Atp7b (ATPase copper transporting beta) - Rat Genome Database

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Gene: Atp7b (ATPase copper transporting beta) Rattus norvegicus
Analyze
Symbol: Atp7b
Name: ATPase copper transporting beta
RGD ID: 2180
Description: Enables copper ion binding activity; copper ion transmembrane transporter activity; and zinc ion binding activity. Involved in several processes, including cellular response to metal ion; copper ion export; and lactation. Located in several cellular components, including basolateral plasma membrane; bicellular tight junction; and trans-Golgi network. Used to study Wilson disease; hepatitis; hepatocellular carcinoma; liver carcinoma; and renal adenoma. Human ortholog(s) of this gene implicated in Wilson disease. Orthologous to human ATP7B (ATPase copper transporting beta); PARTICIPATES IN cisplatin drug pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ATPase Cu++ transporting beta polypeptide (same as Wilson disease); ATPase, Cu++ transporting, beta polypeptide; ATPase, Cu++ transporting, beta polypeptide (same as Wilson disease); copper pump 2; copper-transporting ATPase 2; Hts; PINA; PINA gene, promoter; pineal night-specific ATPase; Wd; wilson disease-associated protein homolog
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Atp7bhts  
Genetic Models: LEC/Tj LEC/Hok WKAH.LEC-Atp7bhts/Tj
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81676,654,725 - 76,726,092 (+)NCBIGRCr8
mRatBN7.21669,952,286 - 70,024,404 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1669,951,778 - 70,023,636 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1675,225,956 - 75,297,317 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01678,664,533 - 78,736,202 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01673,913,825 - 73,985,530 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01674,865,516 - 74,944,935 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1674,865,516 - 74,945,286 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01674,495,179 - 74,575,822 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41674,607,988 - 74,680,080 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11674,608,239 - 74,679,614 (+)NCBI
Celera1667,837,288 - 67,908,140 (+)NCBICelera
RH 3.4 Map16664.21RGD
Cytogenetic Map16q12.5NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
1,1'-azobis(N,N-dimethylformamide)  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,6-dinitrotoluene  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP,ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
ATP  (ISO)
atrazine  (EXP)
bathocuproine disulfonic acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
beta-hexachlorocyclohexane  (ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
brefeldin A  (ISO)
buta-1,3-diene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP)
carboplatin  (ISO)
chloroprene  (ISO)
chlorpyrifos  (ISO)
cholesterol  (EXP)
cisplatin  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (EXP,ISO)
copper(II) sulfate  (ISO)
CU-O LINKAGE  (ISO)
cyclosporin A  (ISO)
cytarabine  (ISO)
D-penicillamine  (ISO)
decabromodiphenyl ether  (EXP)
dichlorine  (EXP)
dimethylarsinic acid  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ferroheme b  (ISO)
folic acid  (ISO)
FR900359  (ISO)
genistein  (EXP)
glutathione  (ISO)
glycidol  (EXP)
glycine betaine  (ISO)
GW 4064  (ISO)
heme b  (ISO)
hydrogen peroxide  (ISO)
inulin  (ISO)
iron atom  (EXP)
iron(0)  (EXP)
lead(0)  (ISO)
luteolin  (EXP)
magnesium atom  (ISO)
malonaldehyde  (EXP)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (EXP)
menadione  (ISO)
methapyrilene  (ISO)
methoxychlor  (EXP)
methylarsonic acid  (ISO)
methylmercury chloride  (ISO)
monosodium L-glutamate  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
nitrofen  (EXP)
nocodazole  (ISO)
oxaliplatin  (ISO)
ozone  (EXP,ISO)
paracetamol  (ISO)
paraquat  (ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
platinum  (ISO)
platinum(0)  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
protoporphyrin  (ISO)
quercetin  (EXP,ISO)
S-adenosyl-L-homocysteine  (ISO)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
satraplatin  (ISO)
SB 431542  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
streptozocin  (EXP)
tetrachloromethane  (EXP)
tetrathiomolybdate(2-)  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
triclosan  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zinc acetate  (ISO)
zinc atom  (ISO)
zinc dichloride  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Expression of copper-transporting P-type adenosine triphosphatase (ATP7B) as a prognostic factor in human endometrial carcinoma. Aida T, etal., Gynecol Oncol. 2005 Apr;97(1):41-5.
2. Effects of copper supplementation on copper absorption, tissue distribution, and copper transporter expression in an infant rat model. Bauerly KA, etal., Am J Physiol Gastrointest Liver Physiol. 2005 May;288(5):G1007-14. Epub 2004 Dec 9.
3. Dominant-stable beta-catenin expression causes cell fate alterations and Wnt signaling antagonist expression in a murine granulosa cell tumor model. Boerboom D, etal., Cancer Res. 2006 Feb 15;66(4):1964-73.
4. A novel pineal night-specific ATPase encoded by the Wilson disease gene. Borjigin J, etal., J Neurosci. 1999 Feb 1;19(3):1018-26.
5. Regulation of copper transport crossing brain barrier systems by Cu-ATPases: effect of manganese exposure. Fu X, etal., Toxicol Sci. 2014 Jun;139(2):432-51. doi: 10.1093/toxsci/kfu048. Epub 2014 Mar 10.
6. Therapeutic potential of hepatocyte-like-cells converted from stem cells from human exfoliated deciduous teeth in fulminant Wilson's disease. Fujiyoshi J, etal., Sci Rep. 2019 Feb 7;9(1):1535. doi: 10.1038/s41598-018-38275-y.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. NH2-terminal signals in ATP7B Cu-ATPase mediate its Cu-dependent anterograde traffic in polarized hepatic cells. Guo Y, etal., Am J Physiol Gastrointest Liver Physiol. 2005 Nov;289(5):G904-16. Epub 2005 Jun 30.
9. ATP7B copper-regulated traffic and association with the tight junctions: copper excretion into the bile. Hernandez S, etal., Gastroenterology. 2008 Apr;134(4):1215-23. Epub 2008 Jan 17.
10. Copper-transporting P-type adenosine triphosphatase (ATP7B) is expressed in human breast carcinoma. Kanzaki A, etal., Jpn J Cancer Res. 2002 Jan;93(1):70-7.
11. Mammary gland copper transport is stimulated by prolactin through alterations in Ctr1 and Atp7A localization. Kelleher SL and Lonnerdal B, Am J Physiol Regul Integr Comp Physiol. 2006 Oct;291(4):R1181-91. Epub 2006 Jun 1.
12. Marginal maternal Zn intake in rats alters mammary gland Cu transporter levels and milk Cu concentration and affects neonatal Cu metabolism. Kelleher SL and Lonnerdal B, J Nutr. 2003 Jul;133(7):2141-8.
13. Maturational arrest of thymocyte development is caused by a deletion in the receptor-like protein tyrosine phosphatase kappa gene in LEC rats. Kose H, etal., Genomics. 2007 Jun;89(6):673-7. doi: 10.1016/j.ygeno.2007.03.001. Epub 2007 Apr 16.
14. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
15. Abnormal hepatobiliary and circulating lipid metabolism in the Long-Evans Cinnamon rat model of Wilson's disease. Levy E, etal., Life Sci. 2007 Mar 27;80(16):1472-83. Epub 2007 Jan 20.
16. Spontaneous hepatic copper accumulation in Long-Evans Cinnamon rats with hereditary hepatitis. A model of Wilson's disease. Li Y, etal., J Clin Invest. 1991 May;87(5):1858-61. doi: 10.1172/JCI115208.
17. Hereditary hepatitis of LEC rats is controlled by a single autosomal recessive gene. Masuda R, etal., Lab Anim. 1988 Apr;22(2):166-9. doi: 10.1258/002367788780864402.
18. Restoration of copper metabolism and rescue of hepatic abnormalities in LEC rats, an animal model of Wilson disease, by expression of human ATP7B gene. Meng Y, etal., Biochim Biophys Acta 2004 Nov 5;1690(3):208-19.
19. Lentiviral gene transfer ameliorates disease progression in Long-Evans cinnamon rats: an animal model for Wilson disease. Merle U, etal., Scand J Gastroenterol. 2006 Aug;41(8):974-82. doi: 10.1080/00365520600554790.
20. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
21. Role of Atp7b gene in spontaneous and N-diethylnitrosamine-induced carcinogenesis in a new congenic strain, WKAH.C-Atp7b rats. Minami T, etal., Jpn J Cancer Res 2001 Aug;92(8):841-7.
22. The LEC rat: a model for human hepatitis, liver cancer, and much more. Mori M, etal., Am J Pathol. 1994 Jan;144(1):200-4.
23. Copper-transporting P-type adenosine triphosphatase (ATP7B) as a cisplatin based chemoresistance marker in ovarian carcinoma: comparative analysis with expression of MDR1, MRP1, MRP2, LRP and BCRP. Nakayama K, etal., Int J Cancer. 2002 Oct 10;101(5):488-95.
24. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
25. Inherited copper toxicity in Long-Evans cinnamon rats exhibiting spontaneous hepatitis: a model of Wilson's disease. Okayasu T, etal., Pediatr Res. 1992 Mar;31(3):253-7. doi: 10.1203/00006450-199203000-00011.
26. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
27. Ceruloplasmin gene expression profile changes in the rat mammary gland during pregnancy, lactation and involution. Platonova NA, etal., J Trace Elem Med Biol. 2017 Sep;43:126-134. doi: 10.1016/j.jtemb.2016.12.013. Epub 2017 Jan 3.
28. GOA pipeline RGD automated data pipeline
29. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
30. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
31. Subcellular targets of cisplatin cytotoxicity: an integrated view. Sancho-Martinez SM, etal., Pharmacol Ther. 2012 Oct;136(1):35-55. doi: 10.1016/j.pharmthera.2012.07.003. Epub 2012 Jul 14.
32. The gene responsible for LEC hepatitis, located on rat chromosome 16, is the homolog to the human Wilson disease gene. Sasaki N, etal., Biochem Biophys Res Commun 1994 Jul 15;202(1):512-8.
33. Evolution of exchangeable copper and relative exchangeable copper through the course of Wilson's disease in the Long Evans Cinnamon rat. Schmitt F, etal., PLoS One. 2013 Dec 17;8(12):e82323. doi: 10.1371/journal.pone.0082323. eCollection 2013.
34. Genetics of Wilson disease and Wilson-like phenotype in a clinical series from eastern Spain. Sánchez-Monteagudo A, etal., Clin Genet. 2020 Feb 11. doi: 10.1111/cge.13719.
35. Identification of the "missing domain" of the rat copper-transporting ATPase, atp7b: insight into the structural and metal binding characteristics of its N-terminal copper-binding domain. Tsay MJ, etal., Biochim Biophys Acta. 2004 Jan 20;1688(1):78-85.
36. The LEC rat has a deletion in the copper transporting ATPase gene homologous to the Wilson disease gene. Wu J, etal., Nat Genet 1994 Aug;7(4):541-5.
37. Expression of the Wilson disease gene is deficient in the Long-Evans Cinnamon rat. Yamaguchi Y, etal., Biochem J 1994 Jul 1;301 ( Pt 1):1-4.
38. New mutation causing hereditary hepatitis in the laboratory rat. Yoshida MC, etal., J Hered 1987 Nov-Dec;78(6):361-5.
Additional References at PubMed
PMID:1588441   PMID:2845190   PMID:6863890   PMID:8040371   PMID:8257436   PMID:9392450   PMID:9465110   PMID:9484715   PMID:9837819   PMID:10441329   PMID:11085952   PMID:11237756  
PMID:12029094   PMID:12572677   PMID:14709553   PMID:15205462   PMID:15269005   PMID:15634671   PMID:15681833   PMID:15950762   PMID:16436657   PMID:16472602   PMID:16567646   PMID:16939419  
PMID:16964378   PMID:17987273   PMID:18637198   PMID:19946888   PMID:20836889   PMID:22130675   PMID:25378584   PMID:26004889  


Genomics

Comparative Map Data
Atp7b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81676,654,725 - 76,726,092 (+)NCBIGRCr8
mRatBN7.21669,952,286 - 70,024,404 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1669,951,778 - 70,023,636 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1675,225,956 - 75,297,317 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01678,664,533 - 78,736,202 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01673,913,825 - 73,985,530 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01674,865,516 - 74,944,935 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1674,865,516 - 74,945,286 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01674,495,179 - 74,575,822 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41674,607,988 - 74,680,080 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11674,608,239 - 74,679,614 (+)NCBI
Celera1667,837,288 - 67,908,140 (+)NCBICelera
RH 3.4 Map16664.21RGD
Cytogenetic Map16q12.5NCBI
ATP7B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381351,932,669 - 52,012,132 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1351,930,436 - 52,012,125 (-)EnsemblGRCh38hg38GRCh38
GRCh371352,506,805 - 52,585,586 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361351,404,806 - 51,483,631 (-)NCBINCBI36Build 36hg18NCBI36
Build 341351,404,805 - 51,483,631NCBI
Celera1333,555,444 - 33,634,269 (-)NCBICelera
Cytogenetic Map13q14.3NCBI
HuRef1333,295,317 - 33,374,147 (-)NCBIHuRef
CHM1_11352,473,433 - 52,553,190 (-)NCBICHM1_1
T2T-CHM13v2.01351,147,339 - 51,226,948 (-)NCBIT2T-CHM13v2.0
Atp7b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39822,482,799 - 22,550,347 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl822,482,801 - 22,550,321 (-)EnsemblGRCm39 Ensembl
GRCm38821,992,783 - 22,060,074 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl821,992,785 - 22,060,305 (-)EnsemblGRCm38mm10GRCm38
MGSCv37823,104,820 - 23,170,546 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36823,459,893 - 23,525,619 (-)NCBIMGSCv36mm8
Celera823,490,671 - 23,556,555 (-)NCBICelera
Cytogenetic Map8A2NCBI
cM Map810.78NCBI
Atp7b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554315,229,126 - 5,269,616 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554315,228,395 - 5,297,120 (-)NCBIChiLan1.0ChiLan1.0
ATP7B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21453,366,970 - 53,447,808 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11352,012,774 - 52,091,309 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01333,063,698 - 33,144,528 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11351,808,491 - 51,888,488 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1351,810,555 - 51,851,839 (-)Ensemblpanpan1.1panPan2
ATP7B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.122162,474 - 225,599 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl22191,888 - 225,266 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha22227,530 - 260,908 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.022144,381 - 208,578 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl22163,718 - 208,552 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12295,838 - 129,431 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.022145,387 - 179,042 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.022163,429 - 197,022 (+)NCBIUU_Cfam_GSD_1.0
Atp7b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945161,210,231 - 161,278,988 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365654,694,281 - 4,763,773 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365654,694,294 - 4,763,661 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ATP7B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1115,876,612 - 15,942,064 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11115,892,549 - 15,942,070 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21116,218,277 - 16,263,614 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ATP7B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1329,817,712 - 29,899,302 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl329,816,860 - 29,899,077 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605713,915,907 - 13,997,411 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Atp7b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247482,113,094 - 2,205,856 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247482,112,574 - 2,183,994 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Atp7b
510 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:356
Count of miRNA genes:198
Interacting mature miRNAs:229
Transcripts:ENSRNOT00000058072
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)161900443575226532Rat
6903294Stl30Serum triglyceride level QTL 302.60.0013blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)162515279370152793Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)163528887080288870Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)163775215682752156Rat
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)163775215682752156Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164239634584729064Rat
8694429Bw164Body weight QTL 16450.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)165272646484729064Rat
8694364Abfw7Abdominal fat weight QTL 712.220.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)165272646484729064Rat
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165272646484729064Rat
631525Pia14Pristane induced arthritis QTL 144.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)165571108783402471Rat
1298527Arunc2Aerobic running capacity QTL 22.9exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)166853271675029966Rat

Markers in Region
RH94694  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21670,022,578 - 70,022,768 (+)MAPPERmRatBN7.2
Rnor_6.01674,943,878 - 74,944,067NCBIRnor6.0
Rnor_5.01674,573,744 - 74,573,933UniSTSRnor5.0
RGSC_v3.41674,679,023 - 74,679,212UniSTSRGSC3.4
Celera1667,907,083 - 67,907,272UniSTS
RH 3.4 Map16664.21UniSTS
Cytogenetic Map16q12.2-q12.4UniSTS
Atp7b  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21669,987,114 - 69,987,972 (+)MAPPERmRatBN7.2
Rnor_6.01674,906,171 - 74,907,028NCBIRnor6.0
Rnor_5.01674,535,834 - 74,536,691UniSTSRnor5.0
RGSC_v3.41674,643,520 - 74,644,377UniSTSRGSC3.4
Celera1667,872,111 - 67,872,968UniSTS
Cytogenetic Map16q12.2-q12.4UniSTS


Genetic Models
This gene Atp7b is modified in the following models/strains:
LEC/Tj     LEC/Hok     WKAH.LEC-Atp7bhts/Tj    


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 2 41 41 3 41 1
Low 2 29 7 10 74 35 39 11
Below cutoff 12 9 6 8 9 1 8

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000058072   ⟹   ENSRNOP00000054880
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1669,986,513 - 70,023,636 (+)Ensembl
Rnor_6.0 Ensembl1674,865,516 - 74,944,935 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000089265   ⟹   ENSRNOP00000069905
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1669,973,188 - 70,023,636 (+)Ensembl
Rnor_6.0 Ensembl1674,886,719 - 74,945,286 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000109904   ⟹   ENSRNOP00000094594
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1669,951,778 - 70,023,636 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000118838   ⟹   ENSRNOP00000086033
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1669,952,286 - 70,023,636 (+)Ensembl
RefSeq Acc Id: NM_012511   ⟹   NP_036643
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81676,654,725 - 76,726,092 (+)NCBI
mRatBN7.21669,952,286 - 70,023,636 (+)NCBI
Rnor_6.01674,865,516 - 74,944,935 (+)NCBI
Rnor_5.01674,495,179 - 74,575,822 (+)NCBI
RGSC_v3.41674,607,988 - 74,680,080 (+)RGD
Celera1667,837,288 - 67,908,140 (+)RGD
Sequence:
RefSeq Acc Id: XM_017599991   ⟹   XP_017455480
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81676,675,876 - 76,726,091 (+)NCBI
mRatBN7.21669,972,856 - 70,024,404 (+)NCBI
Rnor_6.01674,886,737 - 74,944,934 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039094191   ⟹   XP_038950119
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81676,699,248 - 76,726,091 (+)NCBI
mRatBN7.21669,996,812 - 70,023,295 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_036643   ⟸   NM_012511
- UniProtKB: Q9JLY3 (UniProtKB/Swiss-Prot),   Q64535 (UniProtKB/Swiss-Prot),   Q63676 (UniProtKB/Swiss-Prot),   Q9QUG4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017455480   ⟸   XM_017599991
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JWJ5 (UniProtKB/TrEMBL),   F7FE99 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000054880   ⟸   ENSRNOT00000058072
RefSeq Acc Id: ENSRNOP00000069905   ⟸   ENSRNOT00000089265
RefSeq Acc Id: XP_038950119   ⟸   XM_039094191
- Peptide Label: isoform X2
RefSeq Acc Id: ENSRNOP00000094594   ⟸   ENSRNOT00000109904
RefSeq Acc Id: ENSRNOP00000086033   ⟸   ENSRNOT00000118838
Protein Domains
HMA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q64535-F1-model_v2 AlphaFold Q64535 1-1451 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700195
Promoter ID:EPDNEW_R10719
Type:initiation region
Name:Atp7b_1
Description:ATPase copper transporting beta
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01674,865,497 - 74,865,557EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2180 AgrOrtholog
BioCyc Gene G2FUF-10858 BioCyc
Ensembl Genes ENSRNOG00000012878 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000058072.4 UniProtKB/TrEMBL
  ENSRNOT00000089265.2 UniProtKB/TrEMBL
  ENSRNOT00000109904 ENTREZGENE
  ENSRNOT00000109904.1 UniProtKB/TrEMBL
  ENSRNOT00000118838.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.70.100 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.1110.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.1000 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Calcium-transporting ATPase, cytoplasmic transduction domain A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ATPase_P-typ_cyto_dom_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATPase_P-typ_P_site UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATPase_P-typ_TM_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATPase_P-typ_transduc_dom_A_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HAD-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HAD_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Heavy-metal-associated_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HMA_Cu_ion-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HMA_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HMA_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-typ_ATPase_IB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P_typ_ATPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P_typ_ATPase_HD_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24218 UniProtKB/TrEMBL
NCBI Gene 24218 ENTREZGENE
PANTHER ATP7, ISOFORM B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  COPPER-TRANSPORTING ATPASE 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam E1-E2_ATPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HMA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hydrolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB ATP7B RGD
PhenoGen Atp7b PhenoGen
PRINTS CATATPASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CUATPASEI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HATPASE UniProtKB/TrEMBL
PROSITE ATPASE_E1_E2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HMA_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HMA_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000012878 RatGTEx
Superfamily-SCOP SSF55008 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56784 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF81653 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF81665 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JWJ5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AMH8_RAT UniProtKB/TrEMBL
  A0A8I6GEJ1_RAT UniProtKB/TrEMBL
  A6IW89_RAT UniProtKB/TrEMBL
  A6IW90_RAT UniProtKB/TrEMBL
  ATP7B_RAT UniProtKB/Swiss-Prot
  F7FE99 ENTREZGENE, UniProtKB/TrEMBL
  Q63676 ENTREZGENE
  Q64535 ENTREZGENE
  Q9JLY3 ENTREZGENE
  Q9QUG4 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q63676 UniProtKB/Swiss-Prot
  Q9JLY3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-17 Atp7b  ATPase copper transporting beta  Atp7b  ATPase, Cu++ transporting, beta polypeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Atp7b  ATPase, Cu++ transporting, beta polypeptide    ATPase, Cu++ transporting, beta polypeptide (same as Wilson disease)  Name updated 625702 APPROVED
2002-06-10 Atp7b  ATPase, Cu++ transporting, beta polypeptide (same as Wilson disease)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease deletion of 900 bp of the coding region at the 3' end results in the rat model for Wilson disease 631728
gene_function copper transport ATPase 631728
gene_process necessary component of copper transport pathway 631728