Crot (carnitine O-octanoyltransferase) - Rat Genome Database

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Gene: Crot (carnitine O-octanoyltransferase) Rattus norvegicus
Analyze
Symbol: Crot
Name: carnitine O-octanoyltransferase
RGD ID: 70908
Description: Enables carnitine O-octanoyltransferase activity. Involved in response to xenobiotic stimulus. Located in peroxisome. Orthologous to human CROT (carnitine O-octanoyltransferase); PARTICIPATES IN adrenoleukodystrophy pathway; carnitine-acylcarnitine translocase deficiency; fatty acid beta degradation pathway; INTERACTS WITH (+)-schisandrin B; (R)-noradrenaline; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: COT; peroxisomal carnitine O-octanoyltransferase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8426,031,729 - 26,088,057 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl426,052,516 - 26,088,064 (+)EnsemblGRCr8
mRatBN7.2425,068,270 - 25,133,111 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl425,080,587 - 25,133,109 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx430,097,079 - 30,131,595 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0426,023,348 - 26,057,839 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0424,409,862 - 24,444,651 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0422,079,837 - 22,116,265 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl422,081,604 - 22,116,265 (+)Ensemblrn6Rnor6.0
Rnor_5.0422,018,106 - 22,053,087 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4422,023,913 - 22,067,029 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera420,575,938 - 20,626,257 (+)NCBICelera
RGSC_v3.1422,023,912 - 22,067,029 (-)NCBI
Cytogenetic Map4q12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(R)-noradrenaline  (EXP)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
9-cis-retinoic acid  (EXP)
aflatoxin B1  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-naphthoflavone  (EXP)
bexarotene  (EXP)
bezafibrate  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bromuconazole  (EXP)
Butylbenzyl phthalate  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cannabidiol  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
clofibric acid  (EXP)
cobalt dichloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
corn oil  (EXP,ISO)
cyclosporin A  (ISO)
DDT  (EXP)
decabromodiphenyl ether  (ISO)
deoxycholic acid  (ISO)
dibenz[a,h]anthracene  (ISO)
Dibutyl phosphate  (ISO)
dichloroacetic acid  (ISO)
dorsomorphin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fenofibrate  (EXP)
fentin chloride  (EXP)
flutamide  (EXP)
formaldehyde  (ISO)
furan  (EXP)
gentamycin  (EXP)
glafenine  (EXP)
glycidyl methacrylate  (ISO)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
indometacin  (EXP)
ivermectin  (ISO)
lipopolysaccharide  (ISO)
lithocholic acid  (ISO)
maneb  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
metformin  (EXP,ISO)
methapyrilene  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
Muraglitazar  (EXP)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
niclosamide  (ISO)
nimesulide  (EXP)
O-octanoylcarnitine  (ISO)
p-toluidine  (EXP)
paracetamol  (ISO)
paraquat  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP,ISO)
permethrin  (ISO)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP,ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
propiconazole  (ISO)
rac-lactic acid  (ISO)
resveratrol  (EXP,ISO)
ritonavir  (EXP)
rotenone  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
streptozocin  (EXP)
Tesaglitazar  (EXP)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (EXP,ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (EXP)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
peroxisome  (IBA,IDA,IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Cloning, sequencing, and regulation of rat liver carnitine octanoyltransferase: transcriptional stimulation of the enzyme during peroxisome proliferation. Chatterjee B, etal., Biochemistry 1988 Dec 13;27(25):9000-6.
2. Molecular cloning and sequence analysis of the rat liver carnitine octanoyltransferase cDNA, its natural gene and the gene promoter. Choi SJ, etal., Biochim Biophys Acta 1995 Nov 7;1264(2):215-22.
3. Molecular cloning and expression of human carnitine octanoyltransferase: evidence for its role in the peroxisomal beta-oxidation of branched-chain fatty acids. Ferdinandusse S, etal., Biochem Biophys Res Commun. 1999 Sep 16;263(1):213-8.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
7. Gene expression profile of cardiomyocytes in hypertrophic heart induced by continuous norepinephrine infusion in the rats. Li P, etal., Cell Mol Life Sci. 2003 Oct;60(10):2200-9.
8. Gene Data Set MGD Curation, June 12, 2002
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Purification and properties of carnitine octanoyltransferase and carnitine palmitoyltransferase from rat liver. Miyazawa S, etal., J Biochem. 1983 Aug;94(2):529-42.
11. Inhibition by etomoxir of rat liver carnitine octanoyltransferase is produced through the co-ordinate interaction with two histidine residues. Morillas M, etal., Biochem J. 2000 Oct 15;351 Pt 2:495-502.
12. Structural model of a malonyl-CoA-binding site of carnitine octanoyltransferase and carnitine palmitoyltransferase I: mutational analysis of a malonyl-CoA affinity domain. Morillas M, etal., J Biol Chem 2002 Mar 29;277(13):11473-80.
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
15. GOA pipeline RGD automated data pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:6436243   PMID:11553629   PMID:15155769   PMID:15492013   PMID:18614015   PMID:20178365   PMID:21619872  


Genomics

Comparative Map Data
Crot
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8426,031,729 - 26,088,057 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl426,052,516 - 26,088,064 (+)EnsemblGRCr8
mRatBN7.2425,068,270 - 25,133,111 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl425,080,587 - 25,133,109 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx430,097,079 - 30,131,595 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0426,023,348 - 26,057,839 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0424,409,862 - 24,444,651 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0422,079,837 - 22,116,265 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl422,081,604 - 22,116,265 (+)Ensemblrn6Rnor6.0
Rnor_5.0422,018,106 - 22,053,087 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4422,023,913 - 22,067,029 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera420,575,938 - 20,626,257 (+)NCBICelera
RGSC_v3.1422,023,912 - 22,067,029 (-)NCBI
Cytogenetic Map4q12NCBI
CROT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38787,345,664 - 87,399,794 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl787,345,664 - 87,399,800 (+)Ensemblhg38GRCh38
GRCh37786,974,980 - 87,029,110 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36786,812,947 - 86,867,045 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34786,619,661 - 86,673,760NCBI
Celera781,679,821 - 81,733,990 (+)NCBICelera
Cytogenetic Map7q21.12NCBI
HuRef781,585,930 - 81,640,108 (+)NCBIHuRef
CHM1_1786,905,052 - 86,959,218 (+)NCBICHM1_1
T2T-CHM13v2.0788,595,278 - 88,649,555 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2786,306,455 - 86,360,622 (+)NCBI
Crot
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3959,016,033 - 9,047,926 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl59,016,033 - 9,047,324 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3858,966,033 - 8,997,146 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl58,966,033 - 8,997,324 (-)Ensemblmm10GRCm38
MGSCv3758,966,048 - 8,997,146 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3658,972,054 - 9,003,152 (-)NCBIMGSCv36mm8
Celera58,885,457 - 8,916,553 (-)NCBICelera
Cytogenetic Map5A1NCBI
cM Map53.5NCBI
Crot
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955607378,439 - 413,394 (-)Ensembl
ChiLan1.0NW_004955607379,121 - 413,394 (-)NCBIChiLan1.0ChiLan1.0
CROT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26105,224,533 - 105,278,705 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17153,489,171 - 153,543,350 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0779,339,498 - 79,393,676 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1792,989,868 - 93,043,832 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl792,989,868 - 93,043,832 (+)EnsemblpanPan2panpan1.1
CROT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11413,475,130 - 13,532,536 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1413,475,235 - 13,532,536 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1413,046,798 - 13,104,279 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01413,240,042 - 13,298,355 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1413,240,015 - 13,299,882 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11413,443,706 - 13,500,941 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01413,169,264 - 13,227,485 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01413,452,909 - 13,510,196 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Crot
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511826,538,694 - 26,575,933 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367631,424,935 - 1,462,679 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049367631,425,394 - 1,462,638 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CROT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl993,258,619 - 93,308,151 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1993,263,606 - 93,308,150 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29102,743,699 - 102,788,243 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CROT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12161,531,263 - 61,584,448 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2161,531,060 - 61,584,447 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604242,477,754 - 42,533,686 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Crot
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473934,696,511 - 34,730,419 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473934,696,516 - 34,738,143 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Crot
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v16140,816,792 - 140,848,807 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Crot
470 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:109
Count of miRNA genes:84
Interacting mature miRNAs:103
Transcripts:ENSRNOT00000067462
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2302371Stl22Serum triglyceride level QTL 225.15blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)41308014658080146Rat
2303585Bw86Body weight QTL 864body mass (VT:0001259)body weight (CMO:0000012)41564430960644309Rat
8552903Pigfal2Plasma insulin-like growth factor 1 level QTL 27.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)4132668025Rat
724557Plsm1Polydactyly-luxate syndrome (PLS) morphotypes QTL 10.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)4128392287Rat
9590100Sffal4Serum free fatty acids level QTL 47.360.05blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)4132668025Rat
8552906Pigfal3Plasma insulin-like growth factor 1 level QTL 3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)41103870656038706Rat
1357341Gluco5Glucose level QTL 56.4adipocyte free fatty acid secretion trait (VT:0010465)absolute change in adipocyte free fatty acid secretion per unit volume (CMO:0001446)4134142783Rat
1357343Gluco4Glucose level QTL 40.00002adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)4134142783Rat
8552782Vie1Viral induced encephalitis QTL 126.4brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)4135396961Rat
6478766Anxrr47Anxiety related response QTL 470.09637locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)41103870656038706Rat
70222Eae2Experimental allergic encephalomyelitis QTL 24.3nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)42228845340471598Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4589457557613242Rat
6478769Anxrr48Anxiety related response QTL 480.02514locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)41103870656038706Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41170660492690519Rat
61333Gluco16Glucose level QTL 164.30.00001adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)4131106810Rat
2313401Anxrr27Anxiety related response QTL 27aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)41890069763900697Rat
61408Scl23Serum cholesterol level QTL 230.0005blood HDL phospholipid amount (VT:0010504)serum high density lipoprotein phospholipid level (CMO:0001567)4128392287Rat
631209Bw2Body weight QTL24.2retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)4145429897Rat
8552803Bw144Body weight QTL 14416body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)4135396961Rat
8694374Bw155Body weight QTL 1553.390.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)41103870656038706Rat
8552801Bw143Body weight QTL 1437.3body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)4135396961Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45889999148002343Rat
9589046Scfw2Subcutaneous fat weight QTL 25.540.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)4132668025Rat
61412Pia2Pristane induced arthritis QTL 23.9joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)42228845363245191Rat
8552807Vie4Viral induced encephalitis QTL 47.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)41890069763900697Rat
6478724Anxrr35Anxiety related response QTL 350.00449defecation behavior trait (VT:0010462)defecation measurement (CMO:0000997)41103870656038706Rat
61351Bp33Blood pressure QTL 330.0018arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4128392287Rat
61415Eae11Experimental allergic encephalomyelitis QTL 112.9nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)4140471598Rat
1641905Colcr1Colorectal carcinoma resistance QTL 14.30.0003intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)4842855130449094Rat
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4588999950889999Rat
8552809Vie5Viral induced encephalitis QTL 525.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)4135396961Rat
7387227Uae40Urinary albumin excretion QTL 402.90.0052urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)41891315163913151Rat
738021Hcar13Hepatocarcinoma resistance QTL 134.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)4133538816Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)42192515166925151Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)4163900697Rat
9590304Scort17Serum corticosterone level QTL 174.960.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)41103870656038706Rat
9589097Slep11Serum leptin concentration QTL 115.090.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)4132668025Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
1354665Stl10Serum triglyceride level QTL 103.57blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)42228845345429897Rat
1300141Bp178Blood pressure QTL 178arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)41075870140490708Rat

Markers in Region
RH142432  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2425,132,724 - 25,132,963 (+)MAPPERmRatBN7.2
Rnor_6.0422,115,881 - 22,116,119NCBIRnor6.0
Rnor_5.0422,052,703 - 22,052,941UniSTSRnor5.0
RGSC_v3.4422,024,059 - 22,024,297UniSTSRGSC3.4
Celera420,625,873 - 20,626,111UniSTS
Cytogenetic Map4q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000067462   ⟹   ENSRNOP00000063856
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl426,052,516 - 26,088,064 (+)Ensembl
mRatBN7.2 Ensembl425,098,110 - 25,133,105 (+)Ensembl
Rnor_6.0 Ensembl422,081,604 - 22,116,265 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000090968   ⟹   ENSRNOP00000071087
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl426,053,124 - 26,088,060 (+)Ensembl
mRatBN7.2 Ensembl425,107,632 - 25,133,109 (+)Ensembl
Rnor_6.0 Ensembl422,084,954 - 22,111,749 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000091799   ⟹   ENSRNOP00000073847
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl426,053,115 - 26,088,057 (+)Ensembl
mRatBN7.2 Ensembl425,080,587 - 25,133,109 (+)Ensembl
Rnor_6.0 Ensembl422,082,194 - 22,116,241 (+)Ensembl
RefSeq Acc Id: NM_031987   ⟹   NP_114193
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8426,053,124 - 26,088,057 (+)NCBI
mRatBN7.2425,098,174 - 25,133,109 (+)NCBI
Rnor_6.0422,081,604 - 22,116,265 (+)NCBI
Rnor_5.0422,018,106 - 22,053,087 (+)NCBI
RGSC_v3.4422,023,913 - 22,067,029 (-)RGD
Celera420,575,938 - 20,626,257 (+)RGD
Sequence:
RefSeq Acc Id: XM_006236004   ⟹   XP_006236066
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8426,049,329 - 26,088,057 (+)NCBI
mRatBN7.2425,098,279 - 25,133,111 (+)NCBI
Rnor_6.0422,081,673 - 22,116,264 (+)NCBI
Rnor_5.0422,018,106 - 22,053,087 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006236005   ⟹   XP_006236067
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8426,049,329 - 26,088,057 (+)NCBI
mRatBN7.2425,097,399 - 25,133,111 (+)NCBI
Rnor_6.0422,079,837 - 22,116,264 (+)NCBI
Rnor_5.0422,018,106 - 22,053,087 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039108454   ⟹   XP_038964382
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8426,031,729 - 26,088,057 (+)NCBI
mRatBN7.2425,079,428 - 25,133,111 (+)NCBI
RefSeq Acc Id: XM_039108458   ⟹   XP_038964386
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8426,031,729 - 26,088,057 (+)NCBI
mRatBN7.2425,079,428 - 25,133,111 (+)NCBI
RefSeq Acc Id: NP_114193   ⟸   NM_031987
- UniProtKB: P48033 (UniProtKB/Swiss-Prot),   P11466 (UniProtKB/Swiss-Prot),   Q6GMN6 (UniProtKB/TrEMBL),   A6K232 (UniProtKB/TrEMBL),   F7F5D0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006236067   ⟸   XM_006236005
- Peptide Label: isoform X2
- UniProtKB: P48033 (UniProtKB/Swiss-Prot),   P11466 (UniProtKB/Swiss-Prot),   Q6GMN6 (UniProtKB/TrEMBL),   A6K232 (UniProtKB/TrEMBL),   F7F5D0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006236066   ⟸   XM_006236004
- Peptide Label: isoform X1
- UniProtKB: P48033 (UniProtKB/Swiss-Prot),   P11466 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000063856   ⟸   ENSRNOT00000067462
Ensembl Acc Id: ENSRNOP00000071087   ⟸   ENSRNOT00000090968
Ensembl Acc Id: ENSRNOP00000073847   ⟸   ENSRNOT00000091799
RefSeq Acc Id: XP_038964382   ⟸   XM_039108454
- Peptide Label: isoform X2
- UniProtKB: P48033 (UniProtKB/Swiss-Prot),   P11466 (UniProtKB/Swiss-Prot),   A6K232 (UniProtKB/TrEMBL),   F7F5D0 (UniProtKB/TrEMBL),   Q6GMN6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038964386   ⟸   XM_039108458
- Peptide Label: isoform X2
- UniProtKB: P48033 (UniProtKB/Swiss-Prot),   P11466 (UniProtKB/Swiss-Prot),   Q6GMN6 (UniProtKB/TrEMBL),   A6K232 (UniProtKB/TrEMBL),   F7F5D0 (UniProtKB/TrEMBL)
Protein Domains
Choline/carnitine acyltransferase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P11466-F1-model_v2 AlphaFold P11466 1-612 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692826
Promoter ID:EPDNEW_R3351
Type:initiation region
Name:Crot_1
Description:carnitine O-octanoyltransferase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0422,081,564 - 22,081,624EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70908 AgrOrtholog
BioCyc Gene G2FUF-45833 BioCyc
Ensembl Genes ENSRNOG00000006779 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000090968 ENTREZGENE
  ENSRNOT00000091799 ENTREZGENE
Gene3D-CATH 1.10.275.20 UniProtKB/Swiss-Prot
  3.30.559.10 UniProtKB/Swiss-Prot
  3.30.559.70 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7098081 IMAGE-MGC_LOAD
InterPro Carn_acyl_trans UniProtKB/Swiss-Prot
  Carn_acyl_trans_N UniProtKB/Swiss-Prot
  CAT-like_dom_sf UniProtKB/Swiss-Prot
  Cho/carn_acyl_trans UniProtKB/Swiss-Prot
  Cho/carn_acyl_trans_2 UniProtKB/Swiss-Prot
KEGG Report rno:83842 UniProtKB/Swiss-Prot
MGC_CLONE MGC:91606 IMAGE-MGC_LOAD
NCBI Gene 83842 ENTREZGENE
PANTHER PEROXISOMAL CARNITINE O-OCTANOYLTRANSFERASE UniProtKB/Swiss-Prot
  PTHR22589 UniProtKB/Swiss-Prot
Pfam Carn_acyltransf UniProtKB/Swiss-Prot
PhenoGen Crot PhenoGen
PROSITE ACYLTRANSF_C_1 UniProtKB/Swiss-Prot
  ACYLTRANSF_C_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000006779 RatGTEx
Superfamily-SCOP CoA-dependent acyltransferases UniProtKB/Swiss-Prot
UniProt A0A0G2JZK8_RAT UniProtKB/TrEMBL
  A0ABZ3NN86_RAT UniProtKB/TrEMBL
  A6K232 ENTREZGENE, UniProtKB/TrEMBL
  F7F5D0 ENTREZGENE, UniProtKB/TrEMBL
  OCTC_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  P48033 ENTREZGENE
  Q6GMN6 ENTREZGENE
UniProt Secondary P48033 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-07-09 Crot  carnitine O-octanoyltransferase      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_regulation activity is inhibited by malonyl-CoA 727629