Cyp4f4 (cytochrome P450, family 4, subfamily f, polypeptide 4) - Rat Genome Database

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Gene: Cyp4f4 (cytochrome P450, family 4, subfamily f, polypeptide 4) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Cyp4f4
Name: cytochrome P450, family 4, subfamily f, polypeptide 4
RGD ID: 708363
Description: Enables arachidonate monooxygenase activity; heme binding activity; and leukotriene-B4 20-monooxygenase activity. Involved in icosanoid catabolic process; omega-hydroxylase P450 pathway; and response to 3-methylcholanthrene. Predicted to be located in endoplasmic reticulum membrane. Biomarker of hypertrophic cardiomyopathy. Orthologous to human CYP4F2 (cytochrome P450 family 4 subfamily F member 2); PARTICIPATES IN arachidonic acid metabolic pathway; INTERACTS WITH (+)-schisandrin B; 1-benzylpiperazine; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CYPIVF4; cytochrome P450 4F4; leukotriene-B4 20-monooxygenase
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8712,367,711 - 12,384,010 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl712,367,660 - 12,384,010 (+)EnsemblGRCr8
mRatBN7.2711,717,208 - 11,733,507 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl711,717,208 - 11,733,506 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx714,527,006 - 14,543,308 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0716,404,445 - 16,420,747 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0714,284,640 - 14,300,959 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd715,067,541 - 15,083,909 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive715,230,925 - 15,247,297 (+)NCBILyon_Normotensive
Lyon_Hypertensive715,305,922 - 15,322,292 (+)NCBILyon_Hypertensive
F344_StmMcwi713,671,555 - 13,687,923 (+)NCBIF344_StmMcwi
Rnor_6.0714,891,062 - 14,907,250 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl714,891,001 - 14,907,305 (+)Ensemblrn6Rnor6.0
Rnor_5.0715,045,084 - 15,061,272 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4713,293,080 - 13,309,416 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera79,816,959 - 9,833,227 (+)NCBICelera
RGSC_v3.1713,293,079 - 13,309,415 (+)NCBI
Cytogenetic Map7q11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. 3-methylcholanthrene and benzo(a)pyrene modulate cardiac cytochrome P450 gene expression and arachidonic acid metabolism in male Sprague Dawley rats. Aboutabl ME, etal., Br J Pharmacol. 2009 Dec;158(7):1808-19. doi: 10.1111/j.1476-5381.2009.00461.x.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. cDNA cloning of three new forms of rat brain cytochrome P450 belonging to the CYP4F subfamily. Kawashima H and Strobel HW, Biochem Biophys Res Commun 1995 Dec 26;217(3):1137-44.
4. Protein expression, characterization, and regulation of CYP4F4 and CYP4F5 cloned from rat brain. Kawashima H, etal., Arch Biochem Biophys. 1997 Nov 1;347(1):148-54. doi: 10.1006/abbi.1997.0342.
5. Covalent attachment of the heme prosthetic group in the CYP4F cytochrome P450 family. LeBrun LA, etal., Biochemistry. 2002 May 7;41(18):5931-7.
6. Development of cardiac hypertrophy by sunitinib in vivo and in vitro rat cardiomyocytes is influenced by the aryl hydrocarbon receptor signaling pathway. Maayah ZH, etal., Arch Toxicol. 2014 Mar;88(3):725-38. doi: 10.1007/s00204-013-1159-5. Epub 2013 Nov 19.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. GOA pipeline RGD automated data pipeline
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Catalytic activity and isoform-specific inhibition of rat cytochrome p450 4F enzymes. Xu F, etal., J Pharmacol Exp Ther. 2004 Mar;308(3):887-95. Epub 2003 Nov 21.
Additional References at PubMed
PMID:16182239  


Genomics

Variants

.
Variants in Cyp4f4
157 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:33
Count of miRNA genes:33
Interacting mature miRNAs:33
Transcripts:ENSRNOT00000041034
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7166965846669658Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)7123748937Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7721609752216097Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)71051708662346019Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)71011291699900612Rat
2290372Gluco33Glucose level QTL 332.71blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)7131777942Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7170952746709527Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7132612984Rat
1582260Bw72Body weight QTL 723.20.0043body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582261Bw69Body weight QTL 693.20.0048body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582262Bw75Body weight QTL 7530.0038body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)71011291660150541Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7946087754460877Rat
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7129716167Rat
1300138Hrtrt9Heart rate QTL 94.72heart pumping trait (VT:2000009)heart rate (CMO:0000002)71049882055498820Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134650782Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7132612984Rat

Markers in Region
D7Uwm5  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8712,367,091 - 12,367,324 (+)Marker Load Pipeline
mRatBN7.2711,716,588 - 11,716,821 (+)MAPPERmRatBN7.2
Rnor_6.0714,890,443 - 14,890,675NCBIRnor6.0
Rnor_5.0715,044,465 - 15,044,697UniSTSRnor5.0
RGSC_v3.4713,292,461 - 13,292,693UniSTSRGSC3.4
Celera79,816,340 - 9,816,572UniSTS
RGSC_v3.1713,292,460 - 13,292,693RGD
Cytogenetic Map7q11UniSTS
RH130999  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2711,733,137 - 11,733,353 (+)MAPPERmRatBN7.2
Rnor_6.0714,906,881 - 14,907,096NCBIRnor6.0
Rnor_5.0715,060,903 - 15,061,118UniSTSRnor5.0
RGSC_v3.4713,309,047 - 13,309,262UniSTSRGSC3.4
Celera79,832,858 - 9,833,073UniSTS
RH 3.4 Map763.7UniSTS
Cytogenetic Map7q11UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
6 10 5 32 200 91 90 59 24 59 12 188 82 189 38 64 31 5 5

Sequence


Ensembl Acc Id: ENSRNOT00000041034   ⟹   ENSRNOP00000039545
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl712,367,660 - 12,384,010 (+)Ensembl
mRatBN7.2 Ensembl711,717,208 - 11,733,506 (+)Ensembl
Rnor_6.0 Ensembl714,891,001 - 14,907,305 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000126914   ⟹   ENSRNOP00000100523
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl712,367,660 - 12,384,010 (+)Ensembl
RefSeq Acc Id: NM_173123   ⟹   NP_775146
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8712,367,711 - 12,384,010 (+)NCBI
mRatBN7.2711,717,208 - 11,733,507 (+)NCBI
Dahl_SR_JrHsd715,067,541 - 15,083,909 (+)NCBI
Lyon_Normotensive715,230,925 - 15,247,297 (+)NCBI
Lyon_Hypertensive715,305,922 - 15,322,292 (+)NCBI
F344_StmMcwi713,671,555 - 13,687,923 (+)NCBI
Rnor_6.0714,891,062 - 14,907,250 (+)NCBI
Rnor_5.0715,045,084 - 15,061,272 (+)NCBI
RGSC_v3.4713,293,080 - 13,309,416 (+)RGD
Celera79,816,959 - 9,833,227 (+)RGD
Sequence:
RefSeq Acc Id: XM_063263076   ⟹   XP_063119146
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8712,371,003 - 12,384,010 (+)NCBI
Protein Sequences
Protein RefSeqs NP_775146 (Get FASTA)   NCBI Sequence Viewer  
  XP_063119146 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC52358 (Get FASTA)   NCBI Sequence Viewer  
  EDL89477 (Get FASTA)   NCBI Sequence Viewer  
  EDL89478 (Get FASTA)   NCBI Sequence Viewer  
  EDL89479 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000039545
GenBank Protein P51869 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_775146   ⟸   NM_173123
- UniProtKB: P51869 (UniProtKB/Swiss-Prot),   A6K957 (UniProtKB/TrEMBL),   A0A8L2ULC7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000039545   ⟸   ENSRNOT00000041034
RefSeq Acc Id: XP_063119146   ⟸   XM_063263076
- Peptide Label: isoform X1
- UniProtKB: A6K958 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000100523   ⟸   ENSRNOT00000126914

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P51869-F1-model_v2 AlphaFold P51869 1-522 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695074
Promoter ID:EPDNEW_R5598
Type:initiation region
Name:Cyp4f4_1
Description:cytochrome P450, family 4, subfamily f, polypeptide 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0714,891,045 - 14,891,105EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:708363 AgrOrtholog
BioCyc Gene G2FUF-34815 BioCyc
Ensembl Genes ENSRNOG00000032895 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000041034 ENTREZGENE
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot
InterPro Cyt_P450 UniProtKB/Swiss-Prot
  Cyt_P450_CS UniProtKB/Swiss-Prot
  Cyt_P450_E_grp-I UniProtKB/Swiss-Prot
  Cyt_P450_sf UniProtKB/Swiss-Prot
  Cytochrome_P450_Monoox UniProtKB/Swiss-Prot
KEGG Report rno:286904 UniProtKB/Swiss-Prot
NCBI Gene 286904 ENTREZGENE
PANTHER CYTOCHROME P450 4F3 UniProtKB/Swiss-Prot
  CYTOCHROME P450 FAMILY 4 UniProtKB/Swiss-Prot
Pfam p450 UniProtKB/Swiss-Prot
PhenoGen Cyp4f4 PhenoGen
PRINTS EP450I UniProtKB/Swiss-Prot
  P450 UniProtKB/Swiss-Prot
PROSITE CYTOCHROME_P450 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000032895 RatGTEx
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot
UniProt A0A8L2ULC7 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LHX7_RAT UniProtKB/TrEMBL
  A6K957 ENTREZGENE, UniProtKB/TrEMBL
  A6K958 ENTREZGENE, UniProtKB/TrEMBL
  A6K959_RAT UniProtKB/TrEMBL
  CP4F4_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-11-17 Cyp4f4  cytochrome P450, family 4, subfamily f, polypeptide 4    cytochrome P450 4F4  Name updated 1299863 APPROVED
2005-09-30 Cyp4f4        Symbol and Name status set to provisional 70820 PROVISIONAL