Thop1 (thimet oligopeptidase 1) - Rat Genome Database

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Gene: Thop1 (thimet oligopeptidase 1) Rattus norvegicus
Analyze
Symbol: Thop1
Name: thimet oligopeptidase 1
RGD ID: 68330
Description: Enables peptidase activity and peptide binding activity. Involved in peptide catabolic process. Predicted to be located in cytoplasm. Predicted to be active in mitochondrial intermembrane space. Orthologous to human THOP1 (thimet oligopeptidase 1); PARTICIPATES IN renin-angiotensin cascade pathway; sleeping sickness pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: endo-oligopeptidase A; endopeptidase 24.15; EP24.15; metalloendopeptidase; MGC93105; PZ-peptidase; soluble metallo-endopeptidase; Thimet oligopeptidase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr879,283,617 - 9,295,957 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl79,283,617 - 9,295,957 (-)EnsemblGRCr8
mRatBN7.278,632,911 - 8,645,339 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl78,632,916 - 8,645,275 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx711,517,596 - 11,530,108 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0713,393,093 - 13,405,605 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0711,259,596 - 11,272,104 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd712,039,747 - 12,052,253 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive712,203,047 - 12,215,552 (-)NCBILyon_Normotensive
Lyon_Hypertensive712,278,050 - 12,290,554 (-)NCBILyon_Hypertensive
F344_StmMcwi710,644,046 - 10,656,550 (-)NCBIF344_StmMcwi
Rnor_6.0711,501,145 - 11,513,576 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl711,501,146 - 11,513,581 (-)Ensemblrn6Rnor6.0
Rnor_5.0711,668,512 - 11,680,946 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4710,116,822 - 10,129,162 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera76,820,402 - 6,832,744 (-)NCBICelera
RGSC_v3.1710,116,821 - 10,129,088 (-)NCBI
Cytogenetic Map7q11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrotoluene  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2,5-hexanedione  (EXP)
2,6-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-amino-2,6-dinitrotoluene  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
bleomycin A2  (ISO)
Brodifacoum  (EXP)
Butylbenzyl phthalate  (ISO)
capsaicin  (EXP)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chromium(6+)  (ISO)
clofibric acid  (EXP)
cobalt dichloride  (ISO)
cocaine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
fenvalerate  (EXP)
flutamide  (EXP)
folic acid  (ISO)
hydrogen cyanide  (ISO)
indole-3-methanol  (EXP)
indometacin  (ISO)
ivermectin  (ISO)
lead(0)  (ISO)
lovastatin  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-nitrosodiethylamine  (EXP)
okadaic acid  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
potassium cyanide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
thapsigargin  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trimellitic anhydride  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
warfarin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Expression of the thimet oligopeptidase gene is regulated by positively and negatively acting elements. McCool S and Pierotti AR, DNA Cell Biol 2000 Dec;19(12):729-38.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Thimet oligopeptidase expression is differentially regulated in neuroendocrine and spermatid cell lines by transcription factor binding to SRY (sex-determining region Y), CAAT and CREB (cAMP-response-element-binding protein) promoter consensus sequences. Morrison LS and Pierotti AR, Biochem J 2003 Nov 15;376(Pt 1):189-97.
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. Metalloendopeptidases EC 3.4.24.15/16 regulate bradykinin activity in the cerebral microvasculature. Norman MU, etal., Am J Physiol Heart Circ Physiol 2003 Jun;284(6):H1942-8. Epub 2003 Feb 13.
8. Molecular cloning and primary structure of rat testes metalloendopeptidase EC 3.4.24.15. Pierotti A, etal., Biochemistry 1990 Nov 13;29(45):10323-9.
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. Mapping sequence differences between thimet oligopeptidase and neurolysin implicates key residues in substrate recognition. Ray K, etal., Protein Sci 2002 Sep;11(9):2237-46.
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Novel natural peptide substrates for endopeptidase 24.15, neurolysin, and angiotensin-converting enzyme. Rioli V, etal., J Biol Chem. 2003 Mar 7;278(10):8547-55. doi: 10.1074/jbc.M212030200. Epub 2002 Dec 24.
15. Natural intracellular peptides can modulate the interactions of mouse brain proteins and thimet oligopeptidase with 14-3-3epsilon and calmodulin. Russo LC, etal., Proteomics. 2012 Aug;12(17):2641-55. doi: 10.1002/pmic.201200032. Epub 2012 Jul 26.
16. Rat brain contains high levels of mannose-6-phosphorylated glycoproteins including lysosomal enzymes and palmitoyl-protein thioesterase, an enzyme implicated in infantile neuronal lipofuscinosis. Sleat DE, etal., J Biol Chem. 1996 Aug 9;271(32):19191-8.
17. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
18. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:8216239   PMID:10969067   PMID:15955058   PMID:15985312   PMID:16515556   PMID:18571100   PMID:22082260   PMID:22387539   PMID:24041943   PMID:26653570  


Genomics

Comparative Map Data
Thop1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr879,283,617 - 9,295,957 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl79,283,617 - 9,295,957 (-)EnsemblGRCr8
mRatBN7.278,632,911 - 8,645,339 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl78,632,916 - 8,645,275 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx711,517,596 - 11,530,108 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0713,393,093 - 13,405,605 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0711,259,596 - 11,272,104 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd712,039,747 - 12,052,253 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive712,203,047 - 12,215,552 (-)NCBILyon_Normotensive
Lyon_Hypertensive712,278,050 - 12,290,554 (-)NCBILyon_Hypertensive
F344_StmMcwi710,644,046 - 10,656,550 (-)NCBIF344_StmMcwi
Rnor_6.0711,501,145 - 11,513,576 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl711,501,146 - 11,513,581 (-)Ensemblrn6Rnor6.0
Rnor_5.0711,668,512 - 11,680,946 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4710,116,822 - 10,129,162 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera76,820,402 - 6,832,744 (-)NCBICelera
RGSC_v3.1710,116,821 - 10,129,088 (-)NCBI
Cytogenetic Map7q11NCBI
THOP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38192,785,503 - 2,815,807 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl192,785,494 - 2,815,807 (+)Ensemblhg38GRCh38
GRCh37192,785,501 - 2,815,805 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36192,736,506 - 2,764,599 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34192,736,505 - 2,764,598NCBI
Celera192,721,390 - 2,749,643 (+)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef192,554,996 - 2,583,295 (+)NCBIHuRef
CHM1_1192,785,096 - 2,813,188 (+)NCBICHM1_1
T2T-CHM13v2.0192,760,790 - 2,791,094 (+)NCBIT2T-CHM13v2.0
Thop1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391080,905,917 - 80,918,194 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1080,905,869 - 80,918,393 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381081,070,083 - 81,082,360 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1081,070,035 - 81,082,559 (+)Ensemblmm10GRCm38
MGSCv371080,532,828 - 80,545,105 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361080,473,279 - 80,485,687 (+)NCBIMGSCv36mm8
Celera1082,090,182 - 82,102,459 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Thop1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554955,054,986 - 5,071,279 (+)Ensembl
ChiLan1.0NW_0049554955,055,389 - 5,070,710 (+)NCBIChiLan1.0ChiLan1.0
THOP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2207,179,830 - 7,209,333 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1196,412,831 - 6,442,294 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0191,810,316 - 1,839,523 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1192,765,550 - 2,793,235 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl192,765,550 - 2,793,235 (+)EnsemblpanPan2panpan1.1
THOP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12056,412,578 - 56,432,480 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2056,412,908 - 56,432,446 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2056,208,964 - 56,228,856 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02057,146,032 - 57,165,932 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2057,146,042 - 57,165,951 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12056,199,077 - 56,218,944 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02056,683,949 - 56,703,847 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02056,884,291 - 56,904,201 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Thop1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118216,196,995 - 216,216,192 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365881,618,541 - 1,637,821 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365881,618,585 - 1,637,788 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
THOP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl275,853,429 - 75,877,494 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1275,857,788 - 75,877,430 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2276,370,019 - 76,389,661 (-)NCBISscrofa10.2Sscrofa10.2susScr3
THOP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.162,564,445 - 2,590,029 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660816,013,877 - 6,039,353 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Thop1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248285,857,846 - 5,873,462 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248285,857,667 - 5,873,055 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Thop1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11153,807,071 - 153,819,320 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Thop1
50 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:53
Count of miRNA genes:49
Interacting mature miRNAs:51
Transcripts:ENSRNOT00000027045
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7166965846669658Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)7123748937Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7721609752216097Rat
2290372Gluco33Glucose level QTL 332.71blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)7131777942Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7170952746709527Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7132612984Rat
1582260Bw72Body weight QTL 723.20.0043body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582261Bw69Body weight QTL 693.20.0048body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582262Bw75Body weight QTL 7530.0038body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7129716167Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134650782Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7132612984Rat

Markers in Region
D7Wox43  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.278,645,666 - 8,645,826 (+)MAPPERmRatBN7.2
Rnor_6.0711,513,899 - 11,514,058NCBIRnor6.0
Rnor_5.0711,681,263 - 11,681,422UniSTSRnor5.0
RGSC_v3.4710,129,572 - 10,129,731UniSTSRGSC3.4
Celera76,833,154 - 6,833,313UniSTS
Cytogenetic Map7q11UniSTS
UniSTS:236402  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.278,642,216 - 8,642,299 (+)MAPPERmRatBN7.2
Rnor_6.0711,510,451 - 11,510,533NCBIRnor6.0
Rnor_5.0711,677,815 - 11,677,897UniSTSRnor5.0
RGSC_v3.4710,126,124 - 10,126,206UniSTSRGSC3.4
Celera76,829,706 - 6,829,788UniSTS
Cytogenetic Map7q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 160 91 90 59 92 59 6 356 192 11 139 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000027045   ⟹   ENSRNOP00000027045
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl79,283,617 - 9,295,957 (-)Ensembl
mRatBN7.2 Ensembl78,632,916 - 8,645,275 (-)Ensembl
Rnor_6.0 Ensembl711,501,146 - 11,513,581 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000082486   ⟹   ENSRNOP00000075551
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl78,632,916 - 8,645,275 (-)Ensembl
Rnor_6.0 Ensembl711,501,149 - 11,513,415 (-)Ensembl
RefSeq Acc Id: NM_172075   ⟹   NP_742072
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr879,283,617 - 9,295,957 (-)NCBI
mRatBN7.278,632,915 - 8,645,257 (-)NCBI
Dahl_SR_JrHsd712,039,747 - 12,052,253 (-)NCBI
Lyon_Normotensive712,203,047 - 12,215,552 (-)NCBI
Lyon_Hypertensive712,278,050 - 12,290,554 (-)NCBI
F344_StmMcwi710,644,046 - 10,656,550 (-)NCBI
Rnor_6.0711,501,149 - 11,513,489 (-)NCBI
Rnor_5.0711,668,512 - 11,680,946 (-)NCBI
RGSC_v3.4710,116,822 - 10,129,162 (-)RGD
Celera76,820,402 - 6,832,744 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_742072 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41586 (Get FASTA)   NCBI Sequence Viewer  
  AAH81706 (Get FASTA)   NCBI Sequence Viewer  
  EDL89199 (Get FASTA)   NCBI Sequence Viewer  
  EDL89200 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000027045
  ENSRNOP00000027045.5
GenBank Protein P24155 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_742072   ⟸   NM_172075
- UniProtKB: Q66HS4 (UniProtKB/Swiss-Prot),   P24155 (UniProtKB/Swiss-Prot),   A6K8C9 (UniProtKB/TrEMBL),   A0A0G2KAW4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000075551   ⟸   ENSRNOT00000082486
Ensembl Acc Id: ENSRNOP00000027045   ⟸   ENSRNOT00000027045
Protein Domains
Peptidase M3A/M3B catalytic

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P24155-F1-model_v2 AlphaFold P24155 1-687 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694996
Promoter ID:EPDNEW_R5516
Type:multiple initiation site
Name:Thop1_1
Description:thimet oligopeptidase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0711,513,510 - 11,513,570EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68330 AgrOrtholog
BioCyc Gene G2FUF-34992 BioCyc
Ensembl Genes ENSRNOG00000019924 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000027045 ENTREZGENE
  ENSRNOT00000027045.7 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.1370.10 UniProtKB/Swiss-Prot
  3.40.390.10 UniProtKB/Swiss-Prot
  Endopeptidase. Chain P, domain 1 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7111806 IMAGE-MGC_LOAD
InterPro MetalloPept_cat_dom_sf UniProtKB/Swiss-Prot
  Neurolysin/TOP_dom2 UniProtKB/Swiss-Prot
  Neurolysin/TOP_N UniProtKB/Swiss-Prot
  Pept_M3A_M3B UniProtKB/Swiss-Prot
  Pept_M3A_M3B UniProtKB/Swiss-Prot
KEGG Report rno:64517 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93105 IMAGE-MGC_LOAD
NCBI Gene 64517 ENTREZGENE
PANTHER PTHR11804 UniProtKB/Swiss-Prot
  THIMET OLIGOPEPTIDASE UniProtKB/Swiss-Prot
Pfam Peptidase_M3 UniProtKB/Swiss-Prot
PhenoGen Thop1 PhenoGen
PROSITE ZINC_PROTEASE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000019924 RatGTEx
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/Swiss-Prot
TIGR TC229917
UniProt A0A0G2KAW4 ENTREZGENE
  A6K8C9 ENTREZGENE, UniProtKB/TrEMBL
  A6K8D0_RAT UniProtKB/TrEMBL
  P24155 ENTREZGENE
  Q66HS4 ENTREZGENE
  THOP1_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q66HS4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Thop1  thimet oligopeptidase 1       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression highest enzyme activity is detected in testis, also expressed in brain and pituitary 730190
gene_process involved in the degradation of Bradykinin, a vasoactive peptide 1299146