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Gene: Tmub1 (transmembrane and ubiquitin-like domain containing 1) Rattus norvegicus

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Symbol:

Tmub1

Name:

transmembrane and ubiquitin-like domain containing 1

RGD ID:

735120

Description:

Involved in postsynaptic neurotransmitter receptor internalization. Is active in postsynaptic recycling endosome membrane. Orthologous to human TMUB1 (transmembrane and ubiquitin like domain containing 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

REVIEWED

Previously known as:

hepatocyte odd protein shuttling protein; Hops; MGC72996; transmembrane and ubiquitin-like domain-containing protein 1; Unknown (protein for MGC:72996)

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	11,621,931 - 11,624,497 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	4	11,621,508 - 11,624,499 (+)	Ensembl				GRCr8
mRatBN7.2	4	10,729,494 - 10,732,060 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	10,729,250 - 10,732,060 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	4	15,875,716 - 15,878,282 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	11,695,907 - 11,698,473 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	10,047,691 - 10,050,257 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	7,257,752 - 7,260,318 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	7,257,752 - 7,260,317 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	4	7,268,892 - 7,271,682 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	4	6,093,852 - 6,096,418 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	4	6,344,055 - 6,346,621 (+)	NCBI		Celera
RGSC_v3.1	4	6,093,878 - 6,096,413 (+)	NCBI
Cytogenetic Map	4	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

long QT syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

4,4'-sulfonyldiphenol (EXP,ISO)

aflatoxin B1 (ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

beta-lapachone (ISO)

bisphenol A (EXP,ISO)

bisphenol F (EXP)

caffeine (ISO)

chlorpyrifos (ISO)

choline (ISO)

copper(II) sulfate (ISO)

Dibutyl phosphate (ISO)

dibutyl phthalate (ISO)

endosulfan (EXP)

folic acid (ISO)

gallic acid (ISO)

gentamycin (EXP)

L-methionine (ISO)

nitrates (ISO)

paracetamol (EXP,ISO)

perfluorooctane-1-sulfonic acid (ISO)

pirinixic acid (ISO)

sodium arsenite (ISO)

sodium fluoride (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

trichloroethene (EXP)

triptonide (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

ERAD pathway (IBA,IEA,ISO)

postsynaptic neurotransmitter receptor internalization (IDA)

Cellular Component

centrosome (IEA)

cytoplasm (IEA)

membrane (IEA)

nucleolus (IEA)

nucleus (IEA)

postsynaptic membrane (IEA)

postsynaptic recycling endosome membrane (IDA,IEP)

recycling endosome (IEA)

Molecular Function

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	GOA pipeline	RGD automated data pipeline
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
5.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
6.	Transmembrane and ubiquitin-like domain-containing protein 1 (Tmub1/HOPS) facilitates surface expression of GluR2-containing AMPA receptors.	Yang H, etal., PLoS One. 2008 Jul 30;3(7):e2809. doi: 10.1371/journal.pone.0002809.

Additional References at PubMed

PMID:8889548	PMID:16014383	PMID:20582322	PMID:21343306	PMID:22426572	PMID:22871113	PMID:24240191	PMID:25109894	PMID:29344642	PMID:29777440	PMID:29967478

Genomics

Comparative Map Data

Tmub1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	11,621,931 - 11,624,497 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	4	11,621,508 - 11,624,499 (+)	Ensembl				GRCr8
mRatBN7.2	4	10,729,494 - 10,732,060 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	10,729,250 - 10,732,060 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	4	15,875,716 - 15,878,282 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	11,695,907 - 11,698,473 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	10,047,691 - 10,050,257 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	7,257,752 - 7,260,318 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	7,257,752 - 7,260,317 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	4	7,268,892 - 7,271,682 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	4	6,093,852 - 6,096,418 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	4	6,344,055 - 6,346,621 (+)	NCBI		Celera
RGSC_v3.1	4	6,093,878 - 6,096,413 (+)	NCBI
Cytogenetic Map	4	q11	NCBI

