Ripk3 (receptor-interacting serine-threonine kinase 3) - Rat Genome Database

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Gene: Ripk3 (receptor-interacting serine-threonine kinase 3) Rattus norvegicus
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Symbol: Ripk3
Name: receptor-interacting serine-threonine kinase 3
RGD ID: 628899
Description: Predicted to enable identical protein binding activity and protein serine/threonine kinase activity. Predicted to be involved in several processes, including amyloid fibril formation; hematopoietic or lymphoid organ development; and necroptotic process. Predicted to act upstream of or within with a positive effect on non-canonical NF-kappaB signal transduction. Predicted to act upstream of or within positive regulation of intrinsic apoptotic signaling pathway and positive regulation of reactive oxygen species metabolic process. Predicted to be located in cytosol and nucleus. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm. Orthologous to human RIPK3 (receptor interacting serine/threonine kinase 3); INTERACTS WITH 1,3-dichloropropan-2-ol; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Hcyp2; homocysteine respondent protein HCYP2; receptor-interacting protein 3; receptor-interacting serine/threonine-protein kinase 3; RIP-3; RIP-like protein kinase 3; Rip3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81533,253,071 - 33,262,025 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1533,253,071 - 33,262,025 (-)EnsemblGRCr8
mRatBN7.21529,283,153 - 29,292,107 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1529,283,145 - 29,292,121 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1531,128,833 - 31,137,787 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01532,276,043 - 32,284,997 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01530,518,392 - 30,527,346 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01534,470,796 - 34,479,741 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1534,470,796 - 34,479,741 (-)Ensemblrn6Rnor6.0
Rnor_5.01538,359,304 - 38,368,247 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41533,947,406 - 33,956,351 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1528,858,091 - 28,867,036 (-)NCBICelera
RGSC_v3.11533,963,105 - 33,972,051 (-)NCBI
Cytogenetic Map15p13NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1,3-dichloropropan-2-ol  (EXP,ISO)
1-monopalmitoylglycerol  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
2-acetamidofluorene  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP,ISO)
3-methyladenine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5,7-dihydroxy-4'-methoxyflavone  (ISO)
5-Isoxazoleacetic acid, 4,5-dihydro-3-(4-hydroxyphenyl)-, methyl ester  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acetamide  (EXP)
acrolein  (EXP)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amosite asbestos  (ISO)
amphetamine  (EXP)
antirheumatic drug  (ISO)
apabetalone  (ISO)
apocynin  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
betaxolol  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
butanal  (ISO)
butane-2,3-dione  (ISO)
C.I. Natural Red 20  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
captopril  (ISO)
carbon nanotube  (ISO)
carbonyl sulfide  (EXP)
carvedilol  (EXP)
CGP 52608  (ISO)
chromium(6+)  (EXP)
cisplatin  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
D-glucose  (EXP)
D-penicillamine  (ISO)
dextran sulfate  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
Dihydrotanshinone I  (ISO)
dimethyl fumarate  (EXP)
dimethylarsinic acid  (ISO)
dioxygen  (EXP,ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
eritoran  (ISO)
ethanol  (ISO)
ferric oxide  (EXP)
fingolimod hydrochloride  (ISO)
folic acid  (EXP,ISO)
fulvestrant  (ISO)
fumonisin B1  (ISO)
galangin  (EXP)
gallic acid  (ISO)
genistein  (EXP)
gentamycin  (EXP)
glucose  (EXP)
glycerol  (EXP)
glycidol  (EXP)
GSK-J4  (ISO)
hydrogen peroxide  (ISO)
isoprenaline  (EXP)
lipopolysaccharide  (ISO)
lycopene  (EXP)
melatonin  (EXP,ISO)
metformin  (ISO)
methapyrilene  (EXP)
methimazole  (EXP)
methoxyacetic acid  (EXP)
methylarsonic acid  (ISO)
methylmercury chloride  (EXP)
minocycline  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-phosphocreatine  (EXP)
nickel atom  (ISO)
nickel dichloride  (EXP)
ochratoxin A  (ISO)
oleic acid  (ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (EXP)
paracetamol  (ISO)
paraquat  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
phenacetin  (EXP)
phenylephrine  (ISO)
phenylhydrazine  (EXP)
phenylpropanolamine  (ISO)
pirinixic acid  (ISO)
Pranoprofen  (ISO)
pterostilbene  (ISO)
quetiapine fumarate  (ISO)
rac-1-monopalmitoylglycerol  (ISO)
reactive oxygen species  (ISO)
resveratrol  (ISO)
rimonabant  (ISO)
rotenone  (EXP)
selenium atom  (ISO)
serpentine asbestos  (ISO)
sevoflurane  (ISO)
Shikonin  (ISO)
silicon dioxide  (ISO)
simvastatin  (ISO)
SM-164  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP,ISO)
sulfadimethoxine  (EXP)
T-2 toxin  (EXP)
tamoxifen  (ISO)
testosterone  (EXP)
tetrachloromethane  (ISO)
theophylline  (ISO)
thioacetamide  (EXP)
thymoquinone  (EXP)
titanium dioxide  (ISO)
Tributyltin oxide  (EXP)
tricalcium bis(phosphate)  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of protein kinase activity  (ISO)
amyloid fibril formation  (IEA,ISO,ISS)
apoptotic process  (IEA)
cellular response to hydrogen peroxide  (ISO)
defense response to virus  (ISO,ISS)
execution phase of necroptosis  (ISO,ISS)
intracellular signal transduction  (IEA,ISO)
lymph node development  (ISO,ISS)
necroptotic process  (IEA,ISO,ISS)
necroptotic signaling pathway  (IEA,ISO)
non-canonical NF-kappaB signal transduction  (ISO)
positive regulation of intrinsic apoptotic signaling pathway  (ISO)
positive regulation of ligase activity  (ISO)
positive regulation of metabolic process  (IEA)
positive regulation of necroptotic process  (IEA,ISO,ISS)
positive regulation of oxidoreductase activity  (ISO)
positive regulation of reactive oxygen species metabolic process  (ISO)
programmed cell death  (IEA)
programmed necrotic cell death  (ISO)
regulation of activated T cell proliferation  (ISO,ISS)
regulation of activation-induced cell death of T cells  (ISO,ISS)
regulation of adaptive immune response  (ISO,ISS)
regulation of apoptotic process  (ISO,ISS)
regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation  (ISO,ISS)
regulation of gene expression  (IEA)
regulation of reactive oxygen species metabolic process  (ISO)
regulation of T cell mediated cytotoxicity  (ISO,ISS)
regulation of type II interferon production  (ISO,ISS)
ripoptosome assembly involved in necroptotic process  (IEA,ISO)
signal transduction  (IBA,IEA)
spleen development  (ISO,ISS)
T cell differentiation in thymus  (ISO,ISS)
T cell homeostasis  (ISO,ISS)
thymus development  (ISO,ISS)

Cellular Component
cytoplasm  (IBA,IEA,ISO,ISS)
cytosol  (IEA,ISO,ISS)
nucleus  (IEA,ISO,ISS)
protein-containing complex  (IEA,ISO)
ripoptosome  (ISO)

References

References - curated
# Reference Title Reference Citation
1. RIPK3 Promotes JEV Replication in Neurons via Downregulation of IFI44L. Bian P, etal., Front Microbiol. 2020 Mar 24;11:368. doi: 10.3389/fmicb.2020.00368. eCollection 2020.
2. The adaptor protein FADD protects epidermal keratinocytes from necroptosis in vivo and prevents skin inflammation. Bonnet MC, etal., Immunity. 2011 Oct 28;35(4):572-82. doi: 10.1016/j.immuni.2011.08.014. Epub 2011 Oct 13.
3. Dectin-1-induced RIPK1 and RIPK3 activation protects host against Candida albicans infection. Cao M, etal., Cell Death Differ. 2019 Dec;26(12):2622-2636. doi: 10.1038/s41418-019-0323-8. Epub 2019 Apr 3.
4. RIPK3 collaborates with GSDMD to drive tissue injury in lethal polymicrobial sepsis. Chen H, etal., Cell Death Differ. 2020 Sep;27(9):2568-2585. doi: 10.1038/s41418-020-0524-1. Epub 2020 Mar 9.
5. Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation. Cho YS, etal., Cell. 2009 Jun 12;137(6):1112-23. doi: 10.1016/j.cell.2009.05.037.
6. Mitochondrial antiviral signaling protein defect links impaired antiviral response and liver injury in steatohepatitis in mice. Csak T, etal., Hepatology. 2011 Jun;53(6):1917-31. doi: 10.1002/hep.24301. Epub 2011 May 2.
7. RIPK3 interacts with MAVS to regulate type I IFN-mediated immunity to Influenza A virus infection. Downey J, etal., PLoS Pathog. 2017 Apr 14;13(4):e1006326. doi: 10.1371/journal.ppat.1006326. eCollection 2017 Apr.
8. RIP kinase-dependent necrosis drives lethal systemic inflammatory response syndrome. Duprez L, etal., Immunity. 2011 Dec 23;35(6):908-18. doi: 10.1016/j.immuni.2011.09.020.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Pore-forming toxin-mediated ion dysregulation leads to death receptor-independent necroptosis of lung epithelial cells during bacterial pneumonia. González-Juarbe N, etal., Cell Death Differ. 2017 May;24(5):917-928. doi: 10.1038/cdd.2017.49. Epub 2017 Apr 7.
11. Species-independent contribution of ZBP1/DAI/DLM-1-triggered necroptosis in host defense against HSV1. Guo H, etal., Cell Death Dis. 2018 Jul 26;9(8):816. doi: 10.1038/s41419-018-0868-3.
12. Receptor-Interacting Protein Kinase 3 (RIPK3) mRNA Levels Are Elevated in Blood Mononuclear Cells of Patients with Poor Prognosis of Acute-on-Chronic Hepatitis B Liver Failure. Han L, etal., Tohoku J Exp Med. 2019 Apr;247(4):237-245. doi: 10.1620/tjem.247.237.
13. RIPK3 Activates MLKL-mediated Necroptosis and Inflammasome Signaling during Streptococcus Infection. Huang HR, etal., Am J Respir Cell Mol Biol. 2021 May;64(5):579-591. doi: 10.1165/rcmb.2020-0312OC.
14. Necroptosis Promotes Staphylococcus aureus Clearance by Inhibiting Excessive Inflammatory Signaling. Kitur K, etal., Cell Rep. 2016 Aug 23;16(8):2219-2230. doi: 10.1016/j.celrep.2016.07.039. Epub 2016 Aug 11.
15. Transcription modulation by CDK9 regulates inflammatory genes and RIPK3-MLKL-mediated necroptosis in periodontitis progression. Li J, etal., Sci Rep. 2019 Nov 22;9(1):17369. doi: 10.1038/s41598-019-53910-y.
16. Immature mice are more susceptible than adult mice to acetaminophen-induced acute liver injury. Lu Y, etal., Sci Rep. 2017 Feb 16;7:42736. doi: 10.1038/srep42736.
17. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
18. Programmed necrosis, not apoptosis, is a key mediator of cell loss and DAMP-mediated inflammation in dsRNA-induced retinal degeneration. Murakami Y, etal., Cell Death Differ. 2013 Aug 16. doi: 10.1038/cdd.2013.109.
19. Receptor interacting protein kinase mediates necrotic cone but not rod cell death in a mouse model of inherited degeneration. Murakami Y, etal., Proc Natl Acad Sci U S A. 2012 Sep 4;109(36):14598-603. doi: 10.1073/pnas.1206937109. Epub 2012 Aug 20.
20. Kinase RIP3 is dispensable for normal NF-kappa Bs, signaling by the B-cell and T-cell receptors, tumor necrosis factor receptor 1, and Toll-like receptors 2 and 4. Newton K, etal., Mol Cell Biol 2004 Feb;24(4):1464-9.
21. RIPK3 Activates Parallel Pathways of MLKL-Driven Necroptosis and FADD-Mediated Apoptosis to Protect against Influenza A Virus. Nogusa S, etal., Cell Host Microbe. 2016 Jul 13;20(1):13-24. doi: 10.1016/j.chom.2016.05.011. Epub 2016 Jun 16.
22. Close Relationship between cIAP2 and Human ARDS Induced by Severe H7N9 Infection. Qin C, etal., Biomed Res Int. 2019 Apr 7;2019:2121357. doi: 10.1155/2019/2121357. eCollection 2019.
23. GOA pipeline RGD automated data pipeline
24. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
25. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
26. Information Derived from GenBank Report RGD, Sept. 2003
27. Necroptosis mediators RIPK3 and MLKL suppress intracellular Listeria replication independently of host cell killing. Sai K, etal., J Cell Biol. 2019 Jun 3;218(6):1994-2005. doi: 10.1083/jcb.201810014. Epub 2019 Apr 11.
28. TNF-mediated alveolar macrophage necroptosis drives disease pathogenesis during Respiratory Syncytial Virus infection. Santos LD, etal., Eur Respir J. 2020 Dec 10. pii: 13993003.03764-2020. doi: 10.1183/13993003.03764-2020.
29. Loss of periodontal ligament fibroblasts by RIPK3-MLKL-mediated necroptosis in the progress of chronic periodontitis. Shi J, etal., Sci Rep. 2019 Feb 27;9(1):2902. doi: 10.1038/s41598-019-39721-1.
30. Is Receptor-Interacting Protein Kinase 3 a Viable Therapeutic Target for Mycobacterium tuberculosis Infection? Stutz MD, etal., Front Immunol. 2018 May 28;9:1178. doi: 10.3389/fimmu.2018.01178. eCollection 2018.
31. RNA viruses promote activation of the NLRP3 inflammasome through a RIP1-RIP3-DRP1 signaling pathway. Wang X, etal., Nat Immunol. 2014 Dec;15(12):1126-33. doi: 10.1038/ni.3015. Epub 2014 Oct 19.
32. Direct activation of RIP3/MLKL-dependent necrosis by herpes simplex virus 1 (HSV-1) protein ICP6 triggers host antiviral defense. Wang X, etal., Proc Natl Acad Sci U S A. 2014 Oct 28;111(43):15438-43. doi: 10.1073/pnas.1412767111. Epub 2014 Oct 14.
33. RIP1 kinase activity is critical for skin inflammation but not for viral propagation. Webster JD, etal., J Leukoc Biol. 2020 Jun;107(6):941-952. doi: 10.1002/JLB.3MA1219-398R. Epub 2020 Jan 27.
34. Adjunctive dexamethasone therapy improves lung injury by inhibiting inflammation and reducing RIP3 expression during Staphylococcus aureus pneumonia in mice. Wen SH, etal., Int Immunopharmacol. 2014 Dec;23(2):709-18. doi: 10.1016/j.intimp.2014.10.027.
35. Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis. Wu J, etal., Cell Res. 2013 Aug;23(8):994-1006. doi: 10.1038/cr.2013.91. Epub 2013 Jul 9.
36. Depletion of the Receptor-Interacting Protein Kinase 3 (RIP3) Decreases Photoreceptor Cell Death During the Early Stages of Ocular Murine Cytomegalovirus Infection. Xu J, etal., Invest Ophthalmol Vis Sci. 2018 May 1;59(6):2445-2458. doi: 10.1167/iovs.18-24086.
37. Inflammation and outer blood-retina barrier (BRB) compromise following choroidal murine cytomegalovirus (MCMV) infections. Xu J, etal., Mol Vis. 2018 May 18;24:379-394. eCollection 2018.
38. RIP3 deficiency ameliorates inflammatory response in mice infected with influenza H7N9 virus infection. Xu YL, etal., Oncotarget. 2017 Apr 25;8(17):27715-27724. doi: 10.18632/oncotarget.16016.
39. Influenza Virus Z-RNAs Induce ZBP1-Mediated Necroptosis. Zhang T, etal., Cell. 2020 Mar 19;180(6):1115-1129.e13. doi: 10.1016/j.cell.2020.02.050.
40. Bcl-xL mediates RIPK3-dependent necrosis in M. tuberculosis-infected macrophages. Zhao X, etal., Mucosal Immunol. 2017 Nov;10(6):1553-1568. doi: 10.1038/mi.2017.12. Epub 2017 Apr 12.
Additional References at PubMed
PMID:10490590   PMID:12477932   PMID:14743216   PMID:19498109   PMID:20042608   PMID:21052097   PMID:21368763   PMID:21402742   PMID:21737330   PMID:21876153   PMID:21931591   PMID:22037414  
PMID:22265413   PMID:22265414   PMID:22675671   PMID:22817896   PMID:24012422   PMID:24095729   PMID:24920296   PMID:25352744   PMID:25907058   PMID:26559832   PMID:26726877   PMID:26985994  
PMID:27258785   PMID:27281190   PMID:27377128   PMID:27514644   PMID:27622324   PMID:28289909   PMID:28501693   PMID:28579326   PMID:28816233   PMID:29883609   PMID:30215665   PMID:31082470  
PMID:31658855   PMID:32471717   PMID:32580628   PMID:33130681   PMID:33359086   PMID:34056794   PMID:34360749   PMID:34384567   PMID:34481142   PMID:34517258   PMID:34772825   PMID:35165268  
PMID:35464769   PMID:36223414   PMID:36424866   PMID:37909859  


Genomics

Comparative Map Data
Ripk3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81533,253,071 - 33,262,025 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1533,253,071 - 33,262,025 (-)EnsemblGRCr8
mRatBN7.21529,283,153 - 29,292,107 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1529,283,145 - 29,292,121 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1531,128,833 - 31,137,787 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01532,276,043 - 32,284,997 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01530,518,392 - 30,527,346 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01534,470,796 - 34,479,741 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1534,470,796 - 34,479,741 (-)Ensemblrn6Rnor6.0
Rnor_5.01538,359,304 - 38,368,247 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41533,947,406 - 33,956,351 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1528,858,091 - 28,867,036 (-)NCBICelera
RGSC_v3.11533,963,105 - 33,972,051 (-)NCBI
Cytogenetic Map15p13NCBI
RIPK3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381424,336,025 - 24,339,991 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1424,336,025 - 24,340,022 (-)Ensemblhg38GRCh38
GRCh371424,805,231 - 24,809,197 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361423,875,067 - 23,879,082 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341423,875,071 - 23,879,013NCBI
Celera144,669,852 - 4,673,867 (-)NCBICelera
Cytogenetic Map14q12NCBI
HuRef144,920,121 - 4,924,136 (-)NCBIHuRef
CHM1_11424,803,822 - 24,807,837 (-)NCBICHM1_1
T2T-CHM13v2.01418,534,370 - 18,538,336 (-)NCBIT2T-CHM13v2.0
Ripk3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391456,022,452 - 56,026,314 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1456,022,452 - 56,026,322 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381455,784,995 - 55,788,857 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1455,784,995 - 55,788,865 (-)Ensemblmm10GRCm38
MGSCv371456,403,832 - 56,407,694 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361454,739,068 - 54,742,857 (-)NCBIMGSCv36mm8
Celera1453,590,028 - 53,593,890 (-)NCBICelera
Cytogenetic Map14C3NCBI
cM Map1428.19NCBI
Ripk3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540935,937,880 - 35,965,712 (+)Ensembl
ChiLan1.0NW_00495540935,961,604 - 35,965,477 (+)NCBIChiLan1.0ChiLan1.0
RIPK3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21525,691,137 - 25,695,155 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11424,907,629 - 24,911,596 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0145,112,512 - 5,116,486 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11423,235,796 - 23,239,821 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1423,235,796 - 23,239,821 (-)EnsemblpanPan2panpan1.1
RIPK3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.184,304,167 - 4,309,514 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl84,305,250 - 4,309,325 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha84,227,031 - 4,231,283 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.084,416,047 - 4,420,326 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl84,416,051 - 4,420,261 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.184,106,383 - 4,110,679 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.084,168,389 - 4,172,700 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.084,430,799 - 4,435,106 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ripk3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864036,176,140 - 36,180,016 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936722209,013 - 212,839 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936722209,019 - 212,817 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RIPK3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl774,951,145 - 74,955,251 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1774,951,145 - 74,955,255 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2780,222,514 - 80,226,187 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RIPK3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1241,318,265 - 1,322,610 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl241,318,216 - 1,322,462 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603613,002,814 - 13,006,980 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ripk3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248208,165,546 - 8,169,172 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Ripk3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11269,214,912 - 69,218,677 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ripk3
86 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:32
Count of miRNA genes:32
Interacting mature miRNAs:32
Transcripts:ENSRNOT00000027759
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)15231575947315759Rat
5684946Bss98Bone structure and strength QTL 983.90.0026tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)15139411584Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15144836456Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15231575953331089Rat
152025253Hrtrt24Heart rate QTL 243.82heart pumping trait (VT:2000009)153185580392671517Rat
10755503Bp391Blood pressure QTL 3912.37arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)152272835342072050Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152852773273527732Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1525285835104695021Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)152233635152597086Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)1525285835104695021Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151915576287086765Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)15278592347785923Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151492659471614418Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)152233635167336351Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)1525285835104695021Rat

Markers in Region
RH129786  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21529,283,184 - 29,283,381 (+)MAPPERmRatBN7.2
Rnor_6.01534,470,819 - 34,471,015NCBIRnor6.0
Rnor_5.01538,359,330 - 38,359,526UniSTSRnor5.0
RGSC_v3.41533,947,429 - 33,947,625UniSTSRGSC3.4
Celera1528,858,114 - 28,858,310UniSTS
RH 3.4 Map15260.81UniSTS
Cytogenetic Map15p13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 158 91 90 59 92 59 6 356 192 11 137 81 92 31 13 13

Sequence


Ensembl Acc Id: ENSRNOT00000027759   ⟹   ENSRNOP00000027759
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1533,253,071 - 33,262,025 (-)Ensembl
mRatBN7.2 Ensembl1529,283,160 - 29,292,101 (-)Ensembl
Rnor_6.0 Ensembl1534,470,796 - 34,479,741 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097021   ⟹   ENSRNOP00000078176
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1533,253,450 - 33,262,025 (-)Ensembl
mRatBN7.2 Ensembl1529,283,145 - 29,292,110 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000117419   ⟹   ENSRNOP00000087719
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1533,253,071 - 33,262,025 (-)Ensembl
mRatBN7.2 Ensembl1529,283,159 - 29,292,121 (-)Ensembl
RefSeq Acc Id: NM_139342   ⟹   NP_647558
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81533,253,071 - 33,262,025 (-)NCBI
mRatBN7.21529,283,153 - 29,292,107 (-)NCBI
Rnor_6.01534,470,796 - 34,479,741 (-)NCBI
Rnor_5.01538,359,304 - 38,368,247 (-)NCBI
RGSC_v3.41533,947,406 - 33,956,351 (-)RGD
Celera1528,858,091 - 28,867,036 (-)RGD
Sequence:
RefSeq Acc Id: XM_039092983   ⟹   XP_038948911
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81533,253,077 - 33,256,737 (-)NCBI
mRatBN7.21529,283,153 - 29,286,823 (-)NCBI
RefSeq Acc Id: XM_063273965   ⟹   XP_063130035
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81533,253,077 - 33,256,977 (-)NCBI
RefSeq Acc Id: XM_063273966   ⟹   XP_063130036
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81533,253,077 - 33,259,328 (-)NCBI
RefSeq Acc Id: NP_647558   ⟸   NM_139342
- UniProtKB: Q9Z2P5 (UniProtKB/Swiss-Prot),   B0BMV6 (UniProtKB/Swiss-Prot),   A0A8I6A4Y2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000027759   ⟸   ENSRNOT00000027759
RefSeq Acc Id: XP_038948911   ⟸   XM_039092983
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A4Y2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000087719   ⟸   ENSRNOT00000117419
Ensembl Acc Id: ENSRNOP00000078176   ⟸   ENSRNOT00000097021
RefSeq Acc Id: XP_063130036   ⟸   XM_063273966
- Peptide Label: isoform X1
- UniProtKB: Q9Z2P5 (UniProtKB/Swiss-Prot),   B0BMV6 (UniProtKB/Swiss-Prot),   A0A8I6A4Y2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063130035   ⟸   XM_063273965
- Peptide Label: isoform X1
- UniProtKB: Q9Z2P5 (UniProtKB/Swiss-Prot),   B0BMV6 (UniProtKB/Swiss-Prot),   A0A8I6A4Y2 (UniProtKB/TrEMBL)
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z2P5-F1-model_v2 AlphaFold Q9Z2P5 1-478 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699691
Promoter ID:EPDNEW_R10214
Type:multiple initiation site
Name:Ripk3_1
Description:receptor-interacting serine-threonine kinase 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01534,479,752 - 34,479,812EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628899 AgrOrtholog
BioCyc Gene G2FUF-13685 BioCyc
Ensembl Genes ENSRNOG00000020465 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000027759 ENTREZGENE
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7378607 IMAGE-MGC_LOAD
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  RHIM_dom UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
  Ser/Thr_Kinases-Pseudokinases UniProtKB/Swiss-Prot
KEGG Report rno:246240 UniProtKB/Swiss-Prot
MGC_CLONE MGC:187331 IMAGE-MGC_LOAD
NCBI Gene 246240 ENTREZGENE
PANTHER RECEPTOR-INTERACTING SERINE_THREONINE-PROTEIN KINASE 3 UniProtKB/Swiss-Prot
  SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED UniProtKB/Swiss-Prot
Pfam Pkinase UniProtKB/Swiss-Prot
  RHIM UniProtKB/Swiss-Prot
PhenoGen Ripk3 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000020465 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot
UniProt A0A8I5Y215_RAT UniProtKB/TrEMBL
  A0A8I6A4Y2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QEU9_RAT UniProtKB/TrEMBL
  B0BMV6 ENTREZGENE
  Q9Z2P5 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary B0BMV6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-04-22 Ripk3  receptor-interacting serine-threonine kinase 3  Hcyp2  homocysteine respondent protein HCYP2  Symbol and Name updated to reflect Human and Mouse nomenclature 625702 APPROVED
2003-02-27 Hcyp2  homocysteine respondent protein HCYP2      Symbol and Name status set to provisional 70820 PROVISIONAL