Gucy2g (guanylate cyclase 2G) - Rat Genome Database

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Gene: Gucy2g (guanylate cyclase 2G) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Gucy2g
Name: guanylate cyclase 2G
RGD ID: 621853
Description: Predicted to enable guanylate cyclase activity and peptide receptor activity. Predicted to be involved in cGMP biosynthetic process and receptor guanylyl cyclase signaling pathway. Predicted to be located in cytoplasm and membrane. Predicted to be active in plasma membrane; INTERACTS WITH 1-naphthyl isothiocyanate; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: GC-G; guanylyl cyclase receptor G; guanylyl cyclase with kinase-like domain soluble; guanylyl cyclase with kinase-like domain, soluble; kinase-like domain-containing soluble guanylyl cyclase; ksGC
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81264,241,830 - 264,285,615 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1264,244,515 - 264,285,615 (-)EnsemblGRCr8
mRatBN7.21254,237,778 - 254,280,277 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1254,239,174 - 254,280,277 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1262,444,241 - 262,485,282 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01269,150,318 - 269,191,360 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01261,798,024 - 261,839,079 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01276,187,243 - 276,228,574 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1276,187,242 - 276,228,574 (-)Ensemblrn6Rnor6.0
Rnor_5.01283,584,439 - 283,625,770 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41261,500,922 - 261,542,254 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1249,945,941 - 249,986,983 (-)NCBICelera
RGSC_v3.11261,711,965 - 261,753,299 (-)NCBI
Cytogenetic Map1q55NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. A new type soluble guanylyl cyclase, which contains a kinase-like domain: its structure and expression. Kojima M, etal., Biochem Biophys Res Commun 1995 Dec 26;217(3):993-1000.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. The cloning and expression of a new guanylyl cyclase orphan receptor. Schulz S, etal., J Biol Chem 1998 Jan 9;273(2):1032-7.

Genomics

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:33
Count of miRNA genes:31
Interacting mature miRNAs:32
Transcripts:ENSRNOT00000021746
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1208479811269633915Rat
1549910Bw54Body weight QTL 540.05body mass (VT:0001259)body weight (CMO:0000012)1263946994269633915Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1224633915269633915Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1232312773270518180Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1186658830266453731Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1226175591270518180Rat
1578775Iddm21Insulin dependent diabetes mellitus QTL 214.13blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1245782829270518180Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1205233991267096252Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1186658830266453731Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
631837Niddm35Non-insulin dependent diabetes mellitus QTL 350.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1248619887269633915Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
631836Stl31Serum triglyceride level QTL 314.645e-06blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1247133834270518180Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1600390Niddm64Non-insulin dependent diabetes mellitus QTL 640.003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1257624997270518180Rat
1300108Rf8Renal function QTL 83.75renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1237995023269633915Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1233480549270108840Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1234540191270518180Rat
7387289Uae45Urinary albumin excretion QTL 452.860.0021urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1233204160270518180Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1233480549270108840Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1207163993269633915Rat
1598839Rf56Renal function QTL 56renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1255849111270518180Rat
1581544Rf52Renal function QTL 520.05urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)1241569529269633915Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
631536Lnnr2Liver neoplastic nodule remodeling QTL 22.90.0005liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)1243953669270518180Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1225108840270108840Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1185857683270518180Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1226175591270518180Rat
631669Iddm9Insulin dependent diabetes mellitus QTL 92.80.039blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1233349180270518180Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1228174566270518180Rat
724533Rf51Renal function QTL 515.30.0002kidney plasma flow trait (VT:0005524)renal plasma flow (CMO:0001914)1228180370266453608Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 17 66 55 61 30 20 30 6 193 63 11 46 76 65 31 7 7

Sequence


Ensembl Acc Id: ENSRNOT00000021746   ⟹   ENSRNOP00000021744
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1264,244,515 - 264,285,615 (-)Ensembl
mRatBN7.2 Ensembl1254,239,174 - 254,280,277 (-)Ensembl
Rnor_6.0 Ensembl1276,187,242 - 276,228,574 (-)Ensembl
RefSeq Acc Id: NM_139042   ⟹   NP_620611
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81264,244,518 - 264,285,615 (-)NCBI
mRatBN7.21254,239,177 - 254,280,277 (-)NCBI
Rnor_6.01276,187,243 - 276,228,574 (-)NCBI
Rnor_5.01283,584,439 - 283,625,770 (-)NCBI
RGSC_v3.41261,500,922 - 261,542,254 (-)RGD
Celera1249,945,941 - 249,986,983 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039097457   ⟹   XP_038953385
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81264,241,830 - 264,261,113 (-)NCBI
mRatBN7.21254,237,778 - 254,255,771 (-)NCBI
RefSeq Acc Id: XM_039097497   ⟹   XP_038953425
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81264,241,830 - 264,260,914 (-)NCBI
mRatBN7.21254,237,778 - 254,255,572 (-)NCBI
RefSeq Acc Id: NP_620611   ⟸   NM_139042
- UniProtKB: P55205 (UniProtKB/Swiss-Prot),   O54884 (UniProtKB/Swiss-Prot),   F1MA14 (UniProtKB/TrEMBL),   A6JHY5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000021744   ⟸   ENSRNOT00000021746
RefSeq Acc Id: XP_038953385   ⟸   XM_039097457
- Peptide Label: isoform X1
- UniProtKB: A6JHY7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038953425   ⟸   XM_039097497
- Peptide Label: isoform X1
- UniProtKB: A6JHY7 (UniProtKB/TrEMBL)
Protein Domains
Guanylate cyclase   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P55205-F1-model_v2 AlphaFold P55205 1-1100 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621853 AgrOrtholog
BioCyc Gene G2FUF-55347 BioCyc
Ensembl Genes ENSRNOG00000015724 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000021746 ENTREZGENE
Gene3D-CATH 3.30.70.1230 UniProtKB/Swiss-Prot
  3.40.50.2300 UniProtKB/Swiss-Prot
  6.10.250.780 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
InterPro A/G_cyclase UniProtKB/Swiss-Prot
  A/G_cyclase_CS UniProtKB/Swiss-Prot
  ANF_lig-bd_rcpt UniProtKB/Swiss-Prot
  ANPR/GUC UniProtKB/Swiss-Prot
  Cyclic_nucleotide_synthase UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  Nucleotide_cyclase UniProtKB/Swiss-Prot
  Peripla_BP_I UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot
NCBI Gene 245708 ENTREZGENE
PANTHER GUANYLATE CYCLASE 2G UniProtKB/Swiss-Prot
  GUANYLYL CYCLASE UniProtKB/Swiss-Prot
Pfam ANF_receptor UniProtKB/Swiss-Prot
  Guanylate_cyc UniProtKB/Swiss-Prot
  Pkinase_Tyr UniProtKB/Swiss-Prot
PhenoGen Gucy2g PhenoGen
PRINTS NATPEPTIDER UniProtKB/Swiss-Prot
PROSITE GUANYLATE_CYCLASE_1 UniProtKB/Swiss-Prot
  GUANYLATE_CYCLASE_2 UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000015724 RatGTEx
SMART CYCc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF53822 UniProtKB/Swiss-Prot
  SSF55073 UniProtKB/Swiss-Prot
  SSF56112 UniProtKB/Swiss-Prot
UniProt A6JHY5 ENTREZGENE, UniProtKB/TrEMBL
  A6JHY6_RAT UniProtKB/TrEMBL
  A6JHY7 ENTREZGENE, UniProtKB/TrEMBL
  F1MA14 ENTREZGENE, UniProtKB/TrEMBL
  GUC2G_RAT UniProtKB/Swiss-Prot
  O54884 ENTREZGENE
  P55205 ENTREZGENE
UniProt Secondary O54884 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-02-26 Gucy2g  guanylate cyclase 2G  Gucy2g  guanylate cyclase 2g  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Gucy2g  guanylate cyclase 2g  ksGC  guanylyl cyclase with kinase-like domain, soluble  Symbol and Name updated 1299863 APPROVED
2002-08-07 ksGC  guanylyl cyclase with kinase-like domain, soluble      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in lung, kidney and skeletal muscle 633169