Zfp709 (zinc finger protein 709) - Rat Genome Database

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Pathways
Gene: Zfp709 (zinc finger protein 709) Rattus norvegicus
Analyze
Symbol: Zfp709
Name: zinc finger protein 709
RGD ID: 628698
Description: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human ZNF443 (zinc finger protein 443); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride; amphetamine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Hit40; zinc finger protein 14; zinc finger protein 14 (KOX 6); zinc finger protein HIT-40; Znf14
RGD Orthologs
Human
Mouse
Bonobo
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81617,942,986 - 17,953,720 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1617,944,162 - 17,953,463 (-)EnsemblGRCr8
mRatBN7.21617,907,599 - 17,920,047 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1617,909,641 - 17,919,700 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1617,961,552 - 17,970,654 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01619,094,396 - 19,103,531 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01618,014,479 - 18,023,581 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01619,632,954 - 19,643,956 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1619,634,134 - 19,643,236 (-)Ensemblrn6Rnor6.0
Rnor_5.01619,490,577 - 19,501,296 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41618,397,910 - 18,407,047 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1618,117,897 - 18,127,032 (-)NCBICelera
RGSC_v3.11618,397,907 - 18,407,045 (-)NCBI
Cytogenetic Map16p14NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleus  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. Heat stress modulates hepatocyte membrane proteins during endotoxemia. Przkora R, etal., Burns. 2007 Aug;33(5):628-33. Epub 2007 Mar 19.
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Information Derived from GenBank Report RGD, Sept. 2003

Genomics

Comparative Map Data
Zfp709
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81617,942,986 - 17,953,720 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1617,944,162 - 17,953,463 (-)EnsemblGRCr8
mRatBN7.21617,907,599 - 17,920,047 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1617,909,641 - 17,919,700 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1617,961,552 - 17,970,654 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01619,094,396 - 19,103,531 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01618,014,479 - 18,023,581 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01619,632,954 - 19,643,956 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1619,634,134 - 19,643,236 (-)Ensemblrn6Rnor6.0
Rnor_5.01619,490,577 - 19,501,296 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41618,397,910 - 18,407,047 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1618,117,897 - 18,127,032 (-)NCBICelera
RGSC_v3.11618,397,907 - 18,407,045 (-)NCBI
Cytogenetic Map16p14NCBI
ZNF443
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381912,429,706 - 12,441,021 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1912,429,706 - 12,441,021 (-)Ensemblhg38GRCh38
GRCh371912,540,520 - 12,551,835 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361912,401,520 - 12,412,823 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341912,401,520 - 12,412,819NCBI
Celera1912,434,353 - 12,445,750 (-)NCBICelera
Cytogenetic Map19p13.2NCBI
HuRef1912,114,067 - 12,125,478 (-)NCBIHuRef
CHM1_11912,540,734 - 12,552,129 (-)NCBICHM1_1
T2T-CHM13v2.01912,558,105 - 12,569,423 (-)NCBIT2T-CHM13v2.0
Zfp709
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39872,635,912 - 72,646,409 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl872,635,863 - 72,649,571 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38871,882,068 - 71,892,565 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl871,882,019 - 71,895,727 (+)Ensemblmm10GRCm38
MGSCv37874,405,967 - 74,416,464 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36874,811,057 - 74,821,553 (+)NCBIMGSCv36mm8
Celera876,238,516 - 76,249,013 (+)NCBICelera
Cytogenetic Map8B3.3NCBI
cM Map834.57NCBI
ZNF443
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22017,361,041 - 17,376,726 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11916,361,707 - 16,377,354 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01911,991,563 - 12,021,852 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11912,744,411 - 12,747,814 (-)NCBIPanPan1.1PanPan1.1panPan2

Variants

.
Variants in Zfp709
13 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:182
Count of miRNA genes:136
Interacting mature miRNAs:147
Transcripts:ENSRNOT00000021742
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549842Bp248Blood pressure QTL 2480.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1638712345387123Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133425095Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139568015Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16423421253708481Rat
631517Scl9Serum cholesterol level QTL 93.3blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)161574800625801629Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16474422249744222Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16126734272Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16126734272Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16435482249354822Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)1638712345387123Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16423421249757901Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16423421266955197Rat
1600369Hcas8Hepatocarcinoma susceptibility QTL 8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)161627818427244292Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139568015Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683908666195506Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338679049757901Rat
1300133Rf24Renal function QTL 243.64blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)16338679026128267Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683908666195506Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683908666195506Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16126734272Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161773081872536785Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683908652786090Rat
2301406Kidm39Kidney mass QTL 390.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)161590580260905802Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683908666195506Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16330168348301683Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000021742   ⟹   ENSRNOP00000021741
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1617,909,641 - 17,913,987 (-)Ensembl
Rnor_6.0 Ensembl1619,634,134 - 19,637,609 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000087597   ⟹   ENSRNOP00000075334
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1617,944,162 - 17,953,463 (-)Ensembl
mRatBN7.2 Ensembl1617,909,927 - 17,919,301 (-)Ensembl
Rnor_6.0 Ensembl1619,634,656 - 19,643,236 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000098161   ⟹   ENSRNOP00000093615
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1617,909,641 - 17,919,700 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000114513   ⟹   ENSRNOP00000079050
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1617,909,641 - 17,915,388 (-)Ensembl
RefSeq Acc Id: NM_153731   ⟹   NP_714953
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81617,944,162 - 17,953,299 (-)NCBI
mRatBN7.21617,910,164 - 17,919,303 (-)NCBI
Rnor_6.01619,634,134 - 19,643,271 (-)NCBI
Rnor_5.01619,490,577 - 19,501,296 (-)NCBI
RGSC_v3.41618,397,910 - 18,407,047 (-)RGD
Celera1618,117,897 - 18,127,032 (-)RGD
Sequence:
RefSeq Acc Id: XM_006252840   ⟹   XP_006252902
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81617,942,986 - 17,953,720 (-)NCBI
mRatBN7.21617,907,599 - 17,920,047 (-)NCBI
Rnor_6.01619,632,954 - 19,643,206 (-)NCBI
Rnor_5.01619,490,577 - 19,501,296 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006252841   ⟹   XP_006252903
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81617,942,986 - 17,953,720 (-)NCBI
mRatBN7.21617,907,599 - 17,920,047 (-)NCBI
Rnor_6.01619,632,954 - 19,643,956 (-)NCBI
Rnor_5.01619,490,577 - 19,501,296 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008771069   ⟹   XP_008769291
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81617,942,986 - 17,952,375 (-)NCBI
mRatBN7.21617,907,599 - 17,919,856 (-)NCBI
Rnor_6.01619,632,954 - 19,643,952 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008771070   ⟹   XP_008769292
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81617,942,986 - 17,952,375 (-)NCBI
mRatBN7.21617,907,599 - 17,914,842 (-)NCBI
Rnor_6.01619,632,954 - 19,640,362 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008771072   ⟹   XP_008769294
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81617,942,986 - 17,947,922 (-)NCBI
mRatBN7.21617,907,599 - 17,913,924 (-)NCBI
Rnor_6.01619,632,954 - 19,637,834 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039094244   ⟹   XP_038950172
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81617,942,986 - 17,953,718 (-)NCBI
mRatBN7.21617,907,599 - 17,919,856 (-)NCBI
RefSeq Acc Id: NP_714953   ⟸   NM_153731
- UniProtKB: Q99PJ6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006252903   ⟸   XM_006252841
- Peptide Label: isoform X2
- UniProtKB: A0A0G2KAB4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006252902   ⟸   XM_006252840
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AHX4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008769291   ⟸   XM_008771069
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_008769292   ⟸   XM_008771070
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_008769294   ⟸   XM_008771072
- Peptide Label: isoform X4
- Sequence:
Ensembl Acc Id: ENSRNOP00000021741   ⟸   ENSRNOT00000021742
Ensembl Acc Id: ENSRNOP00000075334   ⟸   ENSRNOT00000087597
RefSeq Acc Id: XP_038950172   ⟸   XM_039094244
- Peptide Label: isoform X3
Ensembl Acc Id: ENSRNOP00000079050   ⟸   ENSRNOT00000114513
Ensembl Acc Id: ENSRNOP00000093615   ⟸   ENSRNOT00000098161
Protein Domains
C2H2-type   KRAB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q99PJ6-F1-model_v2 AlphaFold Q99PJ6 1-736 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699991
Promoter ID:EPDNEW_R10514
Type:initiation region
Name:Zfp709_1
Description:zinc finger protein 709
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01619,643,269 - 19,643,329EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628698 AgrOrtholog
BioCyc Gene G2FUF-11861 BioCyc
Ensembl Genes ENSRNOG00000016186 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000087597 ENTREZGENE
  ENSRNOT00000087597.3 UniProtKB/TrEMBL
Gene3D-CATH 6.10.140.140 UniProtKB/TrEMBL
  Classic Zinc Finger UniProtKB/TrEMBL
InterPro Ikaros_C2H2-ZF UniProtKB/TrEMBL
  KRAB_dom_sf UniProtKB/TrEMBL
  Krueppel-associated_box UniProtKB/TrEMBL
  Znf_C2H2/integrase_DNA-bd UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
KEGG Report rno:266773 UniProtKB/TrEMBL
NCBI Gene 266773 ENTREZGENE
PANTHER ZINC FINGER PROTEIN UniProtKB/TrEMBL
  ZINC FINGER PROTEIN 564 UniProtKB/TrEMBL
Pfam KRAB UniProtKB/TrEMBL
  zf-C2H2 UniProtKB/TrEMBL
  zf-C2H2_6 UniProtKB/TrEMBL
  zf-met UniProtKB/TrEMBL
PhenoGen Zfp709 PhenoGen
PROSITE KRAB UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016186 RatGTEx
SMART KRAB UniProtKB/TrEMBL
  ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP Krueppel-associated_box UniProtKB/TrEMBL
  SSF57667 UniProtKB/TrEMBL
UniProt A0A0G2KAB4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AHX4 ENTREZGENE
  Q99PJ6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-25 Zfp709  zinc finger protein 709  Znf14  zinc finger protein 14 (KOX 6)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Znf14  zinc finger protein 14 (KOX 6)  Hit40  zinc finger protein HIT-40  Symbol and Name updated 1299863 APPROVED
2003-02-27 Hit40  zinc finger protein HIT-40      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in brain 634611