Cerk (ceramide kinase) - Rat Genome Database

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Gene: Cerk (ceramide kinase) Rattus norvegicus
Analyze
Symbol: Cerk
Name: ceramide kinase
RGD ID: 1305019
Description: Predicted to enable ceramide kinase activity and magnesium ion binding activity. Predicted to be involved in ceramide metabolic process and phosphorylation. Predicted to be located in plasma membrane. Orthologous to human CERK (ceramide kinase); PARTICIPATES IN Fabry disease pathway; Gaucher's disease pathway; Krabbe disease pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC103694581; LOC300129; uncharacterized LOC103694581
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87119,105,674 - 119,149,885 (-)NCBIGRCr8
mRatBN7.27117,225,855 - 117,269,436 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7117,225,855 - 117,268,759 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7118,977,337 - 119,020,251 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07121,202,971 - 121,245,883 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07121,172,546 - 121,215,466 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07127,015,162 - 127,058,056 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7127,015,162 - 127,058,056 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07126,726,021 - 126,768,650 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47124,139,137 - 124,182,070 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17124,173,366 - 124,216,042 (-)NCBI
Celera7113,516,253 - 113,558,934 (-)NCBICelera
Cytogenetic Map7q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10947957   PMID:11956206   PMID:14769792   PMID:16269826   PMID:18555012   PMID:18614015   PMID:19501188   PMID:21255156   PMID:32246947  


Genomics

Comparative Map Data
Cerk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87119,105,674 - 119,149,885 (-)NCBIGRCr8
mRatBN7.27117,225,855 - 117,269,436 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7117,225,855 - 117,268,759 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7118,977,337 - 119,020,251 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07121,202,971 - 121,245,883 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07121,172,546 - 121,215,466 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07127,015,162 - 127,058,056 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7127,015,162 - 127,058,056 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07126,726,021 - 126,768,650 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47124,139,137 - 124,182,070 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17124,173,366 - 124,216,042 (-)NCBI
Celera7113,516,253 - 113,558,934 (-)NCBICelera
Cytogenetic Map7q34NCBI
CERK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382246,684,410 - 46,738,252 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2246,684,410 - 46,738,252 (-)EnsemblGRCh38hg38GRCh38
GRCh372247,080,307 - 47,134,149 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362245,458,971 - 45,512,816 (-)NCBINCBI36Build 36hg18NCBI36
Build 342245,400,826 - 45,406,632NCBI
Celera2230,995,999 - 31,049,854 (-)NCBICelera
Cytogenetic Map22q13.31NCBI
HuRef2230,025,258 - 30,079,178 (-)NCBIHuRef
CHM1_12247,039,226 - 47,093,493 (-)NCBICHM1_1
T2T-CHM13v2.02247,172,367 - 47,226,215 (-)NCBIT2T-CHM13v2.0
Cerk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391586,023,302 - 86,070,537 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1586,023,329 - 86,070,342 (-)EnsemblGRCm39 Ensembl
GRCm381586,139,101 - 86,186,259 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1586,139,128 - 86,186,141 (-)EnsemblGRCm38mm10GRCm38
MGSCv371585,969,531 - 86,016,571 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361585,966,895 - 86,013,907 (-)NCBIMGSCv36mm8
MGSCv361586,937,923 - 86,985,654 (-)NCBIMGSCv36mm8
Celera1588,281,909 - 88,328,692 (-)NCBICelera
Cytogenetic Map15E2NCBI
cM Map1540.52NCBI
Cerk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541330,660,593 - 30,679,674 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541330,658,472 - 30,693,948 (-)NCBIChiLan1.0ChiLan1.0
CERK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22356,524,324 - 56,580,132 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12259,215,963 - 59,271,769 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02226,849,865 - 26,905,545 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12245,749,887 - 45,786,570 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2245,749,887 - 45,786,570 (-)Ensemblpanpan1.1panPan2
CERK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11019,560,125 - 19,601,223 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1019,556,087 - 19,598,954 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1019,480,876 - 19,522,720 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01020,294,959 - 20,336,847 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1020,294,760 - 20,336,829 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11020,013,088 - 20,054,908 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01020,325,241 - 20,367,020 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01020,507,050 - 20,548,676 (+)NCBIUU_Cfam_GSD_1.0
Cerk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049453,304,236 - 3,346,264 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366293,304,236 - 3,344,136 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366293,304,236 - 3,346,264 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CERK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl52,818,784 - 2,870,195 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.152,818,738 - 2,870,200 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CERK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11929,183,324 - 29,236,857 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604596,276,619 - 96,355,869 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cerk
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247523,285,637 - 3,326,738 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247523,285,649 - 3,328,131 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cerk
165 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:638
Count of miRNA genes:264
Interacting mature miRNAs:337
Transcripts:ENSRNOT00000022882
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)769736226117455174Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)773829340130221005Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)780221299124373579Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)780221299125221299Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)781737938126737938Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)783153392128153392Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
71114Niddm14Non-insulin dependent diabetes mellitus QTL 144.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)784257275129257275Rat
2298475Eau6Experimental allergic uveoretinitis QTL 60.0029uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)784257275129257275Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)786983365131983365Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)791412594129807172Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat
631663Bw6Body weight QTL 63.4body mass (VT:0001259)body weight (CMO:0000012)7111075573134976056Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7111182207135012528Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7112308254133492884Rat
1357339Stl14Serum triglyceride level QTL 143.450.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7112729683133492707Rat
1582240Sffal1Serum free fatty acids level QTL 13.40.0021blood free fatty acid amount (VT:0001553)serum free fatty acids level (CMO:0000547)7116677010124049952Rat
631201Panci1Pancreas inflammation QTL 100.001pancreas integrity trait (VT:0010560)percentage of study population displaying chronic pancreatitis at a point in time (CMO:0001214)7116677189127103496Rat

Markers in Region
RH130617  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27117,225,909 - 117,226,107 (+)MAPPERmRatBN7.2
Rnor_6.07127,015,217 - 127,015,414NCBIRnor6.0
Rnor_5.07126,726,076 - 126,726,273UniSTSRnor5.0
RGSC_v3.47124,139,192 - 124,139,389UniSTSRGSC3.4
Celera7113,516,308 - 113,516,505UniSTS
RH 3.4 Map7931.4UniSTS
Cytogenetic Map7q34UniSTS
RH133828  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27117,227,470 - 117,227,658 (+)MAPPERmRatBN7.2
Rnor_6.07127,016,778 - 127,016,965NCBIRnor6.0
Rnor_5.07126,727,637 - 126,727,824UniSTSRnor5.0
RGSC_v3.47124,140,753 - 124,140,940UniSTSRGSC3.4
Celera7113,517,869 - 113,518,056UniSTS
RH 3.4 Map7931.4UniSTS
Cytogenetic Map7q34UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 34 14 6 19 6 74 21 40 11
Low 9 43 35 35 8 11 14 1 8
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000022882   ⟹   ENSRNOP00000022882
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7117,225,855 - 117,268,759 (-)Ensembl
Rnor_6.0 Ensembl7127,015,162 - 127,058,056 (-)Ensembl
RefSeq Acc Id: NM_001134861   ⟹   NP_001128333
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87119,105,674 - 119,148,570 (-)NCBI
mRatBN7.27117,225,855 - 117,268,759 (-)NCBI
Rnor_6.07127,015,162 - 127,058,056 (-)NCBI
Rnor_5.07126,726,021 - 126,768,650 (-)NCBI
RGSC_v3.47124,139,137 - 124,182,070 (-)RGD
Celera7113,516,253 - 113,558,934 (-)RGD
Sequence:
RefSeq Acc Id: XM_039078853   ⟹   XP_038934781
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87119,105,674 - 119,149,885 (-)NCBI
mRatBN7.27117,225,855 - 117,269,436 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001128333 (Get FASTA)   NCBI Sequence Viewer  
  XP_038934781 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM15560 (Get FASTA)   NCBI Sequence Viewer  
  EDM15561 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000022882
  ENSRNOP00000022882.4
RefSeq Acc Id: NP_001128333   ⟸   NM_001134861
- UniProtKB: D3Z9Y3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000022882   ⟸   ENSRNOT00000022882
RefSeq Acc Id: XP_038934781   ⟸   XM_039078853
- Peptide Label: isoform X1
Protein Domains
DAGKc

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3Z9Y3-F1-model_v2 AlphaFold D3Z9Y3 1-531 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305019 AgrOrtholog
BioCyc Gene G2FUF-32519 BioCyc
Ensembl Genes ENSRNOG00000017022 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000022882 ENTREZGENE
  ENSRNOT00000022882.6 UniProtKB/TrEMBL
Gene3D-CATH 2.60.200.40 UniProtKB/TrEMBL
InterPro ATP-NAD_kinase_dom_1 UniProtKB/TrEMBL
  ATP-NAD_kinase_PpnK-typ UniProtKB/TrEMBL
  CERK_C UniProtKB/TrEMBL
  Diacylglycerol_kinase_cat_dom UniProtKB/TrEMBL
KEGG Report rno:300129 UniProtKB/TrEMBL
NCBI Gene 300129 ENTREZGENE
PANTHER CERAMIDE KINASE UniProtKB/TrEMBL
  SPHINGOSINE KINASE UniProtKB/TrEMBL
Pfam CERK_C UniProtKB/TrEMBL
  DAGK_cat UniProtKB/TrEMBL
PhenoGen Cerk PhenoGen
PROSITE DAGK UniProtKB/TrEMBL
RatGTEx ENSRNOG00000017022 RatGTEx
SMART DAGKc UniProtKB/TrEMBL
Superfamily-SCOP SSF111331 UniProtKB/TrEMBL
UniProt D3Z9Y3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Cerk  ceramide kinase  LOC103694581  uncharacterized LOC103694581  Data merged from RGD:9345335 737654 PROVISIONAL
2014-08-25 LOC103694581  uncharacterized LOC103694581      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-04-30 Cerk  ceramide kinase   Cerk_predicted  ceramide kinase (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Cerk_predicted  ceramide kinase (predicted)      Symbol and Name status set to approved 70820 APPROVED