Abcg3l3 (ATP-binding cassette, subfamily G (WHITE), member 3-like 3) - Rat Genome Database

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Gene: Abcg3l3 (ATP-binding cassette, subfamily G (WHITE), member 3-like 3) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Abcg3l3
Name: ATP-binding cassette, subfamily G (WHITE), member 3-like 3
RGD ID: 1564709
Description: Predicted to enable ATPase-coupled transmembrane transporter activity; efflux transmembrane transporter activity; and riboflavin transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in gout; hematologic cancer (multiple); renal cell carcinoma; and toxic encephalopathy. Orthologous to human ABCG2 (ATP binding cassette subfamily G member 2 (JR blood group)); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ATP-binding cassette, sub-family G (WHITE), member 3 family member; LOC305142; RGD1564709; similar to ATP-binding cassette, sub-family G (WHITE), member 3
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8145,148,826 - 5,196,890 (+)NCBIGRCr8
mRatBN7.2144,844,161 - 4,892,194 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl144,844,218 - 4,892,194 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx144,788,528 - 4,834,728 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0146,088,718 - 6,134,922 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0144,790,545 - 4,836,744 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0145,733,361 - 6,104,164 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl146,058,544 - 6,102,625 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0146,037,995 - 6,085,154 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4145,950,942 - 5,998,413 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera144,984,454 - 5,031,006 (+)NCBICelera
Cytogenetic Map14p22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Abcg3l3
402 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:137
Count of miRNA genes:109
Interacting mature miRNAs:121
Transcripts:ENSRNOT00000061267
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300159Bmd61Bone mineral density QTL 615.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
2300183Bmd60Bone mineral density QTL 605.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
619619Rf4Renal disease susceptibility QTL 44.10.002urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)14132754612Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141131407Rat
71115Niddm15Non-insulin dependent diabetes mellitus QTL 154.8blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14121760611030812Rat
70204Niddm20Non-insulin dependent diabetes mellitus QTL 205.10.000008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)14121760616960180Rat
724541Niddm53Non-insulin dependent diabetes mellitus QTL 530.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1438130749088978Rat
2293089Iddm31Insulin dependent diabetes mellitus QTL 314.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)14381307418274691Rat
2293089Iddm31Insulin dependent diabetes mellitus QTL 314.7blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)14381307418274691Rat
1300114Srn2Serum renin concentration QTL 23.27blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)14381307421217635Rat
70195Mcs8Mammary carcinoma susceptibility QTL 84.28mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)14381307424531477Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14381307430767156Rat

