Pde7a (phosphodiesterase 7A) - Rat Genome Database

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Gene: Pde7a (phosphodiesterase 7A) Rattus norvegicus
Analyze
Symbol: Pde7a
Name: phosphodiesterase 7A
RGD ID: 68391
Description: Enables cyclic-nucleotide phosphodiesterase activity. Predicted to be involved in negative regulation of cAMP/PKA signal transduction. Predicted to be located in cytosol. Orthologous to human PDE7A (phosphodiesterase 7A); PARTICIPATES IN protein kinase A (PKA) signaling pathway; purine metabolic pathway; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cAMP-specific phosphodiesterase 7A; high affinity 3',5'-cyclic-AMP phosphodiesterase 7A; high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A; PDE7-1; rolipram-insensitive phosphodiesterase type 7
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82103,631,655 - 103,723,057 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2103,634,594 - 103,722,890 (-)EnsemblGRCr8
mRatBN7.22101,714,767 - 101,806,853 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2101,718,444 - 101,806,681 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2108,235,543 - 108,323,729 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02106,356,659 - 106,444,849 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02101,331,729 - 101,419,882 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd2103,034,156 - 103,122,341 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive2103,097,122 - 103,185,315 (-)NCBILyon_Normotensive
Lyon_Hypertensive2102,954,360 - 103,042,546 (-)NCBILyon_Hypertensive
F344_StmMcwi2102,759,555 - 102,847,734 (-)NCBIF344_StmMcwi
Rnor_6.02104,042,124 - 104,134,101 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2104,045,811 - 104,134,101 (-)Ensemblrn6Rnor6.0
Rnor_5.02123,764,137 - 123,856,129 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42104,339,910 - 104,429,820 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera297,112,400 - 97,200,488 (-)NCBICelera
RGSC_v3.12104,284,877 - 104,323,840 (-)NCBI
Cytogenetic Map2q24NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2-methylcholine  (ISO)
3',5'-cyclic AMP  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
Azoxymethane  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cadmium sulfate  (ISO)
CGP 52608  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
dextran sulfate  (ISO)
dipyridamole  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ethanol  (ISO)
FR900359  (ISO)
isoprenaline  (ISO)
lead(II) chloride  (ISO)
manganese(II) chloride  (EXP)
methapyrilene  (ISO)
methimazole  (EXP)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
methylparaben  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
nickel atom  (ISO)
papaverine  (ISO)
paracetamol  (ISO)
PCB138  (ISO)
pentanal  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
roflumilast  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
succimer  (ISO)
sulfadimethoxine  (EXP)
Tesaglitazar  (EXP)
testosterone  (EXP)
testosterone enanthate  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Biochemistry and physiology of cyclic nucleotide phosphodiesterases: essential components in cyclic nucleotide signaling. Conti M and Beavo J, Annu Rev Biochem. 2007;76:481-511.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Differential distribution of rat PDE-7 mRNA in embryonic and adult rat brain. Hoffmann R, etal., Cell Biochem Biophys 1998;28(2-3):103-13.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Differential distribution of cAMP-specific phosphodiesterase 7A mRNA in rat brain and peripheral organs. Miro X, etal., Synapse 2001 Jun;40(3):201-14.
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. GOA pipeline RGD automated data pipeline
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
12. Pharmacological profile of a novel phosphodiesterase 7A and -4 dual inhibitor, YM-393059, on acute and chronic inflammation models. Yamamoto S, etal., Eur J Pharmacol. 2006 Nov 21;550(1-3):166-72. Epub 2006 Aug 30.
Additional References at PubMed
PMID:8943082   PMID:27538853  


Genomics

Comparative Map Data
Pde7a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82103,631,655 - 103,723,057 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2103,634,594 - 103,722,890 (-)EnsemblGRCr8
mRatBN7.22101,714,767 - 101,806,853 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2101,718,444 - 101,806,681 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2108,235,543 - 108,323,729 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02106,356,659 - 106,444,849 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02101,331,729 - 101,419,882 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd2103,034,156 - 103,122,341 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive2103,097,122 - 103,185,315 (-)NCBILyon_Normotensive
Lyon_Hypertensive2102,954,360 - 103,042,546 (-)NCBILyon_Hypertensive
F344_StmMcwi2102,759,555 - 102,847,734 (-)NCBIF344_StmMcwi
Rnor_6.02104,042,124 - 104,134,101 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2104,045,811 - 104,134,101 (-)Ensemblrn6Rnor6.0
Rnor_5.02123,764,137 - 123,856,129 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42104,339,910 - 104,429,820 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera297,112,400 - 97,200,488 (-)NCBICelera
RGSC_v3.12104,284,877 - 104,323,840 (-)NCBI
Cytogenetic Map2q24NCBI
PDE7A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38865,714,334 - 65,842,064 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl865,714,334 - 65,842,529 (-)Ensemblhg38GRCh38
GRCh37866,626,569 - 66,754,299 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36866,793,867 - 66,916,297 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34866,796,607 - 66,916,297NCBI
Celera862,621,394 - 62,745,383 (-)NCBICelera
Cytogenetic Map8q13.1NCBI
HuRef862,116,681 - 62,191,314 (-)NCBIHuRef
CHM1_1866,681,227 - 66,808,574 (-)NCBICHM1_1
T2T-CHM13v2.0866,140,012 - 66,267,737 (-)NCBIT2T-CHM13v2.0
Pde7a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39319,277,272 - 19,365,486 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl319,277,272 - 19,365,486 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38319,223,108 - 19,311,322 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl319,223,108 - 19,311,322 (-)Ensemblmm10GRCm38
MGSCv37319,125,918 - 19,211,322 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36319,418,069 - 19,457,108 (-)NCBIMGSCv36mm8
Celera319,216,511 - 19,304,588 (-)NCBICelera
Cytogenetic Map3A2NCBI
cM Map35.36NCBI
Pde7a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544413,349,405 - 13,473,388 (+)Ensembl
ChiLan1.0NW_00495544413,349,405 - 13,475,827 (+)NCBIChiLan1.0ChiLan1.0
PDE7A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2781,450,201 - 81,574,754 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1857,089,749 - 57,213,598 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0862,253,137 - 62,380,198 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1863,921,520 - 64,048,462 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl863,921,520 - 64,048,273 (-)EnsemblpanPan2panpan1.1
PDE7A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12915,398,106 - 15,467,789 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2915,400,522 - 15,467,917 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2915,721,653 - 15,837,636 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02915,485,055 - 15,601,385 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2915,485,057 - 15,602,088 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12915,502,340 - 15,630,381 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02915,617,373 - 15,733,306 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02915,878,523 - 15,994,585 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Pde7a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530366,617,908 - 66,722,919 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364968,062,825 - 8,167,088 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364968,062,606 - 8,167,571 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PDE7A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl468,779,540 - 68,896,577 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1468,777,910 - 68,896,583 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2475,026,382 - 75,055,308 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PDE7A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1861,586,176 - 61,711,487 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl861,582,844 - 61,658,497 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603979,808,871 - 79,935,779 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pde7a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474425,651,313 - 25,803,695 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474425,651,735 - 25,806,525 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Pde7a
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v13134,679,159 - 134,764,650 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Pde7a
967 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:262
Count of miRNA genes:167
Interacting mature miRNAs:185
Transcripts:ENSRNOT00000067725
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578777Stresp15Stress response QTL 1520.05blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)261556902106556902Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1598865Bp296Blood pressure QTL 2962.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)282947902127947902Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1578772Stresp14Stress response QTL 1450.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)284056790132859658Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
152025242Bw191Body weight QTL 1913.62body mass (VT:0001259)240306867124537199Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)278269809208420281Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)227148328145807373Rat
61465Bp13Blood pressure QTL 133.3blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)278269809104744824Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
2317886Alcrsp23Alcohol response QTL 232.40.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)295142371140142371Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)241801363104744824Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
2317058Aia13Adjuvant induced arthritis QTL 132.9joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)278269809123269809Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1300155Bp174Blood pressure QTL 1744.09arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)244537979112567334Rat
5684990Bmd82Bone mineral density QTL 822.8tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)261051541105724065Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)27605533104774005Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1359035Bp276Blood pressure QTL 276arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2100807373145807373Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845182205135428Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)228652666139067443Rat
2299162Iddm32Insulin dependent diabetes mellitus QTL 322.36blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)293602631145807373Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)278269809205135428Rat
631500Bp99Blood pressure QTL 992.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)261051883104684275Rat
61392Bp6Blood pressure QTL 67arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)282214549127214549Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
5684996Bmd85Bone mineral density QTL 854.70.024tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)261051541105724065Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979159440891Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
1558648Smcn1Smooth muscle cell number QTL 10.039blood vessel smooth muscle cell quantity (VT:0010525)aorta smooth muscle cell count per unit vessel length (CMO:0001646)260861391105861391Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979184731399Rat
2306903Bp336Blood pressure QTL 3360.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)238426449111295694Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)230219200171802126Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)276328396209350714Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)230219200171802126Rat
61438Cia7Collagen induced arthritis QTL 74.60.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)261051541143746880Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 66 165 91 90 59 92 59 6 355 191 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000067725   ⟹   ENSRNOP00000060777
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2103,634,594 - 103,722,827 (-)Ensembl
mRatBN7.2 Ensembl2101,718,444 - 101,806,681 (-)Ensembl
Rnor_6.0 Ensembl2104,045,811 - 104,134,101 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000088167   ⟹   ENSRNOP00000069695
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2103,634,594 - 103,679,013 (-)Ensembl
mRatBN7.2 Ensembl2101,720,108 - 101,760,966 (-)Ensembl
Rnor_6.0 Ensembl2104,048,554 - 104,133,985 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000094659   ⟹   ENSRNOP00000091687
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2103,647,158 - 103,677,062 (-)Ensembl
mRatBN7.2 Ensembl2101,731,008 - 101,760,966 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000108651   ⟹   ENSRNOP00000086827
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2103,634,594 - 103,677,062 (-)Ensembl
mRatBN7.2 Ensembl2101,718,444 - 101,760,966 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000143772   ⟹   ENSRNOP00000111863
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2103,634,594 - 103,672,109 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000148915   ⟹   ENSRNOP00000102381
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2103,634,594 - 103,722,890 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000151417   ⟹   ENSRNOP00000101936
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2103,634,594 - 103,722,890 (-)Ensembl
RefSeq Acc Id: NM_031080   ⟹   NP_112342
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82103,634,594 - 103,722,827 (-)NCBI
mRatBN7.22101,718,444 - 101,806,681 (-)NCBI
Dahl_SR_JrHsd2103,034,156 - 103,122,341 (-)NCBI
Lyon_Normotensive2103,097,122 - 103,185,315 (-)NCBI
Lyon_Hypertensive2102,954,360 - 103,042,546 (-)NCBI
F344_StmMcwi2102,759,555 - 102,847,734 (-)NCBI
Rnor_6.02104,045,811 - 104,134,101 (-)NCBI
Rnor_5.02123,764,137 - 123,856,129 (-)NCBI
RGSC_v3.42104,339,910 - 104,429,820 (-)RGD
Celera297,112,400 - 97,200,488 (-)RGD
Sequence:
RefSeq Acc Id: XM_006232188   ⟹   XP_006232250
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82103,631,655 - 103,677,916 (-)NCBI
mRatBN7.22101,714,767 - 101,761,728 (-)NCBI
Rnor_6.02104,042,124 - 104,089,666 (-)NCBI
Rnor_5.02123,764,137 - 123,856,129 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008760880   ⟹   XP_008759102
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82103,631,655 - 103,672,092 (-)NCBI
mRatBN7.22101,714,767 - 101,755,948 (-)NCBI
Rnor_6.02104,042,124 - 104,080,607 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039103227   ⟹   XP_038959155
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82103,631,655 - 103,665,356 (-)NCBI
mRatBN7.22101,714,767 - 101,749,328 (-)NCBI
RefSeq Acc Id: XM_039103228   ⟹   XP_038959156
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82103,639,505 - 103,723,057 (-)NCBI
mRatBN7.22101,723,356 - 101,806,853 (-)NCBI
RefSeq Acc Id: XM_063282631   ⟹   XP_063138701
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82103,631,655 - 103,665,355 (-)NCBI
RefSeq Acc Id: XR_005500379
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82103,636,310 - 103,723,057 (-)NCBI
mRatBN7.22101,720,160 - 101,806,853 (-)NCBI
RefSeq Acc Id: NP_112342   ⟸   NM_031080
- UniProtKB: O08593 (UniProtKB/Swiss-Prot),   F1LM88 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006232250   ⟸   XM_006232188
- Peptide Label: isoform X1
- UniProtKB: O08593 (UniProtKB/Swiss-Prot),   A0A8I6A6L3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008759102   ⟸   XM_008760880
- Peptide Label: isoform X2
- UniProtKB: O08593 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000060777   ⟸   ENSRNOT00000067725
Ensembl Acc Id: ENSRNOP00000069695   ⟸   ENSRNOT00000088167
RefSeq Acc Id: XP_038959155   ⟸   XM_039103227
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038959156   ⟸   XM_039103228
- Peptide Label: isoform X4
Ensembl Acc Id: ENSRNOP00000086827   ⟸   ENSRNOT00000108651
Ensembl Acc Id: ENSRNOP00000091687   ⟸   ENSRNOT00000094659
RefSeq Acc Id: XP_063138701   ⟸   XM_063282631
- Peptide Label: isoform X5
Ensembl Acc Id: ENSRNOP00000102381   ⟸   ENSRNOT00000148915
Ensembl Acc Id: ENSRNOP00000101936   ⟸   ENSRNOT00000151417
Ensembl Acc Id: ENSRNOP00000111863   ⟸   ENSRNOT00000143772
Protein Domains
PDEase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O08593-F1-model_v2 AlphaFold O08593 1-426 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68391 AgrOrtholog
BioCyc Gene G2FUF-53631 BioCyc
Ensembl Genes ENSRNOG00000013048 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000067725 ENTREZGENE
  ENSRNOT00000108651 ENTREZGENE
  ENSRNOT00000143772 ENTREZGENE
Gene3D-CATH 1.10.1300.10 UniProtKB/Swiss-Prot
InterPro HD/PDEase_dom UniProtKB/Swiss-Prot
  PDEase UniProtKB/Swiss-Prot
  PDEase_catalytic_dom UniProtKB/Swiss-Prot
  PDEase_catalytic_dom_sf UniProtKB/Swiss-Prot
  PDEase_CS UniProtKB/Swiss-Prot
NCBI Gene 81744 ENTREZGENE
PANTHER CYCLIC NUCLEOTIDE PHOSPHODIESTERASE UniProtKB/Swiss-Prot
Pfam PDEase_I UniProtKB/Swiss-Prot
PhenoGen Pde7a PhenoGen
PRINTS PDIESTERASE1 UniProtKB/Swiss-Prot
PROSITE PDEASE_I_1 UniProtKB/Swiss-Prot
  PDEASE_I_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000013048 RatGTEx
SMART HDc UniProtKB/Swiss-Prot
Superfamily-SCOP HD-domain/PDEase-like UniProtKB/Swiss-Prot
TIGR TC207327
UniProt A0A0G2JW08_RAT UniProtKB/TrEMBL
  A0A8I6A6L3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AGL5_RAT UniProtKB/TrEMBL
  A0ABK0L116_RAT UniProtKB/TrEMBL
  A0ABK0L1N5_RAT UniProtKB/TrEMBL
  A0ABK0M876_RAT UniProtKB/TrEMBL
  A6IHB4_RAT UniProtKB/TrEMBL
  A6IHB5_RAT UniProtKB/TrEMBL
  F1LM88 ENTREZGENE, UniProtKB/TrEMBL
  O08593 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Pde7a  phosphodiesterase 7A      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference