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Gene: Cacng6 (calcium voltage-gated channel auxiliary subunit gamma 6) Rattus norvegicus

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Symbol:

Cacng6

Name:

calcium voltage-gated channel auxiliary subunit gamma 6

RGD ID:

628806

Description:

Predicted to enable calcium channel regulator activity. Predicted to be involved in regulation of calcium ion transmembrane transport via high voltage-gated calcium channel. Predicted to be located in plasma membrane. Predicted to be part of L-type voltage-gated calcium channel complex. Human ortholog(s) of this gene implicated in aspirin-induced respiratory disease. Orthologous to human CACNG6 (calcium voltage-gated channel auxiliary subunit gamma 6); PARTICIPATES IN arrhythmogenic right ventricular cardiomyopathy pathway; dilated cardiomyopathy pathway; hypertrophic cardiomyopathy pathway; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

calcium channel, voltage-dependent, gamma subunit 6; neuronal voltage-gated calcium channel gamma-6 subunit; voltage-dependent calcium channel gamma-6 subunit

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	74,648,342 - 74,663,351 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	1	74,648,063 - 74,662,753 (-)	Ensembl				GRCr8
mRatBN7.2	1	65,732,910 - 65,747,377 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	65,732,632 - 65,747,341 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	1	71,181,802 - 71,194,434 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	79,604,793 - 79,617,422 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	72,937,662 - 72,950,514 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	64,307,684 - 64,322,124 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	64,305,438 - 64,321,241 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	1	63,300,009 - 63,312,647 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	1	64,046,624 - 64,059,262 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	63,457,558 - 63,470,196 (-)	NCBI		Celera
RGSC_v3.1	1	64,123,370 - 64,136,009 (-)	NCBI
Cytogenetic Map	1	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

aspirin-induced respiratory disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17beta-estradiol (EXP)

17beta-estradiol 3-benzoate (EXP)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

5-aza-2'-deoxycytidine (ISO)

6-propyl-2-thiouracil (EXP)

acetylsalicylic acid (ISO)

acrylamide (EXP)

Aflatoxin B2 alpha (ISO)

all-trans-retinoic acid (ISO)

alpha-Zearalanol (EXP)

ammonium chloride (EXP)

androgen antagonist (EXP)

arsenite(3-) (ISO)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

bis(2-ethylhexyl) phthalate (EXP,ISO)

bisphenol A (EXP)

butan-2-one (ISO)

butanal (ISO)

Butylparaben (EXP)

CGP 52608 (ISO)

cisplatin (ISO)

DDE (EXP)

deoxynivalenol (ISO)

dibutyl phthalate (EXP)

enzacamene (EXP)

epoxiconazole (EXP)

folic acid (ISO)

hydralazine (ISO)

linuron (EXP)

methapyrilene (ISO)

Nor-9-carboxy-delta9-THC (ISO)

paracetamol (EXP)

perfluorooctanoic acid (EXP)

prochloraz (EXP)

procymidone (EXP)

quercetin (EXP)

silicon dioxide (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium arsenite (ISO)

testosterone (EXP)

titanium dioxide (ISO)

triclosan (ISO)

triptonide (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

calcium ion transmembrane transport (IEA)

calcium ion transport (IEA)

monoatomic ion transmembrane transport (IEA)

monoatomic ion transport (IEA)

regulation of calcium ion transmembrane transport via high voltage-gated calcium channel (IBA)

regulation of transmembrane transport (IEA)

Cellular Component

L-type voltage-gated calcium channel complex (IBA,IEA,ISO,ISS)

membrane (IEA)

monoatomic ion channel complex (IEA)

plasma membrane (IEA)

plasma membrane protein complex (IEA)

Molecular Function

calcium channel activity (IEA)

calcium channel regulator activity (IBA,IEA,ISO,ISS)

Molecular Pathway Annotations Click to see Annotation Detail View

arrhythmogenic right ventricular cardiomyopathy pathway (IEA)

dilated cardiomyopathy pathway (IEA)

hypertrophic cardiomyopathy pathway (IEA)

mitogen activated protein kinase signaling pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Calcium channel gamma subunits provide insights into the evolution of this gene family.	Chu PJ, etal., Gene 2001 Dec 12;280(1-2):37-48.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	Association of CACNG6 polymorphisms with aspirin-intolerance asthmatics in a Korean population.	Lee JS, etal., BMC Med Genet. 2010 Sep 23;11:138. doi: 10.1186/1471-2350-11-138.
5.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:21127204

Genomics

Comparative Map Data

Cacng6
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	74,648,342 - 74,663,351 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	1	74,648,063 - 74,662,753 (-)	Ensembl				GRCr8
mRatBN7.2	1	65,732,910 - 65,747,377 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	65,732,632 - 65,747,341 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	1	71,181,802 - 71,194,434 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	79,604,793 - 79,617,422 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	72,937,662 - 72,950,514 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	64,307,684 - 64,322,124 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	64,305,438 - 64,321,241 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	1	63,300,009 - 63,312,647 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	1	64,046,624 - 64,059,262 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	63,457,558 - 63,470,196 (-)	NCBI		Celera
RGSC_v3.1	1	64,123,370 - 64,136,009 (-)	NCBI
Cytogenetic Map	1	q12	NCBI

CACNG6
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	53,991,149 - 54,012,666 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	53,991,637 - 54,012,666 (+)	Ensembl			hg38	GRCh38
GRCh37	19	54,494,403 - 54,515,920 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	59,187,354 - 59,207,732 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	19	59,187,353 - 59,207,730	NCBI
Celera	19	51,535,226 - 51,555,565 (+)	NCBI		Celera
Cytogenetic Map	19	q13.42	NCBI
HuRef	19	50,810,383 - 50,831,805 (+)	NCBI		HuRef
CHM1_1	19	54,496,244 - 54,517,710 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	19	57,069,639 - 57,091,148 (+)	NCBI		T2T-CHM13v2.0

Cacng6
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	3,472,017 - 3,484,183 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	3,472,711 - 3,484,183 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	7	3,423,588 - 3,435,667 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	3,424,195 - 3,435,667 (+)	Ensembl			mm10	GRCm38
MGSCv37	7	3,425,423 - 3,435,658 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	7	3,425,423 - 3,435,658 (+)	NCBI		MGSCv36	mm8
Celera	7	3,377,053 - 3,387,288 (+)	NCBI		Celera
Cytogenetic Map	7	A1	NCBI
cM Map	7	2.0	NCBI

Cacng6
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955604	185,430 - 205,088 (-)	Ensembl
ChiLan1.0	NW_004955604	189,261 - 205,058 (-)	NCBI	ChiLan1.0	ChiLan1.0

CACNG6
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	59,999,202 - 60,023,957 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	61,920,987 - 61,945,772 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	50,927,916 - 50,948,924 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	59,773,543 - 59,793,332 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	59,774,925 - 59,793,079 (+)	Ensembl			panPan2	panpan1.1

CACNG6
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	103,227,936 - 103,244,263 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	1	103,226,597 - 103,244,441 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	103,289,931 - 103,306,120 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	103,878,215 - 103,894,406 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	103,877,486 - 103,893,318 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	103,510,951 - 103,527,115 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	103,272,646 - 103,288,832 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	103,991,621 - 104,007,776 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Cacng6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	2,766,204 - 2,784,098 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936994	158,620 - 171,601 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936994	158,621 - 171,597 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CACNG6
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	56,129,834 - 56,151,133 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	6	56,123,598 - 56,151,145 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	53,064,115 - 53,085,470 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CACNG6
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	46,680,827 - 46,700,959 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	46,682,088 - 46,700,938 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666073	26,756,313 - 26,777,591 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Cacng6
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624832	2,491,281 - 2,500,653 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624832	2,491,372 - 2,500,622 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Cacng6
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	2	178,059,347 - 178,072,140 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Cacng6
90 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	270
Count of miRNA genes:	102
Interacting mature miRNAs:	107
Transcripts:	ENSRNOT00000019191, ENSRNOT00000019211
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1331732	Srn4	Serum renin concentration QTL 4	4.467		renin activity (VT:0005581)	plasma renin activity level (CMO:0000116)	1	43457837	87558729	Rat
1578649	Bmd8	Bone mineral density QTL 8	4.9		femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	1	51940904	101229020	Rat
1358359	Sradr1	Stress Responsive Adrenal Weight QTL 1	4.74		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	1	39728272	132889942	Rat
4889929	Bss87	Bone structure and strength QTL 87	6.7		tibia area (VT:1000281)	tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)	1	46302615	91302615	Rat
634314	Niddm44	Non-insulin dependent diabetes mellitus QTL 44			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	51941022	208479811	Rat
1331792	Rf29	Renal function QTL 29	4.589		urine potassium amount (VT:0010539)	urine potassium level (CMO:0000128)	1	43457837	87558729	Rat
2313062	Bmd73	Bone mineral density QTL 73	3.9	0.0001	tibia mineral mass (VT:1000283)	compact volumetric bone mineral density (CMO:0001730)	1	46302615	91302615	Rat
8552900	Pigfal1	Plasma insulin-like growth factor 1 level QTL 1	7.4		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	1	43509952	88509952	Rat
1578654	Bss10	Bone structure and strength QTL 10	4		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	1	51940904	168768703	Rat
1354643	Foco2	Food consumption QTL 2	7.17	0.0001	eating behavior trait (VT:0001431)	food intake rate (CMO:0000427)	1	42122968	87122968	Rat
2313065	Bss67	Bone structure and strength QTL 67	3.1	0.0001	tibia area (VT:1000281)	tibia total energy absorbed before break (CMO:0001736)	1	46302615	91302615	Rat
2313069	Bss68	Bone structure and strength QTL 68	2.9	0.0001	tibia size trait (VT:0100001)	tibia total energy absorbed before break (CMO:0001736)	1	46302615	91302615	Rat
631495	Bp96	Blood pressure QTL 96	4.52		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	66404680	111404680	Rat
70225	Bp58	Blood pressure QTL 58	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	34184556	172281316	Rat
2313075	Bss66	Bone structure and strength QTL 66	3.4	0.0001	tibia length (VT:0004357)	tibia length (CMO:0000450)	1	46302615	91302615	Rat
2298545	Neuinf8	Neuroinflammation QTL 8	4.6		nervous system integrity trait (VT:0010566)	spinal cord beta-2 microglobulin mRNA level (CMO:0002125)	1	66009857	160501508	Rat
10059597	Bp377	Blood pressure QTL 377	3.42	0.025	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	34565911	208798288	Rat
1331778	Rf28	Renal function QTL 28	4.66		urine potassium amount (VT:0010539)	urine potassium excretion rate (CMO:0000761)	1	43457837	87558729	Rat
2313077	Bss69	Bone structure and strength QTL 69	3.5	0.0001	tibia strength trait (VT:1000284)	bone polar moment of inertia (CMO:0001558)	1	46302615	91302615	Rat
1302788	Scl19	Serum cholesterol QTL 19	4.6	0.001	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	1	66400974	132889942	Rat
2313402	Anxrr24	Anxiety related response QTL 24			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	1	51511344	153680016	Rat
1331785	Rf27	Renal function QTL 27	4.643		urine sodium amount (VT:0006274)	urine sodium level (CMO:0000129)	1	30708375	87558729	Rat
61342	Bp27	Blood pressure QTL 27	3.4	0.0006	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	65405637	96805205	Rat
1300172	Bp172	Blood pressure QTL 172	3.56		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	1	34565726	79565726	Rat
4889962	Bss94	Bone structure and strength QTL 94	3.8		tibia area (VT:1000281)	tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)	1	51909206	91302615	Rat
6903308	Scl36	Serum cholesterol QTL 36	2	0.0125	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	1	58769992	103769992	Rat
2313092	Bmd72	Bone mineral density QTL 72	2.5	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	1	46302615	91302615	Rat
2300164	Bmd44	Bone mineral density QTL 44	5.4	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	1	66077886	111077886	Rat
2313097	Bss70	Bone structure and strength QTL 70	3.5	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	1	46302615	91302615	Rat
9589820	Insglur3	Insulin/glucose ratio QTL 3	10.75	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	1	43509952	88509952	Rat
152025249	Scl82	Serum cholesterol level QTL 82	4.77		blood cholesterol amount (VT:0000180)		1	52891222	109116986	Rat
1354599	Bw29	Body weight QTL 29	3.46	0.001	body mass (VT:0001259)	body weight (CMO:0000012)	1	42122968	87122968	Rat
4889919	Bss86	Bone structure and strength QTL 86	4.1		tibia area (VT:1000281)	tibia midshaft total cross-sectional area (CMO:0001715)	1	46302615	91302615	Rat
8552948	Pigfal11	Plasma insulin-like growth factor 1 level QTL 11	4.7		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	1	43509952	88509952	Rat

Markers in Region

AI502101

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	65,733,423 - 65,733,635 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	64,308,198 - 64,308,409	NCBI	Rnor6.0
Rnor_5.0	1	63,299,801 - 63,300,012	UniSTS	Rnor5.0
RGSC_v3.4	1	64,046,416 - 64,046,627	UniSTS	RGSC3.4
Celera	1	63,457,350 - 63,457,561	UniSTS
Cytogenetic Map	1	q12	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
10	12	62	130	66	65	34	79	34	6	266	174	11	101	40	62	31	4	4

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_080694	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008758749	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC114434	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC128446	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF361343	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF361344	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474101	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000081837 ⟹ ENSRNOP00000074853

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	1	64,305,438 - 64,321,241 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000106854 ⟹ ENSRNOP00000092698

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	74,648,342 - 74,662,753 (-)	Ensembl
mRatBN7.2 Ensembl	1	65,733,632 - 65,747,341 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000111328 ⟹ ENSRNOP00000095459

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	74,648,063 - 74,662,753 (-)	Ensembl
mRatBN7.2 Ensembl	1	65,732,632 - 65,747,341 (-)	Ensembl

RefSeq Acc Id:

NM_080694 ⟹ NP_542425

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	74,648,342 - 74,662,753 (-)	NCBI
mRatBN7.2	1	65,732,910 - 65,747,319 (-)	NCBI
Rnor_6.0	1	64,308,406 - 64,321,044 (-)	NCBI
Rnor_5.0	1	63,300,009 - 63,312,647 (-)	NCBI
RGSC_v3.4	1	64,046,624 - 64,059,262 (-)	RGD
Celera	1	63,457,558 - 63,470,196 (-)	RGD

Sequence:

show sequence

ATGATGTGGTCTAACTTCTTCATGCAAGAGGAAGACCGTCGTCGGACGGCTGTGGGCCGGCGTC
GTGCCCAAGAACAGCAGAATCTCGGCTTGACTCCGGAGCGAGAGGGCAAGATCAAGCTGGGGTT
GCTGGTGGCTATCGTGGGTGCCACTCTGGCTGTGCTAGCTGTGGGCACCGAGTTCTGGGTGGAA
CTCAATACATACAAGACCAACGGCAGCGCCGTCTGTGAGGCCGCCCATTTGGGGCTGTGGAAGG
TGTGCATCAAGCGACTGTGGCAGGCGGATGTACCCGCGGGCAGGGAGACCTGTGGCCCAGCTGA
GCTGCCAGGAGAAGCAAACTGCACCTACTTCAAGTTCTTCACCACGGGGGAAAATGCGCACATC
TTCCAGAGAACCACCAAGAAAGAGGTAAACCTGGCAGCTGCTGTGATAGCTGTGCTGGGCCTGA
CAGCCATGGCCTTGGGCTGCCTCTGTGTCATCATGGTGCTCAGTAAAGGTGCAGAGTTCCTGCT
CCGCTTGGGAGCTGTCTGCTTTGGCCTCTCAGGCCTGCTGCTCTTTGTCAGCCTGGAGGTGTTC
CGGCATTCCGTCAGAGCCCTGCTGCAGGGGGTCAACCCTGAGACCCCTCCAGCTCCACGCCTGG
CCTATGAGTATTCCTGGTCCCTAGGCTGTGGTGTGGGCGCTGGTCTAATCCTGCTGCTGGGGGG
AGTCTGTTTCCTCCTGCTCACCCTGCCTTCCTGGCCCTGGAGGTCACTGTGCCCCAAGCGGGGT
GGCCCAACTGCCTAG

hide sequence

RefSeq Acc Id:

XM_008758749 ⟹ XP_008756971

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	74,648,342 - 74,663,351 (-)	NCBI
mRatBN7.2	1	65,732,910 - 65,747,377 (-)	NCBI
Rnor_6.0	1	64,307,684 - 64,322,124 (-)	NCBI

Sequence:

show sequence

GCAGGGAGCGAGCGCAGCAGGTCCGGAGGGCTGACTGGGTAGTGGCGAGCAAAGCCGGACGCTT
CGGAGGCATCGCGGAGCTGGGGCCGTCGCGGCGCAGAGGCAGGAGAGCTCAAGGGACCCGTGCC
GGGGAGACCCGGGTGGGAAGCCCAAAGGGAGCGCGGGACCCCGAGCTGAGTCTGGAGCGATCCT
GGCCGAGCAGGCCTTGGGAGCCTGGGGGAGGGGGAGCCGAGTGACTGCAGACAGACTGACTGAG
AGTCCCTTTCCAAGCCCTGTGTCCCCCAGGGTATTTATTTTGCCCTGGTTTTCTGAGCCTGAGT
GTGGACCACAGTGCCTTGATCTAAGCCCTGTCCTGACTACAGGTTTTCCTCCTGGGCCCTCAGA
GTGGCCCCCGGCCTCTTTTTCTGGACCTCACTGTGATTCTCAGCCACTGTGGGAGACCTGGACT
CTTTTCTGAGCAGTTCCTGGCTTGCCTATACTCCCTCGAATTCCATTGGGGCCCCGAATTAACT
GTGAATACTGGAGGATTCTCCTTGCCTTTCAGACTTGGAGAGATATCAAACTTTACCTGTGAAA
TCCCAATTCTAACTCTTGTATTGCCCAAAAGTGTACTGATTTCTCCTTTCTCAAAGTCTGAGCC
TGAAGAAACTTAAACTATCTCCTCAAACACATGAAAGACCTCAGCTTCCCTCTTTGGGAAAACT
CTGAGGCTTACTGGAGACCCCATCAGCAGCCTATAGAGACTGGACAAGTTTTCCCCCTGGGTTC
TTCAGTCTTCCTCTTGGGTCCGTAAACTTCAGAGTAGCCTAGCTTTTTTCCTAGGCCTCACCTG
TGCCAACTTCATGTGCACAAGCCCTGGCGGCATCCTTAGGCCAAGACTATAGTTAGTTTCTCTT
CTCAGGGGCAGAGGCCTCCACTCTTGCATTTCGGGTTCAGCTTTTTCTCATTCCCAATCTGATT
GACACTGAGGCCACTACTTCCTTTGAAAGTGCAGGCCCTGCTCCCTGCCCCTTAAGACCCCTCT
GCACGGGTCTTTCTGACTCCTTGAAGCTCTCCTGAGCCCCAGCCGATCCCATCATCATGATGTG
GTCTAACTTCTTCATGCAAGAGGAAGACCGTCGTCGGACGGCTGTGGGCCGGCGTCGTGCCCAA
GAACAGCAGAATCTCGGCTTGACTCCGGAGCGAGAGGGCAAGATCAAGCTGGGGTTGCTGGTGG
CTATCGTGGGTGCCACTCTGGCTGTGCTAGCTGTGGGCACCGAGTTCTGGGTGGAACTCAATAC
ATACAAGACCAACGGCAGCGCCGTCTGTGAGGCCGCCCATTTGGGGCTGTGGAAGGTGTGCATC
AAGCGACTGTGGCAGGCGGATGTACCCGCGGGCAGGGAGACCTGTGGCCCAGCTGAGCTGCCAG
GAGAAGCAAACTGCACCTACTTCAAGTTCTTCACCACGGGGGAAAATGCGCACATCTTCCAGAG
AACCACCAAGAAAGGCCTGCTGCTCTTTGTCAGCCTGGAGGTGTTCCGGCATTCCGTCAGAGCC
CTGCTGCAGGGGGTCAACCCTGAGACCCCTCCAGCTCCACGCCTGGCCTATGAGTATTCCTGGT
CCCTAGGCTGTGGTGTGGGCGCTGGTCTAATCCTGCTGCTGGGGGGAGTCTGTTTCCTCCTGCT
CACCCTGCCTTCCTGGCCCTGGAGGTCACTGTGCCCCAAGCGGGGTGGCCCAACTGCCTAGAGC
GCTGGCCTGCTTTCTGAAGGCATCTGCCAACCCTGCCTCAGTTTCCAGCTTTCTCCTCAGGACT
TTTCATCTCTCTTCTAGAGAAACTGTTTTTCCCACTCTGGTGGGCTCATTTCACAAAATGTCTT
GGTCCCTCATCTTCTCTCTGTAAATAATGCCTTTGGGGGTGTGGGGAATGGCTCAGTAAGTAAA
TCGCTTGCTGAGCAAGCTTGAGGACTTGGAATTTGAGTCCCCAGAACTCACTTTAAAAGCCAGC
ACAGTAGTCCATGTCTATAATTCCAATGTTGGGAAGGCAGAGATTAGAGGAACCTTGGAGCTCA
CTGACCAGTTAGCCTAGTCAATTATTGAGGTCAGGTTCAGTGAGAGACCCTGTCTCAAACAATA
AGGCAGGAGCAACAAAGGAAGATGCCTGATGCTAAACTCTGACACACACACACACACACACACA
CACACACACACACACACACACACACCACAGTAGTTGAATTTGGGTTGCTTGAGGTAGGATGGGA
AGTTCCCTGGGGAAACTTCTAGGGATCCGATGGGAGATGGATGGGTGAAAGGGCTGGGGTCCCA
GAAGGATTTGGGAGCTTTCTTTCCAATTCCTCGCTGATCCACGGAATGGAGAGACGTCCTACAA
CTGCTGGATGGAACAAGGAAGAGCCCGGGTCCAACTTCACTGTCATCAGACTTGGGATTAAAGG
TTTGAAGATGTGACA

hide sequence

Protein Sequences


Protein RefSeqs	NP_542425	(Get FASTA)	NCBI Sequence Viewer
	XP_008756971	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAL50038	(Get FASTA)	NCBI Sequence Viewer
	AAL50039	(Get FASTA)	NCBI Sequence Viewer
	EDL84943	(Get FASTA)	NCBI Sequence Viewer
	EDL84944	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000092698
	ENSRNOP00000092698.1
	ENSRNOP00000095459
	ENSRNOP00000095459.1
GenBank Protein	Q8VHW7	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_542425 ⟸ NM_080694

- UniProtKB:

Q8VHW6 (UniProtKB/Swiss-Prot), Q8VHW7 (UniProtKB/Swiss-Prot), A6KS37 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MMWSNFFMQEEDRRRTAVGRRRAQEQQNLGLTPEREGKIKLGLLVAIVGATLAVLAVGTEFWVE
LNTYKTNGSAVCEAAHLGLWKVCIKRLWQADVPAGRETCGPAELPGEANCTYFKFFTTGENAHI
FQRTTKKEVNLAAAVIAVLGLTAMALGCLCVIMVLSKGAEFLLRLGAVCFGLSGLLLFVSLEVF
RHSVRALLQGVNPETPPAPRLAYEYSWSLGCGVGAGLILLLGGVCFLLLTLPSWPWRSLCPKRG
GPTA

hide sequence

RefSeq Acc Id:	XP_008756971 ⟸ XM_008758749
- Peptide Label:	isoform X1
- UniProtKB:	A6KS36 (UniProtKB/TrEMBL)
- Sequence:	show sequence MMWSNFFMQEEDRRRTAVGRRRAQEQQNLGLTPEREGKIKLGLLVAIVGATLAVLAVGTEFWVE LNTYKTNGSAVCEAAHLGLWKVCIKRLWQADVPAGRETCGPAELPGEANCTYFKFFTTGENAHI FQRTTKKGLLLFVSLEVFRHSVRALLQGVNPETPPAPRLAYEYSWSLGCGVGAGLILLLGGVCF LLLTLPSWPWRSLCPKRGGPTA hide sequence

Ensembl Acc Id:

ENSRNOP00000074853 ⟸ ENSRNOT00000081837

Ensembl Acc Id:

ENSRNOP00000095459 ⟸ ENSRNOT00000111328

Ensembl Acc Id:

ENSRNOP00000092698 ⟸ ENSRNOT00000106854

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q8VHW7-F1-model_v2	AlphaFold	Q8VHW7	1-260	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:628806	AgrOrtholog
BioCyc Gene	G2FUF-61026	BioCyc
Ensembl Genes	ENSRNOG00000057852	Ensembl
	ENSRNOG00000063051	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000106854	ENTREZGENE
	ENSRNOT00000106854.1	UniProtKB/Swiss-Prot
	ENSRNOT00000111328	ENTREZGENE
	ENSRNOT00000111328.1	UniProtKB/Swiss-Prot
Gene3D-CATH	1.20.140.150	UniProtKB/Swiss-Prot
InterPro	PMP22/EMP/MP20/Claudin	UniProtKB/Swiss-Prot
	VDCC_g6su	UniProtKB/Swiss-Prot
	VDCC_gsu	UniProtKB/Swiss-Prot
KEGG Report	rno:140727	UniProtKB/Swiss-Prot
NCBI Gene	140727	ENTREZGENE
PANTHER	VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-1 SUBUNIT-RELATED	UniProtKB/Swiss-Prot
	VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-6 SUBUNIT	UniProtKB/Swiss-Prot
Pfam	Claudin_2	UniProtKB/Swiss-Prot
PhenoGen	Cacng6	PhenoGen
PRINTS	VDCCGAMMA	UniProtKB/Swiss-Prot
	VDCCGAMMA6	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000057852	RatGTEx
	ENSRNOG00000063051	RatGTEx
UniProt	A6KS36	ENTREZGENE, UniProtKB/TrEMBL
	A6KS37	ENTREZGENE, UniProtKB/TrEMBL
	CCG6_RAT	UniProtKB/Swiss-Prot
	Q8VHW6	ENTREZGENE
	Q8VHW7	ENTREZGENE
UniProt Secondary	Q8VHW6	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-02-11	Cacng6	calcium voltage-gated channel auxiliary subunit gamma 6	Cacng6	calcium channel, voltage-dependent, gamma subunit 6	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2004-09-10	Cacng6	calcium channel, voltage-dependent, gamma subunit 6		voltage-dependent calcium channel gamma-6 subunit	Name updated	1299863	APPROVED
2003-02-27	Cacng6	voltage-dependent calcium channel gamma-6 subunit			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_expression	expressed in skeletal and cardiac muscle	70681

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Annotations - KEGG (archival)