Rapsn (receptor-associated protein of the synapse)

Gene: Rapsn (receptor-associated protein of the synapse) Rattus norvegicus

Analyze

Symbol:

Rapsn

Name:

receptor-associated protein of the synapse

RGD ID:

1311592

Description:

Enables ionotropic glutamate receptor binding activity. Involved in establishment of protein localization to postsynaptic membrane; positive regulation of neuromuscular synaptic transmission; and regulation of postsynaptic membrane organization. Located in neuromuscular junction. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 11 and fetal akinesia deformation sequence syndrome 2. Orthologous to human RAPSN (receptor associated protein of the synapse); PARTICIPATES IN acetylcholine signaling pathway via nicotinic acetylcholine receptor; INTERACTS WITH atrazine; bisphenol A; cadmium dichloride.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

43 kDa receptor-associated protein of the synapse; LOC362161; rapsyn; receptor-associated protein of the synapse, 43 kDa

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	RAPSN (receptor associated protein of the synapse)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther
Mus musculus (house mouse):	Rapsn (receptor-associated protein of the synapse)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Rapsn (receptor associated protein of the synapse)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	RAPSN (receptor associated protein of the synapse)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	RAPSN (receptor associated protein of the synapse)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Rapsn (receptor associated protein of the synapse)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	RAPSN (receptor associated protein of the synapse)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Rapsn (receptor associated protein of the synapse)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	PUDP (pseudouridine 5'-phosphatase)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	RAPSN (receptor associated protein of the synapse)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Rapsn (receptor-associated protein of the synapse)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	rapsn (receptor-associated protein of the synapse, 43kD)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG1909	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	rpy-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	rapsn	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	97,470,891 - 97,480,196 (+)	NCBI		GRCr8
mRatBN7.2	3	77,015,073 - 77,024,378 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	76,983,471 - 77,024,373 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	80,493,612 - 80,502,907 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	89,092,627 - 89,101,922 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	86,943,726 - 86,953,069 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	79,859,815 - 79,869,486 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	79,860,179 - 79,869,524 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	86,568,568 - 86,578,239 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	75,396,836 - 75,406,115 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	75,293,208 - 75,302,485 (+)	NCBI
Celera	3	76,223,882 - 76,233,161 (+)	NCBI		Celera
Cytogenetic Map	3	q24	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autoimmune disease (ISO)

congenital disorder of glycosylation type IIc (ISO)

congenital myasthenic syndrome (ISO)

congenital myasthenic syndrome 11 (ISO,ISS)

congenital myasthenic syndrome 4C (ISO)

Congenital Myasthenic Syndrome, with Facial Dysmorphism, associated with Acetylcholine Receptor Deficiency (ISO)

Developmental Disabilities (ISO)

Experimental Autoimmune Myasthenia Gravis (IEP)

fetal akinesia deformation sequence syndrome (ISO)

fetal akinesia deformation sequence syndrome 1 (ISO)

fetal akinesia deformation sequence syndrome 2 (ISO)

genetic disease (ISO)

Hydrops Fetalis (ISO)

hypertrophic cardiomyopathy (ISO)

intellectual disability (ISO)

muscular disease (ISO)

myopathy (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

aristolochic acid A (ISO)

atrazine (EXP)

benzo[a]pyrene (ISO)

bisphenol A (EXP)

cadmium dichloride (EXP)

cyclophosphamide (EXP)

endosulfan (EXP)

fenvalerate (EXP)

folic acid (ISO)

furan (EXP)

gentamycin (EXP)

ozone (ISO)

perfluorohexanesulfonic acid (ISO)

phenylephrine (EXP)

quercetin (ISO)

tamoxifen (ISO)

tetrachloromethane (ISO)

titanium dioxide (ISO)

triptonide (ISO)

urethane (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

establishment of protein localization to postsynaptic membrane (IMP)

motor neuron apoptotic process (ISO)

neuromuscular junction development (ISO)

neurotransmitter receptor localization to postsynaptic specialization membrane (ISO)

positive regulation of motor neuron apoptotic process (ISO)

positive regulation of neuromuscular synaptic transmission (IBA,IMP)

regulation of postsynaptic membrane organization (IMP)

skeletal muscle acetylcholine-gated channel clustering (ISO)

synaptic transmission, cholinergic (IBA,ISO)

Cellular Component

centrosome (IEA,ISO)

cytosol (IEA,ISO)

Golgi apparatus (ISO)

membrane (ISO)

neuromuscular junction (IBA,IDA,ISO)

plasma membrane (IBA,ISO)

postsynaptic membrane (ISO)

postsynaptic specialization membrane (ISO)

synapse (ISO)

Molecular Function

acetylcholine receptor binding (IBA,ISO)

ionotropic glutamate receptor binding (IPI)

metal ion binding (IEA)

protein binding (ISO)

protein-macromolecule adaptor activity (ISO)

protein-membrane adaptor activity (IEA)

structural constituent of postsynaptic specialization (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

acetylcholine signaling pathway via nicotinic acetylcholine receptor (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Glutamatergic reinnervation and assembly of glutamatergic synapses in adult rat skeletal muscle occurs at cholinergic endplates.	Francolini M, etal., J Neuropathol Exp Neurol. 2009 Oct;68(10):1103-15.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	Silencing rapsyn in vivo decreases acetylcholine receptors and augments sodium channels and secondary postsynaptic membrane folding.	Martinez-Martinez P, etal., Neurobiol Dis. 2009 Jul;35(1):14-23. doi: 10.1016/j.nbd.2009.03.008. Epub 2009 Apr 1.
5.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
6.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
7.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
9.	The neuromuscular junction: selective remodeling of synaptic regulators at the nerve/muscle interface.	Witzemann V, etal., Mech Dev. 2013 Jun-Aug;130(6-8):402-11. doi: 10.1016/j.mod.2012.09.004. Epub 2012 Sep 29.

Additional References at PubMed

PMID:8416841	PMID:11312299	PMID:12388596	PMID:12486121	PMID:17119023	PMID:18420419	PMID:20053883	PMID:27225759

Genomics

Comparative Map Data

Rapsn
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	97,470,891 - 97,480,196 (+)	NCBI		GRCr8
mRatBN7.2	3	77,015,073 - 77,024,378 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	76,983,471 - 77,024,373 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	80,493,612 - 80,502,907 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	89,092,627 - 89,101,922 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	86,943,726 - 86,953,069 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	79,859,815 - 79,869,486 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	79,860,179 - 79,869,524 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	86,568,568 - 86,578,239 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	75,396,836 - 75,406,115 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	75,293,208 - 75,302,485 (+)	NCBI
Celera	3	76,223,882 - 76,233,161 (+)	NCBI		Celera
Cytogenetic Map	3	q24	NCBI

RAPSN
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	47,437,764 - 47,449,136 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	47,437,764 - 47,449,143 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	47,459,315 - 47,470,688 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	47,415,891 - 47,427,306 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	11	47,415,890 - 47,427,306	NCBI
Celera	11	47,601,051 - 47,612,463 (-)	NCBI		Celera
Cytogenetic Map	11	p11.2	NCBI
HuRef	11	47,159,075 - 47,170,494 (-)	NCBI		HuRef
CHM1_1	11	47,458,570 - 47,469,991 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	11	47,597,603 - 47,608,976 (-)	NCBI		T2T-CHM13v2.0

Rapsn
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	90,864,594 - 90,876,074 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	90,865,965 - 90,876,074 (+)	Ensembl		GRCm39 Ensembl
GRCm38	2	91,035,472 - 91,045,729 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	91,035,620 - 91,045,729 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	90,875,784 - 90,885,886 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	90,836,478 - 90,846,568 (+)	NCBI		MGSCv36	mm8
Celera	2	92,420,152 - 92,430,248 (+)	NCBI		Celera
Cytogenetic Map	2	E1	NCBI
cM Map	2	50.44	NCBI

Rapsn
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955422	826,727 - 834,289 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955422	826,556 - 834,483 (+)	NCBI	ChiLan1.0	ChiLan1.0

RAPSN
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	49,642,069 - 49,656,586 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	49,661,853 - 49,676,291 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	47,387,324 - 47,398,579 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	47,940,530 - 47,951,667 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	47,940,530 - 47,951,667 (-)	Ensembl	panpan1.1		panPan2

RAPSN
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	18	42,199,160 - 42,210,668 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	18	42,199,412 - 42,210,673 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	18	40,930,029 - 40,941,208 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	18	42,855,197 - 42,866,378 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	18	42,855,420 - 42,866,216 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	18	42,341,801 - 42,352,980 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	18	41,896,689 - 41,907,866 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	18	42,626,215 - 42,637,394 (+)	NCBI		UU_Cfam_GSD_1.0

Rapsn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	19,680,416 - 19,692,511 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936562	1,795,905 - 1,804,181 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936562	1,796,087 - 1,804,153 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

RAPSN
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	17,867,721 - 17,887,162 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	17,868,888 - 17,887,164 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666038	115,165,684 - 115,176,850 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Rapsn
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624767	1,351,370 - 1,358,187 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624767	1,350,820 - 1,358,107 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Rapsn
40 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	76
Count of miRNA genes:	65
Interacting mature miRNAs:	72
Transcripts:	ENSRNOT00000068444
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2290452	Scl56	Serum cholesterol level QTL 56	2.26		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	3	1	91609953	Rat
1358905	Hrtrt17	Heart rate QTL 17	5.9	0.000014	heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	3	10861912	89878372	Rat
1358885	Bp251	Blood pressure QTL 251	3.8		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	14489145	121056321	Rat
1358888	Bp264	Blood pressure QTL 264	4.43		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	14489145	121056321	Rat
737818	Hcar12	Hepatocarcinoma resistance QTL 12	2.6		liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	3	29463235	118376539	Rat
61419	Cia11	Collagen induced arthritis QTL 11	5.6		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	3	30356773	98535386	Rat
70216	Cm14	Cardiac mass QTL 14	2.1		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	31172320	163586636	Rat
1354589	Bw31	Body weight QTL 31	3.3		body mass (VT:0001259)	body weight (CMO:0000012)	3	33703347	78196190	Rat
1354604	Bw36	Body weight QTL 36	2.9		body mass (VT:0001259)	body weight (CMO:0000012)	3	33703347	104104347	Rat
1358362	Srcrt2	Stress Responsive Cort QTL 2	2.78		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	3	38192233	133483320	Rat
738019	Anxrr10	Anxiety related response QTL 10	3.9		exploratory behavior trait (VT:0010471)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	3	38517803	83517803	Rat
1331777	Bw24	Body weight QTL 24	3.503		body mass (VT:0001259)	body weight (CMO:0000012)	3	39454637	89115240	Rat
1331795	Rf30	Renal function QTL 30	3.708		urine potassium amount (VT:0010539)	urine potassium level (CMO:0000128)	3	39454637	89115240	Rat
1354597	Kidm13	Kidney mass QTL 13	2.9		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	3	41874578	104104347	Rat
2301970	Bw81	Body weight QTL 81	5.19		body mass (VT:0001259)	body weight (CMO:0000012)	3	41874578	155617519	Rat
2301971	Cm71	Cardiac mass QTL 71	4.63		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	3	41874578	155617519	Rat
1300178	Hrtrt4	Heart rate QTL 4	3.74		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	3	43827364	90905114	Rat
1581503	Cm58	Cardiac mass QTL 58	2.7	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	43827364	121056321	Rat
1559282	Emca5	Estrogen-induced mammary cancer QTL 5	3.9		mammary gland integrity trait (VT:0010552)	percentage of study population developing mammary tumors during a period of time (CMO:0000948)	3	43827364	169034231	Rat
2292591	Esta4	Estrogen-induced thymic atrophy QTL 4			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	3	47233211	147415807	Rat
1358186	Ept2	Estrogen-induced pituitary tumorigenesis QTL 2	8.3		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	47233430	110362260	Rat
2292613	Ept16	Estrogen-induced pituitary tumorigenesis QTL 16	8.3		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	47233430	110362260	Rat
631665	Bw8	Body weight QTL 8	5.5		body mass (VT:0001259)	body weight (CMO:0000012)	3	50437042	119183768	Rat
724523	Tsu1	Thymus enlargement suppressive QTL 1	3.84		thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	3	50437504	115638231	Rat
1582218	Bw74	Body weight QTL 74	3.9	0.0021	body mass (VT:0001259)	body weight (CMO:0000012)	3	53184593	115665732	Rat
1582238	Bw68	Body weight QTL 68	3.2	0.0064	body mass (VT:0001259)	body weight (CMO:0000012)	3	53184593	115665732	Rat
1582239	Epfw1	Epididymal fat weight QTL 1	4.5	0.0006	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	3	53184593	115665732	Rat
61377	Edpm3	Estrogen-dependent pituitary mass QTL 3	7.05	0.038	pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	53184692	89878207	Rat
731180	Bp152	Blood pressure QTL 152		0.03	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	53781112	91609953	Rat
731180	Bp152	Blood pressure QTL 152		0.03	arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	3	53781112	91609953	Rat
731180	Bp152	Blood pressure QTL 152		0.03	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	53781112	91609953	Rat
1581568	Rf53	Renal function QTL 53			urine total protein amount (VT:0000032)	urine protein excretion rate to body weight ratio (CMO:0001099)	3	56395968	161299569	Rat
8662816	Vetf4	Vascular elastic tissue fragility QTL 4	4		renal artery integrity trait (VT:0010642)	number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)	3	59242096	157323038	Rat
1300111	Rf12	Renal function QTL 12	3.78		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	3	61017749	121056321	Rat
631200	Cm25	Cardiac mass QTL 25	4.8	0.0001	heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	3	61134348	89115068	Rat
1582210	Bw71	Body weight QTL 71	3.3	0.0012	body mass (VT:0001259)	body weight (CMO:0000012)	3	64655305	115665732	Rat
1582221	Kidm30	Kidney mass QTL 30	3.5	0.0008	kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	3	64655305	115665732	Rat
12879848	Bw181	Body weght QTL 181		0.015	body mass (VT:0001259)	body weight (CMO:0000012)	3	70348525	121056321	Rat
2301414	Kidm37	Kidney mass QTL 37		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	3	70653097	121056321	Rat
1600376	Arunc5	Aerobic running capacity QTL 5		0.21	exercise endurance trait (VT:0002332)	maximum distance run on treadmill (CMO:0001406)	3	73376539	118376539	Rat

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium		15					5	8		8	3		5
Low	2	28	26	10	18	10	3	3	54	27	38	11	3
Below cutoff	1		30	30	1	30			20

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001108584	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001399728	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039105428	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473949	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000068444 ⟹ ENSRNOP00000060958

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	77,015,094 - 77,024,373 (+)	Ensembl
Rnor_6.0 Ensembl	3	79,860,207 - 79,869,486 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000081160 ⟹ ENSRNOP00000075166

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	76,983,471 - 77,024,369 (+)	Ensembl
Rnor_6.0 Ensembl	3	79,860,179 - 79,869,524 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000103028 ⟹ ENSRNOP00000092830

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	76,983,471 - 77,024,369 (+)	Ensembl

RefSeq Acc Id:

NM_001108584 ⟹ NP_001102054

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	97,470,891 - 97,480,196 (+)	NCBI
mRatBN7.2	3	77,015,073 - 77,024,378 (+)	NCBI
Rnor_6.0	3	79,860,207 - 79,869,486 (+)	NCBI
Rnor_5.0	3	86,568,568 - 86,578,239 (+)	NCBI
RGSC_v3.4	3	75,396,836 - 75,406,115 (+)	RGD
Celera	3	76,223,882 - 76,233,161 (+)	RGD

Sequence:

show sequence

TGTTCCCAGGGTGGCGCCCGTTGTCCATCCAGGCCCTGCTTAGCTTTTGCCTGGTGTTGCTTTT
CCCTCCCAGAGATCAGCTGGCACTGTGGGTCCAACACCATGAAGGTCTAAAGACACCTAGCCAA
CCACGGTCTTTCCGAGTGGCCAGACTGTGGGAGGATGGGGCAGGACCAGACAAAGCAACAGATC
GAAAAAGGACTGCAGCTGTACCAGTCCAACCAGACAGAGAAGGCACTGCAAGTGTGGATGAAGG
TGCTGGAGAAGGGCTCTGACCTCGTGGGCCGCTTCCGGGTGCTGGGCTGCTTGGTAACAGCTCA
CTCGGAGATGGGCCGCTACAAAGAGATGCTGAAGTTTGCCGTGGTCCAGATCGACACTGCTCGG
GAACTGGAGGATGCGGATTTCCTGCTCGAAAGCTACCTGAACCTGGCACGCAGCAATGAGAAGC
TATGTGAGTTTCACAAAACCATCTCCTACTGCAAGACCTGCCTCGGCCTGCCTGGCACCAGGGC
TGGTGCCCAGCTTGGGGGTCAGGTCAGCCTGAGCATGGGCAATGCTTTCCTGGGCCTCAGCCTC
TTCCAGAAGGCCCTAGAGAGCTTTGAGAAGGCCCTGCGCTATGCCCACAACAATGATGACACCA
TGCTGGAGTGCCGCGTCTGCTGCAGCCTGGGCAGTTTCTACGCCCAGGTCAAGGAGTCCATGAA
GATTGCCCTGCAGCATGGTGACCGCCCACTGCAAGCACTCTGTCTGCTCTGCTTTGCCGATATC
CACCGGAGCCGTGGGGACCTGGAGACAGCCTTCCCTAGGTACGATTCCGCTATGAGCATCATGA
CCGAGATCGGAAACCGCCTGGGGCAAGTGCATGTGCTGCTGGGTGTGGCCAAGTGCTGGATAGC
CAGGAAAGTGCTGGACAAGGCTTTGGATGCCATTGAGAAAGCCCAGGACCTGGCTGAAGAGGTT
GGAAATAAGCTGAGCCAGCTCAAGCTGCACTGCCTGAGTGAGGGCATCTGCCGCAGCAAGGGGC
TGCAGCGTGAGCTGCGCGCGCATGTAGTGAGGTTCCACGAGTGCGTGGAGGAGACTGAGCTCTA
CTGTGGCCTCTGTGGTGAGTCCATTGGGGAGAAGAACAGCCGGCTGCAGGCCCTGCCCTGCTCC
CACATCTTTCATCTCAGATGCCTGCAAAACAACGGCACTAGGAGTTGCCCCAACTGCCGCCGCT
CCTCCATGAAGCCAGGCTTTGTGTGACCTCAGTGGCCATCTTGGCACCTCCACCATCAAGCTGG
AGGCCCTGGTGAAATCCTAGGGTAGCAGCCAGGACCTCCACAGCCAACTCAGGGCCAGAGGCCT
GCCTGCTGCTCCTCTGGGCCTACCTCCCCTCCCTTGCCTCTTTGTACTTTGTTCTTTATAGAAA
AATAAAATGTTTCTACCTGGTG

hide sequence

RefSeq Acc Id:

NM_001399728 ⟹ NP_001386657

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	97,470,891 - 97,480,196 (+)	NCBI
mRatBN7.2	3	77,015,073 - 77,024,378 (+)	NCBI

RefSeq Acc Id:

XM_039105428 ⟹ XP_038961356

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	97,471,248 - 97,480,189 (+)	NCBI
mRatBN7.2	3	77,015,427 - 77,024,371 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001102054	(Get FASTA)	NCBI Sequence Viewer
	NP_001386657	(Get FASTA)	NCBI Sequence Viewer
	XP_038961356	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL79499	(Get FASTA)	NCBI Sequence Viewer
	EDL79500	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000060958
	ENSRNOP00000060958.1
	ENSRNOP00000075166
	ENSRNOP00000075166.1
	ENSRNOP00000092830.1

RefSeq Acc Id:	NP_001102054 ⟸ NM_001108584
- Peptide Label:	isoform 2
- UniProtKB:	D3ZPG2 (UniProtKB/TrEMBL), A6HN99 (UniProtKB/TrEMBL), A0A8I6AIQ1 (UniProtKB/TrEMBL)
- Sequence:	show sequence MGQDQTKQQIEKGLQLYQSNQTEKALQVWMKVLEKGSDLVGRFRVLGCLVTAHSEMGRYKEMLK FAVVQIDTARELEDADFLLESYLNLARSNEKLCEFHKTISYCKTCLGLPGTRAGAQLGGQVSLS MGNAFLGLSLFQKALESFEKALRYAHNNDDTMLECRVCCSLGSFYAQVKESMKIALQHGDRPLQ ALCLLCFADIHRSRGDLETAFPRYDSAMSIMTEIGNRLGQVHVLLGVAKCWIARKVLDKALDAI EKAQDLAEEVGNKLSQLKLHCLSEGICRSKGLQRELRAHVVRFHECVEETELYCGLCGESIGEK NSRLQALPCSHIFHLRCLQNNGTRSCPNCRRSSMKPGFV hide sequence

RefSeq Acc Id:

ENSRNOP00000060958 ⟸ ENSRNOT00000068444

RefSeq Acc Id:

ENSRNOP00000075166 ⟸ ENSRNOT00000081160

RefSeq Acc Id:	XP_038961356 ⟸ XM_039105428
- Peptide Label:	isoform X1

RefSeq Acc Id:

ENSRNOP00000092830 ⟸ ENSRNOT00000103028

RefSeq Acc Id:	NP_001386657 ⟸ NM_001399728
- Peptide Label:	isoform 1
- UniProtKB:	A0A0G2K9X2 (UniProtKB/TrEMBL), A6HN98 (UniProtKB/TrEMBL)

Protein Domains

RING-type

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-A0A0G2K9X2-F1-model_v2	AlphaFold	A0A0G2K9X2	1-412	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13692203

Promoter ID:

EPDNEW_R2728

Type:

single initiation site

Name:

Rapsn_1

Description:

receptor-associated protein of the synapse

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	3	79,860,208 - 79,860,268	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1311592	AgrOrtholog
BioCyc Gene	G2FUF-48754	BioCyc
Ensembl Genes	ENSRNOG00000011208	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000068444	ENTREZGENE
	ENSRNOT00000068444.2	UniProtKB/TrEMBL
	ENSRNOT00000081160	ENTREZGENE
	ENSRNOT00000081160.2	UniProtKB/TrEMBL
	ENSRNOT00000103028.1	UniProtKB/TrEMBL
Gene3D-CATH	1.25.40.10	UniProtKB/TrEMBL
	3.30.40.10	UniProtKB/TrEMBL
InterPro	Postsynaptic	UniProtKB/TrEMBL
	Postsynaptic_CS	UniProtKB/TrEMBL
	Rapsyn_myristoylation/link_N	UniProtKB/TrEMBL
	TPR-like_helical	UniProtKB/TrEMBL
	TPR_repeat	UniProtKB/TrEMBL
	Znf_RING	UniProtKB/TrEMBL
	Znf_RING/FYVE/PHD	UniProtKB/TrEMBL
KEGG Report	rno:362161	UniProtKB/TrEMBL
NCBI Gene	362161	ENTREZGENE
PANTHER	43 KDA RECEPTOR-ASSOCIATED PROTEIN OF THE SYNAPSE	UniProtKB/TrEMBL
	43 KDA RECEPTOR-ASSOCIATED PROTEIN OF THE SYNAPSE	UniProtKB/TrEMBL
Pfam	Rapsyn_N	UniProtKB/TrEMBL
	TPR_8	UniProtKB/TrEMBL
	TPR_MalT	UniProtKB/TrEMBL
	zf-RING_2	UniProtKB/TrEMBL
PhenoGen	Rapsn	PhenoGen
PRINTS	POSTSYNAPTIC	UniProtKB/TrEMBL
PROSITE	43_KD_POSTSYNAPTIC	UniProtKB/TrEMBL
	TPR	UniProtKB/TrEMBL
	ZF_RING_2	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000011208	RatGTEx
SMART	RING	UniProtKB/TrEMBL
	TPR	UniProtKB/TrEMBL
Superfamily-SCOP	RING/U-box	UniProtKB/TrEMBL
	SSF48452	UniProtKB/TrEMBL
UniProt	A0A0G2K9X2	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6AIQ1	ENTREZGENE, UniProtKB/TrEMBL
	A6HN98	ENTREZGENE, UniProtKB/TrEMBL
	A6HN99	ENTREZGENE, UniProtKB/TrEMBL
	D3ZPG2	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-04-30	Rapsn	receptor-associated protein of the synapse	Rapsn_predicted	receptor-associated protein of the synapse (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Rapsn_predicted	receptor-associated protein of the synapse (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

RGD Manual Annotations

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