TMUB1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	151,081,085 - 151,083,493 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	151,081,082 - 151,083,514 (-)	Ensembl			hg38	GRCh38
GRCh37	7	150,778,172 - 150,780,580 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	150,409,105 - 150,411,021 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	7	150,215,820 - 150,217,736	NCBI
Celera	7	145,335,504 - 145,337,952 (-)	NCBI		Celera
Cytogenetic Map	7	q36.1	NCBI
HuRef	7	144,590,546 - 144,592,673 (-)	NCBI		HuRef
CHM1_1	7	150,786,569 - 150,789,017 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	7	152,254,203 - 152,256,611 (-)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	150,107,712 - 150,110,158 (-)	NCBI

Tmub1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	24,650,461 - 24,652,859 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	24,650,456 - 24,652,852 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	5	24,445,463 - 24,447,846 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	24,445,458 - 24,447,854 (-)	Ensembl			mm10	GRCm38
MGSCv37	5	23,951,281 - 23,953,664 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	5	23,955,528 - 23,957,870 (-)	NCBI		MGSCv36	mm8
Celera	5	21,395,384 - 21,397,768 (-)	NCBI		Celera
Cytogenetic Map	5	A3	NCBI
cM Map	5	11.79	NCBI

Tmub1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955491	5,518,193 - 5,520,521 (-)	Ensembl
ChiLan1.0	NW_004955491	5,518,199 - 5,520,743 (-)	NCBI	ChiLan1.0	ChiLan1.0

TMUB1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	187,503,035 - 187,505,596 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	39,513,300 - 39,515,808 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	142,667,937 - 142,670,443 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	154,820,388 - 154,822,511 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	154,820,388 - 154,822,294 (-)	Ensembl			panPan2	panpan1.1

TMUB1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	16	15,131,190 - 15,134,230 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	16	15,131,354 - 15,133,716 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	16	15,739,434 - 15,742,473 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	16	16,853,555 - 16,856,594 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	16	16,853,555 - 16,856,674 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	16	15,225,866 - 15,228,905 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	16	15,807,267 - 15,810,305 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	16	15,857,997 - 15,861,036 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Tmub1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	6,396,820 - 6,398,958 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936527	6,504,455 - 6,506,656 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936527	6,504,471 - 6,506,572 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TMUB1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	18	6,142,023 - 6,144,894 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	18	6,142,451 - 6,144,895 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	18	6,506,557 - 6,509,001 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TMUB1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	21	119,263,465 - 119,266,067 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	21	119,263,447 - 119,265,696 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666072	15,234,256 - 15,236,705 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Tmub1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624800	5,538,279 - 5,541,024 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624800	5,538,328 - 5,541,024 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Tmub1
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	6	153,638,827 - 153,641,480 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Tmub1
8 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	73
Count of miRNA genes:	58
Interacting mature miRNAs:	69
Transcripts:	ENSRNOT00000061992
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
8552903	Pigfal2	Plasma insulin-like growth factor 1 level QTL 2	7.3		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	4	1	32668025	Rat
724557	Plsm1	Polydactyly-luxate syndrome (PLS) morphotypes QTL 1		0.0003	forelimb integrity trait (VT:0010562)	front foot phalanges count (CMO:0001947)	4	1	28392287	Rat
9590100	Sffal4	Serum free fatty acids level QTL 4	7.36	0.05	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	4	1	32668025	Rat
8552906	Pigfal3	Plasma insulin-like growth factor 1 level QTL 3			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	4	11038706	56038706	Rat
1357341	Gluco5	Glucose level QTL 5	6.4		adipocyte free fatty acid secretion trait (VT:0010465)	absolute change in adipocyte free fatty acid secretion per unit volume (CMO:0001446)	4	1	34142783	Rat
1357343	Gluco4	Glucose level QTL 4		0.00002	adipocyte glucose uptake trait (VT:0004185)	adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)	4	1	34142783	Rat
8552782	Vie1	Viral induced encephalitis QTL 1	26.4		brain integrity trait (VT:0010579)	encephalitis incidence/prevalence measurement (CMO:0002361)	4	1	35396961	Rat
6478766	Anxrr47	Anxiety related response QTL 47		0.09637	locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	4	11038706	56038706	Rat
631642	Stl2	Serum triglyceride level QTL 2	3.3		blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	4	5894575	57613242	Rat
6478769	Anxrr48	Anxiety related response QTL 48		0.02514	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	11038706	56038706	Rat
61333	Gluco16	Glucose level QTL 16	4.3	0.00001	adipocyte glucose uptake trait (VT:0004185)	absolute change in adipocyte glucose uptake (CMO:0000873)	4	1	31106810	Rat
61408	Scl23	Serum cholesterol level QTL 23		0.0005	blood HDL phospholipid amount (VT:0010504)	serum high density lipoprotein phospholipid level (CMO:0001567)	4	1	28392287	Rat
631209	Bw2	Body weight QTL2	4.2		retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	4	1	45429897	Rat
8552803	Bw144	Body weight QTL 144	16		body mass (VT:0001259)	change in body weight to body weight ratio (CMO:0002216)	4	1	35396961	Rat
8694374	Bw155	Body weight QTL 155	3.39	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	4	11038706	56038706	Rat
8552801	Bw143	Body weight QTL 143	7.3		body mass (VT:0001259)	change in body weight to body weight ratio (CMO:0002216)	4	1	35396961	Rat
2303168	Bp330	Blood pressure QTL 330	4.25	0.017	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	4	5889999	148002343	Rat
9589046	Scfw2	Subcutaneous fat weight QTL 2	5.54	0.001	subcutaneous adipose mass (VT:1000472)	abdominal subcutaneous fat pad weight (CMO:0002069)	4	1	32668025	Rat
6478724	Anxrr35	Anxiety related response QTL 35		0.00449	defecation behavior trait (VT:0010462)	defecation measurement (CMO:0000997)	4	11038706	56038706	Rat
61351	Bp33	Blood pressure QTL 33		0.0018	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	4	1	28392287	Rat
61415	Eae11	Experimental allergic encephalomyelitis QTL 11	2.9		nervous system integrity trait (VT:0010566)	post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)	4	1	40471598	Rat
1641905	Colcr1	Colorectal carcinoma resistance QTL 1	4.3	0.0003	intestine integrity trait (VT:0010554)	benign colorectal tumor surface area measurement (CMO:0001799)	4	8428551	30449094	Rat
619616	Bp79	Blood pressure QTL 79		0.0292	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	4	5889999	50889999	Rat
8552809	Vie5	Viral induced encephalitis QTL 5	25.3		brain integrity trait (VT:0010579)	encephalitis incidence/prevalence measurement (CMO:0002361)	4	1	35396961	Rat
738021	Hcar13	Hepatocarcinoma resistance QTL 13	4.3		liver integrity trait (VT:0010547)	liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)	4	1	33538816	Rat
70192	BpQTLcluster5	Blood pressure QTL cluster 5	4.183		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	4	1	63900697	Rat
9590304	Scort17	Serum corticosterone level QTL 17	4.96	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	4	11038706	56038706	Rat
9589097	Slep11	Serum leptin concentration QTL 11	5.09	0.001	blood leptin amount (VT:0005667)	plasma leptin level (CMO:0000781)	4	1	32668025	Rat
1300141	Bp178	Blood pressure QTL 178			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	4	10758701	40490708	Rat

Markers in Region

RH128009

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	10,731,773 - 10,731,968 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	7,260,032 - 7,260,226	NCBI	Rnor6.0
Rnor_5.0	4	7,271,396 - 7,271,590	UniSTS	Rnor5.0
RGSC_v3.4	4	6,096,132 - 6,096,326	UniSTS	RGSC3.4
Celera	4	6,346,335 - 6,346,529	UniSTS
Cytogenetic Map	4	q11	UniSTS

RH144436

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	10,730,274 - 10,730,430 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	7,258,533 - 7,258,688	NCBI	Rnor6.0
Rnor_5.0	4	7,269,897 - 7,270,052	UniSTS	Rnor5.0
RGSC_v3.4	4	6,094,633 - 6,094,788	UniSTS	RGSC3.4
Celera	4	6,344,836 - 6,344,991	UniSTS
Cytogenetic Map	4	q11	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	163	91	90	59	92	59	6	356	192	11	142	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001080153	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_198781	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006235945	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC099360	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY603378	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC059162	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BF388625	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CA338898	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474020	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CR470970	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DY313123	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000061992 ⟹ ENSRNOP00000058703

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	11,622,093 - 11,624,347 (+)	Ensembl
mRatBN7.2 Ensembl	4	10,729,922 - 10,732,058 (+)	Ensembl
Rnor_6.0 Ensembl	4	7,258,176 - 7,260,317 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000088357 ⟹ ENSRNOP00000074242

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	11,621,508 - 11,624,499 (+)	Ensembl
mRatBN7.2 Ensembl	4	10,729,250 - 10,732,060 (+)	Ensembl
Rnor_6.0 Ensembl	4	7,257,752 - 7,260,317 (+)	Ensembl

RefSeq Acc Id:

NM_001080153 ⟹ NP_001073622

RefSeq Status:

REVIEWED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	11,622,355 - 11,624,497 (+)	NCBI
mRatBN7.2	4	10,729,918 - 10,732,060 (+)	NCBI
Rnor_6.0	4	7,258,176 - 7,260,318 (+)	NCBI
Rnor_5.0	4	7,268,892 - 7,271,682 (+)	NCBI
RGSC_v3.4	4	6,093,852 - 6,096,418 (+)	RGD
Celera	4	6,344,479 - 6,346,621 (+)	NCBI

Sequence:

show sequence

AGGTTTGGGTAGATGGTAAGGGGGAAGTCAGGGAGGTATAGAGACTCTTCTGTCGGAGAAACTT
AGGAGTCAGGGCGTCAGATGAGCTTTACTATAAATAGGTGAAGGAGTGAACTTTGGGATGAAGT
GGACCAAAGAATAGCTCCTTAGCACCTCTGGCAACACAGGTGCCATGGCCTTGATTGAAGGCGT
AGGGGATGAGGTGACTGTCCTTTTTTCGGTGCTTGCCTGCCTTCTGGTGCTGGCCCTCGCCTGG
GTCTCAACACATACGACTGAGAGTACAGATCCCCTACCACAGTCGTCAGGGACCACAACACCAG
CACAGCCCAGTGAAGCCATGACAGCCATTGATAGCATCAGAGAGGAGGCCCCAGGAGCTGAGAG
TCCCAGCCTGAGGCACAGAGGTCCATCTGCACAGCCAGAGCCTGAGGCAGGGGTCACAGCATCA
ACACCTCCAGACTCTCCACAGGAACCCTTACTGCTACGGTTGAAATTTCTCAATGACTCTGAAC
AGGTGGCCAGGGCCTGGCCTCAGGACACCATTGGCTCCTTGAAAAGAACCCAGTTTCCAGGCCG
GGAACAGCAGGTTCGACTCATCTACCAAGGCCAACTGCTAGGAGACGACACCCAGACACTGGGC
AGTCTCCACCTTCCCCCCAACTGCGTTCTCCACTGCCACGTGTCCACAAGAGTCGGTCCCCCGC
ATCCTCCCTGCCCACCGGGGTCAGAGCCCGGCCCCTCCGGGCTGGAAATCGGCAGCCTTCTGTT
GCCCCTGCTGCTTCTGCTGCTGCTCCTGCTCTGGTACTGCCAGATCCAGTACCGGCCCTTCTTT
CCCCTGACCGCTACCTTGGGCCTGGCCGGCTTCACCCTGCTCCTCAGTCTCCTGGCCTTTGCCA
TGTATCGCCCGTAGTGCCTCCACGGGCTTTTGGCAGTGTCGACGGCCCCTCTGGACCTCATTCC
CCAAGGCGCAAAGGGAGCTGCTGTCTGCCCAGGCCCACCTCACCCGCTGCCTGTCTTTTCCCAC
TACCCTGGAGCCCAGCCTTGCGCAACAGAGGACTCCAGGTGTTAGCGGAGGCCACCCCATGTGA
TCTTCATAGCTCTGGGCCATCTCCTGGGGCTGCTGGCCCTCAGCCTTCTCTGACAGTGGGCTCT
TCTGAATCAGGCACCTGCTGCCGCTGCCTTGGCCTGGCACAGAGCCAGACCACCCCAATGGGCC
CATCTTAGTGTGCTGACAGAGGATCAAGATACATCTAGTTTCAAAGAGATGCCTAGGCTGAATT
GGAAACTGGTGAAGACTGGCGAAGGGGAATTGAGGGGGGGGAGAGTTGTTTTTCTGGAATTTGT
GGAGATTAAAGAAACTGTGATGTTTTCACA

hide sequence

RefSeq Acc Id:

NM_198781 ⟹ NP_942076

RefSeq Status:

REVIEWED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	11,621,931 - 11,624,497 (+)	NCBI
mRatBN7.2	4	10,729,494 - 10,732,060 (+)	NCBI
Rnor_6.0	4	7,257,752 - 7,260,318 (+)	NCBI
Rnor_5.0	4	7,268,892 - 7,271,682 (+)	NCBI
RGSC_v3.4	4	6,093,852 - 6,096,418 (+)	RGD
Celera	4	6,344,055 - 6,346,621 (+)	RGD

Sequence:

show sequence

CTTCGGCCCGGAAGTGCCCGAGGAGCCGAAATGGAGCTGGTGGAGCTGGGCGCTCCTTAGCACC
TCTGGCAACACAGGTGCCATGGCCTTGATTGAAGGCGTAGGGGATGAGGTGACTGTCCTTTTTT
CGGTGCTTGCCTGCCTTCTGGTGCTGGCCCTCGCCTGGGTCTCAACACATACGACTGAGAGTAC
AGATCCCCTACCACAGTCGTCAGGGACCACAACACCAGCACAGCCCAGTGAAGCCATGACAGCC
ATTGATAGCATCAGAGAGGAGGCCCCAGGAGCTGAGAGTCCCAGCCTGAGGCACAGAGGTCCAT
CTGCACAGCCAGAGCCTGAGGCAGGGGTCACAGCATCAACACCTCCAGACTCTCCACAGGAACC
CTTACTGCTACGGTTGAAATTTCTCAATGACTCTGAACAGGTGGCCAGGGCCTGGCCTCAGGAC
ACCATTGGCTCCTTGAAAAGAACCCAGTTTCCAGGCCGGGAACAGCAGGTTCGACTCATCTACC
AAGGCCAACTGCTAGGAGACGACACCCAGACACTGGGCAGTCTCCACCTTCCCCCCAACTGCGT
TCTCCACTGCCACGTGTCCACAAGAGTCGGTCCCCCGCATCCTCCCTGCCCACCGGGGTCAGAG
CCCGGCCCCTCCGGGCTGGAAATCGGCAGCCTTCTGTTGCCCCTGCTGCTTCTGCTGCTGCTCC
TGCTCTGGTACTGCCAGATCCAGTACCGGCCCTTCTTTCCCCTGACCGCTACCTTGGGCCTGGC
CGGCTTCACCCTGCTCCTCAGTCTCCTGGCCTTTGCCATGTATCGCCCGTAGTGCCTCCACGGG
CTTTTGGCAGTGTCGACGGCCCCTCTGGACCTCATTCCCCAAGGCGCAAAGGGAGCTGCTGTCT
GCCCAGGCCCACCTCACCCGCTGCCTGTCTTTTCCCACTACCCTGGAGCCCAGCCTTGCGCAAC
AGAGGACTCCAGGTGTTAGCGGAGGCCACCCCATGTGATCTTCATAGCTCTGGGCCATCTCCTG
GGGCTGCTGGCCCTCAGCCTTCTCTGACAGTGGGCTCTTCTGAATCAGGCACCTGCTGCCGCTG
CCTTGGCCTGGCACAGAGCCAGACCACCCCAATGGGCCCATCTTAGTGTGCTGACAGAGGATCA
AGATACATCTAGTTTCAAAGAGATGCCTAGGCTGAATTGGAAACTGGTGAAGACTGGCGAAGGG
GAATTGAGGGGGGGGAGAGTTGTTTTTCTGGAATTTGTGGAGATTAAAGAAACTGTGATGTTTT
CACA

hide sequence

RefSeq Acc Id:

XM_006235945 ⟹ XP_006236007

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	11,622,114 - 11,624,495 (+)	NCBI
mRatBN7.2	4	10,729,664 - 10,732,060 (+)	NCBI
Rnor_6.0	4	7,257,821 - 7,260,318 (+)	NCBI
Rnor_5.0	4	7,268,892 - 7,271,682 (+)	NCBI

Sequence:

show sequence

GCCGCGCCCACCCGGTCGCCCCAGGCCACAGCTGGGACCTGCTTGCCCCGCCCCGAGATCGCTG
GTGCCCTCCAGTAGCTCTGGGGGGCGGGCAGATGGGAGGAGTGATGGAGCAGTCGGGGGTGGGG
AAGGCTAAATCTAGGCTCGCCCCGAGAGATCAAGGGTCTGGAGGCCTCTGGGTTTGGCGCCCAG
GAGCTCCTTAGCACCTCTGGCAACACAGGTGCCATGGCCTTGATTGAAGGCGTAGGGGATGAGG
TGACTGTCCTTTTTTCGGTGCTTGCCTGCCTTCTGGTGCTGGCCCTCGCCTGGGTCTCAACACA
TACGACTGAGAGTACAGATCCCCTACCACAGTCGTCAGGGACCACAACACCAGCACAGCCCAGT
GAAGCCATGACAGCCATTGATAGCATCAGAGAGGAGGCCCCAGGAGCTGAGAGTCCCAGCCTGA
GGCACAGAGGTCCATCTGCACAGCCAGAGCCTGAGGCAGGGGTCACAGCATCAACACCTCCAGA
CTCTCCACAGGAACCCTTACTGCTACGGTTGAAATTTCTCAATGACTCTGAACAGGTGGCCAGG
GCCTGGCCTCAGGACACCATTGGCTCCTTGAAAAGAACCCAGTTTCCAGGCCGGGAACAGCAGG
TTCGACTCATCTACCAAGGCCAACTGCTAGGAGACGACACCCAGACACTGGGCAGTCTCCACCT
TCCCCCCAACTGCGTTCTCCACTGCCACGTGTCCACAAGAGTCGGTCCCCCGCATCCTCCCTGC
CCACCGGGGTCAGAGCCCGGCCCCTCCGGGCTGGAAATCGGCAGCCTTCTGTTGCCCCTGCTGC
TTCTGCTGCTGCTCCTGCTCTGGTACTGCCAGATCCAGTACCGGCCCTTCTTTCCCCTGACCGC
TACCTTGGGCCTGGCCGGCTTCACCCTGCTCCTCAGTCTCCTGGCCTTTGCCATGTATCGCCCG
TAGTGCCTCCACGGGCTTTTGGCAGTGTCGACGGCCCCTCTGGACCTCATTCCCCAAGGCGCAA
AGGGAGCTGCTGTCTGCCCAGGCCCACCTCACCCGCTGCCTGTCTTTTCCCACTACCCTGGAGC
CCAGCCTTGCGCAACAGAGGACTCCAGGTGTTAGCGGAGGCCACCCCATGTGATCTTCATAGCT
CTGGGCCATCTCCTGGGGCTGCTGGCCCTCAGCCTTCTCTGACAGTGGGCTCTTCTGAATCAGG
CACCTGCTGCCGCTGCCTTGGCCTGGCACAGAGCCAGACCACCCCAATGGGCCCATCTTAGTGT
GCTGACAGAGGATCAAGATACATCTAGTTTCAAAGAGATGCCTAGGCTGAATTGGAAACTGGTG
AAGACTGGCGAAGGGGAATTGAGGGGGGGGAGAGTTGTTTTTCTGGAATTTGTGGAGATTAAAG
AAACTGTGATGTTTTCACA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001073622	(Get FASTA)	NCBI Sequence Viewer
	NP_942076	(Get FASTA)	NCBI Sequence Viewer
	XP_006236007	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAU00154	(Get FASTA)	NCBI Sequence Viewer
	EDL99355	(Get FASTA)	NCBI Sequence Viewer
	Q53AQ4	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_942076 ⟸ NM_198781

- UniProtKB:

Q53AQ4 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MALIEGVGDEVTVLFSVLACLLVLALAWVSTHTTESTDPLPQSSGTTTPAQPSEAMTAIDSIRE
EAPGAESPSLRHRGPSAQPEPEAGVTASTPPDSPQEPLLLRLKFLNDSEQVARAWPQDTIGSLK
RTQFPGREQQVRLIYQGQLLGDDTQTLGSLHLPPNCVLHCHVSTRVGPPHPPCPPGSEPGPSGL
EIGSLLLPLLLLLLLLLWYCQIQYRPFFPLTATLGLAGFTLLLSLLAFAMYRP

hide sequence

RefSeq Acc Id:

NP_001073622 ⟸ NM_001080153

- UniProtKB:

Q53AQ4 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MALIEGVGDEVTVLFSVLACLLVLALAWVSTHTTESTDPLPQSSGTTTPAQPSEAMTAIDSIRE
EAPGAESPSLRHRGPSAQPEPEAGVTASTPPDSPQEPLLLRLKFLNDSEQVARAWPQDTIGSLK
RTQFPGREQQVRLIYQGQLLGDDTQTLGSLHLPPNCVLHCHVSTRVGPPHPPCPPGSEPGPSGL
EIGSLLLPLLLLLLLLLWYCQIQYRPFFPLTATLGLAGFTLLLSLLAFAMYRP

hide sequence

RefSeq Acc Id:	XP_006236007 ⟸ XM_006235945
- Peptide Label:	isoform X1
- UniProtKB:	Q53AQ4 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MALIEGVGDEVTVLFSVLACLLVLALAWVSTHTTESTDPLPQSSGTTTPAQPSEAMTAIDSIRE EAPGAESPSLRHRGPSAQPEPEAGVTASTPPDSPQEPLLLRLKFLNDSEQVARAWPQDTIGSLK RTQFPGREQQVRLIYQGQLLGDDTQTLGSLHLPPNCVLHCHVSTRVGPPHPPCPPGSEPGPSGL EIGSLLLPLLLLLLLLLWYCQIQYRPFFPLTATLGLAGFTLLLSLLAFAMYRP hide sequence

Ensembl Acc Id:

ENSRNOP00000058703 ⟸ ENSRNOT00000061992

Ensembl Acc Id:

ENSRNOP00000074242 ⟸ ENSRNOT00000088357

Protein Domains

Ubiquitin-like

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q53AQ4-F1-model_v2	AlphaFold	Q53AQ4	1-245	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13692788

Promoter ID:

EPDNEW_R3312

Type:

initiation region

Name:

Tmub1_1

Description:

transmembrane and ubiquitin-like domain containing 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	4	7,257,744 - 7,257,804	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:735120	AgrOrtholog
BioCyc Gene	G2FUF-46045	BioCyc
Ensembl Genes	ENSRNOG00000013383	Ensembl
Gene3D-CATH	Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1	UniProtKB/Swiss-Prot
InterPro	TMUB1/2	UniProtKB/Swiss-Prot
	Ubiquitin-like_domsf	UniProtKB/Swiss-Prot
	Ubiquitin_dom	UniProtKB/Swiss-Prot
KEGG Report	rno:362301	UniProtKB/Swiss-Prot
NCBI Gene	362301	ENTREZGENE
PANTHER	PTHR14557	UniProtKB/Swiss-Prot
	TRANSMEMBRANE AND UBIQUITIN-LIKE DOMAIN-CONTAINING PROTEIN 1	UniProtKB/Swiss-Prot
Pfam	ubiquitin	UniProtKB/Swiss-Prot
PhenoGen	Tmub1	PhenoGen
PROSITE	UBIQUITIN_2	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000013383	RatGTEx
SMART	UBQ	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF54236	UniProtKB/Swiss-Prot
UniProt	A0A8L2R8I3_RAT	UniProtKB/TrEMBL
	A0A8L2UN18_RAT	UniProtKB/TrEMBL
	Q53AQ4	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-03-06	Tmub1	transmembrane and ubiquitin-like domain containing 1	MGC72996	Unknown (protein for MGC:72996)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-09-30	MGC72996				Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar