Grid2 (glutamate ionotropic receptor delta type subunit 2) - Rat Genome Database

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Gene: Grid2 (glutamate ionotropic receptor delta type subunit 2) Rattus norvegicus
Analyze
Symbol: Grid2
Name: glutamate ionotropic receptor delta type subunit 2
RGD ID: 68368
Description: Enables PDZ domain binding activity and identical protein binding activity. Involved in regulation of presynapse assembly. Located in postsynaptic membrane. Is active in glutamatergic synapse; parallel fiber to Purkinje cell synapse; and postsynaptic density membrane. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 18. Orthologous to human GRID2 (glutamate ionotropic receptor delta type subunit 2); PARTICIPATES IN long term depression; INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; alpha-Zearalanol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: GluD2; gluR delta-2 subunit; glutamate receptor delta-2 subunit; glutamate receptor ionotropic, delta-2; glutamate receptor, ionotropic, delta 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Is Marker For: Strains:   NP.P-(D4Rat119-D4Rat55)/Iusm
Candidate Gene For: Alc22
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8493,745,165 - 95,222,354 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl493,745,277 - 95,219,868 (+)EnsemblGRCr8
mRatBN7.2492,415,019 - 93,892,472 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl492,415,230 - 93,889,355 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx497,627,719 - 99,083,931 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0493,402,958 - 94,858,882 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0491,821,373 - 93,281,846 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0494,068,112 - 95,476,864 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl494,696,965 - 95,442,778 (+)Ensemblrn6Rnor6.0
Rnor_5.04158,857,267 - 160,262,923 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4492,642,427 - 94,054,757 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera487,164,582 - 88,604,118 (+)NCBICelera
RGSC_v3.1492,886,907 - 94,299,238 (+)NCBI
Cytogenetic Map4q31NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Energetics of glutamate receptor ligand binding domain dimer assembly are modulated by allosteric ions. Chaudhry C, etal., Proc Natl Acad Sci U S A. 2009 Jul 28;106(30):12329-34. doi: 10.1073/pnas.0904175106. Epub 2009 Jul 15.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. CRF and urocortin differentially modulate GluRdelta2 expression and distribution in parallel fiber-Purkinje cell synapses. Gounko NV, etal., Mol Cell Neurosci. 2005 Dec;30(4):513-22. Epub 2005 Sep 27.
5. Differential localization of delta glutamate receptors in the rat cerebellum: coexpression with AMPA receptors in parallel fiber-spine synapses and absence from climbing fiber-spine synapses. Landsend AS, etal., J Neurosci. 1997 Jan 15;17(2):834-42.
6. The rat delta-1 and delta-2 subunits extend the excitatory amino acid receptor family. Lomeli H, etal., FEBS Lett 1993 Jan 11;315(3):318-22.
7. Cbln family proteins promote synapse formation by regulating distinct neurexin signaling pathways in various brain regions. Matsuda K and Yuzaki M, Eur J Neurosci. 2011 Apr;33(8):1447-61. doi: 10.1111/j.1460-9568.2011.07638.x. Epub 2011 Mar 17.
8. Cbln1 is a ligand for an orphan glutamate receptor delta2, a bidirectional synapse organizer. Matsuda K, etal., Science. 2010 Apr 16;328(5976):363-8. doi: 10.1126/science.1185152.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Ionotropic glutamate-like receptor delta2 binds D-serine and glycine. Naur P, etal., Proc Natl Acad Sci U S A. 2007 Aug 28;104(35):14116-21. Epub 2007 Aug 21.
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. GOA pipeline RGD automated data pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Comprehensive gene review and curation RGD comprehensive gene curation
18. Postsynaptic density-93 interacts with the delta2 glutamate receptor subunit at parallel fiber synapses. Roche KW, etal., J Neurosci. 1999 May 15;19(10):3926-34.
19. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
20. PKC regulates the delta2 glutamate receptor interaction with S-SCAM/MAGI-2 protein. Yap CC, etal., Biochem Biophys Res Commun 2003 Feb 21;301(4):1122-8.
Additional References at PubMed
PMID:7766857   PMID:7891151   PMID:10884318   PMID:11488959   PMID:11829466   PMID:12372286   PMID:14572453   PMID:14637233   PMID:15207857   PMID:15579147   PMID:17978051   PMID:18341993  
PMID:18509461   PMID:20537373   PMID:27033232   PMID:27418511   PMID:27926833   PMID:28387240   PMID:29476059   PMID:32512155  


Genomics

Comparative Map Data
Grid2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8493,745,165 - 95,222,354 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl493,745,277 - 95,219,868 (+)EnsemblGRCr8
mRatBN7.2492,415,019 - 93,892,472 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl492,415,230 - 93,889,355 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx497,627,719 - 99,083,931 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0493,402,958 - 94,858,882 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0491,821,373 - 93,281,846 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0494,068,112 - 95,476,864 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl494,696,965 - 95,442,778 (+)Ensemblrn6Rnor6.0
Rnor_5.04158,857,267 - 160,262,923 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4492,642,427 - 94,054,757 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera487,164,582 - 88,604,118 (+)NCBICelera
RGSC_v3.1492,886,907 - 94,299,238 (+)NCBI
Cytogenetic Map4q31NCBI
GRID2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38492,303,966 - 93,810,456 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl492,303,966 - 93,810,157 (+)Ensemblhg38GRCh38
GRCh37493,225,117 - 94,695,717 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36493,444,573 - 94,912,672 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34493,582,985 - 95,050,827NCBI
Celera490,516,237 - 91,989,747 (+)NCBICelera
Cytogenetic Map4q22.1-q22.2NCBI
HuRef488,967,871 - 90,430,993 (+)NCBIHuRef
CHM1_1493,202,022 - 94,670,166 (+)NCBICHM1_1
T2T-CHM13v2.0495,630,513 - 97,125,831 (+)NCBIT2T-CHM13v2.0
Grid2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39663,230,118 - 64,681,305 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl663,232,860 - 64,681,307 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38663,256,006 - 64,704,321 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl663,255,876 - 64,704,323 (+)Ensemblmm10GRCm38
MGSCv37663,206,851 - 64,616,273 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36663,186,435 - 64,595,857 (+)NCBIMGSCv36mm8
Celera665,396,130 - 66,793,674 (+)NCBICelera
Cytogenetic Map6C1NCBI
cM Map629.77NCBI
Grid2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554053,344,763 - 4,443,836 (+)Ensembl
ChiLan1.0NW_0049554053,291,793 - 4,411,249 (+)NCBIChiLan1.0ChiLan1.0
GRID2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2390,328,906 - 91,836,156 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1490,606,840 - 92,114,771 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0484,663,030 - 86,170,778 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1495,339,204 - 96,809,804 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl495,339,460 - 96,807,748 (+)EnsemblpanPan2panpan1.1
GRID2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13215,322,256 - 16,787,966 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3215,322,738 - 16,753,656 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3225,156,550 - 26,624,358 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03215,494,314 - 16,970,466 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3215,494,520 - 16,934,050 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13215,474,650 - 16,942,531 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03215,290,434 - 16,758,200 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03223,136,174 - 24,607,929 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Grid2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530124,925,851 - 26,327,389 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936687549,947 - 1,421,133 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493668720,126 - 1,421,075 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GRID2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8125,819,951 - 127,129,763 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.18125,821,195 - 127,130,617 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28135,414,934 - 135,568,963 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GRID2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1740,585,532 - 42,079,977 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603718,927,676 - 20,401,397 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Grid2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475719,967,840 - 21,498,318 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475719,967,428 - 21,497,009 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Grid2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1677,963,479 - 79,395,135 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Grid2
9225 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:710
Count of miRNA genes:285
Interacting mature miRNAs:370
Transcripts:ENSRNOT00000064696
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582232Gluco25Glucose level QTL 253.60.0023blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)486583980149763391Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)439431983123203361Rat
1549843Bw53Body weight QTL 530.0001body mass (VT:0001259)body weight gain (CMO:0000420)459753119104753119Rat
1578655Bmd11Bone mineral density QTL 1111femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)492406430137406430Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)427730518170099664Rat
1357342Bw40Body weight QTL 400.001body mass (VT:0001259)body weight (CMO:0000012)474233320119233320Rat
631556Bp135Blood pressure QTL 1350.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)480212111119233320Rat
1358363Sradr3Stress Responsive Adrenal Weight QTL 36.19adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)458817672103817672Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)426234499134199155Rat
70167Bw22Body weight QTL 223.1body mass (VT:0001259)body weight (CMO:0000012)474233320119233320Rat
1549839Bw52Body weight QTL 520.0001body mass (VT:0001259)body weight gain (CMO:0000420)471647492116647492Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482944895154403548Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)427862204126119996Rat
61476Aia3Adjuvant induced arthritis QTL 33.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)475939858140508796Rat
1641919Alc22Alcohol consumption QTL 220.0005drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)465060960127749483Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)445429897149763204Rat
2317587Eae26Experimental allergic encephalomyelitis QTL 26nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)489986808101226978Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)451085655113588029Rat
61364Iddm2Insulin dependent diabetes mellitus QTL 2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)480216705104243248Rat
1578670Bss14Bone structure and strength QTL 1416.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)488883695133883695Rat
2317588Eae27Experimental allergic encephalomyelitis QTL 27nervous system integrity trait (VT:0010566)percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)469036742114036742Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)440490442117737312Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)457613339151163960Rat
4889969Bss96Bone structure and strength QTL 964.9tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)457613242102613242Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
1578662Bss15Bone structure and strength QTL 1519.6femur width (VT:1000666)femoral neck width (CMO:0001695)488883695133883695Rat
4889972Bss97Bone structure and strength QTL 975.6tibia size trait (VT:0100001)tibia total bone volume (CMO:0001724)457613242102613242Rat
6478684Anxrr30Anxiety related response QTL 300.00087defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)464084079109084079Rat
5685009Bmd86Bone mineral density QTL 863.7tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)457613242102613242Rat
2306794Ean2Experimental allergic neuritis QTL 26.4nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)48279077797183061Rat
2306547Iddm38Insulin dependent diabetes mellitus QTL 38blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)468353567113353567Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)460916264184426481Rat
2306545Iddm39Insulin dependent diabetes mellitus QTL 39blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)478687630123687630Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)494638356168870820Rat
6478772Anxrr49Anxiety related response QTL 490.15488defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)464084079109084079Rat
631646Stl4Serum triglyceride level QTL 46.50.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)474169813134199155Rat
634334Xhs3X-ray hypersensitivity QTL 310intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)486058928131411333Rat
2312569Pur19Proteinuria QTL 193.40.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)459836842104836842Rat
61406Scwia1Streptococcal cell wall induced arthritis QTL 12.3joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)475939858140508796Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)445429897149763204Rat
634344Hcar7Hepatocarcinoma resistance QTL 77.8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)46104105794638356Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45889999148002343Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264174095838Rat
631662Hcar2Hepatocarcinoma resistance QTL 23.10.0003liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)484349032129349032Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)445429709157555683Rat
631651Bp124Blood pressure QTL 1243arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)464209744109209744Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)463245026129846354Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264184426481Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)486709649168870974Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)457664252127749483Rat
2306899Bp338Blood pressure QTL 3380.071arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)482336765127336765Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)465495851159259805Rat
6478743Anxrr40Anxiety related response QTL 400.83076defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)464084079109084079Rat
12798523Anxrr56Anxiety related response QTL 562.830.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)486583980131583980Rat
61434Cia3Collagen induced arthritis QTL 34.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)463224393108224393Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)433538597116185060Rat

Markers in Region
D4Rat37  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8494,638,214 - 94,638,356 (+)Marker Load Pipeline
mRatBN7.2493,308,315 - 93,308,457 (+)MAPPERmRatBN7.2
Rnor_6.0493,059,789 - 93,059,930NCBIRnor6.0
Rnor_6.0494,893,106 - 94,893,247NCBIRnor6.0
Rnor_5.04159,682,028 - 159,682,169UniSTSRnor5.0
Rnor_5.04157,857,293 - 157,857,434UniSTSRnor5.0
RGSC_v3.4493,498,679 - 93,498,821RGDRGSC3.4
RGSC_v3.4493,498,680 - 93,498,821UniSTSRGSC3.4
Celera488,056,363 - 88,056,504UniSTS
RGSC_v3.1493,743,161 - 93,743,302RGD
RH 3.4 Map4567.7UniSTS
RH 3.4 Map4567.7RGD
SHRSP x BN Map446.45RGD
SHRSP x BN Map446.45UniSTS
FHH x ACI Map457.99RGD
Cytogenetic Map4q24-q31UniSTS
D4Rat173  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8493,819,449 - 93,819,611 (+)Marker Load Pipeline
mRatBN7.2492,489,514 - 92,489,678 (+)MAPPERmRatBN7.2
Rnor_6.0494,143,498 - 94,143,659NCBIRnor6.0
Rnor_5.04158,932,175 - 158,932,336UniSTSRnor5.0
RGSC_v3.4492,716,711 - 92,716,873RGDRGSC3.4
RGSC_v3.4492,716,712 - 92,716,873UniSTSRGSC3.4
Celera487,238,854 - 87,239,015UniSTS
RGSC_v3.1492,961,067 - 92,961,494RGD
SHRSP x BN Map446.41UniSTS
SHRSP x BN Map446.41RGD
Cytogenetic Map4q24-q31UniSTS
D4Got75  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2492,618,232 - 92,618,505 (+)MAPPERmRatBN7.2
Rnor_6.0494,272,837 - 94,273,109NCBIRnor6.0
Rnor_5.04159,061,514 - 159,061,786UniSTSRnor5.0
RGSC_v3.4492,848,586 - 92,848,859RGDRGSC3.4
RGSC_v3.4492,848,587 - 92,848,859UniSTSRGSC3.4
Celera487,367,661 - 87,367,933UniSTS
RGSC_v3.1493,093,068 - 93,093,340RGD
RH 3.4 Map4567.9UniSTS
RH 3.4 Map4567.9RGD
RH 2.0 Map4583.4RGD
Cytogenetic Map4q24-q31UniSTS
D4Got70  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2493,199,262 - 93,199,550 (+)MAPPERmRatBN7.2
Rnor_6.0494,784,373 - 94,784,660NCBIRnor6.0
Rnor_5.04159,573,295 - 159,573,582UniSTSRnor5.0
RGSC_v3.4493,389,635 - 93,389,923RGDRGSC3.4
RGSC_v3.4493,389,636 - 93,389,923UniSTSRGSC3.4
Celera487,947,373 - 87,947,660UniSTS
RGSC_v3.1493,634,117 - 93,634,404RGD
RH 3.4 Map4569.8RGD
RH 3.4 Map4569.8UniSTS
Cytogenetic Map4q24-q31UniSTS
D4Got74  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2492,991,299 - 92,991,462 (+)MAPPERmRatBN7.2
Rnor_6.0492,990,701 - 92,990,863NCBIRnor6.0
Rnor_5.04157,791,118 - 157,791,280UniSTSRnor5.0
RGSC_v3.4491,915,885 - 91,916,048RGDRGSC3.4
RGSC_v3.4491,915,886 - 91,916,048UniSTSRGSC3.4
Celera487,740,682 - 87,740,846UniSTS
RGSC_v3.1492,160,311 - 92,160,473RGD
RH 3.4 Map4567.7RGD
RH 3.4 Map4567.7UniSTS
Cytogenetic Map4q24-q31UniSTS
D4Got77  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2493,362,048 - 93,362,326 (+)MAPPERmRatBN7.2
Rnor_6.0494,947,104 - 94,947,381NCBIRnor6.0
Rnor_5.04159,736,026 - 159,736,303UniSTSRnor5.0
RGSC_v3.4493,552,408 - 93,552,686RGDRGSC3.4
RGSC_v3.4493,552,409 - 93,552,686UniSTSRGSC3.4
Celera488,110,089 - 88,110,366UniSTS
RGSC_v3.1493,796,890 - 93,797,167RGD
RH 3.4 Map4565.6RGD
RH 3.4 Map4565.6UniSTS
Cytogenetic Map4q24-q31UniSTS
D4Got213  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2493,216,536 - 93,216,679 (+)MAPPERmRatBN7.2
Rnor_6.0494,801,647 - 94,801,789NCBIRnor6.0
Rnor_5.04159,590,569 - 159,590,711UniSTSRnor5.0
RGSC_v3.4493,406,910 - 93,407,052UniSTSRGSC3.4
Celera487,964,647 - 87,964,789UniSTS
Cytogenetic Map4q24-q31UniSTS
BF416501  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2492,826,315 - 92,826,463 (+)MAPPERmRatBN7.2
Rnor_6.0494,478,410 - 94,478,557NCBIRnor6.0
Rnor_5.04159,267,087 - 159,267,234UniSTSRnor5.0
RGSC_v3.4493,062,488 - 93,062,635UniSTSRGSC3.4
Celera487,576,622 - 87,576,769UniSTS
RH 3.4 Map4567.7UniSTS
Cytogenetic Map4q24-q31UniSTS
BF390815  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2493,756,555 - 93,756,705 (+)MAPPERmRatBN7.2
Rnor_6.0495,341,515 - 95,341,664NCBIRnor6.0
Rnor_5.04160,127,953 - 160,128,102UniSTSRnor5.0
RGSC_v3.4493,954,149 - 93,954,298UniSTSRGSC3.4
Celera488,503,534 - 88,503,683UniSTS
RH 3.4 Map4579.9UniSTS
Cytogenetic Map4q24-q31UniSTS
Grid2  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8495,185,530 - 95,185,659 (+)Marker Load Pipeline
mRatBN7.2493,855,664 - 93,855,792 (+)MAPPERmRatBN7.2
Rnor_6.0495,441,269 - 95,441,396NCBIRnor6.0
Rnor_5.04160,227,707 - 160,227,834UniSTSRnor5.0
RGSC_v3.4494,053,248 - 94,053,375UniSTSRGSC3.4
Celera488,602,608 - 88,602,735UniSTS
Cytogenetic Map4q24-q31UniSTS
Grid2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2493,855,763 - 93,855,859 (+)MAPPERmRatBN7.2
Rnor_6.0495,441,368 - 95,441,463NCBIRnor6.0
Rnor_5.04160,227,806 - 160,227,901UniSTSRnor5.0
RGSC_v3.4494,053,347 - 94,053,442UniSTSRGSC3.4
Celera488,602,707 - 88,602,802UniSTS
Cytogenetic Map4q24-q31UniSTS
AU049225  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2493,760,867 - 93,761,041 (+)MAPPERmRatBN7.2
Rnor_6.0495,345,827 - 95,345,998NCBIRnor6.0
Rnor_5.04160,132,265 - 160,132,436UniSTSRnor5.0
RGSC_v3.4493,958,461 - 93,958,632UniSTSRGSC3.4
Celera488,507,847 - 88,508,018UniSTS
Cytogenetic Map4q24-q31UniSTS


Related Rat Strains
The following Strains have been annotated to Grid2
NP.P-(D4Rat119-D4Rat55)/Iusm    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
13 8 44 147 49 47 17 24 17 6 182 96 11 126 49 88 30 14 14

Sequence


Ensembl Acc Id: ENSRNOT00000064696   ⟹   ENSRNOP00000060322
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl494,441,275 - 95,187,040 (+)Ensembl
mRatBN7.2 Ensembl493,111,361 - 93,857,174 (+)Ensembl
Rnor_6.0 Ensembl494,696,965 - 95,442,778 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000111210   ⟹   ENSRNOP00000096742
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl493,745,277 - 95,219,868 (+)Ensembl
mRatBN7.2 Ensembl492,415,230 - 93,889,355 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000116787   ⟹   ENSRNOP00000084985
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl493,745,277 - 95,187,040 (+)Ensembl
mRatBN7.2 Ensembl492,415,230 - 93,857,174 (+)Ensembl
RefSeq Acc Id: NM_024379   ⟹   NP_077355
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8493,745,165 - 95,187,040 (+)NCBI
mRatBN7.2492,415,228 - 93,857,174 (+)NCBI
Rnor_6.0494,068,742 - 95,442,778 (+)NCBI
Rnor_5.04158,857,267 - 160,262,923 (+)NCBI
RGSC_v3.4492,642,427 - 94,054,757 (+)RGD
Celera487,164,582 - 88,604,118 (+)RGD
Sequence:
RefSeq Acc Id: XM_017592903   ⟹   XP_017448392
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8493,745,431 - 95,222,354 (+)NCBI
mRatBN7.2492,415,019 - 93,892,472 (+)NCBI
Rnor_6.0494,068,112 - 95,476,864 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039108399   ⟹   XP_038964327
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8493,745,431 - 95,218,766 (+)NCBI
mRatBN7.2492,415,019 - 93,888,934 (+)NCBI
RefSeq Acc Id: NP_077355   ⟸   NM_024379
- Peptide Label: precursor
- UniProtKB: Q63226 (UniProtKB/Swiss-Prot),   Q62641 (UniProtKB/Swiss-Prot),   A6KF16 (UniProtKB/TrEMBL),   F1LXB6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017448392   ⟸   XM_017592903
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AR77 (UniProtKB/TrEMBL),   F1LXB6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000060322   ⟸   ENSRNOT00000064696
RefSeq Acc Id: XP_038964327   ⟸   XM_039108399
- Peptide Label: isoform X2
- UniProtKB: F1LXB6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000096742   ⟸   ENSRNOT00000111210
Ensembl Acc Id: ENSRNOP00000084985   ⟸   ENSRNOT00000116787
Protein Domains
Ionotropic glutamate receptor C-terminal   Ionotropic glutamate receptor L-glutamate and

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63226-F1-model_v2 AlphaFold Q63226 1-1007 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68368 AgrOrtholog
BioCyc Gene G2FUF-44622 BioCyc
Ensembl Genes ENSRNOG00000006174 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000111210 ENTREZGENE
  ENSRNOT00000116787 ENTREZGENE
  ENSRNOT00000116787.1 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot
  3.40.50.2300 UniProtKB/Swiss-Prot
  Periplasmic binding protein-like II UniProtKB/Swiss-Prot
InterPro ANF_lig-bd_rcpt UniProtKB/Swiss-Prot
  Glu/Gly-bd UniProtKB/Swiss-Prot
  Iono_rcpt_met UniProtKB/Swiss-Prot
  Ionotropic_Glu_rcpt UniProtKB/Swiss-Prot
  Iontro_rcpt UniProtKB/Swiss-Prot
  Peripla_BP_I UniProtKB/Swiss-Prot
KEGG Report rno:79220 UniProtKB/Swiss-Prot
NCBI Gene 79220 ENTREZGENE
PANTHER IONOTROPIC GLUTAMATE RECEPTOR UniProtKB/Swiss-Prot
Pfam ANF_receptor UniProtKB/Swiss-Prot
  Lig_chan UniProtKB/Swiss-Prot
  Lig_chan-Glu_bd UniProtKB/Swiss-Prot
PhenoGen Grid2 PhenoGen
PRINTS NMDARECEPTOR UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000006174 RatGTEx
SMART Lig_chan-Glu_bd UniProtKB/Swiss-Prot
  PBPe UniProtKB/Swiss-Prot
Superfamily-SCOP Periplasmic binding protein-like II UniProtKB/Swiss-Prot
  SSF53822 UniProtKB/Swiss-Prot
TIGR TC236961
UniProt A0A8I6AR77 ENTREZGENE, UniProtKB/TrEMBL
  A6KF16 ENTREZGENE, UniProtKB/TrEMBL
  F1LXB6 ENTREZGENE, UniProtKB/TrEMBL
  GRID2_RAT UniProtKB/Swiss-Prot
  Q62641 ENTREZGENE
  Q63226 ENTREZGENE
UniProt Secondary Q62641 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Grid2  glutamate ionotropic receptor delta type subunit 2  Grid2  glutamate receptor, ionotropic, delta 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Grid2  glutamate receptor, ionotropic, delta 2      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference