Tfpi2 (tissue factor pathway inhibitor 2) - Rat Genome Database

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Gene: Tfpi2 (tissue factor pathway inhibitor 2) Rattus norvegicus
Analyze
Symbol: Tfpi2
Name: tissue factor pathway inhibitor 2
RGD ID: 628629
Description: Predicted to enable serine-type endopeptidase inhibitor activity. Involved in cellular response to fluid shear stress. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in acute myeloid leukemia and retinal degeneration. Orthologous to human TFPI2 (tissue factor pathway inhibitor 2); INTERACTS WITH (S)-colchicine; 1-naphthyl isothiocyanate; acrylamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8432,936,462 - 32,941,385 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl432,936,854 - 32,941,426 (-)EnsemblGRCr8
mRatBN7.2431,981,786 - 31,986,707 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl431,982,178 - 31,986,600 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx436,954,886 - 36,959,308 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0432,881,006 - 32,885,428 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0431,245,301 - 31,249,723 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0428,947,951 - 28,953,261 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl428,947,965 - 28,953,067 (-)Ensemblrn6Rnor6.0
Rnor_5.0428,855,875 - 28,860,297 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4428,807,080 - 28,811,502 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera427,368,594 - 27,373,001 (-)NCBICelera
RGSC_v3.1428,825,427 - 28,829,850 (-)NCBI
Cytogenetic Map4q13NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-colchicine  (EXP)
(S)-nicotine  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
8-Br-cAMP  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphibole asbestos  (EXP,ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
avobenzone  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium dichloride  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
chenodeoxycholic acid  (ISO)
chloroprene  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
deoxycholic acid  (ISO)
dexamethasone  (ISO)
dibenzo[a,l]pyrene  (ISO)
dioxygen  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP,ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
etoposide  (ISO)
fonofos  (ISO)
furan  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
lead diacetate  (ISO)
lipopolysaccharide  (ISO)
lucanthone  (ISO)
lycopene  (ISO)
malathion  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
Mecamylamine  (ISO)
medroxyprogesterone acetate  (ISO)
melphalan  (ISO)
mercury dibromide  (ISO)
methotrexate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
mitomycin C  (ISO)
N-nitrosodimethylamine  (EXP)
nickel sulfate  (ISO)
nicotine  (ISO)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
paclitaxel  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
parathion  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
prednisolone  (ISO)
progesterone  (ISO)
quercetin  (EXP,ISO)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
Securinine  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
sotorasib  (ISO)
sunitinib  (ISO)
tartrazine  (ISO)
temozolomide  (ISO)
terbufos  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (EXP)
testosterone  (ISO)
tetrachloromethane  (ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
topotecan  (EXP,ISO)
trametinib  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vincaleukoblastine  (EXP,ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc dichloride  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Tissue factor pathway inhibitor-2 is induced by fluid shear stress in vascular smooth muscle cells and affects cell proliferation and survival. Ekstrand J, etal., J Vasc Surg. 2010 Jul;52(1):167-75. doi: 10.1016/j.jvs.2010.02.282.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. cDNA cloning and tissue distribution of the rat ortholog of tissue factor pathway inhibitor-2. Hisaka T, etal., Thromb Haemost 2002 Aug;88(2):356-7.
5. Promoter of TFPI-2 is hypermethylated in Chinese pediatric acute myeloid leukemia. Jian P, etal., J Pediatr Hematol Oncol. 2012 Jan;34(1):43-6. doi: 10.1097/MPH.0b013e3182277276.
6. A novel function of tissue factor pathway inhibitor-2 (TFPI-2) in human glioma invasion. Konduri SD, etal., Oncogene. 2001 Oct 18;20(47):6938-45.
7. Large-scale characterization of DNA methylation changes in human gastric carcinomas with and without metastasis. Liu Z, etal., Clin Cancer Res. 2014 Sep 1;20(17):4598-612. doi: 10.1158/1078-0432.CCR-13-3380. Epub 2014 Jul 9.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Cloning of the cDNA encoding mouse PP5/TFPI-2 and mapping of the gene to chromosome 6. Miyagi Y, etal., DNA Cell Biol 1996 Nov;15(11):947-54.
10. Retinal degeneration is delayed by tissue factor pathway inhibitor-2 in RCS rats and a sodium-iodate-induced model in rabbits. Obata R, etal., Eye (Lond). 2005 Apr;19(4):464-8.
11. GOA pipeline RGD automated data pipeline
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:23979707   PMID:33794911   PMID:37074506  


Genomics

Comparative Map Data
Tfpi2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8432,936,462 - 32,941,385 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl432,936,854 - 32,941,426 (-)EnsemblGRCr8
mRatBN7.2431,981,786 - 31,986,707 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl431,982,178 - 31,986,600 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx436,954,886 - 36,959,308 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0432,881,006 - 32,885,428 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0431,245,301 - 31,249,723 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0428,947,951 - 28,953,261 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl428,947,965 - 28,953,067 (-)Ensemblrn6Rnor6.0
Rnor_5.0428,855,875 - 28,860,297 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4428,807,080 - 28,811,502 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera427,368,594 - 27,373,001 (-)NCBICelera
RGSC_v3.1428,825,427 - 28,829,850 (-)NCBI
Cytogenetic Map4q13NCBI
TFPI2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38793,885,396 - 93,890,753 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl793,885,396 - 93,890,753 (-)Ensemblhg38GRCh38
GRCh37793,514,708 - 93,520,065 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36793,353,678 - 93,358,001 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34793,160,395 - 93,164,716NCBI
Celera788,214,047 - 88,218,363 (-)NCBICelera
Cytogenetic Map7q21.3NCBI
HuRef788,122,436 - 88,128,017 (-)NCBIHuRef
CHM1_1793,444,941 - 93,450,535 (-)NCBICHM1_1
T2T-CHM13v2.0795,122,034 - 95,127,402 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2792,843,873 - 92,849,467 (-)NCBI
Tfpi2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3963,962,589 - 3,988,977 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl63,962,595 - 3,988,919 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3863,962,589 - 3,988,978 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl63,962,595 - 3,988,919 (-)Ensemblmm10GRCm38
MGSCv3763,912,595 - 3,918,354 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3663,912,595 - 3,918,356 (-)NCBIMGSCv36mm8
Celera64,109,201 - 4,114,968 (-)NCBICelera
Cytogenetic Map6A1NCBI
cM Map61.81NCBI
Tfpi2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543210,631,843 - 10,641,538 (-)Ensembl
ChiLan1.0NW_00495543210,635,626 - 10,641,345 (-)NCBIChiLan1.0ChiLan1.0
TFPI2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26111,722,525 - 111,727,596 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17159,986,355 - 159,992,238 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0785,835,141 - 85,839,515 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1799,425,901 - 99,431,099 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl799,426,006 - 99,431,099 (-)EnsemblpanPan2panpan1.1
TFPI2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11419,399,259 - 19,403,890 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1419,399,720 - 19,403,708 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1418,958,506 - 18,963,434 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01419,213,421 - 19,218,350 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1419,214,182 - 19,218,634 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11419,365,349 - 19,370,276 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01419,101,187 - 19,106,121 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01419,358,489 - 19,363,420 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Tfpi2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511832,709,624 - 32,714,803 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493680373,946 - 90,295 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493680369,296 - 90,270 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TFPI2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl973,673,535 - 73,689,095 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1973,684,236 - 73,694,663 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2980,646,484 - 80,656,913 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TFPI2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12155,134,921 - 55,139,862 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2155,135,198 - 55,140,801 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604249,184,930 - 49,189,763 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tfpi2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624813571,414 - 577,858 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624813571,592 - 577,268 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Tfpi2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v16134,641,348 - 134,646,223 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Tfpi2
27 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:221
Count of miRNA genes:158
Interacting mature miRNAs:175
Transcripts:ENSRNOT00000013989
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2302371Stl22Serum triglyceride level QTL 225.15blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)41308014658080146Rat
2303585Bw86Body weight QTL 864body mass (VT:0001259)body weight (CMO:0000012)41564430960644309Rat
8552906Pigfal3Plasma insulin-like growth factor 1 level QTL 3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)41103870656038706Rat
1357341Gluco5Glucose level QTL 56.4adipocyte free fatty acid secretion trait (VT:0010465)absolute change in adipocyte free fatty acid secretion per unit volume (CMO:0001446)4134142783Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)427730518170099664Rat
1357343Gluco4Glucose level QTL 40.00002adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)4134142783Rat
8552782Vie1Viral induced encephalitis QTL 126.4brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)4135396961Rat
6478766Anxrr47Anxiety related response QTL 470.09637locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)41103870656038706Rat
70222Eae2Experimental allergic encephalomyelitis QTL 24.3nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)42228845340471598Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)426234499134199155Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4589457557613242Rat
6478769Anxrr48Anxiety related response QTL 480.02514locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)41103870656038706Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41170660492690519Rat
2313401Anxrr27Anxiety related response QTL 27aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)41890069763900697Rat
631209Bw2Body weight QTL24.2retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)4145429897Rat
8552803Bw144Body weight QTL 14416body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)4135396961Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)427862204126119996Rat
8694374Bw155Body weight QTL 1553.390.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)41103870656038706Rat
8552801Bw143Body weight QTL 1437.3body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)4135396961Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45889999148002343Rat
61412Pia2Pristane induced arthritis QTL 23.9joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)42228845363245191Rat
8552807Vie4Viral induced encephalitis QTL 47.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)41890069763900697Rat
6478724Anxrr35Anxiety related response QTL 350.00449defecation behavior trait (VT:0010462)defecation measurement (CMO:0000997)41103870656038706Rat
8655906Rf60Renal function QTL 603.8blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)43044896182336920Rat
61415Eae11Experimental allergic encephalomyelitis QTL 112.9nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)4140471598Rat
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4588999950889999Rat
8552809Vie5Viral induced encephalitis QTL 525.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)4135396961Rat
7387227Uae40Urinary albumin excretion QTL 402.90.0052urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)41891315163913151Rat
6909122Insul22Insulin level QTL 224.63blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)42786220462997402Rat
738021Hcar13Hepatocarcinoma resistance QTL 134.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)4133538816Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)42192515166925151Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)4163900697Rat
9590304Scort17Serum corticosterone level QTL 174.960.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)41103870656038706Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
1354665Stl10Serum triglyceride level QTL 103.57blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)42228845345429897Rat
1300141Bp178Blood pressure QTL 178arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)41075870140490708Rat

Markers in Region
RH130733  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2431,981,914 - 31,982,123 (+)MAPPERmRatBN7.2
Rnor_6.0428,948,080 - 28,948,288NCBIRnor6.0
Rnor_5.0428,855,612 - 28,855,820UniSTSRnor5.0
RGSC_v3.4428,806,817 - 28,807,025UniSTSRGSC3.4
Celera427,368,331 - 27,368,539UniSTS
RH 3.4 Map4434.12UniSTS
Cytogenetic Map4q13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 161 91 90 59 27 59 6 272 127 11 140 62 89 31 13 13

Sequence


Ensembl Acc Id: ENSRNOT00000013989   ⟹   ENSRNOP00000013989
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl432,936,854 - 32,941,426 (-)Ensembl
mRatBN7.2 Ensembl431,982,178 - 31,986,600 (-)Ensembl
Rnor_6.0 Ensembl428,947,965 - 28,953,067 (-)Ensembl
RefSeq Acc Id: NM_173141   ⟹   NP_775164
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8432,936,854 - 32,941,276 (-)NCBI
mRatBN7.2431,982,178 - 31,986,600 (-)NCBI
Rnor_6.0428,948,343 - 28,952,765 (-)NCBI
Rnor_5.0428,855,875 - 28,860,297 (-)NCBI
RGSC_v3.4428,807,080 - 28,811,502 (-)RGD
Celera427,368,594 - 27,373,001 (-)RGD
Sequence:
RefSeq Acc Id: XM_017592497   ⟹   XP_017447986
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8432,936,462 - 32,941,385 (-)NCBI
mRatBN7.2431,981,786 - 31,986,707 (-)NCBI
Rnor_6.0428,947,951 - 28,953,261 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_775164 (Get FASTA)   NCBI Sequence Viewer  
  XP_017447986 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAD22046 (Get FASTA)   NCBI Sequence Viewer  
  EDL84390 (Get FASTA)   NCBI Sequence Viewer  
  EDL84391 (Get FASTA)   NCBI Sequence Viewer  
  EDL84392 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000013989.2
RefSeq Acc Id: NP_775164   ⟸   NM_173141
- Peptide Label: precursor
- UniProtKB: G3V7D5 (UniProtKB/TrEMBL),   A6K2A8 (UniProtKB/TrEMBL),   Q8CF99 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017447986   ⟸   XM_017592497
- Peptide Label: isoform X1
- UniProtKB: A6K2A9 (UniProtKB/TrEMBL),   Q8CF99 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000013989   ⟸   ENSRNOT00000013989
Protein Domains
BPTI/Kunitz inhibitor

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V7D5-F1-model_v2 AlphaFold G3V7D5 1-230 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692854
Promoter ID:EPDNEW_R3378
Type:single initiation site
Name:Tfpi2_1
Description:tissue factor pathway inhibitor 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0428,952,769 - 28,952,829EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628629 AgrOrtholog
BioCyc Gene G2FUF-45730 BioCyc
Ensembl Genes ENSRNOG00000010513 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000013989.5 UniProtKB/TrEMBL
Gene3D-CATH 4.10.410.10 UniProtKB/TrEMBL
InterPro Kunitz-type_SerProtInhib UniProtKB/TrEMBL
  Kunitz_BPTI_sf UniProtKB/TrEMBL
  Prot_inh_Kunz-m UniProtKB/TrEMBL
  Prtase_inh_Kunz-CS UniProtKB/TrEMBL
  TFPI-like UniProtKB/TrEMBL
KEGG Report rno:286926 UniProtKB/TrEMBL
NCBI Gene 286926 ENTREZGENE
PANTHER BPTI_KUNITZ INHIBITOR DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  KUNITZ-TYPE PROTEASE INHIBITOR-RELATED UniProtKB/TrEMBL
Pfam Kunitz_BPTI UniProtKB/TrEMBL
PhenoGen Tfpi2 PhenoGen
PIRSF TFPI UniProtKB/TrEMBL
PRINTS BASICPTASE UniProtKB/TrEMBL
PROSITE BPTI_KUNITZ_1 UniProtKB/TrEMBL
  BPTI_KUNITZ_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000010513 RatGTEx
SMART SM00131 UniProtKB/TrEMBL
Superfamily-SCOP Prot_inh_Kunz-m UniProtKB/TrEMBL
UniProt A6K2A8 ENTREZGENE, UniProtKB/TrEMBL
  A6K2A9 ENTREZGENE, UniProtKB/TrEMBL
  G3V7D5 ENTREZGENE, UniProtKB/TrEMBL
  Q8CF99 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-02-26 Tfpi2  tissue factor pathway inhibitor 2      Symbol and Name status set to approved 625702 APPROVED
2003-02-27 Tfpi2  tissue factor pathway inhibitor 2      Symbol and Name status set to provisional 70820 PROVISIONAL