Gas8 (growth arrest specific 8) - Rat Genome Database

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Gene: Gas8 (growth arrest specific 8) Rattus norvegicus
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Symbol: Gas8
Name: growth arrest specific 8
RGD ID: 1307817
Description: Predicted to enable microtubule binding activity and small GTPase binding activity. Predicted to be involved in several processes, including flagellated sperm motility; positive regulation of protein localization to cilium; and positive regulation of smoothened signaling pathway. Predicted to act upstream of or within several processes, including brain development; determination of left/right symmetry; and epithelial cilium movement involved in extracellular fluid movement. Predicted to be located in several cellular components, including cytoskeleton; cytosol; and sperm flagellum. Predicted to be active in Golgi apparatus and microtubule. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 33. Orthologous to human GAS8 (growth arrest specific 8); INTERACTS WITH 2,4-dinitrotoluene; 2,6-dinitrotoluene; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: dynein regulatory complex subunit 4; GAS-11; GAS-8; growth arrest-specific protein 11; growth arrest-specific protein 8; LOC361438; MGC124779
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81968,461,280 - 68,480,810 (+)NCBIGRCr8
mRatBN7.21951,552,770 - 51,572,323 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1951,552,816 - 51,572,305 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1958,351,220 - 58,370,726 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01959,025,183 - 59,044,617 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01961,249,809 - 61,269,317 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01956,316,367 - 56,335,873 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1956,316,268 - 56,335,870 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01967,025,533 - 67,045,034 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41953,838,508 - 53,852,302 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11953,845,757 - 53,862,677 (+)NCBI
Celera1950,784,247 - 50,803,673 (+)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
9+2 motile cilium  (ISO)
axoneme  (ISO,ISS)
ciliary basal body  (ISO,ISS)
cilium  (ISO,ISS)
cytoplasm  (ISO,ISS)
cytosol  (ISO)
extracellular region  (IEA)
Golgi apparatus  (IBA,IEA,ISO)
microtubule  (IBA,IEA,ISO)
microtubule cytoskeleton  (ISO,ISS)
motile cilium  (IEA,ISO,ISS)
plasma membrane  (ISO)
sperm flagellum  (ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10969087   PMID:11751847   PMID:12477932   PMID:16643277   PMID:17366626   PMID:18396146   PMID:21659505   PMID:26387594   PMID:27120127   PMID:27472056   PMID:29317443  


Genomics

Comparative Map Data
Gas8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81968,461,280 - 68,480,810 (+)NCBIGRCr8
mRatBN7.21951,552,770 - 51,572,323 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1951,552,816 - 51,572,305 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1958,351,220 - 58,370,726 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01959,025,183 - 59,044,617 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01961,249,809 - 61,269,317 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01956,316,367 - 56,335,873 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1956,316,268 - 56,335,870 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01967,025,533 - 67,045,034 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41953,838,508 - 53,852,302 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11953,845,757 - 53,862,677 (+)NCBI
Celera1950,784,247 - 50,803,673 (+)NCBICelera
Cytogenetic Map19q12NCBI
GAS8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381690,019,633 - 90,044,960 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1690,019,629 - 90,044,975 (+)EnsemblGRCh38hg38GRCh38
GRCh371690,086,041 - 90,111,368 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361688,616,509 - 88,638,880 (+)NCBINCBI36Build 36hg18NCBI36
Build 341688,616,508 - 88,638,880NCBI
Celera1675,152,846 - 75,175,909 (+)NCBICelera
Cytogenetic Map16q24.3NCBI
HuRef1675,780,971 - 75,803,087 (+)NCBIHuRef
CHM1_11691,500,795 - 91,523,162 (+)NCBICHM1_1
T2T-CHM13v2.01696,105,808 - 96,131,173 (+)NCBIT2T-CHM13v2.0
Gas8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398124,245,630 - 124,263,394 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8124,245,573 - 124,263,389 (+)EnsemblGRCm39 Ensembl
GRCm388123,518,835 - 123,536,657 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8123,518,834 - 123,536,650 (+)EnsemblGRCm38mm10GRCm38
MGSCv378126,042,735 - 126,060,550 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368126,404,925 - 126,422,740 (+)NCBIMGSCv36mm8
Celera8127,758,666 - 127,777,359 (+)NCBICelera
Cytogenetic Map8E1NCBI
cM Map872.1NCBI
Gas8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555413,476,451 - 3,496,572 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555413,477,067 - 3,494,991 (+)NCBIChiLan1.0ChiLan1.0
GAS8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21899,866,451 - 99,895,651 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan116105,754,148 - 105,781,531 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01670,777,446 - 70,806,437 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11690,441,096 - 90,469,533 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1690,444,141 - 90,467,849 (+)Ensemblpanpan1.1panPan2
GAS8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1563,589,196 - 63,609,014 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl563,573,941 - 63,619,476 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha563,601,193 - 63,622,312 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0563,816,046 - 63,837,239 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1563,836,478 - 63,857,592 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0563,675,685 - 63,695,315 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0564,080,348 - 64,101,462 (-)NCBIUU_Cfam_GSD_1.0
LOC101960318
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934924,337,994 - 24,355,538 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493664192,893 - 109,006 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GAS8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl664,714 - 105,993 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1686,817 - 105,987 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26181,968 - 198,141 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GAS8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1575,353,493 - 75,370,012 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl575,354,117 - 75,371,796 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604742,425 - 74,415 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gas8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474629,776 - 44,741 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474629,776 - 44,825 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gas8
100 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:36
Count of miRNA genes:35
Interacting mature miRNAs:36
Transcripts:ENSRNOT00000029999
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)192932249057337602Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum insulin level (CMO:0000358)193383821455283146Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)193383821455283146Rat
5135224Leukc1Leukocyte quantity QTL 1eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)194434021455283277Rat
2313395Anxrr26Anxiety related response QTL 26aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)194997648153225766Rat

Markers in Region
BE106712  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21951,572,085 - 51,572,242 (+)MAPPERmRatBN7.2
Rnor_6.01956,335,636 - 56,335,792NCBIRnor6.0
Rnor_5.01967,044,797 - 67,044,953UniSTSRnor5.0
Celera1950,803,439 - 50,803,595UniSTS
RH 3.4 Map19714.0UniSTS
Cytogenetic Map19q12UniSTS
AA943006  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21951,570,928 - 51,571,100 (+)MAPPERmRatBN7.2
Rnor_6.01956,334,479 - 56,334,650NCBIRnor6.0
Rnor_5.01967,043,640 - 67,043,811UniSTSRnor5.0
RGSC_v3.41953,856,916 - 53,857,087UniSTSRGSC3.4
Celera1950,802,282 - 50,802,453UniSTS
RH 3.4 Map19710.91UniSTS
Cytogenetic Map19q12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 66 8 22 3
Low 3 43 45 29 19 29 8 11 8 27 19 8 8
Below cutoff 12 12 12

Sequence


RefSeq Acc Id: ENSRNOT00000029999   ⟹   ENSRNOP00000031180
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1951,552,816 - 51,572,305 (+)Ensembl
Rnor_6.0 Ensembl1956,316,268 - 56,335,870 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000101403   ⟹   ENSRNOP00000084663
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1951,552,816 - 51,570,913 (+)Ensembl
RefSeq Acc Id: NM_001039030   ⟹   NP_001034119
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81968,461,381 - 68,480,807 (+)NCBI
mRatBN7.21951,552,894 - 51,572,320 (+)NCBI
Rnor_6.01956,316,444 - 56,335,870 (+)NCBI
Rnor_5.01967,025,533 - 67,045,034 (+)NCBI
RGSC_v3.41953,838,508 - 53,852,302 (+)RGD
Celera1950,784,247 - 50,803,673 (+)RGD
Sequence:
RefSeq Acc Id: XM_006255779   ⟹   XP_006255841
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81968,461,280 - 68,474,412 (+)NCBI
mRatBN7.21951,552,770 - 51,565,646 (+)NCBI
Rnor_6.01956,316,367 - 56,329,174 (+)NCBI
Rnor_5.01967,025,533 - 67,045,034 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008772635   ⟹   XP_008770857
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81968,468,924 - 68,480,810 (+)NCBI
mRatBN7.21951,560,435 - 51,572,323 (+)NCBI
Rnor_6.01956,324,035 - 56,335,873 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008772636   ⟹   XP_008770858
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81968,468,929 - 68,480,810 (+)NCBI
mRatBN7.21951,552,821 - 51,572,323 (+)NCBI
Rnor_6.01956,324,040 - 56,335,873 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008772637   ⟹   XP_008770859
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81968,468,924 - 68,480,810 (+)NCBI
mRatBN7.21951,560,435 - 51,572,323 (+)NCBI
Rnor_6.01956,324,035 - 56,335,873 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039097896   ⟹   XP_038953824
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81968,461,280 - 68,479,630 (+)NCBI
mRatBN7.21951,552,770 - 51,571,621 (+)NCBI
RefSeq Acc Id: XM_039097897   ⟹   XP_038953825
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81968,468,929 - 68,480,810 (+)NCBI
mRatBN7.21951,560,440 - 51,572,323 (+)NCBI
RefSeq Acc Id: XM_039097898   ⟹   XP_038953826
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81968,468,929 - 68,480,810 (+)NCBI
mRatBN7.21951,560,440 - 51,572,323 (+)NCBI
RefSeq Acc Id: XM_063278166   ⟹   XP_063134236
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81968,464,027 - 68,480,810 (+)NCBI
RefSeq Acc Id: NP_001034119   ⟸   NM_001039030
- UniProtKB: Q499U4 (UniProtKB/Swiss-Prot),   A6IZY9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006255841   ⟸   XM_006255779
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_008770857   ⟸   XM_008772635
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_008770859   ⟸   XM_008772637
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_008770858   ⟸   XM_008772636
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: ENSRNOP00000031180   ⟸   ENSRNOT00000029999
RefSeq Acc Id: XP_038953824   ⟸   XM_039097896
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZZT3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038953825   ⟸   XM_039097897
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038953826   ⟸   XM_039097898
- Peptide Label: isoform X6
RefSeq Acc Id: ENSRNOP00000084663   ⟸   ENSRNOT00000101403
RefSeq Acc Id: XP_063134236   ⟸   XM_063278166
- Peptide Label: isoform X1
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q499U4-F1-model_v2 AlphaFold Q499U4 1-478 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307817 AgrOrtholog
BioCyc Gene G2FUF-5320 BioCyc
Ensembl Genes ENSRNOG00000026964 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000029999 ENTREZGENE
  ENSRNOT00000029999.7 UniProtKB/Swiss-Prot
  ENSRNOT00000101403.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7929646 IMAGE-MGC_LOAD
InterPro GAS8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GAS8_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:361438 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:124779 IMAGE-MGC_LOAD
NCBI Gene 361438 ENTREZGENE
PANTHER DYNEIN REGULATORY COMPLEX SUBUNIT 4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR31543 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam GAS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gas8 PhenoGen
RatGTEx ENSRNOG00000026964 RatGTEx
UniProt A0A8I5ZZT3 ENTREZGENE, UniProtKB/TrEMBL
  A6IZY9 ENTREZGENE, UniProtKB/TrEMBL
  DRC4_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Gas8  growth arrest specific 8  Gas8_predicted  growth arrest specific 8 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Gas8_predicted  growth arrest specific 8 (predicted)      Symbol and Name status set to approved 70820 APPROVED