Elavl3 (ELAV like RNA binding protein 3) - Rat Genome Database

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Pathways
Gene: Elavl3 (ELAV like RNA binding protein 3) Rattus norvegicus
Analyze
Symbol: Elavl3
Name: ELAV like RNA binding protein 3
RGD ID: 628892
Description: Predicted to enable mRNA 3'-UTR AU-rich region binding activity. Predicted to be part of ribonucleoprotein complex. Orthologous to human ELAVL3 (ELAV like RNA binding protein 3); INTERACTS WITH 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil; amitrole.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C); ELAV like neuron-specific RNA binding protein 3; ELAV-like protein 3; Huc
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8828,823,120 - 28,859,395 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl828,825,707 - 28,859,659 (-)EnsemblGRCr8
mRatBN7.2820,547,108 - 20,583,369 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl820,550,201 - 20,583,641 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx824,579,147 - 24,611,936 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0822,876,290 - 22,909,074 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0820,779,781 - 20,812,548 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0823,029,980 - 23,063,477 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl823,030,118 - 23,063,041 (-)Ensemblrn6Rnor6.0
Rnor_5.0823,084,379 - 23,118,191 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4821,124,168 - 21,158,232 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera821,940,907 - 21,973,831 (-)NCBICelera
RGSC_v3.1821,124,167 - 21,158,232 (-)NCBI
Cytogenetic Map8q13NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Two different RNA binding activities for the AU-rich element and the poly(A) sequence of the mouse neuronal protein mHuC. Abe R, etal., Nucleic Acids Res 1996 Dec 15;24(24):4895-901.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10710437   PMID:10734193   PMID:17534028   PMID:21139978  


Genomics

Comparative Map Data
Elavl3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8828,823,120 - 28,859,395 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl828,825,707 - 28,859,659 (-)EnsemblGRCr8
mRatBN7.2820,547,108 - 20,583,369 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl820,550,201 - 20,583,641 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx824,579,147 - 24,611,936 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0822,876,290 - 22,909,074 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0820,779,781 - 20,812,548 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0823,029,980 - 23,063,477 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl823,030,118 - 23,063,041 (-)Ensemblrn6Rnor6.0
Rnor_5.0823,084,379 - 23,118,191 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4821,124,168 - 21,158,232 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera821,940,907 - 21,973,831 (-)NCBICelera
RGSC_v3.1821,124,167 - 21,158,232 (-)NCBI
Cytogenetic Map8q13NCBI
ELAVL3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381911,451,326 - 11,481,046 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1911,451,326 - 11,481,051 (-)Ensemblhg38GRCh38
GRCh371911,562,141 - 11,591,861 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361911,423,143 - 11,452,803 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341911,423,142 - 11,452,803NCBI
Celera1911,456,881 - 11,486,541 (-)NCBICelera
Cytogenetic Map19p13.2NCBI
HuRef1911,137,134 - 11,166,414 (-)NCBIHuRef
CHM1_11911,562,173 - 11,591,868 (-)NCBICHM1_1
T2T-CHM13v2.01911,578,845 - 11,608,554 (-)NCBIT2T-CHM13v2.0
Elavl3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39921,926,301 - 21,963,442 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl921,926,301 - 21,963,319 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38922,015,005 - 22,052,146 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl922,015,005 - 22,052,023 (-)Ensemblmm10GRCm38
MGSCv37921,819,449 - 21,856,467 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36921,768,178 - 21,802,412 (-)NCBIMGSCv36mm8
Celera919,284,693 - 19,320,956 (-)NCBICelera
Cytogenetic Map9A3NCBI
cM Map98.07NCBI
Elavl3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554952,338,939 - 2,360,403 (-)Ensembl
ChiLan1.0NW_0049554952,338,939 - 2,360,843 (-)NCBIChiLan1.0ChiLan1.0
ELAVL3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22016,363,952 - 16,393,714 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11915,362,956 - 15,392,733 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01910,997,557 - 11,027,182 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11911,711,640 - 11,738,203 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1911,711,767 - 11,737,764 (-)EnsemblpanPan2panpan1.1
ELAVL3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12049,886,379 - 49,904,706 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2049,886,786 - 49,901,523 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2049,757,532 - 49,776,022 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02050,404,673 - 50,423,192 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2050,404,647 - 50,422,015 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12049,614,995 - 49,633,488 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02050,041,138 - 50,059,631 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02050,284,316 - 50,302,818 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Elavl3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118208,823,223 - 208,841,455 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366591,515,149 - 1,531,569 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366591,514,632 - 1,531,486 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ELAVL3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl270,117,060 - 70,134,348 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1270,114,475 - 70,134,348 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2270,469,885 - 70,487,104 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ELAVL3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1610,378,651 - 10,405,198 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660749,481,215 - 9,510,828 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Elavl3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248283,229,283 - 3,248,476 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248283,227,766 - 3,248,488 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Elavl3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1818,268,199 - 18,302,289 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Elavl3
176 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:57
Count of miRNA genes:40
Interacting mature miRNAs:49
Transcripts:ENSRNOT00000018416
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357398Slep3Serum leptin concentration QTL 33.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)81799410550763951Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)81699464261994642Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)81038254055382540Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)81296416557964165Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)81595227960952279Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)81296416557964165Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)81799386262252873Rat
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)81038254055382540Rat
9590084Insglur5Insulin/glucose ratio QTL 518.540.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)8132882639Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)81038254055382540Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)81699464261994642Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)81296416557964165Rat
2302367Slep5Serum leptin concentration QTL 53.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)81799410550763951Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)81038254055382540Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
13 9 54 160 65 62 33 50 33 6 256 131 7 142 71 72 29 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000018416   ⟹   ENSRNOP00000018416
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl828,826,106 - 28,859,013 (-)Ensembl
mRatBN7.2 Ensembl820,550,696 - 20,583,002 (-)Ensembl
Rnor_6.0 Ensembl823,030,118 - 23,063,041 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000094895   ⟹   ENSRNOP00000097959
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl828,825,707 - 28,859,659 (-)Ensembl
mRatBN7.2 Ensembl820,550,201 - 20,583,641 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000113602   ⟹   ENSRNOP00000092942
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl820,550,201 - 20,569,204 (-)Ensembl
RefSeq Acc Id: NM_172324   ⟹   NP_758827
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8828,826,250 - 28,859,013 (-)NCBI
mRatBN7.2820,550,242 - 20,583,002 (-)NCBI
Rnor_6.0823,030,252 - 23,063,015 (-)NCBI
Rnor_5.0823,084,379 - 23,118,191 (-)NCBI
RGSC_v3.4821,124,168 - 21,158,232 (-)RGD
Celera821,940,907 - 21,973,831 (-)RGD
Sequence:
RefSeq Acc Id: XM_006242616   ⟹   XP_006242678
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8828,823,120 - 28,859,395 (-)NCBI
mRatBN7.2820,547,108 - 20,583,369 (-)NCBI
Rnor_6.0823,029,980 - 23,063,477 (-)NCBI
Rnor_5.0823,084,379 - 23,118,191 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017595490   ⟹   XP_017450979
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8828,823,120 - 28,859,393 (-)NCBI
mRatBN7.2820,547,108 - 20,583,369 (-)NCBI
Rnor_6.0823,029,980 - 23,063,477 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063264993   ⟹   XP_063121063
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8828,823,120 - 28,859,380 (-)NCBI
RefSeq Acc Id: NP_758827   ⟸   NM_172324
- UniProtKB: Q76IJ9 (UniProtKB/TrEMBL),   A0A8I6AIP7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242678   ⟸   XM_006242616
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AIP7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017450979   ⟸   XM_017595490
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AIP7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000018416   ⟸   ENSRNOT00000018416
Ensembl Acc Id: ENSRNOP00000097959   ⟸   ENSRNOT00000094895
Ensembl Acc Id: ENSRNOP00000092942   ⟸   ENSRNOT00000113602
RefSeq Acc Id: XP_063121063   ⟸   XM_063264993
- Peptide Label: isoform X3
- UniProtKB: A0A8I6AIP7 (UniProtKB/TrEMBL)
Protein Domains
RRM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q76IJ9-F1-model_v2 AlphaFold Q76IJ9 1-367 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628892 AgrOrtholog
BioCyc Gene G2FUF-31395 BioCyc
Ensembl Genes ENSRNOG00000013752 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000018416 ENTREZGENE
  ENSRNOT00000018416.7 UniProtKB/TrEMBL
  ENSRNOT00000094895.2 UniProtKB/TrEMBL
Gene3D-CATH 3.30.70.330 UniProtKB/TrEMBL
InterPro ELAD_HUD_SF UniProtKB/TrEMBL
  HuC_RRM3 UniProtKB/TrEMBL
  Hud_Sxl_RNA UniProtKB/TrEMBL
  Nucleotide-bd_a/b_plait_sf UniProtKB/TrEMBL
  RBD_domain_sf UniProtKB/TrEMBL
  RRM_dom_euk UniProtKB/TrEMBL
  RRM_RNP1 UniProtKB/TrEMBL
KEGG Report rno:282824 UniProtKB/TrEMBL
NCBI Gene 282824 ENTREZGENE
PANTHER EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G UniProtKB/TrEMBL
Pfam RRM_1 UniProtKB/TrEMBL
PhenoGen Elavl3 PhenoGen
PRINTS HUDSXLRNA UniProtKB/TrEMBL
PROSITE RRM UniProtKB/TrEMBL
RatGTEx ENSRNOG00000013752 RatGTEx
SMART RRM UniProtKB/TrEMBL
  RRM_1 UniProtKB/TrEMBL
Superfamily-SCOP SSF54928 UniProtKB/TrEMBL
UniProt A0A8I6AIP7 ENTREZGENE
  A0A8I6ATM0_RAT UniProtKB/TrEMBL
  A6JNX6_RAT UniProtKB/TrEMBL
  F7F578_RAT UniProtKB/TrEMBL
  Q76IJ9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-09-09 Elavl3  ELAV like RNA binding protein 3  Elavl3  ELAV like neuron-specific RNA binding protein 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-11-11 Elavl3  ELAV like neuron-specific RNA binding protein 3  Elavl3  ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Elavl3  ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)      Symbol and Name status set to approved 1299863 APPROVED
2003-02-27 Elavl3  ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)      Symbol and Name status set to provisional 70820 PROVISIONAL