Markers in Region
RH134993  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2144,844,374 - 4,844,567 (+)MAPPERmRatBN7.2
Rnor_6.0146,058,738 - 6,058,930NCBIRnor6.0
Rnor_5.0146,038,140 - 6,038,332UniSTSRnor5.0
RGSC_v3.4145,951,087 - 5,951,279UniSTSRGSC3.4
RGSC_v3.4145,567,368 - 5,567,551UniSTSRGSC3.4
Celera144,984,599 - 4,984,791UniSTS
Celera144,649,045 - 4,649,229UniSTS
RH 3.4 Map1487.3UniSTS
Cytogenetic Map14p22UniSTS
RH139136  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2144,866,537 - 4,866,773 (+)MAPPERmRatBN7.2
Rnor_6.0146,077,869 - 6,078,104NCBIRnor6.0
Rnor_5.0146,058,862 - 6,059,097UniSTSRnor5.0
RGSC_v3.4145,974,299 - 5,974,534UniSTSRGSC3.4
Celera145,006,892 - 5,007,127UniSTS
RH 3.4 Map1486.4UniSTS
Cytogenetic Map14p22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 24 39 23 19 23 2 30 34 11
Low 19 18 18 18 8 10 72 5 7 8
Below cutoff 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000061267   ⟹   ENSRNOP00000057979
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl146,058,544 - 6,102,625 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000093929   ⟹   ENSRNOP00000089408
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl144,844,218 - 4,892,194 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000105825   ⟹   ENSRNOP00000087595
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl144,844,218 - 4,892,194 (+)Ensembl
RefSeq Acc Id: NM_001107205   ⟹   NP_001100675
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8145,148,931 - 5,195,350 (+)NCBI
mRatBN7.2144,844,230 - 4,890,654 (+)NCBI
Rnor_6.0146,058,593 - 6,102,621 (+)NCBI
Rnor_5.0146,037,995 - 6,085,154 (+)NCBI
RGSC_v3.4145,950,942 - 5,998,413 (+)RGD
Celera144,984,454 - 5,031,006 (+)RGD
Sequence:
RefSeq Acc Id: XM_039091817   ⟹   XP_038947745
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8145,166,853 - 5,196,890 (+)NCBI
mRatBN7.2144,857,800 - 4,892,194 (+)NCBI
RefSeq Acc Id: XM_039091819   ⟹   XP_038947747
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8145,148,826 - 5,187,462 (+)NCBI
mRatBN7.2144,844,161 - 4,882,766 (+)NCBI
RefSeq Acc Id: XM_063273045   ⟹   XP_063129115
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8145,166,824 - 5,196,890 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001100675 (Get FASTA)   NCBI Sequence Viewer  
  XP_038947745 (Get FASTA)   NCBI Sequence Viewer  
  XP_038947747 (Get FASTA)   NCBI Sequence Viewer  
  XP_063129115 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL99478 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000087595.1
  ENSRNOP00000089408
  ENSRNOP00000089408.1
Reference Protein Sequences
RefSeq Acc Id: NP_001100675   ⟸   NM_001107205
- UniProtKB: A0A8I6ACK9 (UniProtKB/TrEMBL),   A6K5Q8 (UniProtKB/TrEMBL),   A0A8I6A653 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000057979   ⟸   ENSRNOT00000061267
RefSeq Acc Id: XP_038947747   ⟸   XM_039091819
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038947745   ⟸   XM_039091817
- Peptide Label: isoform X1
RefSeq Acc Id: ENSRNOP00000087595   ⟸   ENSRNOT00000105825
RefSeq Acc Id: ENSRNOP00000089408   ⟸   ENSRNOT00000093929
RefSeq Acc Id: XP_063129115   ⟸   XM_063273045
- Peptide Label: isoform X1
Protein Domains
ABC transporter

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A896-F1-model_v2 AlphaFold D4A896 1-647 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699167
Promoter ID:EPDNEW_R9692
Type:initiation region
Name:Abcg3l3_1
Description:ATP-binding cassette, subfamily G , member 3-like 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0146,058,558 - 6,058,618EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1564709 AgrOrtholog
BioCyc Gene G2FUF-16525 BioCyc
Ensembl Genes ENSRNOG00000039890 Ensembl
  ENSRNOG00000069246 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000093929 ENTREZGENE
  ENSRNOT00000093929.1 UniProtKB/TrEMBL
  ENSRNOT00000105825.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
InterPro ABC_2_trans UniProtKB/TrEMBL
  ABC_transporter-like UniProtKB/TrEMBL
  ABCG_dom UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
KEGG Report rno:305142 UniProtKB/TrEMBL
NCBI Gene 305142 ENTREZGENE
PANTHER ABC TRANSPORTER G FAMILY MEMBER 28 UniProtKB/TrEMBL
  ATP-BINDING CASSETTE SUB-FAMILY G MEMBER 3 UniProtKB/TrEMBL
Pfam ABC2_membrane UniProtKB/TrEMBL
  ABC2_membrane_7 UniProtKB/TrEMBL
  ABC_tran UniProtKB/TrEMBL
PhenoGen Abcg3l3 PhenoGen
PROSITE ABC_TRANSPORTER_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000039890 RatGTEx
  ENSRNOG00000069246 RatGTEx
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt A0A8I6A653 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ACK9 ENTREZGENE, UniProtKB/TrEMBL
  A6K5Q8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 RGD1564709  similar to ATP-binding cassette, sub-family G (WHITE), member 3   RGD1564709_predicted  similar to ATP-binding cassette, sub-family G (WHITE), member 3 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1564709_predicted  similar to ATP-binding cassette, sub-family G (WHITE), member 3 (predicted)  LOC305142  similar to ATP-binding cassette, sub-family G (WHITE), member 3  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC305142  similar to ATP-binding cassette, sub-family G (WHITE), member 3      Symbol and Name status set to provisional 70820 PROVISIONAL