Spag11a (sperm associated antigen 11A) - Rat Genome Database

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Gene: Spag11a (sperm associated antigen 11A) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Spag11a
Name: sperm associated antigen 11A
RGD ID: 628905
Description: Predicted to be involved in defense response to bacterium. Predicted to act upstream of or within antimicrobial humoral response and negative regulation of interleukin-1 production. Predicted to be located in cell surface and extracellular space.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: anti-microbial-like protein BIN-1B; antimicrobial-like protein Bin-1b; Bin-1b; Bin1b; Spag11; Spag11b; sperm associated antigen 11; sperm associated antigen 11B; sperm-associated antigen 11; sperm-associated antigen 11A
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81677,384,755 - 77,386,496 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1677,384,755 - 77,386,498 (-)EnsemblGRCr8
mRatBN7.21670,682,326 - 70,684,067 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1670,682,326 - 70,684,069 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1675,959,154 - 75,960,895 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01679,421,704 - 79,423,437 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01674,671,140 - 74,672,873 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01675,666,439 - 75,668,180 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1675,666,439 - 75,668,182 (-)Ensemblrn6Rnor6.0
Rnor_5.01675,266,193 - 75,267,885 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41675,474,894 - 75,476,586 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1668,549,292 - 68,551,033 (-)NCBICelera
RGSC_v3.11675,475,158 - 75,476,851 (-)NCBI
Cytogenetic Map16q12.5NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11230693   PMID:15122269   PMID:20826730   PMID:24777385   PMID:31691005   PMID:35438340  


Genomics

Variants

.
Variants in Spag11a
17 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:84
Count of miRNA genes:72
Interacting mature miRNAs:78
Transcripts:ENSRNOT00000018741
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)164445512389455123Rat
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165942871491442908Rat
1298529Arunc1Aerobic running capacity QTL 14exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)163439829479398294Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)163692878281928782Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)164199206486992064Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)164445512389455123Rat
8694364Abfw7Abdominal fat weight QTL 712.220.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)165942871491442908Rat
8694429Bw164Body weight QTL 16450.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)165942871491442908Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164909919691442908Rat
1298527Arunc2Aerobic running capacity QTL 22.9exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)167523528581732231Rat


Expression

RNA-SEQ Expression

appendage
ectoderm
endocrine system
endoderm
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
1 2 3 3 4 1 1 2 3 5 3

Sequence


Ensembl Acc Id: ENSRNOT00000018741   ⟹   ENSRNOP00000018741
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1677,384,755 - 77,386,498 (-)Ensembl
mRatBN7.2 Ensembl1670,682,326 - 70,684,069 (-)Ensembl
Rnor_6.0 Ensembl1675,666,439 - 75,668,182 (-)Ensembl
RefSeq Acc Id: NM_145087   ⟹   NP_659555
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81677,384,755 - 77,386,496 (-)NCBI
mRatBN7.21670,682,326 - 70,684,067 (-)NCBI
Rnor_6.01675,666,439 - 75,668,180 (-)NCBI
Rnor_5.01675,266,193 - 75,267,885 (-)NCBI
RGSC_v3.41675,474,894 - 75,476,586 (-)RGD
Celera1668,549,292 - 68,551,033 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_659555 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAL55636 (Get FASTA)   NCBI Sequence Viewer  
  AAL55637 (Get FASTA)   NCBI Sequence Viewer  
  EDM08966 (Get FASTA)   NCBI Sequence Viewer  
  EDM08967 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000018741
  ENSRNOP00000018741.1
GenBank Protein Q8VBV2 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_659555   ⟸   NM_145087
- Peptide Label: precursor
- UniProtKB: Q8VBV2 (UniProtKB/Swiss-Prot),   A6IWA6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000018741   ⟸   ENSRNOT00000018741
Protein Domains
Beta-defensin-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8VBV2-F1-model_v2 AlphaFold Q8VBV2 1-68 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700213
Promoter ID:EPDNEW_R10737
Type:single initiation site
Name:Spag11a_1
Description:sperm associated antigen 11A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01675,668,182 - 75,668,242EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628905 AgrOrtholog
BioCyc Gene G2FUF-10818 BioCyc
Ensembl Genes ENSRNOG00000013957 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000018741 ENTREZGENE
  ENSRNOT00000018741.3 UniProtKB/Swiss-Prot
InterPro Defensin_beta-typ UniProtKB/Swiss-Prot
  Sperm_Ag_HE2 UniProtKB/Swiss-Prot
KEGG Report rno:246305 UniProtKB/Swiss-Prot
NCBI Gene 246305 ENTREZGENE
PANTHER PTHR14081 UniProtKB/Swiss-Prot
  SPERM-ASSOCIATED ANTIGEN 11 UniProtKB/Swiss-Prot
Pfam Defensin_beta UniProtKB/Swiss-Prot
PhenoGen Spag11a PhenoGen
RatGTEx ENSRNOG00000013957 RatGTEx
Superfamily-SCOP Defensin-like UniProtKB/Swiss-Prot
UniProt A6IWA6 ENTREZGENE, UniProtKB/TrEMBL
  Q8VBV2 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-08-29 Spag11a  sperm associated antigen 11A  Spag11b  sperm associated antigen 11B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-18 Spag11b  sperm associated antigen 11B  Spag11  sperm associated antigen 11  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Spag11  sperm associated antigen 11  Bin1b  anti-microbial-like protein BIN-1B  Symbol and Name updated 1299863 APPROVED
2003-02-27 Bin1b  anti-microbial-like protein BIN-1B      Symbol and Name status set to provisional 70820 PROVISIONAL