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Gene: Sipa1l1 (signal-induced proliferation-associated 1 like 1) Rattus norvegicus

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Symbol:

Sipa1l1

Name:

signal-induced proliferation-associated 1 like 1

RGD ID:

708497

Description:

Enables actin filament binding activity; protein kinase binding activity; and ubiquitin protein ligase binding activity. Involved in several processes, including activation of GTPase activity; postsynaptic actin cytoskeleton organization; and regulation of postsynapse organization. Located in dendritic spine; neuronal cell body; and postsynaptic density. Part of protein-containing complex. Is active in glutamatergic synapse and postsynapse. Orthologous to human SIPA1L1 (signal induced proliferation associated 1 like 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 3,4-methylenedioxymethamphetamine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

signal-induced proliferation-associated 1-like protein 1; SIPA1-like protein 1; Spa-1; SPA-1 like protein; SPA-1 like protein p1294; SPA-1-like protein p1294; Spa1; SPAL; Spar; spine-associated Rap GTPase-activating protein; spine-associated Rap guanosine triphosphatase (GTPase) activating protein (GAP)

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	107,570,569 - 107,849,613 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	6	107,737,392 - 107,848,160 (+)	Ensembl				GRCr8
mRatBN7.2	6	101,839,351 - 102,118,408 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	101,839,404 - 102,116,950 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	6	101,994,376 - 102,272,374 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	102,293,579 - 102,571,594 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	101,662,460 - 101,940,422 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd	6	108,821,311 - 109,099,283 (+)	NCBI		Dahl_SR_JrHsd
Lyon_Normotensive	6	108,230,824 - 108,508,794 (+)	NCBI		Lyon_Normotensive
Lyon_Hypertensive	6	106,024,420 - 106,302,387 (+)	NCBI		Lyon_Hypertensive
F344_StmMcwi	6	105,176,733 - 105,454,694 (+)	NCBI		F344_StmMcwi
Rnor_6.0	6	106,052,212 - 106,163,249 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	106,039,991 - 106,163,302 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	6	114,193,905 - 114,304,588 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	6	106,171,896 - 106,283,008 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	6	99,843,230 - 99,954,347 (+)	NCBI		Celera
RGSC_v3.1	6	106,175,351 - 106,286,464 (+)	NCBI
Cytogenetic Map	6	q24	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

diastolic heart failure (ISO)

systemic juvenile rheumatoid arthritis (ISO)

Weight Gain (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

1,1-dichloroethene (ISO)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

3,4-methylenedioxymethamphetamine (EXP,ISO)

4,4'-sulfonyldiphenol (ISO)

acrolein (ISO)

acrylamide (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

alpha-pinene (ISO)

ammonium chloride (EXP)

amphetamine (EXP)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bisphenol A (EXP,ISO)

Bufotalin (ISO)

Butylbenzyl phthalate (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

caffeine (ISO)

carbon nanotube (ISO)

chlorpyrifos (ISO)

cisplatin (ISO)

cocaine (EXP)

cyclosporin A (ISO)

dexamethasone (ISO)

Dibutyl phosphate (ISO)

dicrotophos (ISO)

Diisodecyl phthalate (ISO)

dioxygen (ISO)

disodium selenite (ISO)

diuron (ISO)

dorsomorphin (ISO)

endosulfan (EXP)

entinostat (ISO)

ethanol (ISO)

fenthion (ISO)

flavonoids (EXP)

folic acid (ISO)

FR900359 (ISO)

hydralazine (ISO)

hypochlorous acid (ISO)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (ISO)

methidathion (ISO)

nickel atom (ISO)

ozone (ISO)

phenytoin (EXP)

pirinixic acid (ISO)

potassium chromate (ISO)

progesterone (ISO)

quercetin (ISO)

rimonabant (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

sulforaphane (ISO)

tamoxifen (ISO)

tert-butyl hydroperoxide (ISO)

testosterone (ISO)

tetrachloromethane (ISO)

titanium dioxide (ISO)

Tributyltin oxide (ISO)

triphenyl phosphate (ISO)

troglitazone (ISO)

tungsten (ISO)

urethane (ISO)

valproic acid (ISO)

venlafaxine hydrochloride (EXP)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

actin cytoskeleton organization (IBA,IDA)

activation of GTPase activity (IDA)

ephrin receptor signaling pathway (IEA,ISO,ISS)

postsynaptic actin cytoskeleton organization (IDA,IMP)

regulation of axonogenesis (IEA,ISO,ISS)

regulation of dendrite morphogenesis (IMP)

regulation of dendritic spine morphogenesis (IBA,IDA)

regulation of postsynaptic density assembly (IDA,IMP)

regulation of small GTPase mediated signal transduction (IEA)

regulation of synaptic plasticity (IBA,IDA,IMP)

Cellular Component

actin cytoskeleton (IEA,ISO)

cytoskeleton (IEA)

cytosol (TAS)

dendritic spine (IDA)

glutamatergic synapse (IDA,IMP)

neuron projection (IEA)

neuronal cell body (IDA)

plasma membrane (IEA,ISO)

postsynapse (IDA)

postsynaptic density (IDA,IEA)

protein-containing complex (IDA)

synapse (IEA)

Molecular Function

actin filament binding (IDA)

ephrin receptor binding (IEA,ISO)

GTPase activator activity (IBA,IEA,TAS)

protein binding (IPI,ISO)

protein kinase binding (IPI)

protein-containing complex binding (IPI)

ubiquitin protein ligase binding (IDA)

References

References - curated

#	Reference Title	Reference Citation
1.	Regulation of postsynaptic RapGAP SPAR by Polo-like kinase 2 and the SCFbeta-TRCP ubiquitin ligase in hippocampal neurons.	Ang XL, etal., J Biol Chem. 2008 Oct 24;283(43):29424-32. doi: 10.1074/jbc.M802475200. Epub 2008 Aug 22.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Postsynaptic PDLIM5/Enigma Homolog binds SPAR and causes dendritic spine shrinkage.	Herrick S, etal., Mol Cell Neurosci. 2010 Feb;43(2):188-200. doi: 10.1016/j.mcn.2009.10.009. Epub 2009 Nov 10.
4.	Requirement for Plk2 in orchestrated ras and rap signaling, homeostatic structural plasticity, and memory.	Lee KJ, etal., Neuron. 2011 Mar 10;69(5):957-73. doi: 10.1016/j.neuron.2011.02.004.
5.	Collaboration of PSD-Zip70 with its binding partner, SPAR, in dendritic spine maturity.	Maruoka H, etal., J Neurosci. 2005 Feb 9;25(6):1421-30.
6.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
7.	Identification of a multiprotein "motor" complex binding to water channel aquaporin-2.	Noda Y, etal., Biochem Biophys Res Commun. 2005 May 20;330(4):1041-7.
8.	Targeted protein degradation and synapse remodeling by an inducible protein kinase.	Pak DT and Sheng M, Science 2003 Nov 21;302(5649):1368-73. Epub 2003 Oct 23.
9.	Regulation of dendritic spine morphology by SPAR, a PSD-95-associated RapGAP.	Pak DT, etal., Neuron. 2001 Aug 2;31(2):289-303.
10.	GOA pipeline	RGD automated data pipeline
11.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
13.	SPAL, a Rap-specific GTPase activating protein, is present in the NMDA receptor-PSD-95 complex in the hippocampus.	Roy BC, etal., Genes Cells 2002 Jun;7(6):607-17.
14.	Critical role of CDK5 and Polo-like kinase 2 in homeostatic synaptic plasticity during elevated activity.	Seeburg DP, etal., Neuron. 2008 May 22;58(4):571-83. doi: 10.1016/j.neuron.2008.03.021.
15.	ProSAP-interacting protein 1 (ProSAPiP1), a novel protein of the postsynaptic density that links the spine-associated Rap-Gap (SPAR) to the scaffolding protein ProSAP2/Shank3.	Wendholt D, etal., J Biol Chem. 2006 May 12;281(19):13805-16. Epub 2006 Mar 7.

Additional References at PubMed

PMID:9756850	PMID:15196935	PMID:15458844	PMID:17785183	PMID:18094260	PMID:18678258	PMID:20146300	PMID:21987493	PMID:23850969	PMID:25931508	PMID:29180226

Genomics

Comparative Map Data

Sipa1l1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	107,570,569 - 107,849,613 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	6	107,737,392 - 107,848,160 (+)	Ensembl				GRCr8
mRatBN7.2	6	101,839,351 - 102,118,408 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	101,839,404 - 102,116,950 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	6	101,994,376 - 102,272,374 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	102,293,579 - 102,571,594 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	101,662,460 - 101,940,422 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd	6	108,821,311 - 109,099,283 (+)	NCBI		Dahl_SR_JrHsd
Lyon_Normotensive	6	108,230,824 - 108,508,794 (+)	NCBI		Lyon_Normotensive
Lyon_Hypertensive	6	106,024,420 - 106,302,387 (+)	NCBI		Lyon_Hypertensive
F344_StmMcwi	6	105,176,733 - 105,454,694 (+)	NCBI		F344_StmMcwi
Rnor_6.0	6	106,052,212 - 106,163,249 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	106,039,991 - 106,163,302 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	6	114,193,905 - 114,304,588 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	6	106,171,896 - 106,283,008 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	6	99,843,230 - 99,954,347 (+)	NCBI		Celera
RGSC_v3.1	6	106,175,351 - 106,286,464 (+)	NCBI
Cytogenetic Map	6	q24	NCBI

SIPA1L1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	14	71,320,476 - 71,741,209 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	14	71,320,277 - 71,741,230 (+)	Ensembl			hg38	GRCh38
GRCh37	14	71,787,193 - 72,207,926 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	14	71,065,795 - 71,275,875 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	14	71,065,794 - 71,275,871	NCBI
Celera	14	52,059,323 - 52,269,351 (+)	NCBI		Celera
Cytogenetic Map	14	q24.2	NCBI
HuRef	14	52,162,703 - 52,372,954 (+)	NCBI		HuRef
CHM1_1	14	71,934,305 - 72,144,298 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	14	65,525,922 - 65,946,692 (+)	NCBI		T2T-CHM13v2.0

Sipa1l1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	12	82,216,138 - 82,498,560 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	12	82,216,094 - 82,498,560 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	12	82,169,377 - 82,451,786 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	12	82,169,320 - 82,451,786 (+)	Ensembl			mm10	GRCm38
MGSCv37	12	83,271,003 - 83,552,773 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	12	83,230,197 - 83,369,119 (+)	NCBI		MGSCv36	mm8
Celera	12	83,693,171 - 83,908,580 (+)	NCBI		Celera
Cytogenetic Map	12	D1	NCBI
cM Map	12	38.14	NCBI

Sipa1l1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955523	3,545,708 - 3,797,572 (-)	Ensembl
ChiLan1.0	NW_004955523	3,545,807 - 3,908,329 (-)	NCBI	ChiLan1.0	ChiLan1.0

SIPA1L1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	15	72,439,880 - 72,859,090 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	14	71,656,390 - 72,075,603 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	14	51,909,444 - 52,328,719 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	14	70,776,089 - 71,192,916 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	14	71,038,600 - 71,192,916 (+)	Ensembl			panPan2	panpan1.1

SIPA1L1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	8	44,916,309 - 45,260,197 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	8	44,990,495 - 45,258,614 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	8	44,543,228 - 44,922,482 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	8	45,102,510 - 45,476,140 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	8	45,102,544 - 45,474,511 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	8	44,762,748 - 45,148,005 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	8	44,801,685 - 45,176,501 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	8	45,162,889 - 45,538,133 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Sipa1l1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	30,893,917 - 31,249,447 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936488	860,129 - 1,175,051 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936488	819,503 - 1,175,043 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SIPA1L1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	95,022,924 - 95,167,107 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	7	94,789,794 - 95,168,728 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	101,036,283 - 101,416,110 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SIPA1L1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	24	48,542,976 - 48,965,378 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	24	48,636,323 - 48,965,371 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666053	36,766,457 - 37,176,731 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Sipa1l1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624734	29,611,978 - 29,914,317 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624734	29,612,867 - 29,998,602 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Sipa1l1
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	7	96,326,644 - 96,601,146 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Sipa1l1
2001 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	134
Count of miRNA genes:	116
Interacting mature miRNAs:	121
Transcripts:	ENSRNOT00000058195
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2293088	Iddm28	Insulin dependent diabetes mellitus QTL 28	5.21		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	6	68767270	135411972	Rat
1331799	Bp211	Blood pressure QTL 211	3.66407		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	6	88019181	136741135	Rat
1358355	Srcrt4	Stress Responsive Cort QTL 4	6.39		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	6	106095977	147156653	Rat
61329	Eae9	Experimental allergic encephalomyelitis QTL 9	3.7		body mass (VT:0001259)	change in body weight (CMO:0002045)	6	84490437	129490437	Rat
2313399	Anxrr28	Anxiety related response QTL 28			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	6	101593607	138161926	Rat
1331789	Rf37	Renal function QTL 37	3.224		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	6	86494122	112380234	Rat
1331725	Bp212	Blood pressure QTL 212	3.52475		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	6	99437079	125323237	Rat
1331722	Thshl1	Thyroid stimulating hormone level QTL 1	11.7	0.0001	blood thyroid-stimulating hormone amount (VT:0005119)	serum thyroid stimulating hormone level (CMO:0001248)	6	99708426	112483760	Rat
4145119	Mcs25	Mammary carcinoma susceptibility QTL 25		0.0001	mammary gland integrity trait (VT:0010552)	ratio of deaths to total study population during a period of time (CMO:0001023)	6	71278722	116278722	Rat
70176	Mcsm1	Mammary carcinoma susceptibility modifier QTL 1			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	6	64367996	109367996	Rat
10054138	Gmadr3	Adrenal mass QTL 3	3.68	0.00045	adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	6	90871046	135871046	Rat
1581563	Uae33	Urinary albumin excretion QTL 33			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	6	93560258	136550638	Rat
1641917	Colcr5	Colorectal carcinoma resistance QTL 5	3.18	0.0009	intestine integrity trait (VT:0010554)	benign colorectal tumor number (CMO:0001795)	6	98944780	143944780	Rat
61414	Pia3	Pristane induced arthritis QTL 3	4.5		joint integrity trait (VT:0010548)	post-insult time to onset of experimental arthritis (CMO:0001450)	6	100704576	136029228	Rat
724524	Uae2	Urinary albumin excretion QTL 2	2.7	0.0005	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	6	79198463	144254945	Rat
737827	Hcar11	Hepatocarcinoma resistance QTL 11	4.4		liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	6	46050607	116278722	Rat
2303624	Vencon5	Ventilatory control QTL 5	4.45		respiration trait (VT:0001943)	minute ventilation (CMO:0000132)	6	93778632	138778632	Rat
1576309	Emca7	Estrogen-induced mammary cancer QTL 7	4		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	6	20859430	113082285	Rat
2293837	Kiddil1	Kidney dilation QTL 1	3.7		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	6	86867923	110125012	Rat
2293842	Kiddil3	Kidney dilation QTL 3	4.3		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	6	86867923	110125012	Rat
10054123	Srcrt6	Stress Responsive Cort QTL 6	2.5	0.0043	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	6	90871046	135871046	Rat
724536	Uae7	Urinary albumin excretion QTL 7	3.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	6	93560258	136550638	Rat
1576302	Schws4	Schwannoma susceptibility QTL 4		0.0078	nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	6	78204640	123204640	Rat
1581550	Pur8	Proteinuria QTL 8			urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	6	93560258	136550638	Rat
1300075	Glom7	Glomerulus QTL 7	5.6	0.0000002	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)	6	76937178	121937178	Rat
12801471	Schws9	Schwannoma susceptibility QTL 9			nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	6	101593607	146593607	Rat

Markers in Region

BE116899

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	6	102,116,661 - 102,116,836 (+)	MAPPER	mRatBN7.2
Rnor_6.0	6	106,163,007 - 106,163,181	NCBI	Rnor6.0
Rnor_5.0	6	114,304,346 - 114,304,520	UniSTS	Rnor5.0
RGSC_v3.4	6	106,282,766 - 106,282,940	UniSTS	RGSC3.4
Celera	6	99,954,105 - 99,954,279	UniSTS
RH 3.4 Map	6	732.0	UniSTS
Cytogenetic Map	6	q24	UniSTS

RH138739

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	6	102,105,871 - 102,106,184 (+)	MAPPER	mRatBN7.2
Rnor_6.0	6	106,152,216 - 106,152,528	NCBI	Rnor6.0
Rnor_5.0	6	114,293,555 - 114,293,867	UniSTS	Rnor5.0
RGSC_v3.4	6	106,271,976 - 106,272,288	UniSTS	RGSC3.4
Celera	6	99,943,315 - 99,943,627	UniSTS
RH 3.4 Map	6	733.0	UniSTS
Cytogenetic Map	6	q24	UniSTS

ksks223

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	6	102,008,403 - 102,008,703 (+)	MAPPER	mRatBN7.2
Rnor_6.0	6	106,054,436 - 106,054,735	NCBI	Rnor6.0
Rnor_5.0	6	114,196,129 - 114,196,428	UniSTS	Rnor5.0
RGSC_v3.4	6	106,174,120 - 106,174,419	UniSTS	RGSC3.4
Celera	6	99,845,454 - 99,845,753	UniSTS
Cytogenetic Map	6	q24	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	163	91	90	59	92	59	6	356	192	11	142	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001389245	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_139330	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039111776	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039111778	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039111779	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039111780	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039111781	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063261545	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063261546	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063261547	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063261548	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063261549	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063261550	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF026504	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY043226	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473982	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000010626 ⟹ ENSRNOP00000010626

