Entpd2 (ectonucleoside triphosphate diphosphohydrolase 2) - Rat Genome Database

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Gene: Entpd2 (ectonucleoside triphosphate diphosphohydrolase 2) Rattus norvegicus
Analyze
Symbol: Entpd2
Name: ectonucleoside triphosphate diphosphohydrolase 2
RGD ID: 69266
Description: Enables identical protein binding activity and pyrophosphatase activity. Involved in several processes, including cellular response to cytokine stimulus; cellular response to lipopolysaccharide; and response to auditory stimulus. Located in cell body; cell projection membrane; and cell surface. Biomarker of hypertension. Human ortholog(s) of this gene implicated in high grade glioma. Orthologous to human ENTPD2 (ectonucleoside triphosphate diphosphohydrolase 2); PARTICIPATES IN purine metabolic pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,4-dinitrotoluene; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CD39 antigen-like 1; Cd39l1; ecto-ATP diphosphohydrolase 2; ecto-ATPase 2; ecto-ATPDase 2; NTPDase 2; NTPDase2; nucleoside triphosphate diphosphohydrolase 2; testicular ecto-ATPase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8328,611,722 - 28,617,237 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl328,611,772 - 28,618,184 (+)EnsemblGRCr8
mRatBN7.238,213,575 - 8,219,094 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl38,213,663 - 8,226,866 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx311,318,790 - 11,324,211 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0319,905,020 - 19,910,441 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0318,094,862 - 18,100,283 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd326,174,834 - 26,180,299 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive333,123,714 - 33,129,179 (+)NCBILyon_Normotensive
Lyon_Hypertensive325,023,203 - 25,028,668 (+)NCBILyon_Hypertensive
F344_StmMcwi36,225,839 - 6,231,304 (+)NCBIF344_StmMcwi
Rnor_6.032,617,795 - 2,623,818 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl32,617,805 - 2,623,445 (+)Ensemblrn6Rnor6.0
Rnor_5.032,599,211 - 2,605,231 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.433,564,380 - 3,569,801 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera33,038,775 - 3,044,196 (+)NCBICelera
RGSC_v3.133,564,379 - 3,569,800 (+)NCBI
Cytogenetic Map3p13NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acetylsalicylic acid  (EXP)
aconitine  (EXP)
acrylamide  (EXP)
Aflatoxin B2 alpha  (ISO)
alachlor  (EXP)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
antimycin A  (ISO)
Aroclor 1254  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-naphthoflavone  (EXP)
bisphenol A  (EXP,ISO)
butyric acid  (EXP)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
choline  (ISO)
cisplatin  (ISO)
cocaine  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
coumestrol  (ISO)
Cuprizon  (EXP)
cyhalothrin  (EXP)
decabromodiphenyl ether  (EXP)
diethylstilbestrol  (ISO)
diquat  (ISO)
diuron  (EXP)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
fructose  (EXP)
furan  (EXP)
L-methionine  (ISO)
lead diacetate  (ISO)
lipopolysaccharide  (ISO)
methyl methanesulfonate  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
nitrofen  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
pirinixic acid  (ISO)
pravastatin  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
raloxifene  (EXP)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
Soman  (EXP)
sotorasib  (ISO)
sulforaphane  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trametinib  (ISO)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
vincristine  (ISO)
zaragozic acid A  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Selective NTPDase2 expression modulates in vivo rat glioma growth. Braganhol E, etal., Cancer Sci. 2009 Aug;100(8):1434-42. doi: 10.1111/j.1349-7006.2009.01219.x. Epub 2009 May 18.
2. Expression of ecto-nucleoside triphosphate diphosphohydrolase1-3 (NTPDase1-3) by cortical astrocytes after exposure to pro-inflammatory factors in vitro. Brisevac D, etal., J Mol Neurosci. 2013 Nov;51(3):871-9. doi: 10.1007/s12031-013-0088-3. Epub 2013 Aug 29.
3. The ecto-nucleoside triphosphate diphosphohydrolase NTPDase2/CD39L1 is expressed in a novel functional compartment within the liver. Dranoff JA, etal., Hepatology 2002 Nov;36(5):1135-44.
4. Ectonucleotidase NTPDase2 is selectively down-regulated in biliary cirrhosis. Dranoff JA, etal., J Investig Med. 2004 Nov;52(7):475-82.
5. Determination of native oligomeric state and substrate specificity of rat NTPDase1 and NTPDase2 after heterologous expression in Xenopus oocytes. Failer BU, etal., Eur J Biochem. 2003 Apr;270(8):1802-9.
6. L-NAME-treatment alters ectonucleotidase activities in kidney membranes of rats. Furstenau CR, etal., Life Sci. 2010 Aug 28;87(9-10):325-32. doi: 10.1016/j.lfs.2010.07.008. Epub 2010 Jul 23.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Functional characterization of rat ecto-ATPase and ecto-ATP diphosphohydrolase after heterologous expression in CHO cells. Heine P, etal., Eur J Biochem. 1999 May;262(1):102-7. doi: 10.1046/j.1432-1327.1999.00347.x.
9. An ecto-ATPase and an ecto-ATP diphosphohydrolase are expressed in rat brain. Kegel B, etal., Neuropharmacology 1997 Sep;36(9):1189-200.
10. Ecto-ATPase mRNA is regulated by FSH in Sertoli cells. Lu Q, etal., J Androl 2001 Mar-Apr;22(2):289-301.
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. GOA pipeline RGD automated data pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
18. Evidence for alternative splicing of ecto-ATPase associated with termination of purinergic transmission. Vlajkovic SM, etal., Brain Res Mol Brain Res 1999 Nov 10;73(1-2):85-92.
19. Noise exposure induces up-regulation of ecto-nucleoside triphosphate diphosphohydrolases 1 and 2 in rat cochlea. Vlajkovic SM, etal., Neuroscience. 2004;126(3):763-73.
20. C-terminal splicing of NTPDase2 provides distinctive catalytic properties, cellular distribution and enzyme regulation. Wang CJ, etal., Biochem J. 2005 Feb 1;385(Pt 3):729-36. doi: 10.1042/BJ20040852.
21. Nucleoside triphosphate diphosphohydrolase-2 (NTPDase2/CD39L1) is the dominant ectonucleotidase expressed by rat astrocytes. Wink MR, etal., Neuroscience. 2006;138(2):421-32. Epub 2006 Jan 18.
22. IL-6 downregulates transcription of NTPDase2 via specific promoter elements. Yu J, etal., Am J Physiol Gastrointest Liver Physiol. 2008 Mar;294(3):G748-56. doi: 10.1152/ajpgi.00208.2007. Epub 2008 Jan 17.
23. Crystallographic snapshots along the reaction pathway of nucleoside triphosphate diphosphohydrolases. Zebisch M, etal., Structure. 2013 Aug 6;21(8):1460-75. doi: 10.1016/j.str.2013.05.016. Epub 2013 Jul 3.
Additional References at PubMed
PMID:10510450   PMID:11929769   PMID:12477932   PMID:12832497   PMID:14730706   PMID:14764443   PMID:15004436   PMID:15799977   PMID:17574764   PMID:17910474   PMID:18201730   PMID:18458329  
PMID:19524108   PMID:21325440   PMID:22038661   PMID:23010799   PMID:23533145   PMID:23677997   PMID:26080748   PMID:35593054   PMID:38055119   PMID:38158780  


Genomics

Comparative Map Data
Entpd2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8328,611,722 - 28,617,237 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl328,611,772 - 28,618,184 (+)EnsemblGRCr8
mRatBN7.238,213,575 - 8,219,094 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl38,213,663 - 8,226,866 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx311,318,790 - 11,324,211 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0319,905,020 - 19,910,441 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0318,094,862 - 18,100,283 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd326,174,834 - 26,180,299 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive333,123,714 - 33,129,179 (+)NCBILyon_Normotensive
Lyon_Hypertensive325,023,203 - 25,028,668 (+)NCBILyon_Hypertensive
F344_StmMcwi36,225,839 - 6,231,304 (+)NCBIF344_StmMcwi
Rnor_6.032,617,795 - 2,623,818 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl32,617,805 - 2,623,445 (+)Ensemblrn6Rnor6.0
Rnor_5.032,599,211 - 2,605,231 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.433,564,380 - 3,569,801 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera33,038,775 - 3,044,196 (+)NCBICelera
RGSC_v3.133,564,379 - 3,569,800 (+)NCBI
Cytogenetic Map3p13NCBI
ENTPD2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389137,048,107 - 137,054,061 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9137,048,107 - 137,054,061 (-)Ensemblhg38GRCh38
GRCh379139,942,559 - 139,948,513 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369139,062,374 - 139,068,326 (-)NCBIBuild 36Build 36hg18NCBI36
Build 349137,218,389 - 137,224,342NCBI
Celera9110,455,967 - 110,461,919 (-)NCBICelera
Cytogenetic Map9q34.3NCBI
HuRef9109,402,078 - 109,408,246 (-)NCBIHuRef
CHM1_19140,091,345 - 140,097,263 (-)NCBICHM1_1
T2T-CHM13v2.09149,283,232 - 149,291,667 (-)NCBIT2T-CHM13v2.0
Entpd2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39225,285,886 - 25,291,335 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl225,285,886 - 25,291,333 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38225,395,874 - 25,401,323 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl225,395,874 - 25,401,321 (+)Ensemblmm10GRCm38
MGSCv37225,251,394 - 25,256,843 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36225,217,967 - 25,223,327 (+)NCBIMGSCv36mm8
Celera225,123,341 - 25,128,787 (+)NCBICelera
Cytogenetic Map2A3NCBI
cM Map217.22NCBI
Entpd2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555135,068,875 - 5,075,098 (-)Ensembl
ChiLan1.0NW_0049555135,070,050 - 5,075,098 (-)NCBIChiLan1.0ChiLan1.0
ENTPD2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2112,344,532 - 2,350,408 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan192,346,687 - 2,352,742 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v09108,108,780 - 108,114,806 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19137,077,207 - 137,083,031 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9137,077,207 - 137,083,031 (-)EnsemblpanPan2panpan1.1
ENTPD2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1948,589,408 - 48,594,852 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl948,570,891 - 48,594,452 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha947,803,203 - 47,808,473 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0949,467,623 - 49,472,893 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl949,467,627 - 49,472,890 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1948,243,870 - 48,249,128 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0948,542,603 - 48,547,873 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0948,589,911 - 48,595,183 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Entpd2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947202,468,293 - 202,475,008 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936669901,104 - 906,782 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936669901,192 - 906,765 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ENTPD2
(Sus scrofa - pig)		 No map positions available.
ENTPD2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1121,137,500 - 1,142,798 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl121,137,495 - 1,143,231 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660584,159,835 - 4,165,592 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Entpd2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624760859,637 - 866,804 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624760859,598 - 865,194 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Entpd2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1511,781,232 - 11,786,870 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Entpd2
47 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:199
Count of miRNA genes:123
Interacting mature miRNAs:139
Transcripts:ENSRNOT00000017829, ENSRNOT00000018560
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558647Cm46Cardiac mass QTL 465.40.0000055heart mass (VT:0007028)heart wet weight (CMO:0000069)32267715050766390Rat
6893355Bw101Body weight QTL 1010.40.38body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
10450811Scl73Serum cholesterol level QTL 734.70.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
2292615Ept17Estrogen-induced pituitary tumorigenesis QTL 176.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3655634751556347Rat
10450808Scl72Serum cholesterol level QTL 724.40.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
10450806Scl71Serum cholesterol level QTL 715.80.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
1558654Bw56Body weight QTL 564.50.0000171body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)3612543751125437Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3136721849Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3655634751556347Rat
1558657Cm43Cardiac mass QTL 436.63e-08heart mass (VT:0007028)heart wet weight (CMO:0000069)32267715050766390Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)31527234860272348Rat
6893363Bw105Body weight QTL 1052.60.0036body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358185Ept6Estrogen-induced pituitary tumorigenesis QTL 66.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3655634751556347Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 155 91 90 59 91 59 6 355 191 11 134 81 92 31 12 12

Sequence


Ensembl Acc Id: ENSRNOT00000017829   ⟹   ENSRNOP00000017829
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl38,213,663 - 8,220,040 (+)Ensembl
Rnor_6.0 Ensembl32,617,805 - 2,623,445 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000018927   ⟹   ENSRNOP00000018927
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl38,220,678 - 8,226,866 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000094013   ⟹   ENSRNOP00000086303
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl38,213,663 - 8,226,862 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000102806   ⟹   ENSRNOP00000091377
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl38,214,833 - 8,220,040 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000112091   ⟹   ENSRNOP00000096205
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl38,220,678 - 8,226,866 (+)Ensembl
RefSeq Acc Id: NM_001429439   ⟹   NP_001416368
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Dahl_SR_JrHsd326,174,834 - 26,180,299 (+)NCBI
Lyon_Normotensive333,123,714 - 33,129,179 (+)NCBI
Lyon_Hypertensive325,023,203 - 25,028,668 (+)NCBI
F344_StmMcwi36,225,839 - 6,231,304 (+)NCBI
RefSeq Acc Id: NM_172030   ⟹   NP_742027
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8328,611,816 - 28,617,237 (+)NCBI
mRatBN7.238,213,673 - 8,219,094 (+)NCBI
Dahl_SR_JrHsd326,174,834 - 26,180,299 (+)NCBI
Lyon_Normotensive333,123,714 - 33,129,179 (+)NCBI
Lyon_Hypertensive325,023,203 - 25,028,668 (+)NCBI
F344_StmMcwi36,225,839 - 6,231,304 (+)NCBI
Rnor_6.032,617,895 - 2,623,316 (+)NCBI
Rnor_5.032,599,211 - 2,605,231 (+)NCBI
RGSC_v3.433,564,380 - 3,569,801 (+)RGD
Celera33,038,775 - 3,044,196 (+)RGD
Sequence:
RefSeq Acc Id: XM_006233644   ⟹   XP_006233706
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8328,611,722 - 28,617,237 (+)NCBI
mRatBN7.238,213,576 - 8,219,041 (+)NCBI
Rnor_6.032,617,796 - 2,623,818 (+)NCBI
Rnor_5.032,599,211 - 2,605,231 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017592023   ⟹   XP_017447512
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8328,611,723 - 28,617,237 (+)NCBI
mRatBN7.238,213,575 - 8,219,041 (+)NCBI
Rnor_6.032,617,795 - 2,623,818 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017592024   ⟹   XP_017447513
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8328,611,725 - 28,617,184 (+)NCBI
mRatBN7.238,213,576 - 8,219,041 (+)NCBI
Rnor_6.032,617,796 - 2,623,818 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039105790   ⟹   XP_038961718
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8328,611,724 - 28,617,184 (+)NCBI
mRatBN7.238,213,576 - 8,219,041 (+)NCBI
RefSeq Acc Id: XM_063284518   ⟹   XP_063140588
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8328,611,726 - 28,617,184 (+)NCBI
RefSeq Acc Id: XM_063284519   ⟹   XP_063140589
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8328,613,238 - 28,617,237 (+)NCBI
RefSeq Acc Id: NP_742027   ⟸   NM_172030
- Peptide Label: precursor
- UniProtKB: Q9WVE7 (UniProtKB/Swiss-Prot),   Q9JHY5 (UniProtKB/Swiss-Prot),   O35795 (UniProtKB/Swiss-Prot),   Q5RJP4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233706   ⟸   XM_006233644
- Peptide Label: isoform X2
- UniProtKB: F1M7N2 (UniProtKB/TrEMBL),   A0A8I6AFG9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017447512   ⟸   XM_017592023
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AFG9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017447513   ⟸   XM_017592024
- Peptide Label: isoform X4
- Sequence:
Ensembl Acc Id: ENSRNOP00000017829   ⟸   ENSRNOT00000017829
RefSeq Acc Id: XP_038961718   ⟸   XM_039105790
- Peptide Label: isoform X3
- UniProtKB: Q9WVE7 (UniProtKB/Swiss-Prot),   Q9JHY5 (UniProtKB/Swiss-Prot),   O35795 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSRNOP00000091377   ⟸   ENSRNOT00000102806
Ensembl Acc Id: ENSRNOP00000096205   ⟸   ENSRNOT00000112091
Ensembl Acc Id: ENSRNOP00000086303   ⟸   ENSRNOT00000094013
Ensembl Acc Id: ENSRNOP00000018927   ⟸   ENSRNOT00000018927
RefSeq Acc Id: XP_063140588   ⟸   XM_063284518
- Peptide Label: isoform X5
- UniProtKB: Q9WVE7 (UniProtKB/Swiss-Prot),   Q9JHY5 (UniProtKB/Swiss-Prot),   O35795 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063140589   ⟸   XM_063284519
- Peptide Label: isoform X6
RefSeq Acc Id: NP_001416368   ⟸   NM_001429439

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35795-F1-model_v2 AlphaFold O35795 1-495 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691875
Promoter ID:EPDNEW_R2400
Type:initiation region
Name:Entpd2_1
Description:ectonucleoside triphosphate diphosphohydrolase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.032,617,851 - 2,617,911EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69266 AgrOrtholog
BioCyc Gene G2FUF-50457 BioCyc
Ensembl Genes ENSRNOG00000013102 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000017829 ENTREZGENE
  ENSRNOT00000094013 ENTREZGENE
  ENSRNOT00000167123 ENTREZGENE
Gene3D-CATH 3.30.420.40 UniProtKB/Swiss-Prot
  Exopolyphosphatase. Domain 2 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7302083 IMAGE-MGC_LOAD
InterPro GDA1_CD39_NTPase UniProtKB/Swiss-Prot
KEGG Report rno:64467 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105301 IMAGE-MGC_LOAD
NCBI Gene 64467 ENTREZGENE
PANTHER ECTONUCLEOSIDE TRIPHOSPHATE DIPHOSPHOHYDROLASE 2 UniProtKB/Swiss-Prot
  PTHR11782 UniProtKB/Swiss-Prot
Pfam GDA1_CD39 UniProtKB/Swiss-Prot
PhenoGen Entpd2 PhenoGen
PROSITE GDA1_CD39_NTPASE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000013102 RatGTEx
TIGR TC230447
UniProt A0A8I6A5S8_RAT UniProtKB/TrEMBL
  A0A8I6AFG9 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LNF4_RAT UniProtKB/TrEMBL
  A3FKJ7_RAT UniProtKB/TrEMBL
  ENTP2_RAT UniProtKB/Swiss-Prot
  F1M7N2 ENTREZGENE, UniProtKB/TrEMBL
  O35795 ENTREZGENE
  Q5RJP4 ENTREZGENE, UniProtKB/TrEMBL
  Q9JHY5 ENTREZGENE
  Q9WVE7 ENTREZGENE
UniProt Secondary Q9JHY5 UniProtKB/Swiss-Prot
  Q9WVE7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Entpd2  ectonucleoside triphosphate diphosphohydrolase 2      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in portal fibroblasts near hepatic bile duct epithelial basolateral membranes 728486