Cldn4 (claudin 4) - Rat Genome Database

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Gene: Cldn4 (claudin 4) Rattus norvegicus
Analyze
Symbol: Cldn4
Name: claudin 4
RGD ID: 1307932
Description: Predicted to enable chloride channel activity. Involved in circadian rhythm; female pregnancy; and response to progesterone. Located in several cellular components, including apicolateral plasma membrane; basal plasma membrane; and lateral plasma membrane. Biomarker of peptic esophagitis. Human ortholog(s) of this gene implicated in ovarian cancer and pancreatic cancer. Orthologous to human CLDN4 (claudin 4); PARTICIPATES IN hepatitis C pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 2-acetamidofluorene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: claudin-4; LOC304407
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81227,388,160 - 27,389,958 (+)NCBIGRCr8
mRatBN7.21221,751,638 - 21,753,436 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1221,751,331 - 21,753,436 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1222,892,308 - 22,894,101 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01223,504,632 - 23,506,425 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01222,572,828 - 22,574,626 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01224,761,210 - 24,763,008 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1224,761,210 - 24,763,005 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01226,761,480 - 26,763,278 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41222,816,134 - 22,817,932 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11222,686,996 - 22,688,792 (+)NCBI
Celera1223,512,667 - 23,514,465 (+)NCBICelera
Cytogenetic Map12q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-acetamidofluorene  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
acetamide  (EXP)
acrolein  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP,ISO)
Altertoxin II  (ISO)
anthocyanin  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
butanal  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
chloroprene  (ISO)
chlorpyrifos  (EXP,ISO)
choline  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclophosphamide  (EXP)
cyclosporin A  (EXP,ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
diallyl disulfide  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dibenziodolium  (EXP)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (EXP)
dioxygen  (ISO)
diquat  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
ethanol  (ISO)
flavonoids  (ISO)
folic acid  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glutathione  (EXP)
inulin  (ISO)
L-methionine  (ISO)
leuprolide  (ISO)
manganese(II) chloride  (EXP)
megestrol acetate  (ISO)
melanins  (ISO)
mercury dibromide  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Monobutylphthalate  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-acetylsphingosine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
naphthalene  (ISO)
nicotine  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (EXP)
paraquat  (EXP)
patulin  (ISO)
PCB138  (ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosgene  (ISO)
phoxim  (EXP)
pirinixic acid  (ISO)
progesterone  (ISO)
propanal  (ISO)
quercetin  (EXP,ISO)
quercitrin  (ISO)
rottlerin  (ISO)
sanguinarine  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
simvastatin  (EXP)
sodium arsenite  (ISO)
sodium chloride  (EXP)
sulforaphane  (ISO)
T-2 toxin  (ISO)
tacrolimus hydrate  (EXP)
tamoxifen  (ISO)
testosterone  (ISO)
tetrathiomolybdate(2-)  (ISO)
thalidomide  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tributylstannane  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vanadyl sulfate  (ISO)
vitamin E  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Distribution of the tight junction proteins ZO-1, occludin, and claudin-4, -8, and -12 in bladder epithelium. Acharya P, etal., Am J Physiol Renal Physiol. 2004 Aug;287(2):F305-18. Epub 2004 Apr 6.
2. Altered localization and expression of tight-junction proteins in a rat model with chronic acid reflux esophagitis. Asaoka D, etal., J Gastroenterol. 2005 Aug;40(8):781-90.
3. [Claudin expression in different pancreatic cancers and its significance in differential diagnostics]. Borka K, Magy Onkol. 2009 Sep;53(3):273-8. doi: 10.1556/MOnkol.53.2009.3.7.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Different changes in the expression of multiple kinds of tight-junction proteins during ischemia-reperfusion injury of the rat ileum. Inoue K, etal., Acta Histochem Cytochem. 2006 Apr 22;39(2):35-45. Epub 2006 Mar 17.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Ovarian hormones control the changing expression of claudins and occludin in rat uterine epithelial cells during early pregnancy. Nicholson MD, etal., Acta Histochem. 2010;112(1):42-52. Epub 2009 Jun 24.
9. Tissue-specific expression of the tight junction proteins claudins and occludin in the rat salivary glands. Peppi M and Ghabriel MN, J Anat. 2004 Oct;205(4):257-66.
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. GOA pipeline RGD automated data pipeline
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Comprehensive gene review and curation RGD comprehensive gene curation
14. Therapeutic antitumor efficacy of monoclonal antibody against Claudin-4 for pancreatic and ovarian cancers. Suzuki M, etal., Cancer Sci. 2009 Sep;100(9):1623-30. Epub 2009 Jun 1.
15. Distinct expression patterns of claudin-1 and claudin-4 in intraductal papillary-mucinous tumors of the pancreas. Tsukahara M, etal., Pathol Int. 2005 Feb;55(2):63-9.
16. E-cadherin and claudin-4 expression has circadian rhythm in adult rat kidney. Yamato M, et al., J Nephrol. 2010 Jan-Feb;23(1):102-10.
Additional References at PubMed
PMID:9892664   PMID:12477932   PMID:15602007   PMID:15775979   PMID:16103090   PMID:16520537   PMID:16670314   PMID:17964719   PMID:18036336   PMID:18774778   PMID:18855016   PMID:19447895  
PMID:20375010   PMID:20921420   PMID:21388515   PMID:21515662   PMID:22696678   PMID:23407391   PMID:23610556   PMID:23816505   PMID:23963446   PMID:25503106   PMID:28493961   PMID:29179201  
PMID:30734065   PMID:33343804   PMID:37866316  


Genomics

Comparative Map Data
Cldn4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81227,388,160 - 27,389,958 (+)NCBIGRCr8
mRatBN7.21221,751,638 - 21,753,436 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1221,751,331 - 21,753,436 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1222,892,308 - 22,894,101 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01223,504,632 - 23,506,425 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01222,572,828 - 22,574,626 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01224,761,210 - 24,763,008 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1224,761,210 - 24,763,005 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01226,761,480 - 26,763,278 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41222,816,134 - 22,817,932 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11222,686,996 - 22,688,792 (+)NCBI
Celera1223,512,667 - 23,514,465 (+)NCBICelera
Cytogenetic Map12q12NCBI
CLDN4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38773,830,996 - 73,832,690 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl773,799,542 - 73,832,690 (+)EnsemblGRCh38hg38GRCh38
GRCh37773,245,326 - 73,247,020 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36772,883,129 - 72,884,951 (+)NCBINCBI36Build 36hg18NCBI36
Build 34772,689,843 - 72,691,665NCBI
Celera768,723,847 - 68,725,669 (+)NCBICelera
Cytogenetic Map7q11.23NCBI
HuRef769,128,478 - 69,130,300 (+)NCBIHuRef
CHM1_1773,390,573 - 73,392,395 (+)NCBICHM1_1
T2T-CHM13v2.0775,031,891 - 75,033,585 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2772,578,265 - 72,580,087 (+)NCBI
Cldn4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395134,973,977 - 134,975,788 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5134,973,973 - 134,975,788 (-)EnsemblGRCm39 Ensembl
GRCm385134,945,123 - 134,946,934 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5134,945,119 - 134,946,934 (-)EnsemblGRCm38mm10GRCm38
MGSCv375135,420,993 - 135,422,804 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365135,229,754 - 135,231,542 (-)NCBIMGSCv36mm8
Celera5131,955,947 - 131,957,758 (-)NCBICelera
Cytogenetic Map5G2NCBI
cM Map574.9NCBI
Cldn4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545613,962,497 - 13,963,126 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545613,961,743 - 13,965,498 (-)NCBIChiLan1.0ChiLan1.0
CLDN4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2691,069,664 - 91,070,822 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17139,333,445 - 139,338,058 (-)NCBINHGRI_mPanPan1
PanPan1.1780,981,237 - 80,985,320 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl780,983,832 - 80,984,461 (+)Ensemblpanpan1.1panPan2
CLDN4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.166,492,706 - 6,506,750 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl66,493,513 - 6,494,145 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha68,190,345 - 8,192,020 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.066,307,743 - 6,309,418 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.166,297,469 - 6,299,144 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.066,245,334 - 6,247,009 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.066,409,111 - 6,410,786 (-)NCBIUU_Cfam_GSD_1.0
Cldn4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344131,050,004 - 131,051,960 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365432,984,996 - 2,985,625 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365432,984,797 - 2,986,563 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CLDN4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl311,039,706 - 11,053,925 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1311,039,711 - 11,053,930 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2310,776,896 - 10,788,804 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CLDN4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1289,242,054 - 9,244,972 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl289,242,909 - 9,243,538 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660707,261,229 - 7,265,337 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cldn4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474014,033,848 - 14,035,854 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cldn4
12 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:103
Count of miRNA genes:88
Interacting mature miRNAs:92
Transcripts:ENSRNOT00000002003
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10755457Coatc14Coat color QTL 140.01759coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)12122591684Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12123297788Rat
1581516Cm56Cardiac mass QTL 564.20.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)12129333307Rat
1598855Bp294Blood pressure QTL 2943.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12134851688Rat
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6556449546669029Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12610757946669029Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat
2293086Iddm30Insulin dependent diabetes mellitus QTL 303.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12844949028302290Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12852542328064601Rat
1300157Rf21Renal function QTL 214.4renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)12931821632103380Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121047413746669029Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121047413746669029Rat
1331786Kidm11Kidney mass QTL 113.571kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)121107382524234895Rat
1331755Bp219Blood pressure QTL 2193.041arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382528064557Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382545055165Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121235161946669029Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121281238546669029Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121281238546669029Rat
1549902Bp269Blood pressure QTL 269arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121318273646669029Rat
1549912Bp268Blood pressure QTL 268arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)101318273646669029Rat
2302060Pia37Pristane induced arthritis QTL 376.10.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)121319815746669029Rat
61416Pia4Pristane induced arthritis QTL 48.4joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)121363552330827399Rat
61421Cia12Collagen induced arthritis QTL 124.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121363552335682913Rat
631543Bp83Blood pressure QTL 835.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121555082638478808Rat
2293684Bmd26Bone mineral density QTL 264.40.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)121587265332974238Rat
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)121914436246669029Rat
2306789Ean6Experimental allergic neuritis QTL 64.9nervous system integrity trait (VT:0010566)experimental autoimmune neuritis severity score (CMO:0001528)121961087024139202Rat
737822Alc10Alcohol consumption QTL 102.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)121961087040218516Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121961087042828880Rat
61324Eae5Experimental allergic encephalomyelitis QTL 514nervous system integrity trait (VT:0010566)percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402)121961087046669029Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121961088935682913Rat
70213Niddm27Non-insulin dependent diabetes mellitus QTL 273.72blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121983578938193007Rat
631521Pia12Pristane induced arthritis QTL 128.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)122025941723672083Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122032881946669029Rat

Markers in Region
RH136879  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21221,753,074 - 21,753,231 (+)MAPPERmRatBN7.2
Rnor_6.01224,762,647 - 24,762,803NCBIRnor6.0
Rnor_5.01226,762,917 - 26,763,073UniSTSRnor5.0
RGSC_v3.41222,817,571 - 22,817,727UniSTSRGSC3.4
Celera1223,514,104 - 23,514,260UniSTS
RH 3.4 Map12310.01UniSTS
Cytogenetic Map12q12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 2 31 14
Low 4 27 18 14 18 1 1 11 4 19 11 1
Below cutoff 21 28 21 5 21 6 7 44 7 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000002003   ⟹   ENSRNOP00000002003
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1221,751,331 - 21,753,436 (+)Ensembl
Rnor_6.0 Ensembl1224,761,210 - 24,763,005 (+)Ensembl
RefSeq Acc Id: NM_001012022   ⟹   NP_001012022
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81227,388,160 - 27,389,958 (+)NCBI
mRatBN7.21221,751,638 - 21,753,436 (+)NCBI
Rnor_6.01224,761,210 - 24,763,008 (+)NCBI
Rnor_5.01226,761,480 - 26,763,278 (+)NCBI
RGSC_v3.41222,816,134 - 22,817,932 (+)RGD
Celera1223,512,667 - 23,514,465 (+)RGD
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_001012022   ⟸   NM_001012022
- UniProtKB: Q5XIT8 (UniProtKB/TrEMBL),   A6J0G5 (UniProtKB/TrEMBL),   F7FBN1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000002003   ⟸   ENSRNOT00000002003

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5XIT8-F1-model_v2 AlphaFold Q5XIT8 1-210 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698564
Promoter ID:EPDNEW_R9089
Type:single initiation site
Name:Cldn4_1
Description:claudin 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01224,761,218 - 24,761,278EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307932 AgrOrtholog
BioCyc Gene G2FUF-19595 BioCyc
Ensembl Genes ENSRNOG00000001476 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000002003 ENTREZGENE
  ENSRNOT00000002003.5 UniProtKB/TrEMBL
Gene3D-CATH 1.20.140.150 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7130270 IMAGE-MGC_LOAD
InterPro Claudin UniProtKB/TrEMBL
  Claudin4 UniProtKB/TrEMBL
  Claudin_CS UniProtKB/TrEMBL
  PMP22/EMP/MP20/Claudin UniProtKB/TrEMBL
KEGG Report rno:304407 UniProtKB/TrEMBL
MGC_CLONE MGC:94208 IMAGE-MGC_LOAD
NCBI Gene 304407 ENTREZGENE
PANTHER Claudin UniProtKB/TrEMBL
  CLAUDIN-4 UniProtKB/TrEMBL
Pfam PMP22_Claudin UniProtKB/TrEMBL
PhenoGen Cldn4 PhenoGen
PRINTS CLAUDIN UniProtKB/TrEMBL
  CLAUDIN4 UniProtKB/TrEMBL
PROSITE CLAUDIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000001476 RatGTEx
UniProt A6J0G5 ENTREZGENE
  F7FBN1 ENTREZGENE, UniProtKB/TrEMBL
  Q5XIT8 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A6J0G5 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Cldn4  claudin 4  Cldn4_predicted  claudin 4 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Cldn4_predicted  claudin 4 (predicted)      Symbol and Name status set to approved 70820 APPROVED