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	6	106,052,212 - 106,072,703 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000058195 ⟹ ENSRNOP00000054996

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	6	107,737,392 - 107,848,160 (+)	Ensembl
mRatBN7.2 Ensembl	6	101,839,404 - 102,116,950 (+)	Ensembl
Rnor_6.0 Ensembl	6	106,084,815 - 106,163,249 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000088917 ⟹ ENSRNOP00000075549

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	6	107,738,589 - 107,848,156 (+)	Ensembl
mRatBN7.2 Ensembl	6	101,839,404 - 102,116,950 (+)	Ensembl
Rnor_6.0 Ensembl	6	106,039,991 - 106,163,302 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000092065 ⟹ ENSRNOP00000072447

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	6	106,153,045 - 106,163,295 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000168984 ⟹ ENSRNOP00000109852

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	6	107,737,392 - 107,848,160 (+)	Ensembl

RefSeq Acc Id:

NM_001389245 ⟹ NP_001376174

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	107,570,638 - 107,848,160 (+)	NCBI
mRatBN7.2	6	101,839,420 - 102,116,950 (+)	NCBI
Dahl_SR_JrHsd	6	108,821,311 - 109,099,283 (+)	NCBI
Lyon_Normotensive	6	108,230,824 - 108,508,794 (+)	NCBI
Lyon_Hypertensive	6	106,024,420 - 106,302,387 (+)	NCBI
F344_StmMcwi	6	105,176,733 - 105,454,694 (+)	NCBI

RefSeq Acc Id:

NM_139330 ⟹ NP_647546

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	107,737,392 - 107,848,160 (+)	NCBI
mRatBN7.2	6	102,006,180 - 102,116,950 (+)	NCBI
Dahl_SR_JrHsd	6	108,988,325 - 109,099,283 (+)	NCBI
Lyon_Normotensive	6	108,397,838 - 108,508,794 (+)	NCBI
Lyon_Hypertensive	6	106,191,432 - 106,302,387 (+)	NCBI
F344_StmMcwi	6	105,343,749 - 105,454,694 (+)	NCBI
Rnor_6.0	6	106,052,212 - 106,163,249 (+)	NCBI
Rnor_5.0	6	114,193,905 - 114,304,588 (+)	NCBI
RGSC_v3.4	6	106,171,896 - 106,283,008 (+)	RGD
Celera	6	99,843,230 - 99,954,347 (+)	RGD

Sequence:

show sequence

GAATTCGGCACGAGAAGAATTTAAAGGCCACCTCTTGTGTGTTTGTGGAATGCTGGAGGAGGCT
GCTCTGCCTCTCTCTTCAGGATGTACGCACCCATGCAGGATTCTGTGCTCAAGCTCTGTGCCTG
CCGCCTCCTGCTTGACGAGCTTCTGAGGAAGTTCGTCTTACTGTCCGTCACCTGGGAAGGATGG
TAACAGTCCTCTGTAATCTGGTAGAGGACATGGAGCCAGCTGCCTTGAGCGGTCTTTTGCTTCT
GTCGTCGTCGTTGTCATCATCATAAATCAGCACTGATGGGGCGGAGGGGGCCGCTCTGCTTAAG
GAAACGCAGGCATTTTGTGAATTAGTGAAAGGCTTCCAGCTCAGAGTAAATGGAAGTCGGGAGA
TCTTGGGAAGAAGTGGCTGTGAATGCTGGGCTCCTGCAGTGCTCTTCTTGTGGGGGGAGCATGG
GATTATGGCAACCACAGAACCCCAGTGATGCCAGTTCTGTTCAATCTTTTCTGAAGGAAGCCTG
CTGTTAGAGCACAGGAACTGTTGTGGATTACAATGTTTGAAAGATACGGGTTCTCAGTGGTCTG
AAAACACGGCATCATTTAACCTTTTAAATGACAAGGCTTAAGATCTCAACACTACTGCTGTATT
TTCTGGAAGCCATTCTCTAAAGCAAAAGTGCACATTTAAAATGCAAACATGGTGATCCTTTCTC
CAGGGATTTAAGTGATCACTTTTTACGTCATGACCAGCTTGAAGAGGTCGCAGACCGAAAGGCC
TGTCACTGCTGACAGAGCCTCTGTTGTCAGCACAGATGGCACCCCCAAAGTTCACACTGATGAT
TTCTACATGCGTCGCTTCCGGTCCCAAAATGGCAGCTTAGGATCATCAGTCATGGCTGCAGTAG
GGCCCCCTCGAAGTGAAGGTCCTCACCATATAACCTCAACCCCCGGAGTCCCCAAGATGGGGGT
TAGGGCAAGAATTGCAGATTGGCCTCCAAGAAAGGAAAATGTAAAAGAATCTAGCCGTTCAAGC
CAGGAAATAGAAACCTCAAGTTGCCTTGAGAGCCTGTCCTCCAAAGGCAGTCCTGTGAGTCAGG
GGAGTTCTGTTAGCCTCAATTCCAATGACTCAGCCATGCTGAAGAGCATCCAGAACACCCTGAA
GAACAAGACGGGGCCAGCGGAGAGCATGGACTCGAGATTCCTCATGCCTGAAGCCTACCCCAGC
TCCCCCAGGAAAGCCCTTCGCCGAATCCGTCAGCGTAGCAACAGTGATATCACCATAAGTGAGC
TTGATGTGGATAGTTTTGATGAATGTATCTCCCCAACCTACAAGTCGGGGCCATCATTGCACAG
GGAATATGGTAGCACATCTTCAATCGACAAGCAGGGGACATCCGGAGAAAGCTTCTTCGGTTTG
TTAAAGGGCTATAAAGACGACAGAGCTGACCGAGGTCCAACTCCAACCAAACTCAGTGACTTCC
TCATCACTGGTGGGGGCAAGGGTTCTGGTTTCTCCTTGGATGTGATCGATGGACCCATTTCACA
GAGAGAGAACCTCAGGCTATTCAAGGAAAGGGAAAAACCACTCAAGCGACGTTCTAAGTCTGAA
ACTGGAGACTCATCCATTTTTCGTAAATTACGCAATGCCAAAGGTGAAGAACTCGGGAAGTCAT
CAGACCTTGAAGACAACAGATCAGAGGATTCTGTGAGGCCCTGGACATGTCCAAAGTGCTTTGC
CCACTATGATGTCCAGAGCATATTGTTTGACTTGAATGAAGCCATTATGAACAGGCATAATGTG
ATTAAGAGGAGAAACACCACAACGGGAGCTTCTGCAGCCGCTGTGGCGTCCTTAGTCTCGGGAC
CTTTGTCTCACTCAACCAGCTTCAGCTCTCCTATGGGCAGCACAGAGGACTTCAATTCCAAAGG
AAGCCTCGGCATGGACCAGGGAGATGACAAGAGCAATGAACTCGTCATGAGCTGTCCGTACTTT
CGGAATGAGATTGGGGGAGAAGGTGAGAGGAAAATCAGCCTGTCCAAGTCCAATTCTGGCTCAT
TCAGTGGGTGTGAGAGCACGTCCTTTGAGTCTGCCCTCAGCTCTCACTGCACAAACGCAGGAGT
GGCGGTTCTCGAAGTGCCCAAGGAGAGCTTGATGCTGCATCTAGACAGAGTGAGACGGTACACT
GTGGAGCACGTGGATCTTGGAGCATACTATTACAGGAAGTGCTTCTACCAAAAGGAACACTGGA
ACTATTTTGGGGCTGATGAAAACCTCGGTCCAGTGGCTGTGAGCATTCGAAGGGAAAAACCAGA
AGACATGAAGGAAAATGGATCTCCCTACAACTACCGAATAATTTTTAGAACTAGTGAGCTCATG
ACACTGAGAGGGTCTGTCCTGGAGGATGCCATTCCCTCCACAGCCAAGCACTCGACAGCCAGAG
GATTGCCGCTGAAAGAGGTGCTGGAACATGTGATCCCAGAGCTCAACGTGCAGTGCCTGCGTTT
GGCCTTCAACACGCCCAAAGTCACCGAGCAGCTTATGAAACTGGACGAGCAAGGGCTGAACTAT
CAGCAGAAAGTAGGCATCATGTACTGCAAAGCAGGCCAGAGCACCGAGGAGGAGATGTACAACA
CGCCCAAAGTCACGGAGCAGTTTATGAAACTGGACGAGCAAGGGCTGAATTATCAGCAGAAAGT
AGGCATCATGTACTGCAAAGCAGGCCAGAGCACCGAGGAGGAGATGTACAATAATGAGTCCGCT
GGCCCGGCCTTTGAGGAATTTCTTCAGCTACTGGGAGAGCGAGTTCGCCTAAAAGGATTTGAAA
AGTATCGTGCGCAGCTCGACACCAAAACTGACTCCACTGGAACCCACTCTCTGTACACAACCTA
CAAAGACTATGAGATAATGTTCCACGTCTCCACCATGCTGCCCTACACACCTAACAACAAGCAA
CAGCTCCTGAGGAAGCGGCACATTGGGAATGACATTGTGACAATAGTTTTCCAGGAGCCTGGAG
CACAACCATTTAGCCCGAAAAACATCCGATCTCACTTTCAGCATGTTTTTGTCATTGTCCGGGC
TCACAACCCCTGCACTGAGAGTGTCTGTTACAGTGTGGCAGTCACCAGGTCCAGAGATGTGCCT
TCTTTTGGACCTCCCATCCCTAAAGGGGTCACCTTCCCCAAGTCAAACGTGTTCAGGGACTTCC
TTTTGGCCAAAGTGATTAATGCAGAAAACGCTGCTCATAAATCAGAGAAGTTCAGGGCCATGGC
AACAAGGACCCGCCAGGAATACCTGAAAGATCTGGCAGAAAAGAATGTCACCAACACACCTATT
GACCCTTCTGGCAAGTTTCCATTTATTTCTCTGGCTTCTAAGAAGAAGGAAAAGTCTAAGCCTT
ACCCAGGAGCTGAGCTCAGTAGCATGGGGGCCATTGTGTGGGCAGTCCGGGCCAAAGACTACAA
CAAGGCCATGGAATTCGACTGCCTCCTTGGAATCTCCAATGAGTTCATCGTCCTCATTGAGCAG
GAAACAAAGAGCGTGGTTTTCAATTGCTCCTGCAGAGATGTGATAGGGTGGACTTCCAGCGACA
GCAGCCTTAAGATCTTCTATGAGCGTGGAGAATGCATTTCTGTGGAGAGCTTCATGAGCAGTGA
AGATATCAAAGAAATTGTCAAAAGGCTGCAGTTTGTTTCAAAAGGTTGTGAATCAGTGGAGATG
ACGCTGCGAAGAAATGGGCTAGGCCAGCTTGGCTTCCATGTCAACTATGAGGGCATCGTGGCGG
ATGTAGAACCCTATGGCTATGCATGGCAAGCAGGTTTGAAGCAGGGCAGCCGCCTGGTGGAGAT
CTGCAAGGTGGCAGTGGCCACCCTGAGCCATGAACAGATGATCGATCTCTTGAGAACGTCAGTC
ACAGTGAAAGTTGTCATTATCCCTCCCCATGATGACTGCACCCCTCGGAGGAGTTGCTCAGAAA
CCTACCGCATGCCAGTGATGGAGTACAAGATGAATGAAGGCGTTTCCTATGAGTACAAGTTTCC
CTTCCGGAGTAACAACAAATGGCAGCGTAATGCCGGCAAGGGTGCCCATTCGCCCCAGGTTCCA
TTGCAGCTGCAGAGCCCCATGATTTCACGGGTGAATGCTGGGAAGGGAGATGGAAAGATGCCCC
TTCCAGAAAGAGCCGCCAACATCCCTCGAAGCATCTCCAGTGATGGGCGCCCACTGGAAAGGAG
GCTGTCTCCTGGTTCGGACATCTATGTGACAGTCTCATCCATGGCTTTGGCGAGATCCCAGTGC
CGTAACTCCCCCAGCAACTTGTCATCGTCCAGCGAGACTGGCTCTGGGGGTGGCACTTACAGAC
AAAAATCCATGCCTGAAGGGTTTGGAGTGAGCCGAAGATCCCCAGCTTCCATCGACAGGCAAAA
CACCCAGTCGGATATTGGTGGCAGTGGAAAATCCACACCCAGCTGGCAGAGAAGTGAGGACAGC
CTTGCCGACCAGATGGAGCCTACATGCCATCTCCCAGCAGTATCTAAGGTACTGCCTGCTTTCC
GAGAGAGCCCCAGTGGGAGGTTGATGCGGCAGGATCCCGTGGTTCACTTGTCTCCAAACAAGCA
AGGCCATTCTGACAGCCACTACTCCAGCCACTCCAGCAGCAACACTCTGTCCAGCAACGCCTCG
AGTGCCCACAGTGACGAGAAGTGGTACGATGGAGACCGCACCGAGTCCGACCTCAACAGCTATA
ACTACCTACAGGGCACATCTGCTGACAGCGGCATCGACACCGCCTCATACGGCCTCAGCCATGG
CAGCACGGCCTCCCTGGGAGCCTCCACATCCTCACCTCGTTCAGGGCCAGGCAAAGAGAAGGTG
GCACCCCTGTGGCACAGCTCCAGTGAGGTGCTCTCCCTGGCAGATCGGACCTTAGAGACTGAGG
GCCATGGCATGGACAGGAAAACAGAGTCCTCCCTGAGCCTGGACATCCACAGCAAGAGCCAAGG
CGGTTCAAGCCCGCTGACAAGGGAGAACAGCACCTTCAGCATAAATGATGCCACATCTCACACC
AGTACCATGAGCTCCCGACACTCTGCCAGCCCAGTGGTGTTCTCCAGTGCCAGAAGTTCACCCA
AAGAAGAGCTTCACCCCACCACGTCCTCCCAGCTCGCACCTTCCTTCTCTTCCTCTTCCTCATC
TTCCTCTGGACCTAGGACTTTCTATCCCCGCCAGGGCGCCACTAGCAAATACCTGATTGGATGG
AAAAAGCCAGAAGGAACCATTAACTCCGTGGGATTTATGGATACAAGAAAGCGACATCAGAGTG
ATGGTAATGAGATAGCCCACACTAGGCTTCGAGCCTCAACCAGGGACCTTCGGGCATCCCCAAA
GCCAACTTCCAAGTCCACCATTGAGGAGGATCTAAAGAAACTCATCGACCTTGAGAGCCCAACT
CCTGAATCACAGAAAAACTTCAAGTTCCATGGACTGTCCTCCCCACAGTCCCCGTTCCCCAGCA
CCCCTACCTCCCGGCGGGCCCTGCACAGGACTCTGTCTGATGAGAGCATTTACAGCAGCCAGAG
GGAGCATTTCTTCACCTCCAGGGCCTCACTTCTAGACCAAGCCCTGCCCAATGATGTCTTTTTC
AGCAGCACTTACCCATCTCTCCCCAAGTCGCTTCCACTGAGGAGGCCATCTTACACATTGGGAA
TGAAGTCGCTGCATGGAGAGTTCTTTGCTTCCGACAGCTCCCTTACCGACATCCAGGAGACCCG
GAGGCAGCCTATTCCTGACCCTGGCCTGATGCCCCTGCCTGACACTGCTTCGGACTTGGACTGG
TCCAACCTAGTAGATGCCGCCAAAGCCTATGAGGTCCAGAGAGCCTCATTTTTTGCTGCTAGTG
ATGAAAACCATCGCCCCTTGAGTGCGGCCTCCAACAGCGACCAGCTAGAGGAGCAGGCCCTGGT
CCAGATGAAGTCGTACAGCAGCAGTAAGGACTCCTCTCCCACTCTGGCTTCTAAAGTGGACCAG
TTGGAAGGTATGCTGAAAATGCTTCGAGAAGATTTGAAGAAGGAAAAGGAAGACAAGGCCCACC
TGCAGGCAGAGGTTGAGCACTTGCGGGAGGACAACCTGAGGCTGCAGGAGGAGTCCCAGAATGC
CTCGGACAAGCTGAAGAAGTTCACAGAGTGGGTCTTCAACACCATAGACATGAGCTAGGGCCAG
CTGAGGGGAAAGGAGGAGGGCAGGCTGCTCTGTATGGGCACCCTAAAGCACCCATTCATGCCTT
GGAAAGTATTCTCAGAGTCCCAGCTTCCCAGTCTGCTCATATTGGACAGTGCACAATACAACAA
CTGCAGATCAACAATCATTATCTGCCTTTTATAGAAAAGAAAAAACAAAACNCGTGCCGAATTC

hide sequence

RefSeq Acc Id:

XM_039111776 ⟹ XP_038967704

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	107,725,151 - 107,849,613 (+)	NCBI
mRatBN7.2	6	101,993,927 - 102,118,408 (+)	NCBI

RefSeq Acc Id:

XM_039111778 ⟹ XP_038967706

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	107,571,374 - 107,849,613 (+)	NCBI
mRatBN7.2	6	101,840,141 - 102,118,408 (+)	NCBI

RefSeq Acc Id:

XM_039111779 ⟹ XP_038967707

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	107,570,569 - 107,849,613 (+)	NCBI
mRatBN7.2	6	101,839,352 - 102,118,408 (+)	NCBI

RefSeq Acc Id:

XM_039111780 ⟹ XP_038967708

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	107,617,261 - 107,849,613 (+)	NCBI
mRatBN7.2	6	101,886,047 - 102,118,408 (+)	NCBI

RefSeq Acc Id:

XM_039111781 ⟹ XP_038967709

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	107,737,100 - 107,849,613 (+)	NCBI
mRatBN7.2	6	102,005,850 - 102,118,408 (+)	NCBI

RefSeq Acc Id:

XM_063261545 ⟹ XP_063117615

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	107,570,746 - 107,849,613 (+)	NCBI

RefSeq Acc Id:

XM_063261546 ⟹ XP_063117616

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	107,616,828 - 107,849,613 (+)	NCBI

RefSeq Acc Id:

XM_063261547 ⟹ XP_063117617

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	107,725,175 - 107,849,613 (+)	NCBI

RefSeq Acc Id:

XM_063261548 ⟹ XP_063117618

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	107,725,175 - 107,849,613 (+)	NCBI

RefSeq Acc Id:

XM_063261549 ⟹ XP_063117619

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	107,725,175 - 107,849,613 (+)	NCBI

RefSeq Acc Id:

XM_063261550 ⟹ XP_063117620

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	107,725,143 - 107,814,537 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001376174	(Get FASTA)	NCBI Sequence Viewer
	NP_647546	(Get FASTA)	NCBI Sequence Viewer
	XP_038967704	(Get FASTA)	NCBI Sequence Viewer
	XP_038967706	(Get FASTA)	NCBI Sequence Viewer
	XP_038967707	(Get FASTA)	NCBI Sequence Viewer
	XP_038967708	(Get FASTA)	NCBI Sequence Viewer
	XP_038967709	(Get FASTA)	NCBI Sequence Viewer
	XP_063117615	(Get FASTA)	NCBI Sequence Viewer
	XP_063117616	(Get FASTA)	NCBI Sequence Viewer
	XP_063117617	(Get FASTA)	NCBI Sequence Viewer
	XP_063117618	(Get FASTA)	NCBI Sequence Viewer
	XP_063117619	(Get FASTA)	NCBI Sequence Viewer
	XP_063117620	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAB81526	(Get FASTA)	NCBI Sequence Viewer
	AAL02129	(Get FASTA)	NCBI Sequence Viewer
	EDL81435	(Get FASTA)	NCBI Sequence Viewer
	EDL81436	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000075549
	ENSRNOP00000109852
GenBank Protein	O35412	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_647546 ⟸ NM_139330
- Peptide Label:	isoform 1
- UniProtKB:	A0A0G2KAW2 (UniProtKB/TrEMBL), F1LS65 (UniProtKB/TrEMBL)
- Sequence:	show sequence MTSLKRSQTERPVTADRASVVSTDGTPKVHTDDFYMRRFRSQNGSLGSSVMAAVGPPRSEGPHH ITSTPGVPKMGVRARIADWPPRKENVKESSRSSQEIETSSCLESLSSKGSPVSQGSSVSLNSND SAMLKSIQNTLKNKTGPAESMDSRFLMPEAYPSSPRKALRRIRQRSNSDITISELDVDSFDECI SPTYKSGPSLHREYGSTSSIDKQGTSGESFFGLLKGYKDDRADRGPTPTKLSDFLITGGGKGSG FSLDVIDGPISQRENLRLFKEREKPLKRRSKSETGDSSIFRKLRNAKGEELGKSSDLEDNRSED SVRPWTCPKCFAHYDVQSILFDLNEAIMNRHNVIKRRNTTTGASAAAVASLVSGPLSHSTSFSS PMGSTEDFNSKGSLGMDQGDDKSNELVMSCPYFRNEIGGEGERKISLSKSNSGSFSGCESTSFE SALSSHCTNAGVAVLEVPKESLMLHLDRVRRYTVEHVDLGAYYYRKCFYQKEHWNYFGADENLG PVAVSIRREKPEDMKENGSPYNYRIIFRTSELMTLRGSVLEDAIPSTAKHSTARGLPLKEVLEH VIPELNVQCLRLAFNTPKVTEQLMKLDEQGLNYQQKVGIMYCKAGQSTEEEMYNTPKVTEQFMK LDEQGLNYQQKVGIMYCKAGQSTEEEMYNNESAGPAFEEFLQLLGERVRLKGFEKYRAQLDTKT DSTGTHSLYTTYKDYEIMFHVSTMLPYTPNNKQQLLRKRHIGNDIVTIVFQEPGAQPFSPKNIR SHFQHVFVIVRAHNPCTESVCYSVAVTRSRDVPSFGPPIPKGVTFPKSNVFRDFLLAKVINAEN AAHKSEKFRAMATRTRQEYLKDLAEKNVTNTPIDPSGKFPFISLASKKKEKSKPYPGAELSSMG AIVWAVRAKDYNKAMEFDCLLGISNEFIVLIEQETKSVVFNCSCRDVIGWTSSDSSLKIFYERG ECISVESFMSSEDIKEIVKRLQFVSKGCESVEMTLRRNGLGQLGFHVNYEGIVADVEPYGYAWQ AGLKQGSRLVEICKVAVATLSHEQMIDLLRTSVTVKVVIIPPHDDCTPRRSCSETYRMPVMEYK MNEGVSYEYKFPFRSNNKWQRNAGKGAHSPQVPLQLQSPMISRVNAGKGDGKMPLPERAANIPR SISSDGRPLERRLSPGSDIYVTVSSMALARSQCRNSPSNLSSSSETGSGGGTYRQKSMPEGFGV SRRSPASIDRQNTQSDIGGSGKSTPSWQRSEDSLADQMEPTCHLPAVSKVLPAFRESPSGRLMR QDPVVHLSPNKQGHSDSHYSSHSSSNTLSSNASSAHSDEKWYDGDRTESDLNSYNYLQGTSADS GIDTASYGLSHGSTASLGASTSSPRSGPGKEKVAPLWHSSSEVLSLADRTLETEGHGMDRKTES SLSLDIHSKSQGGSSPLTRENSTFSINDATSHTSTMSSRHSASPVVFSSARSSPKEELHPTTSS QLAPSFSSSSSSSSGPRTFYPRQGATSKYLIGWKKPEGTINSVGFMDTRKRHQSDGNEIAHTRL RASTRDLRASPKPTSKSTIEEDLKKLIDLESPTPESQKNFKFHGLSSPQSPFPSTPTSRRALHR TLSDESIYSSQREHFFTSRASLLDQALPNDVFFSSTYPSLPKSLPLRRPSYTLGMKSLHGEFFA SDSSLTDIQETRRQPIPDPGLMPLPDTASDLDWSNLVDAAKAYEVQRASFFAASDENHRPLSAA SNSDQLEEQALVQMKSYSSSKDSSPTLASKVDQLEGMLKMLREDLKKEKEDKAHLQAEVEHLRE DNLRLQEESQNASDKLKKFTEWVFNTIDMS hide sequence

Ensembl Acc Id:

ENSRNOP00000072447 ⟸ ENSRNOT00000092065

Ensembl Acc Id:

ENSRNOP00000054996 ⟸ ENSRNOT00000058195

Ensembl Acc Id:

ENSRNOP00000010626 ⟸ ENSRNOT00000010626

Ensembl Acc Id:

ENSRNOP00000075549 ⟸ ENSRNOT00000088917

RefSeq Acc Id:	XP_038967707 ⟸ XM_039111779
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2KAW2 (UniProtKB/TrEMBL), F1LS65 (UniProtKB/TrEMBL)

RefSeq Acc Id:	NP_001376174 ⟸ NM_001389245
- Peptide Label:	isoform 2
- UniProtKB:	A6JDP1 (UniProtKB/TrEMBL), F1LS65 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038967706 ⟸ XM_039111778
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2KAW2 (UniProtKB/TrEMBL), F1LS65 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038967708 ⟸ XM_039111780
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2KAW2 (UniProtKB/TrEMBL), F1LS65 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038967704 ⟸ XM_039111776
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2KAW2 (UniProtKB/TrEMBL), F1LS65 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038967709 ⟸ XM_039111781
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2KAW2 (UniProtKB/TrEMBL), F1LS65 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063117615 ⟸ XM_063261545
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2KAW2 (UniProtKB/TrEMBL), F1LS65 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063117616 ⟸ XM_063261546
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2KAW2 (UniProtKB/TrEMBL), F1LS65 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063117620 ⟸ XM_063261550
- Peptide Label:	isoform X5

RefSeq Acc Id:	XP_063117617 ⟸ XM_063261547
- Peptide Label:	isoform X2
- UniProtKB:	A6JDP1 (UniProtKB/TrEMBL), F1LS65 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063117618 ⟸ XM_063261548
- Peptide Label:	isoform X3
- UniProtKB:	F1LS65 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063117619 ⟸ XM_063261549
- Peptide Label:	isoform X4
- UniProtKB:	F1LS65 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000109852 ⟸ ENSRNOT00000168984

Protein Domains

PDZ Rap-GAP

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-O35412-F1-model_v2	AlphaFold	O35412	1-1822	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:708497	AgrOrtholog
BioCyc Gene	G2FUF-36872	BioCyc
Ensembl Genes	ENSRNOG00000007646	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000088917	ENTREZGENE
	ENSRNOT00000168984	ENTREZGENE
Gene3D-CATH	2.30.42.10	UniProtKB/Swiss-Prot
	3.30.1120.160	UniProtKB/Swiss-Prot
	3.40.50.11210	UniProtKB/Swiss-Prot
InterPro	PDZ	UniProtKB/Swiss-Prot
	PDZ_sf	UniProtKB/Swiss-Prot
	Rap/Ran-GAP_sf	UniProtKB/Swiss-Prot
	Rap1_Ran_GAP	UniProtKB/Swiss-Prot
	Rap_GAP_dom	UniProtKB/Swiss-Prot
	SIPA1L_C	UniProtKB/Swiss-Prot
KEGG Report	rno:246212	UniProtKB/Swiss-Prot
NCBI Gene	246212	ENTREZGENE
PANTHER	PTHR15711:SF10	UniProtKB/Swiss-Prot
	RAP GTPASE-ACTIVATING PROTEIN	UniProtKB/Swiss-Prot
Pfam	PDZ	UniProtKB/Swiss-Prot
	Rap-GAP_dimer	UniProtKB/Swiss-Prot
	Rap_GAP	UniProtKB/Swiss-Prot
	SPAR_C	UniProtKB/Swiss-Prot
PhenoGen	Sipa1l1	PhenoGen
PROSITE	PDZ	UniProtKB/Swiss-Prot
	RAPGAP	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000007646	RatGTEx
SMART	PDZ	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF111347	UniProtKB/Swiss-Prot
	SSF50156	UniProtKB/Swiss-Prot
UniProt	A0A0G2KAW2	ENTREZGENE, UniProtKB/TrEMBL
	A0ABK0LGB5_RAT	UniProtKB/TrEMBL
	A6JDP1	ENTREZGENE, UniProtKB/TrEMBL
	A6JDP2_RAT	UniProtKB/TrEMBL
	F1LS65	ENTREZGENE, UniProtKB/TrEMBL
	O35412	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2004-09-10	Sipa1l1	signal-induced proliferation-associated 1 like 1	Spa1	SPA-1 like protein p1294	Symbol and Name updated	1299863	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD