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Gene: Rasgrf2 (RAS protein-specific guanine nucleotide-releasing factor 2) Rattus norvegicus

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Symbol:

Rasgrf2

Name:

RAS protein-specific guanine nucleotide-releasing factor 2

RGD ID:

69413

Description:

Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in Ras protein signal transduction; postsynaptic modulation of chemical synaptic transmission; and response to endoplasmic reticulum stress. Predicted to act upstream of or within long-term synaptic potentiation. Is active in glutamatergic synapse and postsynapse. Orthologous to human RASGRF2 (Ras protein specific guanine nucleotide releasing factor 2); PARTICIPATES IN mitogen activated protein kinase signaling pathway; INTERACTS WITH ammonium chloride; benzo[a]pyrene; bisphenol A.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

guanine nucleotide-releasing factor 2; ras guanine nucleotide exchange factor 2; ras-GRF2; ras-specific guanine nucleotide-releasing factor 2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Candidate Gene For:

Bp115

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	24,848,699 - 25,096,773 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	2	24,848,699 - 25,147,558 (-)	Ensembl				GRCr8
mRatBN7.2	2	23,113,613 - 23,361,537 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	23,117,004 - 23,361,240 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	2	30,154,119 - 30,396,141 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	28,254,458 - 28,496,490 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	23,080,067 - 23,323,713 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	21,460,041 - 21,698,937 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	2	40,664,646 - 40,904,636 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	2	22,113,649 - 22,360,970 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	2	19,216,953 - 19,453,016 (-)	NCBI		Celera
RGSC_v3.1	2	22,034,017 - 22,281,339 (-)	NCBI
Cytogenetic Map	2	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Animal Mammary Neoplasms (ISO)

carcinoma (ISO)

Experimental Mammary Neoplasms (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,1-dichloroethene (ISO)

3,4-methylenedioxymethamphetamine (ISO)

4-hydroxyphenyl retinamide (ISO)

acrylamide (ISO)

aflatoxin B1 (ISO)

Aflatoxin B2 alpha (ISO)

ammonium chloride (EXP)

antirheumatic drug (ISO)

arsenite(3-) (ISO)

benzo[a]pyrene (EXP,ISO)

benzo[e]pyrene (ISO)

bisphenol A (EXP)

butanal (ISO)

caffeine (ISO)

CGP 52608 (ISO)

chlordecone (ISO)

cisplatin (ISO)

clofibrate (ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

dibenz[a,h]anthracene (ISO)

dibutyl phthalate (ISO)

dioxygen (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

entinostat (ISO)

ethanol (ISO)

folic acid (ISO)

fulvestrant (ISO)

leflunomide (ISO)

maneb (ISO)

mercury dibromide (ISO)

methapyrilene (ISO)

mono(2-ethylhexyl) phthalate (ISO)

N-Nitrosopyrrolidine (ISO)

Nor-9-carboxy-delta9-THC (ISO)

O-methyleugenol (ISO)

ozone (ISO)

paracetamol (ISO)

paraquat (ISO)

pentanal (ISO)

phenylmercury acetate (ISO)

PhIP (EXP)

propanal (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

titanium dioxide (ISO)

trichloroethene (EXP)

triphenyl phosphate (ISO)

triptonide (ISO)

valproic acid (EXP,ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological_process (ND)

long-term synaptic potentiation (ISO)

postsynaptic modulation of chemical synaptic transmission (IEA,ISO)

Ras protein signal transduction (IBA)

regulation of NMDA receptor activity (ISO)

response to endoplasmic reticulum stress (IEA,ISO)

small GTPase-mediated signal transduction (IEA)

Cellular Component

cytoplasm (IEA)

endoplasmic reticulum (IEA,ISO)

endoplasmic reticulum membrane (IEA)

glutamatergic synapse (IDA,IEA,ISO)

plasma membrane (IBA,IEA)

postsynapse (IDA,IEA)

Molecular Function

calmodulin binding (IEA)

guanyl-nucleotide exchange factor activity (IBA,IEA,ISO)

protein binding (IPI)

Molecular Pathway Annotations Click to see Annotation Detail View

mitogen activated protein kinase signaling pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Ras-specific exchange factor GRF: oligomerization through its Dbl homology domain and calcium-dependent activation of Raf.	Anborgh PH, etal., Mol Cell Biol. 1999 Jul;19(7):4611-22.
2.	Activation of H-Ras in the endoplasmic reticulum by the RasGRF family guanine nucleotide exchange factors.	Arozarena I, etal., Mol Cell Biol 2004 Feb;24(4):1516-30.
3.	The exchange factor Ras-GRF2 activates Ras-dependent and Rac-dependent mitogen-activated protein kinase pathways.	Fan WT, etal., Curr Biol 1998 Jul 30-Aug 13;8(16):935-8.
4.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5.	Analysis of candidate genes included in the mammary cancer susceptibility 1 (Mcs1) region.	Laes JF, etal., Mamm Genome 2001 Mar;12(3):199-206.
6.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
7.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
8.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
9.	GOA pipeline	RGD automated data pipeline
10.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
12.	Comprehensive gene review and curation	RGD comprehensive gene curation
13.	RasGRF2 Rac-GEF activity couples NMDA receptor calcium flux to enhanced synaptic transmission.	Schwechter B, etal., Proc Natl Acad Sci U S A. 2013 Aug 27;110(35):14462-7. doi: 10.1073/pnas.1304340110. Epub 2013 Aug 12.
14.	Tentative Sequence Identification Numbers	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data

Additional References at PubMed

PMID:15029245	PMID:17931779	PMID:20661302	PMID:27856453	PMID:30053369

Genomics

Comparative Map Data

Rasgrf2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	24,848,699 - 25,096,773 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	2	24,848,699 - 25,147,558 (-)	Ensembl				GRCr8
mRatBN7.2	2	23,113,613 - 23,361,537 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	23,117,004 - 23,361,240 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	2	30,154,119 - 30,396,141 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	28,254,458 - 28,496,490 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	23,080,067 - 23,323,713 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	21,460,041 - 21,698,937 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	2	40,664,646 - 40,904,636 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	2	22,113,649 - 22,360,970 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	2	19,216,953 - 19,453,016 (-)	NCBI		Celera
RGSC_v3.1	2	22,034,017 - 22,281,339 (-)	NCBI
Cytogenetic Map	2	q12	NCBI

RASGRF2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	80,960,363 - 81,230,162 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	80,960,310 - 81,230,162 (+)	Ensembl			hg38	GRCh38
GRCh37	5	80,256,182 - 80,525,981 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	80,292,314 - 80,557,709 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	5	80,292,313 - 80,557,709	NCBI
Celera	5	76,160,831 - 76,426,223 (+)	NCBI		Celera
Cytogenetic Map	5	q14.1	NCBI
HuRef	5	75,465,367 - 75,734,900 (+)	NCBI		HuRef
CHM1_1	5	79,689,169 - 79,958,778 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	5	81,444,995 - 81,714,744 (+)	NCBI		T2T-CHM13v2.0

Rasgrf2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	92,028,526 - 92,268,584 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	13	92,028,519 - 92,268,164 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	13	91,880,407 - 92,131,828 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	91,880,400 - 92,131,656 (-)	Ensembl			mm10	GRCm38
MGSCv37	13	92,020,012 - 92,127,647 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv37	13	92,792,695 - 92,901,449 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	13	92,358,671 - 92,462,280 (-)	NCBI		MGSCv36	mm8
Celera	13	95,507,627 - 95,744,228 (-)	NCBI		Celera
Cytogenetic Map	13	C3	NCBI
cM Map	13	47.43	NCBI

Rasgrf2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955418	28,930,616 - 29,065,110 (-)	Ensembl
ChiLan1.0	NW_004955418	28,930,666 - 29,126,495 (-)	NCBI	ChiLan1.0	ChiLan1.0

RASGRF2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	34,071,454 - 34,349,753 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	32,225,079 - 32,503,237 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	34,048,832 - 34,326,755 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	34,359,896 - 34,635,488 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	34,359,896 - 34,635,488 (-)	Ensembl			panPan2	panpan1.1

RASGRF2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	3	26,047,304 - 26,286,919 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	3	26,050,260 - 26,286,819 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	3	27,282,954 - 27,522,340 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	3	25,961,452 - 26,200,939 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	3	25,964,823 - 26,201,470 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	3	25,917,048 - 26,141,554 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	3	25,882,708 - 26,122,066 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	3	26,162,682 - 26,402,121 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Rasgrf2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	182,051,996 - 182,288,402 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936469	337,130 - 573,776 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936469	337,340 - 573,763 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

RASGRF2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	89,528,111 - 89,790,719 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	2	89,525,948 - 89,794,103 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	91,513,920 - 91,699,524 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

RASGRF2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	4	75,114,512 - 75,378,228 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	4	75,115,109 - 75,373,851 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666049	23,980,283 - 24,251,523 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Rasgrf2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624743	1,604,915 - 1,790,473 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Rasgrf2
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	3	204,129,552 - 204,342,718 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Rasgrf2
2274 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	55
Count of miRNA genes:	54
Interacting mature miRNAs:	55
Transcripts:	ENSRNOT00000019087
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1331764	Bp205	Blood pressure QTL 205	3.476		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	14368707	59368707	Rat
10755430	Coatc6	Coat color QTL 6		0.02576	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	2	13325041	58325041	Rat
1600379	Mcs18	Mammary carcinoma susceptibility QTL 18	2.6		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	2	9623581	44538110	Rat
1331760	Bp206	Blood pressure QTL 206	3.62454		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	4265106	205135428	Rat
7387318	Stl32	Serum triglyceride level QTL 32	3.2	0.0003	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	2	24117813	69117813	Rat
61355	Bp36	Blood pressure QTL 36	2.9		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	2	7605533	104774005	Rat
10755499	Bp389	Blood pressure QTL 389	2.61		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	20695736	231474293	Rat
1578664	Bmd9	Bone mineral QTL density 9	5		femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	2	5736325	50736325	Rat
738010	Lnnr3	Liver neoplastic nodule remodeling QTL 3	2.94		liver integrity trait (VT:0010547)	liver remodeling tumorous lesion number (CMO:0001461)	2	1	42977529	Rat
9590080	Insglur4	Insulin/glucose ratio QTL 4	28.7	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	2	6152767	51152767	Rat
1579916	Bp270	Blood pressure QTL 270		0.003	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	16051883	61051883	Rat
731167	Glom4	Glomerulus QTL 4	2.4	0.0082	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)	2	22038044	67038044	Rat
731166	Mamtr2	Mammary tumor resistance QTL 2		0.0001	mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	2	9623581	54623581	Rat
61368	Mcs1	Mammary carcinoma susceptibility QTL 1	4.4		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	2	9623581	25054526	Rat
731184	Mamtr4	Mammary tumor resistance QTL 4		0.0003	mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	2	18227137	63227137	Rat

Markers in Region

D2Uwm15

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	2	25,054,375 - 25,054,526 (+)	Marker Load Pipeline
mRatBN7.2	2	23,319,296 - 23,319,447 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	21,657,309 - 21,657,459	NCBI	Rnor6.0
Rnor_5.0	2	40,862,862 - 40,863,012	UniSTS	Rnor5.0
RGSC_v3.4	2	22,318,697 - 22,318,848	RGD	RGSC3.4
RGSC_v3.4	2	22,318,698 - 22,318,848	UniSTS	RGSC3.4
Celera	2	19,411,090 - 19,411,268	UniSTS
RGSC_v3.1	2	22,239,066 - 22,239,217	RGD
Cytogenetic Map	2	q12-q14	UniSTS

RH144277

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	23,238,054 - 23,238,199 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	21,578,034 - 21,578,178	NCBI	Rnor6.0
Rnor_5.0	2	40,782,837 - 40,782,981	UniSTS	Rnor5.0
RGSC_v3.4	2	22,237,057 - 22,237,201	UniSTS	RGSC3.4
Celera	2	19,334,802 - 19,334,946	UniSTS
RH 3.4 Map	15	499.68	UniSTS
Cytogenetic Map	2	q12-q14	UniSTS

RH141995

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	23,174,166 - 23,174,354 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	21,514,115 - 21,514,302	NCBI	Rnor6.0
Rnor_5.0	2	40,719,025 - 40,719,212	UniSTS	Rnor5.0
RGSC_v3.4	2	22,172,288 - 22,172,475	UniSTS	RGSC3.4
Celera	2	19,271,090 - 19,271,277	UniSTS
Cytogenetic Map	2	q12-q14	UniSTS

BG372540

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	23,118,803 - 23,118,941 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	21,461,190 - 21,461,327	NCBI	Rnor6.0
Rnor_5.0	2	40,665,795 - 40,665,932	UniSTS	Rnor5.0
RGSC_v3.4	2	22,115,129 - 22,115,266	UniSTS	RGSC3.4
Celera	2	19,218,126 - 19,218,263	UniSTS
RH 3.4 Map	2	1222.7	UniSTS
Cytogenetic Map	2	q12-q14	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	hemolymphoid system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	sensory system	visual system
7	1	18	40	7	75	35	11	35	33	32	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_053721	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039101563	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063281151	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AJ276774	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473955	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000080165 ⟹ ENSRNOP00000069761

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	23,231,220 - 23,361,240 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000096916 ⟹ ENSRNOP00000096121

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	23,117,004 - 23,361,240 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000116049 ⟹ ENSRNOP00000094036

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	23,257,663 - 23,361,240 (-)	Ensembl

RefSeq Acc Id:

NM_053721 ⟹ NP_446173

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	24,848,699 - 25,096,611 (-)	NCBI
mRatBN7.2	2	23,113,613 - 23,361,537 (-)	NCBI
Rnor_6.0	2	21,460,041 - 21,698,937 (-)	NCBI
Rnor_5.0	2	40,664,646 - 40,904,636 (-)	NCBI
RGSC_v3.4	2	22,113,649 - 22,360,970 (-)	RGD
Celera	2	19,216,953 - 19,453,016 (-)	RGD

Sequence:

show sequence

ATGCAGAAGAGCGTGCGCTACAACGAGGGGCACGCCCTGTACCTGGCCTTCCTGGCGCGCAAGG
AGGGCACCAAGCGCGGTTTCCTGAGCAAAAAGGCTGCCGAGGCGAGCCGCTGGCACGAGAAGTG
GTTCGCTCTCTATCAGAATGTGCTCTTTTACTTCGAAGGCGAACAGAGCGGCCGCCCAGCGGGC
ATGTACCTCCTAGAGGGCTGCAGCTGTGAGCGGACGCCCGCCCCACCAAGGACCAACGCAGGAC
CCGCAGGCGCCCGGGACGCGCTGGACAAACAGTATTACTTCACTGTCCTTTTTGGTCACGAAGG
TCAGAAACCACTGGAGCTGCGCTGTGAGGAGGAGCAAGCAGGGAAAGAGTGGATGGAGGCCATT
CACCAAGCCAGTTACGCAGACATTTTGATTGAGAGGGAAGTGTTAATGCAAAAGTACATTCATC
TAGTTCAGATTGTGGAGACAGAAAAAATTGCTGCTAACCAACTCCGACATCAACTCGAAGATCA
AGATACCGAAATTGAAAGACTTAAATCAGAGATTGTTGCTCTTAATAAGACCAAGGAACGGATG
CGCCCGTATCATACCCATCAAGAGGAGGAGGATCCAGACATCAAGAAGATCAAGAAGGTTCAGA
GCTTCATGAGAGGGTGGCTGTGCAGGAGGAAGTGGAAGACCATCGTTCAGGACTACATTTGTTC
CCCCCATGCTGAGAGCATGAGGAAGAGGAACCAGATTGTCTTCACGATGGTGGAGGCCGAGTCA
GAATATGTGCACCAGCTCTACATCCTGGTGAACGGTTTCCTCAGGCCTCTGCGCATGGCAGCCA
GCTCCAAGAAGCCCCCCATTAGCCATGATGATGTCAGCAGCATTTTCCTCAACAGTGAAACAAT
CATGTTTCTTCATGAAATATTCCATCAAGGTCTAAAGGCAAGGCTGGCAAATTGGCCCACTTTG
GTTTTAGCTGATCTCTTTGATATTTTGCTGCCTATGCTCAACATTTATCAAGAATTTGTGCGTA
ATCATCAGTACAGCCTCCAAGTACTTGCCAACTGTAAGCAAAATAGAGATTTTGACAAGCTCTT
AAAGCAGTATGAAGGCAACCCTGCCTGTGAGGGAAGGATGCTGGAGACATTCTTGACTTACCCA
ATGTTTCAGATCCCCAGGTATATCATCACGCTGCACGAACTCCTGGCTCACACCCCCCATGAAC
ACGTGGAGAGGAAAAGTCTGGAGTTCGCTAAGTCAAAGCTGGAGGAACTGTCCAGAGTGATGCA
CGACGAAGTCAGTGACACCGAAAACATACGGAAAAATCTTGCCATTGAGAGGATGATCGTGGAG
GGCTGCGACATTTTGCTAGACACCAGTCAAACTTTCATCCGACAAGGTTCTCTTATCCAAGTAC
CTTCTGTGGAGAGGGGGAAACTCAGTAAAGTCCGCCTGGGCTCCCTGTCTTTGAAAAAGGAAGG
CGAGAGACAATGTTTCTTATTCACGAAGCACTTTCTGATCTGTACCCGAAGTTCAGGAGGAAAG
CTTCATTTGCTCAAGACAGGTGGGGTTCTCTCCCTCATTCAGTGTACGTTGATTGAGGAGCCGG
ACACAAGTGATGATGACACCAAAGGTCCTGGTCACATGTTCGGACATCTGGATTTTAAAATCGT
CGTGGAGCCTCCTGATGCTGCCCCGTTCACTGTGGTCTTGCTAGCACCTTCGCGCCAGGAGAAG
GCTGCCTGGATGAGCGACATCAGCCAGTGCGTGGACAATATCCGATGCAATGGATTGATGACTA
TAGTCTTCGAAGAGAATTCTAAAGTTACTGTGCCCCATATGATAAAGTCTGATGCCCGTCTTCA
TAAAGACGACACTGACATCTGTTTCAGTAAAACACTCAATTCCTGCAAAGTGCCCCAGATCCGC
TACGCCAGCGTGGAGCGCCTCTTGGAGCGGTTGACGGATTTGCGGTTTCTGAGCATCGATTTCC
TCAACACCTTCCTGCACACCTACCGCATTTTCACCACGGCTGCCGTAGTGCTGGGGAAGCTCTC
CGACATCTACAAGAGGCCTTTCACCTCCATTCCTGTCAGATCACTAGAGTTATTTTTTGCCACG
AGCCAGAACAACAGAGAACATTTGGTCGATGGAAAATCCCCACGTCTTTGTCGCAAGTTCTCTT
CCCCACCTCCCCTGGCTGTATCCAGAACGTCCTCCCCAGTGAGGGCCAGAAAGCTGTCTTTGAC
ATCTTCCTTGAACTCAAGGATCGGAGCCTTGGACCTGACTACATCCTCATCTTCCAGTAGTCCC
ACCACCACTGTCCACAGTCCTGCTGCGTCCCCACCACCTCACACTGCTGTCCCAGAGTCTGCAC
CAGCCGACCGAGCAGGAGACTCCACAGACATGTCACCTTGTAGATCTCCCTCAACCACTCCCCG
GCACCTCCGATATCGCCAGCCTGGAGGACAGGTAGCTGACAGCACCCACTGTGCTGTTTCACCT
GCTTCTGCTTTTGCGATCGCCACAGCAGCAGCAGGACATGGGAGTCCGCCAGGATTTAACAACG
AGAGGACATGTGACAAGGAGTTCATCATACGGAGAACAGCCACCAATCGAGTCCTGAATGTCCT
CCGCCACTGGGTTTCAAAGCACTCACAGGATTTTGAACTCAATAATGAACTCAAAATGAATGTT
CTGAACTTGCTAGAAGAAGTTCTACGAGACCCGGACCTTCTTCCTCAAGAAAGGAAAGCCACGG
CGAACATCCTGAGGGCTCTTTCACAAGATGATCAAGATGACATCCACCTAAAATTAGAGGATAT
AATTCAAATGACAGACTGTCCAAAGGCCGAGTGCTTTGAGACATTGTCAGCCATGGAGCTGGCT
GAGCAGATCACTCTCCTGGACCACATTGTTTTCAGAAGCATCCCCTATGAAGAGTTTCTTGGGC
AGGGCTGGATGAAGCTGGATAAAAACGAAAGGACTCCTTATATCATGAAAACCAGCCAGCACTT
CAATGAGATGAGTAACCTGGTGGCCTCCCAGATAATGAATTATGCTGACATCAGTTCCCGTGCC
AATGCCATTGAGAAGTGGGTAGCAGTGGCGGACATCTGCCGATGTCTACACAACTACAATGGTG
TGCTGGAGATCACCTCGGCCTTAAACAGAAGTGCCATCTACAGGCTGAAGAAAACCTGGACCAA
GGTGTCCAAGCAGACAAAAGCTCTGATGGACAAACTTCAGAAGACTGTCTCGTCTGAAGGAAGA
TTTAAAAACCTCAGAGAAACTCTCAAAAACTGTAACCCCCCAGCTGTCCCTTACCTTGGGATGT
ACTTGACAGACCTGGCATTCATTGAAGAAGGGACACCGAACTTTACCGAAGAAGGCCTTGTCAA
TTTCTCCAAAATGCGAATGATATCACACATCATTCGTGAGATACGCCAGTTCCAGCAGACCGCT
TACCGCATAGACCAGCAGCCAAAGGTCATACAATACCTGCTTGACAAAGCCCTTGTCATAGATG
AAGATACACTCTATGAGCTGTCACTCAAAATTGAACCTCGACTCCCTGCTTGA

hide sequence

RefSeq Acc Id:

XM_039101563 ⟹ XP_038957491

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	24,848,699 - 25,096,773 (-)	NCBI
mRatBN7.2	2	23,113,613 - 23,361,537 (-)	NCBI

RefSeq Acc Id:

XM_063281151 ⟹ XP_063137221

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	24,848,699 - 25,003,528 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_446173	(Get FASTA)	NCBI Sequence Viewer
	XP_038957491	(Get FASTA)	NCBI Sequence Viewer
	XP_063137221	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	CAC37407	(Get FASTA)	NCBI Sequence Viewer
	EDM10011	(Get FASTA)	NCBI Sequence Viewer
	EDM10012	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000069761
GenBank Protein	Q99JE4	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_446173 ⟸ NM_053721

- UniProtKB:

Q99JE4 (UniProtKB/Swiss-Prot), A0A8I6AL55 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MQKSVRYNEGHALYLAFLARKEGTKRGFLSKKAAEASRWHEKWFALYQNVLFYFEGEQSGRPAG
MYLLEGCSCERTPAPPRTNAGPAGARDALDKQYYFTVLFGHEGQKPLELRCEEEQAGKEWMEAI
HQASYADILIEREVLMQKYIHLVQIVETEKIAANQLRHQLEDQDTEIERLKSEIVALNKTKERM
RPYHTHQEEEDPDIKKIKKVQSFMRGWLCRRKWKTIVQDYICSPHAESMRKRNQIVFTMVEAES
EYVHQLYILVNGFLRPLRMAASSKKPPISHDDVSSIFLNSETIMFLHEIFHQGLKARLANWPTL
VLADLFDILLPMLNIYQEFVRNHQYSLQVLANCKQNRDFDKLLKQYEGNPACEGRMLETFLTYP
MFQIPRYIITLHELLAHTPHEHVERKSLEFAKSKLEELSRVMHDEVSDTENIRKNLAIERMIVE
GCDILLDTSQTFIRQGSLIQVPSVERGKLSKVRLGSLSLKKEGERQCFLFTKHFLICTRSSGGK
LHLLKTGGVLSLIQCTLIEEPDTSDDDTKGPGHMFGHLDFKIVVEPPDAAPFTVVLLAPSRQEK
AAWMSDISQCVDNIRCNGLMTIVFEENSKVTVPHMIKSDARLHKDDTDICFSKTLNSCKVPQIR
YASVERLLERLTDLRFLSIDFLNTFLHTYRIFTTAAVVLGKLSDIYKRPFTSIPVRSLELFFAT
SQNNREHLVDGKSPRLCRKFSSPPPLAVSRTSSPVRARKLSLTSSLNSRIGALDLTTSSSSSSP
TTTVHSPAASPPPHTAVPESAPADRAGDSTDMSPCRSPSTTPRHLRYRQPGGQVADSTHCAVSP
ASAFAIATAAAGHGSPPGFNNERTCDKEFIIRRTATNRVLNVLRHWVSKHSQDFELNNELKMNV
LNLLEEVLRDPDLLPQERKATANILRALSQDDQDDIHLKLEDIIQMTDCPKAECFETLSAMELA
EQITLLDHIVFRSIPYEEFLGQGWMKLDKNERTPYIMKTSQHFNEMSNLVASQIMNYADISSRA
NAIEKWVAVADICRCLHNYNGVLEITSALNRSAIYRLKKTWTKVSKQTKALMDKLQKTVSSEGR
FKNLRETLKNCNPPAVPYLGMYLTDLAFIEEGTPNFTEEGLVNFSKMRMISHIIREIRQFQQTA
YRIDQQPKVIQYLLDKALVIDEDTLYELSLKIEPRLPA

hide sequence

RefSeq Acc Id:	XP_038957491 ⟸ XM_039101563
- Peptide Label:	isoform X1
- UniProtKB:	Q99JE4 (UniProtKB/Swiss-Prot)

Ensembl Acc Id:

ENSRNOP00000096121 ⟸ ENSRNOT00000096916

Ensembl Acc Id:

ENSRNOP00000094036 ⟸ ENSRNOT00000116049

Ensembl Acc Id:

ENSRNOP00000069761 ⟸ ENSRNOT00000080165

RefSeq Acc Id:	XP_063137221 ⟸ XM_063281151
- Peptide Label:	isoform X2
- UniProtKB:	Q99JE4 (UniProtKB/Swiss-Prot)

Protein Domains

DH IQ N-terminal Ras-GEF PH Ras-GEF

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-A0A0G2JW65-F1-model_v2	AlphaFold	A0A0G2JW65	1-849	view protein structure
AF-Q99JE4-F1-model_v2	AlphaFold	Q99JE4	1-1190	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:69413	AgrOrtholog
BioCyc Gene	G2FUF-54873	BioCyc
Ensembl Genes	ENSRNOG00000056151	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000080165	ENTREZGENE
Gene3D-CATH	1.10.840.10	UniProtKB/Swiss-Prot
	1.20.900.10	UniProtKB/Swiss-Prot
	2.30.29.30	UniProtKB/Swiss-Prot
	Son of sevenless (SoS) protein Chain: S domain 1	UniProtKB/Swiss-Prot
InterPro	DBL_dom_sf	UniProtKB/Swiss-Prot
	DH-domain	UniProtKB/Swiss-Prot
	PH-like_dom_sf	UniProtKB/Swiss-Prot
	PH_domain	UniProtKB/Swiss-Prot
	Ras-like_GEF	UniProtKB/Swiss-Prot
	Ras-like_Gua-exchang_fac_N	UniProtKB/Swiss-Prot
	Ras_G-nucl-exch_fac_CS	UniProtKB/Swiss-Prot
	Ras_GEF_dom_sf	UniProtKB/Swiss-Prot
	RASGEF_cat_dom	UniProtKB/Swiss-Prot
	RASGEF_cat_dom_sf	UniProtKB/Swiss-Prot
KEGG Report	rno:114513	UniProtKB/Swiss-Prot
NCBI Gene	114513	ENTREZGENE
PANTHER	PTHR23113	UniProtKB/Swiss-Prot
	PTHR23113:SF187	UniProtKB/Swiss-Prot
Pfam	PF00169	UniProtKB/Swiss-Prot
	RasGEF	UniProtKB/Swiss-Prot
	RasGEF_N	UniProtKB/Swiss-Prot
	RhoGEF	UniProtKB/Swiss-Prot
PhenoGen	Rasgrf2	PhenoGen
PROSITE	DH_2	UniProtKB/Swiss-Prot
	PH_DOMAIN	UniProtKB/Swiss-Prot
	PS50096	UniProtKB/Swiss-Prot
	RASGEF	UniProtKB/Swiss-Prot
	RASGEF_CAT	UniProtKB/Swiss-Prot
	RASGEF_NTER	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000056151	RatGTEx
SMART	RasGEF	UniProtKB/Swiss-Prot
	RasGEFN	UniProtKB/Swiss-Prot
	RhoGEF	UniProtKB/Swiss-Prot
	SM00233	UniProtKB/Swiss-Prot
Superfamily-SCOP	PH domain-like	UniProtKB/Swiss-Prot
	SSF48065	UniProtKB/Swiss-Prot
	SSF48366	UniProtKB/Swiss-Prot
TIGR	TC202173
UniProt	A0A0G2JW65_RAT	UniProtKB/TrEMBL
	A0A8I6AKS2_RAT	UniProtKB/TrEMBL
	A0A8I6AL55	ENTREZGENE, UniProtKB/TrEMBL
	A0ABK0LMJ3_RAT	UniProtKB/TrEMBL
	A6I4Q3_RAT	UniProtKB/TrEMBL
	A6I4Q4_RAT	UniProtKB/TrEMBL
	Q99JE4	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2002-06-10	Rasgrf2	RAS protein-specific guanine nucleotide-releasing factor 2			Symbol and Name status set to approved	70586	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_process	controls the RAS oncoprotein GTPase activity	68725

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)