Gatm (glycine amidinotransferase) - Rat Genome Database

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Gene: Gatm (glycine amidinotransferase) Rattus norvegicus
Analyze
Symbol: Gatm
Name: glycine amidinotransferase
RGD ID: 71090
Description: Enables glycine amidinotransferase activity. Involved in several processes, including embryonic liver development; response to flavonoid; and response to mercury ion. Located in cytosol and mitochondrial inner membrane. Biomarker of acute kidney failure and kidney disease. Human ortholog(s) of this gene implicated in AGAT deficiency and Fanconi renotubular syndrome 1. Orthologous to human GATM (glycine amidinotransferase); PARTICIPATES IN creatine metabolic pathway; AGAT deficiency pathway; arginine and proline metabolic pathway; INTERACTS WITH 2,2,2-tetramine; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AT; glycine amidinotransferase (L-arginine:glycine amidinotransferase); glycine amidinotransferase, mitochondrial; L-arginine: glycine amidinotransferase; L-arginine:glycine amidinotransferase; MGC93388; transamidinase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83130,112,508 - 130,137,664 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3130,112,509 - 130,129,355 (-)EnsemblGRCr8
mRatBN7.23109,658,919 - 109,675,508 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3109,658,951 - 109,684,129 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3113,555,275 - 113,571,827 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03122,150,802 - 122,167,354 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03119,811,184 - 119,827,736 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03114,711,570 - 114,728,155 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3114,711,562 - 114,728,410 (-)Ensemblrn6Rnor6.0
Rnor_5.03121,249,707 - 121,266,292 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43109,558,043 - 109,565,432 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3108,536,141 - 108,553,426 (-)NCBICelera
RGSC_v3.13109,463,621 - 109,470,996 (-)NCBI
RH 3.4 Map3965.7RGD
Cytogenetic Map3q35NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
17beta-estradiol  (ISO)
2,2,2-tetramine  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-amino-2-deoxy-D-glucopyranose  (EXP)
2-hydroxypropanoic acid  (ISO)
3,7-dihydropurine-6-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (EXP)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
ammonia  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
beta-D-glucosamine  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
clozapine  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
corticosterone  (EXP)
creatine  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
D-penicillamine  (EXP)
dibutyl phthalate  (EXP)
diquat  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
entinostat  (ISO)
ethyl methanesulfonate  (ISO)
eugenol  (EXP)
fipronil  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
gentamycin  (EXP)
GW 4064  (ISO)
hydrogen peroxide  (ISO)
indometacin  (EXP)
iron dichloride  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
mercaptopurine  (EXP)
mercury dichloride  (EXP)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
N-nitrosomorpholine  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
pentanal  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
progesterone  (EXP,ISO)
purine-6-thiol  (EXP)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (EXP)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
streptozocin  (EXP)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
T-2 toxin  (EXP)
tamoxifen  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Creatine synthesis and transport during rat embryogenesis: spatiotemporal expression of AGAT, GAMT and CT1. Braissant O, etal., BMC Dev Biol. 2005 May 26;5:9.
2. Homoarginine levels are regulated by L-arginine:glycine amidinotransferase and affect stroke outcome: results from human and murine studies. Choe CU, etal., Circulation. 2013 Sep 24;128(13):1451-61. doi: 10.1161/CIRCULATIONAHA.112.000580. Epub 2013 Sep 4.
3. Myocardial expression of the arginine:glycine amidinotransferase gene is elevated in heart failure and normalized after recovery: potential implications for local creatine synthesis. Cullen ME, etal., Circulation. 2006 Jul 4;114(1 Suppl):I16-20. doi: 10.1161/CIRCULATIONAHA.105.000448.
4. The Effects of Early-Onset Pre-Eclampsia on Placental Creatine Metabolism in the Third Trimester. Ellery SJ, etal., Int J Mol Sci. 2020 Jan 26;21(3):806. doi: 10.3390/ijms21030806.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Cloning and sequencing of rat kidney L-arginine:glycine amidinotransferase. Studies on the mechanism of regulation by growth hormone and creatine. Guthmiller P, etal., J Biol Chem 1994 Jul 1;269(26):17556-60.
8. Novel pathways in the pathobiology of human abdominal aortic aneurysms. Hinterseher I, etal., Pathobiology. 2013;80(1):1-10. doi: 10.1159/000339303. Epub 2012 Jul 12.
9. [Study of impaired metabolism of guanidinoacetic acid in uremia--the compensatory role of the pancreas in guanidinoacetic acid synthesis] Hirata M Nippon Jinzo Gakkai Shi. 1989 Sep;31(9):951-61.
10. SERUM TRANSAMIDINASE IN RENAL DISEASE. HORNER WH, etal., Proc Soc Exp Biol Med. 1965 Jan;118:65-9. doi: 10.3181/00379727-118-29757.
11. Potential biomarkers associated with diabetic glomerulopathy through proteomics. Hsu YC, etal., Ren Fail. 2015;37(8):1308-15. doi: 10.3109/0886022X.2015.1077321. Epub 2015 Sep 12.
12. Oxidative stress alters arginine metabolism in rat brain: effect of sub-convulsive hyperbaric oxygen exposure. Ito T, etal., Neurochem Int. 1996 Aug;29(2):187-95.
13. [Creatine biosynthesis enzymes in the postnatal development of rats: the role of cyclo-3',5'-AMP and glucagon in the postnatal induction of liver guanidine acetate-N-methyltransferase]. Karelin AA, Ontogenez. 1978;9(2):154-9.
14. Genetic Depletion of Adipocyte Creatine Metabolism Inhibits Diet-Induced Thermogenesis and Drives Obesity. Kazak L, etal., Cell Metab. 2017 Oct 3;26(4):660-671.e3. doi: 10.1016/j.cmet.2017.08.009. Epub 2017 Aug 24.
15. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
16. Urinary guanidinoacetic acid excretion as an indicator of gentamicin nephrotoxicity in rats. Kiyatake I, etal., Ren Fail. 2004 Jul;26(4):339-44. doi: 10.1081/jdi-120039812.
17. Interrelation of urinary and plasma levels of guanidinoacetic acid with alteration in renal activity of glycine amidinotransferase in acute renal failure rats. Kuwagaki Y and Sudo J, Chem Pharm Bull (Tokyo). 1989 Mar;37(3):781-4.
18. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
19. Metabolomic profiling of metoprolol-induced cardioprotection in a murine model of acute myocardial ischemia. Lai Q, etal., Biomed Pharmacother. 2020 Apr;124:109820. doi: 10.1016/j.biopha.2020.109820. Epub 2020 Jan 20.
20. On the biosynthesis of creatine. Intramitochondrial localization of transamidinase from rat kidney. Magri E, etal., FEBS Lett. 1975 Jul 15;55(1):91-3. doi: 10.1016/0014-5793(75)80966-5.
21. Gene Data Set MGD Curation, June 12, 2002
22. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
23. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
24. Lespeflan, a bioflavonoid, and amidinotransferase interaction in mercury chloride intoxication. Nikolic J and Sokolovic D, Ren Fail. 2004 Nov;26(6):607-11.
25. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
26. Identification of genes involved in gentamicin-induced nephrotoxicity in rats--a toxicogenomic investigation. Ozaki N, etal., Exp Toxicol Pathol. 2010 Sep;62(5):555-66. doi: 10.1016/j.etp.2009.07.004. Epub 2009 Aug 7.
27. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
28. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
29. GOA pipeline RGD automated data pipeline
30. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
31. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
32. Comprehensive gene review and curation RGD comprehensive gene curation
33. Evidence for the role of pancreatic acinar cells in the production of ornithine and guanidinoacetic acid by L-arginine:glycine amidinotransferase. Sorenson RL, etal., Pancreas. 1995 May;10(4):389-94. doi: 10.1097/00006676-199505000-00011.
34. Methylation demand and homocysteine metabolism: effects of dietary provision of creatine and guanidinoacetate. Stead LM, etal., Am J Physiol Endocrinol Metab. 2001 Nov;281(5):E1095-100.
35. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
36. Changes in kidney transaminase activity during development in male and female rats. Tormanen CD and Sutter BE, Biosci Rep. 1985 Apr;5(4):309-14. doi: 10.1007/BF01116902.
37. Comparison of the properties of purified mitochondrial and cytosolic rat kidney transamidinase. Tormanen CD, Int J Biochem. 1990;22(11):1243-50. doi: 10.1016/0020-711x(90)90305-m.
38. Synthesis of neuroactive guanidino compounds by rat kidney L-arginine: glycine amidinotransferase. Watanabe Y, etal., Life Sci. 1994;55(5):351-8.
39. Proteomic analysis of differential protein expression in early process of pancreatic regeneration in pancreatectomized rats. Yang M, etal., Acta Pharmacol Sin. 2006 May;27(5):568-78.
Additional References at PubMed
PMID:3057136   PMID:9218780   PMID:14651853   PMID:15489334   PMID:18614015   PMID:23376485   PMID:23533145   PMID:26490222   PMID:27233232  


Genomics

Comparative Map Data
Gatm
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83130,112,508 - 130,137,664 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3130,112,509 - 130,129,355 (-)EnsemblGRCr8
mRatBN7.23109,658,919 - 109,675,508 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3109,658,951 - 109,684,129 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3113,555,275 - 113,571,827 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03122,150,802 - 122,167,354 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03119,811,184 - 119,827,736 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03114,711,570 - 114,728,155 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3114,711,562 - 114,728,410 (-)Ensemblrn6Rnor6.0
Rnor_5.03121,249,707 - 121,266,292 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43109,558,043 - 109,565,432 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3108,536,141 - 108,553,426 (-)NCBICelera
RGSC_v3.13109,463,621 - 109,470,996 (-)NCBI
RH 3.4 Map3965.7RGD
Cytogenetic Map3q35NCBI
GATM
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381545,361,124 - 45,402,227 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1545,361,124 - 45,402,327 (-)Ensemblhg38GRCh38
GRCh371545,653,322 - 45,694,425 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361543,440,614 - 43,458,272 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341543,440,613 - 43,457,998NCBI
Celera1522,544,733 - 22,562,401 (-)NCBICelera
Cytogenetic Map15q21.1NCBI
HuRef1522,477,507 - 22,495,086 (-)NCBIHuRef
CHM1_11545,771,808 - 45,789,455 (-)NCBICHM1_1
T2T-CHM13v2.01543,169,297 - 43,210,402 (-)NCBIT2T-CHM13v2.0
Gatm
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392122,424,954 - 122,441,758 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2122,424,948 - 122,441,784 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm382122,594,473 - 122,611,277 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2122,594,467 - 122,611,303 (-)Ensemblmm10GRCm38
MGSCv372122,420,209 - 122,437,013 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv362122,285,913 - 122,302,703 (-)NCBIMGSCv36mm8
Celera2123,756,992 - 123,773,746 (-)NCBICelera
Cytogenetic Map2E5NCBI
cM Map260.63NCBI
Gatm
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554098,068,476 - 8,084,603 (+)Ensembl
ChiLan1.0NW_0049554098,068,524 - 8,084,603 (+)NCBIChiLan1.0ChiLan1.0
GATM
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21634,601,733 - 34,619,192 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11538,778,402 - 38,795,861 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01524,309,045 - 24,326,673 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11542,639,597 - 42,657,209 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1542,639,597 - 42,657,209 (-)EnsemblpanPan2panpan1.1
GATM
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13011,724,446 - 11,742,214 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3011,723,519 - 11,742,214 (-)EnsemblcanFam3CanFam3.1
ROS_Cfam_1.03011,861,543 - 11,879,299 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3011,859,577 - 11,879,307 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13011,782,971 - 11,800,732 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03011,889,472 - 11,907,009 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03012,009,534 - 12,027,312 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Gatm
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864090,169,547 - 90,184,640 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364718,017,603 - 8,032,703 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364718,017,611 - 8,032,703 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GATM
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1126,361,945 - 126,380,871 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11126,361,968 - 126,378,705 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21140,845,025 - 140,861,764 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GATM
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12637,836,207 - 37,853,811 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2637,836,335 - 37,852,822 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666048103,208,357 - 103,226,225 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gatm
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473113,941,049 - 13,955,461 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473113,941,084 - 13,954,910 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Gatm
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v15100,670,873 - 100,687,713 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Gatm
187 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:597
Count of miRNA genes:268
Interacting mature miRNAs:330
Transcripts:ENSRNOT00000000181
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)396509147141509147Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)3129154923182114333Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)373592512136118980Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)358601291153936591Rat
1582216Bw65Body weight QTL 656.3body mass (VT:0001259)body weight (CMO:0000012)3122654702136118980Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)349872657138829559Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1582219Bw63Body weight QTL 633.80.001body mass (VT:0001259)body weight (CMO:0000012)3116582412136118980Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)385062224136118980Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)385062224136118980Rat
7387306Bw124Body weight QTL 1243.20.0003body mass (VT:0001259)body weight (CMO:0000012)3104545086149545086Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)381425008141509147Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)370845569136091483Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)393829559138829559Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)3112250810157250810Rat
2302273Gluco35Glucose level QTL 355.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)3101255536134750886Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)396509147141509147Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)3117537367162537367Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3125116475170116475Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3110225882155225882Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)390755164141509147Rat
5686842Rf59Renal function QTL 59urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)3122395989167395989Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)398651826167012663Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)3125814931139636791Rat
1331758Bp207Blood pressure QTL 2072.848arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3110634702155634702Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)3116188400161188400Rat

Markers in Region
RH134360  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr83130,112,661 - 130,112,861 (+)Marker Load Pipeline
mRatBN7.23109,659,072 - 109,659,272 (+)MAPPERmRatBN7.2
Rnor_6.03114,711,724 - 114,711,923NCBIRnor6.0
Rnor_5.03121,249,861 - 121,250,060UniSTSRnor5.0
Celera3108,536,295 - 108,536,494UniSTS
RH 3.4 Map3965.7UniSTS
Cytogenetic Map3q35UniSTS
RH142307  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr83130,112,661 - 130,112,862 (+)Marker Load Pipeline
mRatBN7.23109,659,072 - 109,659,273 (+)MAPPERmRatBN7.2
Rnor_6.03114,711,724 - 114,711,924NCBIRnor6.0
Rnor_5.03121,249,861 - 121,250,061UniSTSRnor5.0
Celera3108,536,295 - 108,536,495UniSTS
RH 3.4 Map3965.7UniSTS
Cytogenetic Map3q35UniSTS
BG377645  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr83130,115,883 - 130,116,640 (+)Marker Load Pipeline
mRatBN7.23109,662,293 - 109,663,051 (+)MAPPERmRatBN7.2
Rnor_6.03114,714,945 - 114,715,702NCBIRnor6.0
Rnor_5.03121,253,082 - 121,253,839UniSTSRnor5.0
Celera3108,540,216 - 108,540,973UniSTS
Celera3108,539,516 - 108,540,973UniSTS
RH 3.4 Map3956.2UniSTS
Cytogenetic Map3q35UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000000181   ⟹   ENSRNOP00000000181
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3130,112,509 - 130,129,355 (-)Ensembl
mRatBN7.2 Ensembl3109,658,951 - 109,684,129 (-)Ensembl
Rnor_6.0 Ensembl3114,711,562 - 114,728,410 (-)Ensembl
RefSeq Acc Id: NM_031031   ⟹   NP_112293
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83130,112,508 - 130,129,093 (-)NCBI
mRatBN7.23109,658,919 - 109,675,508 (-)NCBI
Rnor_6.03114,711,570 - 114,728,155 (-)NCBI
Rnor_5.03121,249,707 - 121,266,292 (-)NCBI
RGSC_v3.43109,558,043 - 109,565,432 (-)RGD
Celera3108,536,141 - 108,553,426 (-)RGD
Sequence:
RefSeq Acc Id: XM_063284631   ⟹   XP_063140701
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83130,112,508 - 130,137,664 (-)NCBI
Protein Sequences
Protein RefSeqs NP_112293 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140701 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA21250 (Get FASTA)   NCBI Sequence Viewer  
  AAH81785 (Get FASTA)   NCBI Sequence Viewer  
  AAT39897 (Get FASTA)   NCBI Sequence Viewer  
  EDL80041 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000000181
GenBank Protein P50442 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_112293   ⟸   NM_031031
- Peptide Label: precursor
- UniProtKB: Q6ITZ7 (UniProtKB/Swiss-Prot),   P50442 (UniProtKB/Swiss-Prot),   A0A140TA89 (UniProtKB/TrEMBL),   A6HPT9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000000181   ⟸   ENSRNOT00000000181
RefSeq Acc Id: XP_063140701   ⟸   XM_063284631
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P50442-F1-model_v2 AlphaFold P50442 1-423 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692370
Promoter ID:EPDNEW_R2894
Type:single initiation site
Name:Gatm_1
Description:glycine amidinotransferase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03114,728,403 - 114,728,463EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:71090 AgrOrtholog
BioCyc Gene G2FUF-48090 BioCyc
BioCyc Pathway GLYCGREAT-PWY [creatine biosynthesis] BioCyc
BioCyc Pathway Image GLYCGREAT-PWY BioCyc
Ensembl Genes ENSRNOG00000000168 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000000181 ENTREZGENE
Gene3D-CATH L-arginine/glycine Amidinotransferase, Chain A UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7132560 IMAGE-MGC_LOAD
InterPro AmidinoTrfase UniProtKB/Swiss-Prot
KEGG Report rno:81660 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93388 IMAGE-MGC_LOAD
NCBI Gene 81660 ENTREZGENE
PANTHER GLYCINE AMIDINOTRANSFERASE, MITOCHONDRIAL UniProtKB/Swiss-Prot
  PTHR10488 UniProtKB/Swiss-Prot
PhenoGen Gatm PhenoGen
RatGTEx ENSRNOG00000000168 RatGTEx
Superfamily-SCOP Pentein UniProtKB/Swiss-Prot
UniProt A0A140TA89 ENTREZGENE, UniProtKB/TrEMBL
  A6HPT9 ENTREZGENE, UniProtKB/TrEMBL
  GATM_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q6ITZ7 ENTREZGENE
UniProt Secondary Q6ITZ7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-20 Gatm  glycine amidinotransferase  Gatm  glycine amidinotransferase (L-arginine:glycine amidinotransferase)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-07-09 Gatm  glycine amidinotransferase (L-arginine:glycine amidinotransferase)      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization protein localized to mitochondrial membrane 70746
gene_expression mRNA found in significant amounts only in kidney and pancreas 70746
gene_homology protein shares 37% aa identity with yeast (S. griseus) amidinotranserase 70746
gene_regulation mRNA epxression may be regulated by creatine and/or growth hormone 70746