2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam p450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB CYP1A2 RGD
PhenoGen Cyp1a2 PhenoGen
PRINTS EP450I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EP450ICYP1A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CYTOCHROME_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016173 RatGTEx
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC221270
UniProt A0A8I6AD25 ENTREZGENE, UniProtKB/TrEMBL
  A1L120 ENTREZGENE
  A6J4X2_RAT UniProtKB/TrEMBL
  CP1A2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q64588 ENTREZGENE
UniProt Secondary A1L120 UniProtKB/Swiss-Prot
  Q64588 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Cyp1a2  cytochrome P450, family 1, subfamily a, polypeptide 2    cytochrome P450, 1a2  Name updated 1299863 APPROVED
2002-06-10 Cyp1a2  cytochrome P450, 1a2      Name updated 70585 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_regulation expression is induced by 3-methylcholanthrene 727649