Ltbp1 (latent transforming growth factor beta binding protein 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Ltbp1 (latent transforming growth factor beta binding protein 1) Rattus norvegicus
Analyze
Symbol: Ltbp1
Name: latent transforming growth factor beta binding protein 1
RGD ID: 68379
Description: Predicted to enable several functions, including microfibril binding activity; receptor ligand inhibitor activity; and transforming growth factor beta binding activity. Involved in several processes, including cellular response to mechanical stimulus; cellular response to parathyroid hormone stimulus; and cellular response to platelet-derived growth factor stimulus. Located in several cellular components, including dendrite; neuronal cell body; and perinuclear region of cytoplasm. Part of large latent transforming growth factor-beta complex. Biomarker of glomerulonephritis and transient cerebral ischemia. Human ortholog(s) of this gene implicated in cutis laxa. Orthologous to human LTBP1 (latent transforming growth factor beta binding protein 1); PARTICIPATES IN transforming growth factor-beta superfamily mediated signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LanC (bacterial lantibiotic synthetase component C)-like 1; latent-transforming growth factor beta-binding protein 1; LTBP-1; TGF-beta-1-BP-1; transforming growth factor beta-1-binding protein 1; transforming growth factor beta-1-masking protein large subunit; transforming growth factor-beta (TGF-beta) masking protein large subunit
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8625,781,625 - 26,177,346 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl625,781,638 - 26,454,036 (-)EnsemblGRCr8
mRatBN7.2620,029,629 - 20,425,339 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl620,029,629 - 20,425,349 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx620,357,932 - 20,753,550 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0620,673,805 - 21,069,397 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0620,154,255 - 20,549,858 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0621,203,502 - 21,600,441 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl621,203,502 - 21,600,451 (-)Ensemblrn6Rnor6.0
Rnor_5.0631,097,090 - 31,491,815 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4619,942,626 - 20,355,084 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera619,596,894 - 19,988,483 (-)NCBICelera
RGSC_v3.1620,157,811 - 20,358,038 (-)NCBI
Cytogenetic Map6q13NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
apigenin  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
asbestos  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-naphthoflavone  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bucladesine  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (EXP,ISO)
cobalt dichloride  (EXP,ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
dexamethasone  (ISO)
Dibutyl phosphate  (ISO)
diquat  (ISO)
disodium selenite  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
endosulfan  (EXP)
ethanol  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
furan  (EXP)
genistein  (EXP)
gentamycin  (EXP)
glyphosate  (EXP,ISO)
graphite  (EXP)
GW 4064  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
isotretinoin  (ISO)
L-methionine  (ISO)
Licochalcone B  (ISO)
maneb  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
medroxyprogesterone acetate  (ISO)
methamphetamine  (EXP)
methimazole  (EXP)
methoxychlor  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
Muraglitazar  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
nickel atom  (ISO)
nitrates  (ISO)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
p-toluidine  (EXP)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
pirinixic acid  (ISO)
progesterone  (ISO)
raloxifene  (ISO)
SB 431542  (ISO)
SCH 23390  (EXP)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sotorasib  (ISO)
sulfadimethoxine  (EXP)
tamoxifen  (ISO)
Tesaglitazar  (EXP)
testosterone enanthate  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trametinib  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP,ISO)
tris(2-butoxyethyl) phosphate  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Anti-latent TGF-beta binding protein-1 antibody or synthetic oligopeptides inhibit extracellular matrix expression induced by stretch in cultured rat mesangial cells. Hori Y, etal., Kidney Int. 1998 Jun;53(6):1616-25.
3. Parathyroid hormone stimulation and PKA signaling of latent transforming growth factor-beta binding protein-1 (LTBP-1) mRNA expression in osteoblastic cells. Kwok S, etal., J Cell Biochem. 2005 Aug 1;95(5):1002-11.
4. Chronic hyperglycaemia increases TGFbeta2 signaling and the expression of extracellular matrix proteins in the rat parotid gland. Lamers ML, etal., Matrix Biol. 2007 Sep;26(7):572-82. Epub 2007 May 16.
5. The first stage of transforming growth factor beta1 activation is release of the large latent complex from the extracellular matrix of growth plate chondrocytes by matrix vesicle stromelysin-1 (MMP-3). Maeda S, etal., Calcif Tissue Int. 2002 Jan;70(1):54-65. Epub 2001 Dec 21.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. Vitamin D3 metabolites regulate LTBP1 and latent TGF-beta1 expression and latent TGF-beta1 incorporation in the extracellular matrix of chondrocytes. Pedrozo HA, etal., J Cell Biochem. 1999 Jan 1;72(1):151-65.
9. Growth plate chondrocytes store latent transforming growth factor (TGF)-beta 1 in their matrix through latent TGF-beta 1 binding protein-1. Pedrozo HA, etal., J Cell Physiol. 1998 Nov;177(2):343-54.
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. Induction and coexpression of latent transforming growth factor beta-binding protein-1 and fibrillin-1 in experimental glomerulonephritis. Porst M, etal., Nephron Exp Nephrol. 2006;102(3-4):e99-104. Epub 2005 Nov 11.
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Comprehensive gene review and curation RGD comprehensive gene curation
16. Subcellular localization of (latent) transforming growth factor beta and the latent TGF-beta binding protein in rat hepatocytes and hepatic stellate cells. Roth-Eichhorn S, etal., Hepatology. 1998 Dec;28(6):1588-96.
17. Differential expression of fibromodulin, a transforming growth factor-beta modulator, in fetal skin development and scarless repair. Soo C, etal., Am J Pathol. 2000 Aug;157(2):423-33.
18. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
19. Molecular cloning of the large subunit of transforming growth factor type beta masking protein and expression of the mRNA in various rat tissues. Tsuji T, etal., Proc Natl Acad Sci U S A 1990 Nov;87(22):8835-9.
20. PDGF-BB induces expression of LTBP-1 but not TGF-beta1 in a rat cirrhotic fat storing cell line. Westhoff JH, etal., Growth Factors. 2003 Sep-Dec;21(3-4):121-30.
21. Beta(2)-adrenoceptor stimulation enhances latent transforming growth factor-beta-binding protein-1 and transforming growth factor-beta1 expression in rat hippocampus after transient forebrain ischemia. Zhu Y, etal., Neuroscience. 2001;107(4):593-602.
Additional References at PubMed
PMID:2022183   PMID:7593177   PMID:8617200   PMID:9008713   PMID:10743502   PMID:10930463   PMID:11104663   PMID:12429738   PMID:12606526   PMID:15677465   PMID:16157329   PMID:18672106  
PMID:20551380   PMID:23979707   PMID:24006456   PMID:25807483   PMID:27068509  


Genomics

Comparative Map Data
Ltbp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8625,781,625 - 26,177,346 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl625,781,638 - 26,454,036 (-)EnsemblGRCr8
mRatBN7.2620,029,629 - 20,425,339 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl620,029,629 - 20,425,349 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx620,357,932 - 20,753,550 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0620,673,805 - 21,069,397 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0620,154,255 - 20,549,858 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0621,203,502 - 21,600,441 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl621,203,502 - 21,600,451 (-)Ensemblrn6Rnor6.0
Rnor_5.0631,097,090 - 31,491,815 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4619,942,626 - 20,355,084 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera619,596,894 - 19,988,483 (-)NCBICelera
RGSC_v3.1620,157,811 - 20,358,038 (-)NCBI
Cytogenetic Map6q13NCBI
LTBP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38232,946,953 - 33,399,509 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl232,946,472 - 33,399,509 (+)Ensemblhg38GRCh38
GRCh37233,172,020 - 33,624,576 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36233,025,896 - 33,478,080 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34233,084,042 - 33,536,224NCBI
Celera233,011,085 - 33,463,289 (+)NCBICelera
Cytogenetic Map2p22.3NCBI
HuRef232,905,956 - 33,358,305 (+)NCBIHuRef
CHM1_1233,101,861 - 33,553,940 (+)NCBICHM1_1
T2T-CHM13v2.0232,992,680 - 33,445,650 (+)NCBIT2T-CHM13v2.0
Ltbp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391775,312,475 - 75,699,507 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1775,312,563 - 75,699,507 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381775,005,480 - 75,392,512 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1775,005,568 - 75,392,512 (+)Ensemblmm10GRCm38
MGSCv371775,404,869 - 75,791,109 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361774,910,589 - 75,296,829 (+)NCBIMGSCv36mm8
Celera1779,300,183 - 79,689,321 (+)NCBICelera
Cytogenetic Map17E2NCBI
cM Map1746.24NCBI
Ltbp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554411,232,041 - 1,627,470 (+)Ensembl
ChiLan1.0NW_0049554411,405,340 - 1,626,668 (+)NCBIChiLan1.0ChiLan1.0
LTBP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21293,101,396 - 93,553,600 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A93,105,234 - 93,557,610 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A32,956,937 - 33,409,286 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A33,854,604 - 34,120,593 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A33,667,191 - 34,120,602 (+)EnsemblpanPan2panpan1.1
LTBP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11726,129,528 - 26,521,782 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1726,130,781 - 26,521,779 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1725,920,743 - 26,311,820 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01726,696,150 - 27,088,547 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1726,695,727 - 27,088,544 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11725,992,669 - 26,384,315 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01726,065,391 - 26,457,908 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01726,223,816 - 26,614,580 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ltbp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629270,199,425 - 70,586,169 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936493253,216 - 640,140 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936493253,390 - 640,140 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LTBP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3106,300,750 - 106,724,737 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.13106,300,748 - 106,724,538 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23113,356,459 - 113,442,576 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LTBP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11474,063,258 - 74,441,042 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1474,064,087 - 74,548,825 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604537,507,594 - 37,952,425 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ltbp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473814,602,805 - 15,034,805 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473814,602,790 - 15,035,610 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Ltbp1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1717,890,765 - 18,096,261 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ltbp1
2371 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:442
Count of miRNA genes:233
Interacting mature miRNAs:280
Transcripts:ENSRNOT00000047674
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552962Pigfal16Plasma insulin-like growth factor 1 level QTL 169.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)6197587946975879Rat
8693699Alc37Alcohol consumption QTL 372.60.224drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)61371716927053860Rat
8693645Alc31Alcohol consumption QTL 313.70.038drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)62328466429732046Rat
10401812Kidm54Kidney mass QTL 54kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)62009763565097635Rat
8552910Pigfal5Plasma insulin-like growth factor 1 level QTL 54.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)62265388967653889Rat
2292589Emca10Estrogen-induced mammary cancer QTL 100.048mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)62228825727729050Rat
10401800Kidm49Kidney mass QTL 49kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)62009763565097635Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6323998948239989Rat
9589129Insul24Insulin level QTL 2419.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)6197587946975879Rat
7411603Foco13Food consumption QTL 135.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6197587946975879Rat
1598843Cm63Cardiac mass QTL 632.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)6144788383Rat
7411542Bw127Body weight QTL 1275.50.001body mass (VT:0001259)body weight gain (CMO:0000420)6197587946975879Rat
2292616Ept15Estrogen-induced pituitary tumorigenesis QTL 154.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)6144788383Rat
9589048Scfw3Subcutaneous fat weight QTL 34.570.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)6197587946975879Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)620859430113082285Rat
2301964Bp323Blood pressure QTL 3234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6186868070Rat
2293709Bss23Bone structure and strength QTL 235.180.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)6323998948239989Rat
2293650Bss31Bone structure and strength QTL 315.050.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)6323998948239989Rat
1300128Rf16Renal function QTL 163.89renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6140163351Rat
70199Coreg1Compensatory renal growth QTL 111.8kidney mass (VT:0002707)compensatory renal growth score (CMO:0001894)61459947363457687Rat
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)61608937261967788Rat
1358190Ept1Estrogen-induced pituitary tumorigenesis QTL 14.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)6144788383Rat
2293656Bss28Bone structure and strength QTL 286.790.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)6323998948239989Rat
1359023Bp272Blood pressure QTL 2722.5arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)62228825732981219Rat
1354664Slep2Serum leptin concentration QTL 24.49blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)62228825767288257Rat
8693690Alc35Alcohol consumption QTL 352.20.606drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)61371716927053860Rat

Markers in Region
D6Rat39  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2620,338,777 - 20,338,915 (+)MAPPERmRatBN7.2
Rnor_6.0621,515,302 - 21,515,439NCBIRnor6.0
Rnor_5.0631,405,370 - 31,405,507UniSTSRnor5.0
Celera619,903,413 - 19,903,550UniSTS
RH 2.0 Map6179.7RGD
SHRSP x BN Map620.6398RGD
FHH x ACI Map620.5099RGD
Cytogenetic Map6q12UniSTS
D6Got317  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2620,128,530 - 20,128,637 (+)MAPPERmRatBN7.2
Rnor_6.0621,302,503 - 21,302,609NCBIRnor6.0
Rnor_5.0631,195,928 - 31,196,034UniSTSRnor5.0
RGSC_v3.4620,040,716 - 20,040,822UniSTSRGSC3.4
Celera619,695,651 - 19,695,757UniSTS
Cytogenetic Map6q12UniSTS
D6Got300  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2620,258,115 - 20,258,220 (+)MAPPERmRatBN7.2
Rnor_6.0621,434,002 - 21,434,106NCBIRnor6.0
Rnor_5.0631,324,070 - 31,324,174UniSTSRnor5.0
RGSC_v3.4620,168,131 - 20,168,235UniSTSRGSC3.4
Celera619,823,913 - 19,824,017UniSTS
Cytogenetic Map6q12UniSTS
RH141349  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2620,029,854 - 20,030,038 (+)MAPPERmRatBN7.2
Rnor_6.0621,203,728 - 21,203,911NCBIRnor6.0
Rnor_5.0631,097,316 - 31,097,499UniSTSRnor5.0
RGSC_v3.4619,942,852 - 19,943,035UniSTSRGSC3.4
Celera619,597,120 - 19,597,303UniSTS
Cytogenetic Map6q12UniSTS
BE100782  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2620,029,782 - 20,029,893 (+)MAPPERmRatBN7.2
Rnor_6.0621,203,656 - 21,203,766NCBIRnor6.0
Rnor_5.0631,097,244 - 31,097,354UniSTSRnor5.0
RGSC_v3.4619,942,780 - 19,942,890UniSTSRGSC3.4
Celera619,597,048 - 19,597,158UniSTS
Cytogenetic Map6q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 92 59 6 356 192 11 141 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000006505   ⟹   ENSRNOP00000006505
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl626,303,535 - 26,454,036 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000047674   ⟹   ENSRNOP00000040099
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl625,781,638 - 26,177,311 (-)Ensembl
mRatBN7.2 Ensembl620,029,629 - 20,425,349 (-)Ensembl
Rnor_6.0 Ensembl621,203,502 - 21,600,451 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000098888   ⟹   ENSRNOP00000087809
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl620,029,629 - 20,425,349 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000101612   ⟹   ENSRNOP00000088104
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl625,781,638 - 26,177,311 (-)Ensembl
mRatBN7.2 Ensembl620,029,629 - 20,425,349 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000112287   ⟹   ENSRNOP00000078120
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl625,781,638 - 26,177,311 (-)Ensembl
mRatBN7.2 Ensembl620,029,629 - 20,425,349 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000116986   ⟹   ENSRNOP00000094996
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl626,310,696 - 26,454,036 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000127991   ⟹   ENSRNOP00000111213
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl626,298,711 - 26,454,036 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000132162   ⟹   ENSRNOP00000104378
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl626,115,401 - 26,454,036 (-)Ensembl
RefSeq Acc Id: NM_021587   ⟹   NP_067598
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8625,781,638 - 26,177,301 (-)NCBI
mRatBN7.2620,029,629 - 20,425,339 (-)NCBI
Rnor_6.0621,203,502 - 21,600,441 (-)NCBI
Rnor_5.0631,097,090 - 31,491,815 (-)NCBI
RGSC_v3.4619,942,626 - 20,355,084 (-)RGD
Celera619,596,894 - 19,988,483 (-)RGD
Sequence:
RefSeq Acc Id: XM_063262385   ⟹   XP_063118455
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8625,781,625 - 26,177,346 (-)NCBI
RefSeq Acc Id: XM_063262386   ⟹   XP_063118456
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8625,781,625 - 26,177,306 (-)NCBI
RefSeq Acc Id: XM_063262387   ⟹   XP_063118457
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8625,781,625 - 26,177,306 (-)NCBI
RefSeq Acc Id: XM_063262388   ⟹   XP_063118458
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8625,781,625 - 26,177,323 (-)NCBI
RefSeq Acc Id: XM_063262389   ⟹   XP_063118459
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8625,781,625 - 26,112,155 (-)NCBI
RefSeq Acc Id: XM_063262390   ⟹   XP_063118460
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8625,781,625 - 25,997,483 (-)NCBI
RefSeq Acc Id: XM_063262391   ⟹   XP_063118461
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8625,781,625 - 25,997,333 (-)NCBI
RefSeq Acc Id: XM_063262392   ⟹   XP_063118462
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8625,781,625 - 25,997,333 (-)NCBI
RefSeq Acc Id: XM_063262393   ⟹   XP_063118463
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8625,781,625 - 25,997,333 (-)NCBI
RefSeq Acc Id: NP_067598   ⟸   NM_021587
- Peptide Label: precursor
- UniProtKB: Q00918 (UniProtKB/Swiss-Prot),   D3ZAA3 (UniProtKB/TrEMBL),   A6H9X2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000040099   ⟸   ENSRNOT00000047674
Ensembl Acc Id: ENSRNOP00000087809   ⟸   ENSRNOT00000098888
Ensembl Acc Id: ENSRNOP00000088104   ⟸   ENSRNOT00000101612
Ensembl Acc Id: ENSRNOP00000078120   ⟸   ENSRNOT00000112287
RefSeq Acc Id: XP_063118455   ⟸   XM_063262385
- Peptide Label: isoform X1
- UniProtKB: Q00918 (UniProtKB/Swiss-Prot),   A0A8I6AA33 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063118458   ⟸   XM_063262388
- Peptide Label: isoform X4
- UniProtKB: Q00918 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063118457   ⟸   XM_063262387
- Peptide Label: isoform X3
- UniProtKB: Q00918 (UniProtKB/Swiss-Prot),   A0A8I5Y739 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063118456   ⟸   XM_063262386
- Peptide Label: isoform X2
- UniProtKB: Q00918 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063118459   ⟸   XM_063262389
- Peptide Label: isoform X5
- UniProtKB: Q00918 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063118460   ⟸   XM_063262390
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063118463   ⟸   XM_063262393
- Peptide Label: isoform X9
RefSeq Acc Id: XP_063118462   ⟸   XM_063262392
- Peptide Label: isoform X8
RefSeq Acc Id: XP_063118461   ⟸   XM_063262391
- Peptide Label: isoform X7
- UniProtKB: Q00918 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSRNOP00000006505   ⟸   ENSRNOT00000006505
Ensembl Acc Id: ENSRNOP00000104378   ⟸   ENSRNOT00000132162
Ensembl Acc Id: ENSRNOP00000094996   ⟸   ENSRNOT00000116986
Ensembl Acc Id: ENSRNOP00000111213   ⟸   ENSRNOT00000127991
Protein Domains
EGF-like   TB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q00918-F1-model_v2 AlphaFold Q00918 1-1712 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694407
Promoter ID:EPDNEW_R4932
Type:single initiation site
Name:Ltbp1_1
Description:latent transforming growth factor beta binding protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0621,600,451 - 21,600,511EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68379 AgrOrtholog
BioCyc Gene G2FUF-38461 BioCyc
Ensembl Genes ENSRNOG00000033090 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000047674 ENTREZGENE
  ENSRNOT00000101612 ENTREZGENE
  ENSRNOT00000112287 ENTREZGENE
Gene3D-CATH 3.90.290.10 UniProtKB/Swiss-Prot
  Laminin UniProtKB/Swiss-Prot
InterPro EGF-like_Ca-bd_dom UniProtKB/Swiss-Prot
  EGF-like_dom UniProtKB/Swiss-Prot
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/Swiss-Prot
  EGF_Ca-bd_CS UniProtKB/Swiss-Prot
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot
  NOTCH1_EGF-like UniProtKB/Swiss-Prot
  TB_dom UniProtKB/Swiss-Prot
  TB_dom_sf UniProtKB/Swiss-Prot
  vWF_C/EGF_Fibrillin UniProtKB/Swiss-Prot
KEGG Report rno:59107 UniProtKB/Swiss-Prot
NCBI Gene 59107 ENTREZGENE
PANTHER FIBRILLIN-3 UniProtKB/Swiss-Prot
  VON WILLEBRAND FACTOR C AND EGF DOMAIN-CONTAINING PROTEIN UniProtKB/Swiss-Prot
Pfam EGF_CA UniProtKB/Swiss-Prot
  PF00683 UniProtKB/Swiss-Prot
PhenoGen Ltbp1 PhenoGen
PIRSF Fibrillin UniProtKB/Swiss-Prot
PROSITE ASX_HYDROXYL UniProtKB/Swiss-Prot
  EGF_1 UniProtKB/Swiss-Prot
  EGF_2 UniProtKB/Swiss-Prot
  EGF_3 UniProtKB/Swiss-Prot
  EGF_CA UniProtKB/Swiss-Prot
  PS51364 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000033090 RatGTEx
SMART EGF UniProtKB/Swiss-Prot
  EGF_CA UniProtKB/Swiss-Prot
Superfamily-SCOP EGF/Laminin UniProtKB/Swiss-Prot
  SSF57184 UniProtKB/Swiss-Prot
  SSF57581 UniProtKB/Swiss-Prot
TIGR TC217900
UniProt A0A8I5Y739 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AA33 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LQQ3_RAT UniProtKB/TrEMBL
  A0ABK0LXP0_RAT UniProtKB/TrEMBL
  A6H9X2 ENTREZGENE, UniProtKB/TrEMBL
  D3ZAA3 ENTREZGENE, UniProtKB/TrEMBL
  LTBP1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Ltbp1  latent transforming growth factor beta binding protein 1    LanC (bacterial lantibiotic synthetase component C)-like 1  Name updated 1299863 APPROVED
2003-04-09 Ltbp1  LanC (bacterial lantibiotic synthetase component C)-like 1    latent transforming growth factor beta binding protein 1   Name updated 629478 APPROVED
2002-06-10 Ltbp1  latent transforming growth factor beta binding protein 1       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains precursor contains seven N-linked glycosylation sites, 18 epidermal growth factor-like domains and four cysteine-rich internal repeats 68275