Taar6 (trace amine-associated receptor 6) - Rat Genome Database

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Gene: Taar6 (trace amine-associated receptor 6) Rattus norvegicus
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Symbol: Taar6
Name: trace amine-associated receptor 6
RGD ID: 631384
Description: Predicted to enable trace-amine receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human TAAR6 (trace amine associated receptor 6); INTERACTS WITH ammonium chloride; bisphenol A; trichloroethene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Ta4; taR-4; taR-6; trace amine receptor 4; trace amine receptor 6; trace-amine-associated receptor 6; TRAR4
RGD Orthologs
Human
Mouse
Bonobo
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8123,277,717 - 23,278,754 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl123,277,717 - 23,278,754 (+)EnsemblGRCr8
mRatBN7.2121,458,475 - 21,459,512 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl121,458,111 - 21,460,652 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx121,235,555 - 21,236,592 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0127,235,596 - 27,236,633 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0121,435,339 - 21,436,376 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0122,536,199 - 22,537,236 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl122,536,199 - 22,537,236 (+)Ensemblrn6Rnor6.0
Rnor_5.0124,011,141 - 24,012,178 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4121,984,658 - 21,985,695 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera120,202,914 - 20,203,951 (+)NCBICelera
RGSC_v3.1121,987,602 - 21,988,640 (+)NCBI
Cytogenetic Map1p12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
membrane  (IEA)
plasma membrane  (IBA,IEA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Trace amines: identification of a family of mammalian G protein-coupled receptors. Borowsky B, etal., Proc Natl Acad Sci U S A 2001 Jul 31;98(16):8966-71.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Taar6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8123,277,717 - 23,278,754 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl123,277,717 - 23,278,754 (+)EnsemblGRCr8
mRatBN7.2121,458,475 - 21,459,512 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl121,458,111 - 21,460,652 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx121,235,555 - 21,236,592 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0127,235,596 - 27,236,633 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0121,435,339 - 21,436,376 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0122,536,199 - 22,537,236 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl122,536,199 - 22,537,236 (+)Ensemblrn6Rnor6.0
Rnor_5.0124,011,141 - 24,012,178 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4121,984,658 - 21,985,695 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera120,202,914 - 20,203,951 (+)NCBICelera
RGSC_v3.1121,987,602 - 21,988,640 (+)NCBI
Cytogenetic Map1p12NCBI
TAAR6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386132,570,322 - 132,571,359 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6132,570,322 - 132,571,359 (+)Ensemblhg38GRCh38
GRCh376132,891,461 - 132,892,498 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366132,933,154 - 132,934,191 (+)NCBIBuild 36Build 36hg18NCBI36
Build 346132,933,153 - 132,934,191NCBI
Celera6133,638,298 - 133,639,335 (+)NCBICelera
Cytogenetic Map6q23.2NCBI
HuRef6130,466,379 - 130,467,416 (+)NCBIHuRef
CHM1_16133,155,132 - 133,156,169 (+)NCBICHM1_1
T2T-CHM13v2.06133,765,283 - 133,766,320 (+)NCBIT2T-CHM13v2.0
Taar6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391023,860,507 - 23,861,544 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1023,860,507 - 23,861,544 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381023,984,609 - 23,985,646 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1023,984,609 - 23,985,646 (-)Ensemblmm10GRCm38
MGSCv371023,704,415 - 23,705,452 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361023,674,025 - 23,675,062 (-)NCBIMGSCv36mm8
Celera1024,918,005 - 24,919,042 (-)NCBICelera
Cytogenetic Map10A4NCBI
cM Map1011.4NCBI
TAAR6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25152,552,749 - 152,554,953 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16150,459,858 - 150,462,058 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06130,346,489 - 130,348,689 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16134,454,665 - 134,455,730 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6134,454,665 - 134,455,615 (+)EnsemblpanPan2panpan1.1
LOC100154422
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl131,124,103 - 31,125,693 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1131,124,661 - 31,125,693 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2134,661,232 - 34,671,105 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TAAR6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11340,972,175 - 40,975,089 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1340,972,618 - 40,973,691 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604013,160,358 - 13,161,395 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Taar6
3 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:58
Count of miRNA genes:53
Interacting mature miRNAs:55
Transcripts:ENSRNOT00000021529
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313090Bmd69Bone mineral density QTL 694.40.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)1529322934184556Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1774611852746118Rat
4889451Eae29Experimental allergic encephalomyelitis QTL 295.51nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1774612152746121Rat
70179Xhs2X-ray hypersensitivity QTL 23.2intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)1143965634Rat
1354647Despr8Despair related QTL 80.0000341locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1126564886Rat
1558642Prcr2Prostate cancer resistance QTL 24.3prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)11037949255379492Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1694102251941022Rat
2313070Bss52Bone structure and strength QTL 524.40.0001body length (VT:0001256)body length (CMO:0000013)1529322934184556Rat
1357401Bw43Body weight QTL 433.75body mass (VT:0001259)body weight (CMO:0000012)1690935351909353Rat
631494Bp95Blood pressure QTL 95400.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)11731537851816258Rat
1600360Mcs16Mammary carcinoma susceptibility QTL 162.4mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1126564886Rat
5684998Bss101Bone structure and strength QTL 1013.6tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)1690935351909353Rat
5684999Bss102Bone structure and strength QTL 1025.57e-07tibia strength trait (VT:1000284)tibia stiffness (CMO:0001735)1690935351909353Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11282049457820494Rat
2317755Glom22Glomerulus QTL 223.8urine protein amount (VT:0005160)urine protein level (CMO:0000591)1134184556Rat
634353Rends2Renal damage susceptibility QTL 20.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)12065642065656420Rat
1300170Rf6Renal function QTL 63.14renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)1128483164Rat
1578756Iddm22Insulin dependent diabetes mellitus QTL 222.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12050832665508326Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)11168446456684464Rat
2313053Bss51Bone structure and strength QTL 513.80.0001tibia length (VT:0004357)tibia length (CMO:0000450)1529322934184556Rat


Expression

RNA-SEQ Expression

endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
reproductive system
respiratory system
1 2 1 1 1 2 1 9 1

Sequence


Ensembl Acc Id: ENSRNOT00000021529   ⟹   ENSRNOP00000070620
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl121,458,111 - 21,460,652 (+)Ensembl
Rnor_6.0 Ensembl122,536,199 - 22,537,236 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000146632   ⟹   ENSRNOP00000101059
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl123,277,717 - 23,278,754 (+)Ensembl
RefSeq Acc Id: NM_175584   ⟹   NP_783174
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8123,277,717 - 23,278,754 (+)NCBI
mRatBN7.2121,458,475 - 21,459,512 (+)NCBI
Rnor_6.0122,536,199 - 22,537,236 (+)NCBI
Rnor_5.0124,011,141 - 24,012,178 (+)NCBI
RGSC_v3.4121,984,658 - 21,985,695 (+)RGD
Celera120,202,914 - 20,203,951 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_783174 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAK71242 (Get FASTA)   NCBI Sequence Viewer  
  EDL87752 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000070620.1
  ENSRNOP00000101059
GenBank Protein Q923Y5 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_783174   ⟸   NM_175584
- UniProtKB: Q923Y5 (UniProtKB/Swiss-Prot),   A6JUM7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000070620   ⟸   ENSRNOT00000021529
Ensembl Acc Id: ENSRNOP00000101059   ⟸   ENSRNOT00000146632
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q923Y5-F1-model_v2 AlphaFold Q923Y5 1-345 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:631384 AgrOrtholog
BioCyc Gene G2FUF-62085 BioCyc
Ensembl Genes ENSRNOG00000016089 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00000091324 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000021529.5 UniProtKB/Swiss-Prot
  ENSRNOT00000146632 ENTREZGENE
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
  TAAR UniProtKB/Swiss-Prot
  TAAR_fam UniProtKB/Swiss-Prot
KEGG Report rno:294124 UniProtKB/Swiss-Prot
NCBI Gene 294124 ENTREZGENE
PANTHER HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR UniProtKB/Swiss-Prot
  TRACE AMINE-ASSOCIATED RECEPTOR 6 UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PhenoGen Taar6 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot
  TRACEAMINER UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000016089 RatGTEx
  ENSRNOG00000091324 RatGTEx
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
UniProt A6JUM7 ENTREZGENE, UniProtKB/TrEMBL
  Q923Y5 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-11-20 Taar6  trace amine-associated receptor 6  Taar6  trace-amine-associated receptor 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-02-23 Taar6  trace-amine-associated receptor 6  TRAR4  trace amine receptor 4  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2004-09-10 TRAR4  trace amine receptor 4  Ta4    Symbol updated 1299863 APPROVED
2004-02-11 Tar4  trace amine receptor 4      Symbol and Name status set to approved 625702 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function functions as neurotransmitters for biogenic amines along with the orphan receptor PNR 634071
gene_product member of the rhodopsin mammalian G protein-coupled receptor family 634071