Spo11 (SPO11 initiator of meiotic double strand breaks) - Rat Genome Database

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Gene: Spo11 (SPO11 initiator of meiotic double strand breaks) Rattus norvegicus
Analyze
Symbol: Spo11
Name: SPO11 initiator of meiotic double strand breaks (Ensembl:SPO11, initiator of meiotic double stranded breaks)
RGD ID: 1306454
Description: Predicted to enable DNA binding activity. Predicted to be involved in meiotic DNA double-strand break formation; meiotic DNA double-strand break processing; and reciprocal meiotic recombination. Predicted to act upstream of or within several processes, including germ cell development; meiosis I; and ovarian follicle development. Predicted to be located in chromosome, telomeric region. Predicted to be active in nuclear chromosome. Orthologous to human SPO11 (SPO11 initiator of meiotic double strand breaks); INTERACTS WITH 17beta-estradiol; amphetamine; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC366261; meiotic recombination protein SPO11; SPO11 meiotic protein covalently bound to DSB; SPO11 meiotic protein covalently bound to DSB homolog; SPO11 meiotic protein covalently bound to DSB homolog (S. cerevisiae); SPO11, initiator of meiotic double stranded breaks; sporulation protein, meiosis-specific, SPO11 homolog; sporulation protein, meiosis-specific, SPO11 homolog (S. cerevisiae)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83182,173,615 - 182,189,273 (+)NCBIGRCr8
mRatBN7.23161,755,299 - 161,770,930 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3161,757,519 - 161,770,925 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3165,571,645 - 165,582,906 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03174,070,591 - 174,081,852 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03171,812,404 - 171,823,665 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03170,991,573 - 171,008,226 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3170,994,038 - 171,013,185 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03177,058,150 - 177,081,041 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43163,842,817 - 163,854,067 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13163,746,748 - 163,759,641 (+)NCBI
Celera3160,953,190 - 160,964,440 (+)NCBICelera
Cytogenetic Map3q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15640358   PMID:16307920   PMID:17010969   PMID:17696610   PMID:18694567   PMID:20336070   PMID:20551173   PMID:22530760   PMID:24589552   PMID:27760146  


Genomics

Comparative Map Data
Spo11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83182,173,615 - 182,189,273 (+)NCBIGRCr8
mRatBN7.23161,755,299 - 161,770,930 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3161,757,519 - 161,770,925 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3165,571,645 - 165,582,906 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03174,070,591 - 174,081,852 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03171,812,404 - 171,823,665 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03170,991,573 - 171,008,226 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3170,994,038 - 171,013,185 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03177,058,150 - 177,081,041 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43163,842,817 - 163,854,067 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13163,746,748 - 163,759,641 (+)NCBI
Celera3160,953,190 - 160,964,440 (+)NCBICelera
Cytogenetic Map3q42NCBI
SPO11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382057,329,803 - 57,343,993 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2057,329,803 - 57,343,994 (+)EnsemblGRCh38hg38GRCh38
GRCh372055,904,859 - 55,919,049 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362055,338,238 - 55,352,456 (+)NCBINCBI36Build 36hg18NCBI36
Build 342055,338,237 - 55,352,455NCBI
Celera2052,645,068 - 52,659,286 (+)NCBICelera
Cytogenetic Map20q13.31NCBI
HuRef2052,686,790 - 52,701,008 (+)NCBIHuRef
CHM1_12055,805,942 - 55,820,160 (+)NCBICHM1_1
T2T-CHM13v2.02059,107,550 - 59,121,740 (+)NCBIT2T-CHM13v2.0
Spo11
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392172,819,172 - 172,835,369 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2172,819,493 - 172,835,369 (+)EnsemblGRCm39 Ensembl
GRCm382172,977,379 - 172,993,576 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2172,977,700 - 172,993,576 (+)EnsemblGRCm38mm10GRCm38
MGSCv372172,805,343 - 172,819,077 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362172,622,784 - 172,636,504 (+)NCBIMGSCv36mm8
MGSCv362174,209,775 - 174,223,792 (+)NCBIMGSCv36mm8
Celera2178,918,642 - 178,957,539 (+)NCBICelera
Cytogenetic Map2H3NCBI
cM Map295.64NCBI
Spo11
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554452,088,144 - 2,103,385 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554452,088,144 - 2,103,385 (-)NCBIChiLan1.0ChiLan1.0
SPO11
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22163,080,959 - 63,095,174 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12063,074,078 - 63,088,293 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02053,669,128 - 53,684,328 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12054,948,664 - 54,962,908 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2054,948,661 - 54,963,384 (+)Ensemblpanpan1.1panPan2
SPO11
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12442,345,595 - 42,360,851 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2442,345,547 - 42,384,481 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2441,593,229 - 41,608,456 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02443,211,094 - 43,226,379 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2443,211,048 - 43,250,014 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12442,296,075 - 42,311,271 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02442,435,814 - 42,451,039 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02443,093,993 - 43,109,232 (+)NCBIUU_Cfam_GSD_1.0
Spo11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640183,108,577 - 183,122,976 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936530183,271 - 197,335 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936530183,271 - 197,549 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPO11
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1757,730,675 - 57,745,875 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11757,730,676 - 57,745,875 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21764,894,962 - 64,910,090 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SPO11
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.126,778,442 - 6,792,736 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl26,778,985 - 6,792,643 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605054,840,590 - 54,854,921 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Spo11
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474123,784,298 - 23,800,168 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474123,784,362 - 23,800,127 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Spo11
51 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:43
Count of miRNA genes:37
Interacting mature miRNAs:43
Transcripts:ENSRNOT00000008959
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141074471169034231Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3131635904169034231Rat
8552791Vie2Viral induced encephalitis QTL 24.1brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)3145956084169034231Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3124122556169034231Rat
8552952Pigfal13Plasma insulin-like growth factor 1 level QTL 13blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)3138799500169034231Rat
1300161Rf10Renal function QTL 103.57renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)3161192952169034231Rat
1331726Bp208Blood pressure QTL 2083.129arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141339013162184794Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3130656562169034231Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3130656562169034231Rat
1598877Bp285Blood pressure QTL 2851.50.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3120538241165538241Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3118839124163839124Rat
1578666Vnigr1Vascular neointimal growth QTL 14.6artery morphology trait (VT:0002191)artery lumen area (CMO:0001409)3149040888168026850Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
2298477Eau4Experimental allergic uveoretinitis QTL 40.0011uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)3137398739169034231Rat
2301411Bp320Blood pressure QTL 3200.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3145925360166177555Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3127162703168026850Rat
2317883Alcrsp26Alcohol response QTL 261.80.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)3145526770169034231Rat
12879873Cm96Cardiac mass QTL 960.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)3145925360166177555Rat
12879875Kidm64Kidney mass QTL 640.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3145925360166177555Rat
12879876Bw182Body weight QTL 1820.003body mass (VT:0001259)body weight (CMO:0000012)3145925360166177555Rat
12879872Cm97Cardiac mass QTL 970.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3145925360166177555Rat
12879871Am7Aortic mass QTL 70.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)3145925360166177555Rat
12879874Cm98Cardiac mass QTL 980.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)3145925360166177555Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3122438700167438700Rat

Markers in Region
AI232279  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23161,770,760 - 161,770,878 (+)MAPPERmRatBN7.2
Rnor_6.03171,007,279 - 171,007,396NCBIRnor6.0
Rnor_5.03177,073,744 - 177,073,861UniSTSRnor5.0
RGSC_v3.43163,853,903 - 163,854,020UniSTSRGSC3.4
Celera3160,964,276 - 160,964,393UniSTS
RH 3.4 Map31496.8UniSTS
Cytogenetic Map3q42UniSTS
AW532251  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23161,763,931 - 161,764,085 (+)MAPPERmRatBN7.2
Rnor_6.03171,000,450 - 171,000,603NCBIRnor6.0
Rnor_5.03177,066,915 - 177,067,068UniSTSRnor5.0
RGSC_v3.43163,847,074 - 163,847,227UniSTSRGSC3.4
Celera3160,957,447 - 160,957,600UniSTS
RH 3.4 Map31498.4UniSTS
Cytogenetic Map3q42UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 7 7 8 9
Low 2 1 12 2 2 21 19 6 2
Below cutoff 37 14 10 10 6 9 66 6 13 5 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000008959   ⟹   ENSRNOP00000008959
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3161,757,519 - 161,770,925 (+)Ensembl
Rnor_6.0 Ensembl3170,996,193 - 171,007,443 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000081823   ⟹   ENSRNOP00000075147
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl3170,994,038 - 171,013,185 (+)Ensembl
RefSeq Acc Id: NM_001415816   ⟹   NP_001402745
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83182,175,856 - 182,189,270 (+)NCBI
mRatBN7.23161,757,513 - 161,770,927 (+)NCBI
RefSeq Acc Id: XM_039105609   ⟹   XP_038961537
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83182,175,845 - 182,189,273 (+)NCBI
mRatBN7.23161,757,493 - 161,770,930 (+)NCBI
RefSeq Acc Id: XM_039105610   ⟹   XP_038961538
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83182,173,615 - 182,189,273 (+)NCBI
mRatBN7.23161,755,299 - 161,770,930 (+)NCBI
RefSeq Acc Id: XR_005501951
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83182,175,845 - 182,187,820 (+)NCBI
mRatBN7.23161,757,493 - 161,769,482 (+)NCBI
RefSeq Acc Id: XR_005501952
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83182,175,845 - 182,187,835 (+)NCBI
mRatBN7.23161,757,493 - 161,769,492 (+)NCBI
RefSeq Acc Id: XR_005501953
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83182,175,845 - 182,185,736 (+)NCBI
mRatBN7.23161,757,493 - 161,767,393 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000008959   ⟸   ENSRNOT00000008959
RefSeq Acc Id: ENSRNOP00000075147   ⟸   ENSRNOT00000081823
RefSeq Acc Id: XP_038961538   ⟸   XM_039105610
- Peptide Label: isoform X2
- UniProtKB: A6KKY2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038961537   ⟸   XM_039105609
- Peptide Label: isoform X1
RefSeq Acc Id: NP_001402745   ⟸   NM_001415816
- UniProtKB: D3Z8A8 (UniProtKB/TrEMBL)
Protein Domains
Meiosis-specific protein Spo11   Spo11/DNA topoisomerase VI subunit A N-terminal   Topoisomerase 6 subunit A/Spo11 TOPRIM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K9V7-F1-model_v2 AlphaFold A0A0G2K9V7 1-367 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692717
Promoter ID:EPDNEW_R3234
Type:single initiation site
Name:Spo11_1
Description:SPO11, initiator of meiotic double stranded breaks
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03170,994,056 - 170,994,116EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306454 AgrOrtholog
BioCyc Gene G2FUF-46524 BioCyc
Ensembl Genes ENSRNOG00000006732 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000008959 ENTREZGENE
  ENSRNOT00000008959.5 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/TrEMBL
  3.40.1360.10 UniProtKB/TrEMBL
InterPro Meiosis_Spo11 UniProtKB/TrEMBL
  Meiotic_Spo11 UniProtKB/TrEMBL
  Spo11/TopoVI_A UniProtKB/TrEMBL
  Spo11/TopoVI_A_N UniProtKB/TrEMBL
  Spo11/TopoVI_A_sf UniProtKB/TrEMBL
  TOPRIM_Topo6A/Spo11 UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/TrEMBL
NCBI Gene 366261 ENTREZGENE
PANTHER MEIOTIC RECOMBINATION PROTEIN SPO11 UniProtKB/TrEMBL
  Spo11/TopoVI_A UniProtKB/TrEMBL
Pfam SPO11_like UniProtKB/TrEMBL
  TOP6A-Spo11_Toprim UniProtKB/TrEMBL
  TP6A_N UniProtKB/TrEMBL
PhenoGen Spo11 PhenoGen
PRINTS SPO11HOMOLOG UniProtKB/TrEMBL
  TOP6AFAMILY UniProtKB/TrEMBL
RatGTEx ENSRNOG00000006732 RatGTEx
Superfamily-SCOP Spo11/TopoVI_A UniProtKB/TrEMBL
UniProt A6KKY2 ENTREZGENE, UniProtKB/TrEMBL
  D3Z8A8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-05-25 Spo11  SPO11 initiator of meiotic double strand breaks  Spo11  SPO11, initiator of meiotic double stranded breaks  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-05-04 Spo11  SPO11, initiator of meiotic double stranded breaks  Spo11  SPO11 meiotic protein covalently bound to DSB  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-06-14 Spo11  SPO11 meiotic protein covalently bound to DSB  Spo11  SPO11 meiotic protein covalently bound to DSB homolog (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-08-29 Spo11  SPO11 meiotic protein covalently bound to DSB homolog (S. cerevisiae)  Spo11  sporulation protein, meiosis-specific, SPO11 homolog (S. cerevisiae)   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Spo11  sporulation protein, meiosis-specific, SPO11 homolog (S. cerevisiae)   Spo11_predicted  sporulation protein, meiosis-specific, SPO11 homolog (S. cerevisiae) (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Spo11_predicted  sporulation protein, meiosis-specific, SPO11 homolog (S. cerevisiae) (predicted)      Symbol and Name status set to approved 70820 APPROVED