Vapb (VAMP associated protein B and C) - Rat Genome Database

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Gene: Vapb (VAMP associated protein B and C) Rattus norvegicus
Analyze
Symbol: Vapb
Name: VAMP associated protein B and C
RGD ID: 68326
Description: Predicted to enable several functions, including FFAT motif binding activity; protein dimerization activity; and tubulin binding activity. Predicted to be involved in several processes, including IRE1-mediated unfolded protein response; endoplasmic reticulum organization; and host-mediated activation of viral genome replication. Is active in several cellular components, including glutamatergic synapse; postsynapse; and presynapse. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; amyotrophic lateral sclerosis type 8; autosomal dominant adult-onset proximal spinal muscular atrophy; and spinal muscular atrophy. Orthologous to human VAPB (VAMP associated protein B and C); INTERACTS WITH 17beta-estradiol; 4-phenylbutyric acid; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: MGC72459; VAMP (vesicle-associated membrane protein)-associated protein B and C; VAMP-associated protein B; VAMP-B; VAP-B; vesicle-associated membrane protein, associated protein B and C; vesicle-associated membrane protein-associated protein B
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Eau4
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83182,954,247 - 182,997,018 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3182,954,240 - 183,028,619 (+)EnsemblGRCr8
mRatBN7.23162,535,974 - 162,578,747 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3162,535,905 - 162,573,763 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3166,335,144 - 166,371,611 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03174,838,730 - 174,875,679 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03172,575,947 - 172,612,410 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd3181,040,653 - 181,083,923 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive3187,901,395 - 187,944,669 (+)NCBILyon_Normotensive
Lyon_Hypertensive3179,868,331 - 179,911,605 (+)NCBILyon_Hypertensive
F344_StmMcwi3160,753,633 - 160,796,503 (+)NCBIF344_StmMcwi
Rnor_6.03171,832,558 - 171,871,042 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3171,832,500 - 171,868,647 (+)Ensemblrn6Rnor6.0
Rnor_5.03177,890,856 - 177,931,543 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43164,632,388 - 164,669,187 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3161,718,437 - 161,754,637 (+)NCBICelera
RGSC_v3.13164,538,238 - 164,576,441 (+)NCBI
Cytogenetic Map3q42NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,6-dimethoxyphenol  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-phenylbutyric acid  (EXP)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
aconitine  (EXP)
ammonium chloride  (EXP)
antimycin A  (ISO)
antirheumatic drug  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Brodifacoum  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
celecoxib  (ISO)
CGP 52608  (ISO)
chloroprene  (ISO)
clozapine  (ISO)
cocaine  (EXP)
coumarin  (ISO)
Cuprizon  (ISO)
deguelin  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fenpyroximate  (ISO)
finasteride  (EXP)
flufenoxuron  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
furfural  (ISO)
geldanamycin  (ISO)
hydrogen cyanide  (ISO)
ivermectin  (ISO)
lanthanum trichloride  (EXP)
lead(0)  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
pentachlorophenol  (ISO)
picoxystrobin  (ISO)
potassium cyanide  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
pyrimidifen  (ISO)
quercetin  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sulindac  (EXP)
tebufenpyrad  (ISO)
thapsigargin  (ISO)
thimerosal  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA,ISO)
endoplasmic reticulum  (IDA,IEA,IEP,ISO,ISS)
endoplasmic reticulum exit site  (ISO)
endoplasmic reticulum membrane  (IBA,IEA,ISO,ISS)
glutamatergic synapse  (IDA,IEP)
Golgi apparatus  (IEA,ISO,ISS)
membrane  (ISO)
plasma membrane  (IBA)
postsynapse  (IDA,IEP)
presynapse  (IDA,IEP)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. The VAPB-PTPIP51 endoplasmic reticulum-mitochondria tethering proteins are present in neuronal synapses and regulate synaptic activity. Gómez-Suaga P, etal., Acta Neuropathol Commun. 2019 Mar 6;7(1):35. doi: 10.1186/s40478-019-0688-4.
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. A mutation in the vesicle-trafficking protein VAPB causes late-onset spinal muscular atrophy and amyotrophic lateral sclerosis. Nishimura AL, etal., Am J Hum Genet. 2004 Nov;75(5):822-31. Epub 2004 Sep 15.
6. Molecular cloning and characterization of mammalian homologues of vesicle-associated membrane protein-associated (VAMP-associated) proteins. Nishimura Y, etal., Biochem Biophys Res Commun 1999 Jan 8;254(1):21-6.
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:12477932   PMID:14561759   PMID:15489334   PMID:16227268   PMID:16891305   PMID:17540579   PMID:18713837   PMID:19515777   PMID:20940299   PMID:21275991   PMID:22131369   PMID:23736259  
PMID:24105263   PMID:25468996   PMID:29941597  


Genomics

Comparative Map Data
Vapb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83182,954,247 - 182,997,018 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3182,954,240 - 183,028,619 (+)EnsemblGRCr8
mRatBN7.23162,535,974 - 162,578,747 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3162,535,905 - 162,573,763 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3166,335,144 - 166,371,611 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03174,838,730 - 174,875,679 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03172,575,947 - 172,612,410 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd3181,040,653 - 181,083,923 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive3187,901,395 - 187,944,669 (+)NCBILyon_Normotensive
Lyon_Hypertensive3179,868,331 - 179,911,605 (+)NCBILyon_Hypertensive
F344_StmMcwi3160,753,633 - 160,796,503 (+)NCBIF344_StmMcwi
Rnor_6.03171,832,558 - 171,871,042 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3171,832,500 - 171,868,647 (+)Ensemblrn6Rnor6.0
Rnor_5.03177,890,856 - 177,931,543 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43164,632,388 - 164,669,187 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3161,718,437 - 161,754,637 (+)NCBICelera
RGSC_v3.13164,538,238 - 164,576,441 (+)NCBI
Cytogenetic Map3q42NCBI
VAPB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382058,389,229 - 58,451,101 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2058,389,119 - 58,451,101 (+)Ensemblhg38GRCh38
GRCh372056,964,285 - 57,026,157 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362056,397,651 - 56,455,369 (+)NCBIBuild 36Build 36hg18NCBI36
Build 342056,397,650 - 56,455,367NCBI
Celera2053,704,711 - 53,762,426 (+)NCBICelera
Cytogenetic Map20q13.32NCBI
HuRef2053,747,058 - 53,809,032 (+)NCBIHuRef
CHM1_12056,865,734 - 56,927,715 (+)NCBICHM1_1
T2T-CHM13v2.02060,170,197 - 60,232,150 (+)NCBIT2T-CHM13v2.0
Vapb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392173,579,378 - 173,626,132 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2173,579,304 - 173,626,132 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm382173,737,571 - 173,784,336 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2173,737,511 - 173,784,339 (+)Ensemblmm10GRCm38
MGSCv372173,563,072 - 173,609,837 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv362173,380,510 - 173,427,275 (+)NCBIMGSCv36mm8
Celera2179,705,544 - 179,751,066 (+)NCBICelera
Cytogenetic Map2H4NCBI
cM Map297.37NCBI
Vapb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554451,098,454 - 1,120,823 (-)Ensembl
ChiLan1.0NW_0049554451,098,454 - 1,122,879 (-)NCBIChiLan1.0ChiLan1.0
VAPB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22164,147,622 - 64,209,801 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12064,140,742 - 64,202,911 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02054,736,035 - 54,798,155 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12056,010,782 - 56,071,185 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2056,010,782 - 56,064,363 (+)EnsemblpanPan2panpan1.1
VAPB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12443,182,158 - 43,238,019 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2443,182,196 - 43,231,336 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2442,428,808 - 42,484,615 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02444,048,066 - 44,104,061 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2444,048,014 - 44,098,692 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12443,152,527 - 43,208,360 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02443,270,720 - 43,326,518 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02443,929,924 - 43,985,979 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Vapb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640182,275,951 - 182,320,727 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936530985,488 - 1,031,125 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936530985,488 - 1,030,270 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
VAPB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1758,594,749 - 58,644,914 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11758,594,749 - 58,644,925 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21765,806,107 - 65,856,325 (+)NCBISscrofa10.2Sscrofa10.2susScr3
VAPB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.125,686,294 - 5,740,855 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl25,687,611 - 5,740,740 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605053,733,097 - 53,795,120 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Vapb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474124,716,716 - 24,766,480 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474124,716,835 - 24,767,806 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Vapb
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v15144,197,379 - 144,242,591 (-)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:271
Count of miRNA genes:164
Interacting mature miRNAs:199
Transcripts:ENSRNOT00000007554
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2301411Bp320Blood pressure QTL 3200.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141555229186555229Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3152055202189428310Rat
12879876Bw182Body weight QTL 1820.003body mass (VT:0001259)body weight (CMO:0000012)3141555229186555229Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3142898802187898802Rat
12879872Cm97Cardiac mass QTL 970.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3141555229186555229Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)3145335553189428310Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3151075912189428310Rat
12879873Cm96Cardiac mass QTL 960.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)3141555229186555229Rat
12879874Cm98Cardiac mass QTL 980.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)3141555229186555229Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3161492708189428310Rat
12879875Kidm64Kidney mass QTL 640.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3141555229186555229Rat
1582256Insul9Insulin level QTL 94.40.0016blood insulin amount (VT:0001560)absolute change in serum insulin level (CMO:0002038)3155759447189428310Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3139299381184299381Rat
1582248Insul7Insulin level QTL 73.90.0041blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
1578666Vnigr1Vascular neointimal growth QTL 14.6artery morphology trait (VT:0002191)artery lumen area (CMO:0001409)3151075912189428310Rat
1300161Rf10Renal function QTL 103.57renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)3181611379189428310Rat
8552791Vie2Viral induced encephalitis QTL 24.1brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)3166376089189428310Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3151075912189428310Rat
1331726Bp208Blood pressure QTL 2083.129arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3161799270187311134Rat
12879871Am7Aortic mass QTL 70.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)3141555229186555229Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3144575244189428310Rat
1582213Insul6Insulin level QTL 63.70.0009blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
1598854Memor10Memory QTL 102exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)3166376089189428310Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
22 13 81 212 91 90 59 157 59 6 481 281 22 190 111 124 31 34 34

Sequence


Ensembl Acc Id: ENSRNOT00000007554   ⟹   ENSRNOP00000007554
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3182,954,249 - 182,992,034 (+)Ensembl
mRatBN7.2 Ensembl3162,535,905 - 162,573,763 (+)Ensembl
Rnor_6.0 Ensembl3171,832,500 - 171,868,647 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000122080   ⟹   ENSRNOP00000106660
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3182,954,240 - 183,028,619 (+)Ensembl
RefSeq Acc Id: NM_021847   ⟹   NP_068619
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83182,954,247 - 182,997,018 (+)NCBI
mRatBN7.23162,535,974 - 162,578,747 (+)NCBI
Dahl_SR_JrHsd3181,040,653 - 181,083,923 (+)NCBI
Lyon_Normotensive3187,901,395 - 187,944,669 (+)NCBI
Lyon_Hypertensive3179,868,331 - 179,911,605 (+)NCBI
F344_StmMcwi3160,753,633 - 160,796,503 (+)NCBI
Rnor_6.03171,832,558 - 171,868,449 (+)NCBI
Rnor_5.03177,890,856 - 177,931,543 (+)NCBI
RGSC_v3.43164,632,388 - 164,669,187 (+)RGD
Celera3161,718,437 - 161,754,637 (+)RGD
Sequence:
RefSeq Acc Id: XM_006235706   ⟹   XP_006235768
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83182,954,884 - 182,992,034 (+)NCBI
mRatBN7.23162,536,616 - 162,578,738 (+)NCBI
Rnor_6.03171,833,018 - 171,871,042 (+)NCBI
Rnor_5.03177,890,856 - 177,931,543 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_068619 (Get FASTA)   NCBI Sequence Viewer  
  XP_006235768 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD13580 (Get FASTA)   NCBI Sequence Viewer  
  AAH65576 (Get FASTA)   NCBI Sequence Viewer  
  EDL85103 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000007554
  ENSRNOP00000007554.2
  ENSRNOP00000106660
GenBank Protein Q9Z269 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_068619   ⟸   NM_021847
- UniProtKB: Q9Z269 (UniProtKB/Swiss-Prot),   A6KL13 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006235768   ⟸   XM_006235706
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000007554   ⟸   ENSRNOT00000007554
Ensembl Acc Id: ENSRNOP00000106660   ⟸   ENSRNOT00000122080
Protein Domains
MSP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z269-F1-model_v2 AlphaFold Q9Z269 1-243 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692716
Promoter ID:EPDNEW_R3241
Type:initiation region
Name:Vapb_1
Description:VAMP associated protein B and C
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03171,832,442 - 171,832,502EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68326 AgrOrtholog
BioCyc Gene G2FUF-46485 BioCyc
Ensembl Genes ENSRNOG00000005331 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000007554 ENTREZGENE
  ENSRNOT00000007554.5 UniProtKB/Swiss-Prot
  ENSRNOT00000122080 ENTREZGENE
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5598396 IMAGE-MGC_LOAD
InterPro Ig-like_fold UniProtKB/Swiss-Prot
  MSP_dom UniProtKB/Swiss-Prot
  PapD-like_sf UniProtKB/Swiss-Prot
  VAP UniProtKB/Swiss-Prot
KEGG Report rno:60431 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72459 IMAGE-MGC_LOAD
NCBI Gene 60431 ENTREZGENE
PANTHER PTHR10809 UniProtKB/Swiss-Prot
  VESICLE-ASSOCIATED MEMBRANE PROTEIN-ASSOCIATED PROTEIN B/C UniProtKB/Swiss-Prot
Pfam Motile_Sperm UniProtKB/Swiss-Prot
PhenoGen Vapb PhenoGen
PIRSF VAMP-associated UniProtKB/Swiss-Prot
PROSITE MSP UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000005331 RatGTEx
Superfamily-SCOP SSF49354 UniProtKB/Swiss-Prot
UniProt A0ABK0LLY4_RAT UniProtKB/TrEMBL
  A6KL13 ENTREZGENE, UniProtKB/TrEMBL
  Q9Z269 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-22 Vapb  VAMP associated protein B and C  Vapb  VAMP (vesicle-associated membrane protein)-associated protein B and C  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-12-15 Vapb  VAMP (vesicle-associated membrane protein)-associated protein B and C  Vapb  vesicle-associated membrane protein, associated protein B and C   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Vapb  vesicle-associated membrane protein, associated protein B and C       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_homology 88% amino acid identity to human homolog 61779