Scrg1 (stimulator of chondrogenesis 1) - Rat Genome Database

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Gene: Scrg1 (stimulator of chondrogenesis 1) Rattus norvegicus
Analyze
Symbol: Scrg1
Name: stimulator of chondrogenesis 1
RGD ID: 68377
Description: Predicted to be involved in mesenchymal stem cell proliferation. Predicted to be located in cytoplasm. Predicted to be active in Golgi apparatus and neuron projection terminus. Orthologous to human SCRG1 (stimulator of chondrogenesis 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: scrapie responsive gene 1; scrapie-responsive gene 1 protein; scrapie-responsive protein 1; scRG-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81637,770,739 - 37,799,010 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1637,770,739 - 37,799,010 (-)EnsemblGRCr8
mRatBN7.21632,760,028 - 32,788,299 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1632,760,028 - 32,788,299 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1636,352,690 - 36,380,930 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01639,764,030 - 39,792,270 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01635,983,847 - 36,011,977 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01636,127,536 - 36,161,041 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1636,125,904 - 36,161,089 (-)Ensemblrn6Rnor6.0
Rnor_5.01635,936,797 - 35,940,130 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41636,182,355 - 36,210,980 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1632,699,050 - 32,726,910 (-)NCBICelera
RGSC_v3.11636,182,429 - 36,211,055 (-)NCBI
Cytogenetic Map16p11NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA,ISO)
extracellular region  (IEA)
Golgi apparatus  (IBA,IEA,ISO)
neuron projection terminus  (IBA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Gene expression in scrapie. Cloning of a new scrapie-responsive gene and the identification of increased levels of seven other mRNA transcripts. Dandoy-Dron F, etal., J Biol Chem 1998 Mar 27;273(13):7691-7.
2. Mouse scrapie responsive gene 1 (Scrg1): genomic organization, physical linkage to sap30, genetic mapping on chromosome 8, and expression in neuronal primary cell cultures. Dron M, etal., Genomics 2000 Nov 15;70(1):140-9.
3. Characterization of the human analogue of a Scrapie-responsive gene. Dron M, etal., J Biol Chem 1998 Jul 17;273(29):18015-8.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:14622145  


Genomics

Comparative Map Data
Scrg1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81637,770,739 - 37,799,010 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1637,770,739 - 37,799,010 (-)EnsemblGRCr8
mRatBN7.21632,760,028 - 32,788,299 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1632,760,028 - 32,788,299 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1636,352,690 - 36,380,930 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01639,764,030 - 39,792,270 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01635,983,847 - 36,011,977 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01636,127,536 - 36,161,041 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1636,125,904 - 36,161,089 (-)Ensemblrn6Rnor6.0
Rnor_5.01635,936,797 - 35,940,130 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41636,182,355 - 36,210,980 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1632,699,050 - 32,726,910 (-)NCBICelera
RGSC_v3.11636,182,429 - 36,211,055 (-)NCBI
Cytogenetic Map16p11NCBI
SCRG1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384173,384,701 - 173,519,144 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4173,384,701 - 173,410,218 (-)Ensemblhg38GRCh38
GRCh374174,305,852 - 174,440,295 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364174,545,874 - 174,557,192 (-)NCBIBuild 36Build 36hg18NCBI36
Build 344174,684,029 - 174,695,347NCBI
Celera4171,634,399 - 171,645,725 (-)NCBICelera
Cytogenetic Map4q34.1NCBI
HuRef4170,057,217 - 170,068,546 (-)NCBIHuRef
CHM1_14174,285,753 - 174,297,067 (-)NCBICHM1_1
T2T-CHM13v2.04176,724,109 - 176,858,933 (-)NCBIT2T-CHM13v2.0
Scrg1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39857,909,093 - 57,932,441 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl857,908,957 - 57,930,619 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38857,455,882 - 57,479,360 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl857,455,923 - 57,477,585 (+)Ensemblmm10GRCm38
MGSCv37859,934,720 - 59,956,382 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36860,348,177 - 60,369,728 (+)NCBIMGSCv36mm8
Celera860,094,930 - 60,116,631 (+)NCBICelera
Cytogenetic Map8B2NCBI
cM Map829.8NCBI
Scrg1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540333,599,019 - 33,626,484 (+)Ensembl
ChiLan1.0NW_00495540333,599,197 - 33,626,095 (+)NCBIChiLan1.0ChiLan1.0
SCRG1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23171,148,532 - 171,159,743 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14171,529,476 - 171,540,674 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04165,616,284 - 165,627,563 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14177,853,633 - 177,983,092 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4177,853,633 - 177,864,917 (-)EnsemblpanPan2panpan1.1
SCRG1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12523,986,911 - 24,010,522 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2523,986,994 - 24,010,357 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2524,637,793 - 24,661,452 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02524,150,260 - 24,173,937 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2524,150,344 - 24,173,722 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12524,096,512 - 24,120,175 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02523,986,872 - 24,011,628 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02524,136,764 - 24,160,429 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Scrg1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494324,150,992 - 24,170,017 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365164,565,446 - 4,584,259 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365164,565,282 - 4,584,431 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SCRG1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1416,634,776 - 16,664,558 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11416,620,592 - 16,664,082 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
SCRG1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17119,498,835 - 119,502,082 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl7119,496,047 - 119,502,082 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603799,520,759 - 99,536,793 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Scrg1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247694,867,114 - 4,889,482 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Scrg1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11331,410,758 - 31,432,552 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Scrg1
64 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:112
Count of miRNA genes:82
Interacting mature miRNAs:87
Transcripts:ENSRNOT00000017888
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16435482249354822Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)1638712345387123Rat
1549842Bp248Blood pressure QTL 2480.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1638712345387123Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16423421249757901Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)163692878281928782Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16423421266955197Rat
2302057Pia29Pristane induced arthritis QTL 293.60.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)162846870173468701Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139568015Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139568015Rat
1357403Slep4Serum leptin concentration QTL 43.91blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)163236104377361043Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16423421253708481Rat
8694453Bw172Body weight QTL 1728.330.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)163105803976058039Rat
1298529Arunc1Aerobic running capacity QTL 14exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)163439829479398294Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683908666195506Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16474422249744222Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338679049757901Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683908666195506Rat
6903294Stl30Serum triglyceride level QTL 302.60.0013blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)163188527176885271Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683908666195506Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161773081872536785Rat
2301406Kidm39Kidney mass QTL 390.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)161590580260905802Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683908652786090Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683908666195506Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16330168348301683Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
5 6 50 131 38 39 17 27 17 2 135 95 10 119 13 60 22 11 11

Sequence


Ensembl Acc Id: ENSRNOT00000017888   ⟹   ENSRNOP00000017888
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1636,125,904 - 36,161,089 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000110541   ⟹   ENSRNOP00000084059
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1637,770,739 - 37,799,010 (-)Ensembl
mRatBN7.2 Ensembl1632,760,028 - 32,788,299 (-)Ensembl
RefSeq Acc Id: NM_033499   ⟹   NP_277034
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81637,770,739 - 37,799,010 (-)NCBI
mRatBN7.21632,760,028 - 32,788,299 (-)NCBI
Rnor_6.01636,127,536 - 36,161,041 (-)NCBI
Rnor_5.01635,936,797 - 35,940,130 (-)NCBI
RGSC_v3.41636,182,355 - 36,210,980 (-)RGD
Celera1632,699,050 - 32,726,910 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_277034 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA10668 (Get FASTA)   NCBI Sequence Viewer  
  EDL87167 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000084059
  ENSRNOP00000084059.1
GenBank Protein Q9Z0K6 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_277034   ⟸   NM_033499
- Peptide Label: precursor
- UniProtKB: Q9Z0K6 (UniProtKB/Swiss-Prot),   A6KIV2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000017888   ⟸   ENSRNOT00000017888
Ensembl Acc Id: ENSRNOP00000084059   ⟸   ENSRNOT00000110541

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z0K6-F1-model_v2 AlphaFold Q9Z0K6 1-98 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68377 AgrOrtholog
BioCyc Gene G2FUF-11533 BioCyc
Ensembl Genes ENSRNOG00000013228 Ensembl
  ENSRNOG00000069516 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000110541 ENTREZGENE
  ENSRNOT00000110541.1 UniProtKB/Swiss-Prot
InterPro SCRG1 UniProtKB/Swiss-Prot
KEGG Report rno:64458 UniProtKB/Swiss-Prot
NCBI Gene 64458 ENTREZGENE
PANTHER PTHR17463 UniProtKB/Swiss-Prot
  SCRAPIE-RESPONSIVE PROTEIN 1 UniProtKB/Swiss-Prot
Pfam SCRG1 UniProtKB/Swiss-Prot
PhenoGen Scrg1 PhenoGen
RatGTEx ENSRNOG00000013228 RatGTEx
  ENSRNOG00000069516 RatGTEx
TIGR TC233874
UniProt A6KIV2 ENTREZGENE, UniProtKB/TrEMBL
  Q9Z0K6 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-12-15 Scrg1  stimulator of chondrogenesis 1  Scrg1  scrapie responsive gene 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Scrg1  scrapie responsive gene 1      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference