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Gene: Unc50 (unc-50 inner nuclear membrane RNA binding protein) Rattus norvegicus

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Symbol:

Unc50

Name:

unc-50 inner nuclear membrane RNA binding protein

RGD ID:

621749

Description:

Enables RNA binding activity. Involved in protein localization to cell surface. Located in nuclear inner membrane. Orthologous to human UNC50 (unc-50 inner nuclear membrane RNA binding protein); INTERACTS WITH 17alpha-ethynylestradiol; 4,4'-sulfonyldiphenol; ammonium chloride.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

unc-50 homolog; unc-50 homolog (C. elegans); unc-50 related protein (UNCL); Uncl; uncoordinated-like protein

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	UNC50 (unc-50 inner nuclear membrane RNA binding protein)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Unc50 (unc-50 homolog)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Unc50 (unc-50 inner nuclear membrane RNA binding protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	UNC50 (unc-50 inner nuclear membrane RNA binding protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	UNC50 (unc-50 inner nuclear membrane RNA binding protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Unc50 (unc-50 inner nuclear membrane RNA binding protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	UNC50 (unc-50 inner nuclear membrane RNA binding protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	UNC50 (unc-50 inner nuclear membrane RNA binding protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Unc50 (unc-50 inner nuclear membrane RNA binding protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Unc50 (unc-50 inner nuclear membrane RNA binding protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Unc50 (unc-50 homolog)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	UNC50 (unc-50 inner nuclear membrane RNA binding protein)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	unc50 (unc-50 homolog (C. elegans))	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	GMH1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG9773	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	unc-50	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	unc50	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	unc50	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	47,160,723 - 47,169,710 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	9	47,160,796 - 47,168,688 (+)	Ensembl				GRCr8
mRatBN7.2	9	39,664,944 - 39,674,369 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	39,664,971 - 39,672,890 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	9	48,161,080 - 48,168,954 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	53,283,830 - 53,291,704 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	51,565,699 - 51,573,573 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	44,024,994 - 44,032,896 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	44,025,020 - 44,032,888 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	9	43,726,196 - 43,734,124 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	9	36,375,661 - 36,383,535 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	9	37,419,271 - 37,427,145 (+)	NCBI		Celera
RGSC_v3.1	9	36,377,074 - 36,384,946 (+)	NCBI
RH 3.4 Map	9	365.9	RGD
Cytogenetic Map	9	q21	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

fetal akinesia deformation sequence syndrome 1 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (EXP,ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2-hydroxypropanoic acid (ISO)

2-methylcholine (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (EXP,ISO)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

antimycin A (ISO)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

beta-lapachone (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol F (EXP,ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

CGP 52608 (ISO)

chlorpyrifos (ISO)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

deguelin (ISO)

dexamethasone (ISO)

dicrotophos (ISO)

folic acid (ISO)

gentamycin (EXP)

GSK-J4 (ISO)

indometacin (ISO)

nitrates (ISO)

ozone (ISO)

paracetamol (ISO)

potassium chromate (ISO)

quercetin (ISO)

rac-lactic acid (ISO)

resveratrol (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

Soman (EXP)

tamoxifen (ISO)

thapsigargin (ISO)

trichostatin A (ISO)

triphenyl phosphate (ISO)

urethane (ISO)

valproic acid (ISO)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

protein localization to cell surface (IDA)

Cellular Component

Golgi apparatus (IEA,ISO)

Golgi membrane (IBA,IEA)

nuclear inner membrane (IDA,IEA)

Molecular Function

protein binding (ISO)

RNA binding (IDA,IEA,IMP)

References

References - curated

#	Reference Title	Reference Citation
1.	UNCL, the mammalian homologue of UNC-50, is an inner nuclear membrane RNA-binding protein.	Fitzgerald J, etal., Brain Res 2000 Sep 15;877(1):110-23.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence.	Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
4.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
5.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
7.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:16359841

Genomics

Comparative Map Data

Unc50
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	47,160,723 - 47,169,710 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	9	47,160,796 - 47,168,688 (+)	Ensembl				GRCr8
mRatBN7.2	9	39,664,944 - 39,674,369 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	39,664,971 - 39,672,890 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	9	48,161,080 - 48,168,954 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	53,283,830 - 53,291,704 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	51,565,699 - 51,573,573 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	44,024,994 - 44,032,896 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	44,025,020 - 44,032,888 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	9	43,726,196 - 43,734,124 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	9	36,375,661 - 36,383,535 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	9	37,419,271 - 37,427,145 (+)	NCBI		Celera
RGSC_v3.1	9	36,377,074 - 36,384,946 (+)	NCBI
RH 3.4 Map	9	365.9	RGD
Cytogenetic Map	9	q21	NCBI

UNC50
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	98,608,589 - 98,618,515 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	98,608,434 - 98,618,515 (+)	Ensembl			hg38	GRCh38
GRCh37	2	99,225,052 - 99,234,978 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	98,591,474 - 98,601,410 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	2	98,683,559 - 98,693,493	NCBI
Celera	2	93,428,766 - 93,438,703 (+)	NCBI		Celera
Cytogenetic Map	2	q11.2	NCBI
HuRef	2	92,989,630 - 92,999,566 (+)	NCBI		HuRef
CHM1_1	2	99,229,365 - 99,239,301 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	99,066,916 - 99,076,837 (+)	NCBI		T2T-CHM13v2.0

Unc50
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	37,469,220 - 37,478,068 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	37,469,220 - 37,478,205 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	1	37,430,139 - 37,438,987 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	37,430,139 - 37,439,124 (+)	Ensembl			mm10	GRCm38
MGSCv37	1	37,487,017 - 37,495,969 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	1	37,374,718 - 37,383,670 (+)	NCBI		MGSCv36	mm8
Celera	1	37,212,232 - 37,220,930 (+)	NCBI		Celera
Cytogenetic Map	1	B	NCBI
cM Map	1	15.46	NCBI

Unc50
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955470	5,051,475 - 5,059,890 (+)	Ensembl
ChiLan1.0	NW_004955470	5,050,982 - 5,059,890 (+)	NCBI	ChiLan1.0	ChiLan1.0

UNC50
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	12	29,826,095 - 29,835,997 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2A	29,828,976 - 29,838,759 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2A	100,693,433 - 100,703,371 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2A	99,516,848 - 99,526,785 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2A	99,516,857 - 99,526,785 (+)	Ensembl			panPan2	panpan1.1

UNC50
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	10	44,057,617 - 44,073,153 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	10	44,057,775 - 44,073,074 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	10	43,980,524 - 43,995,508 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	10	44,931,041 - 44,946,061 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	10	44,931,025 - 44,945,866 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	10	44,641,462 - 44,656,444 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	10	44,932,398 - 44,947,410 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	10	45,108,149 - 45,123,136 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Unc50
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024406292	84,449,010 - 84,457,064 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936744	1,701,632 - 1,709,826 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936744	1,701,988 - 1,710,007 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

UNC50
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	55,667,826 - 55,676,978 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	3	55,667,821 - 55,676,995 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	58,220,278 - 58,229,446 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

UNC50
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	14	2,322,167 - 2,333,518 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	14	2,322,206 - 2,333,495 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666041	169,842,761 - 169,858,697 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Unc50
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624749	3,645,869 - 3,655,666 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624749	3,646,365 - 3,655,666 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Unc50
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	4	113,633,195 - 113,641,019 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Unc50
108 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	121
Count of miRNA genes:	102
Interacting mature miRNAs:	109
Transcripts:	ENSRNOT00000024582
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2303170	Bp332	Blood pressure QTL 332	3.73	0.027	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	9	6714888	84474983	Rat
631211	Bw4	Body weight QTL4	5.31		retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	9	5346479	50346479	Rat
7411571	Bw138	Body weight QTL 138	14.3	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	9	40029925	85029925	Rat
2303559	Gluco54	Glucose level QTL 54	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	9	8750492	53750492	Rat
1300180	Bw14	Body weight QTL 14	3.776		body mass (VT:0001259)	body weight (CMO:0000012)	9	31250432	68875676	Rat
8662828	Vetf6	Vascular elastic tissue fragility QTL 6	3.9		artery integrity trait (VT:0010639)	patent ductus arteriosus score (CMO:0002566)	9	44458256	99506504	Rat
61450	Ciaa3	CIA Autoantibody QTL 3	6.5		blood autoantibody amount (VT:0003725)	calculated serum anti-type 2 collagen antibody titer (CMO:0001279)	9	29567664	74567664	Rat
1598834	Memor11	Memory QTL 11	2.5		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	9	44458256	85262605	Rat
70186	Niddm26	Non-insulin dependent diabetes mellitus QTL 26	3.87		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	9	29567664	83835942	Rat
70218	Cm28	Cardiac mass QTL 28	8.3	0.0001	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	9	41720295	86720295	Rat
1641911	Alcrsp13	Alcohol response QTL 13			response to alcohol trait (VT:0010489)	brain neurotensin receptor 1 density (CMO:0002068)	9	6214995	51214995	Rat
1354650	Despr5	Despair related QTL 5	4.01	0.0017	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	9	8750492	53750492	Rat
7207805	Bmd88	Bone mineral density QTL 88	4		femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	9	31250432	65651574	Rat
2290450	Scl57	Serum cholesterol level QTL 57	4.15		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	9	44458256	121768150	Rat
61425	Cia15	Collagen induced arthritis QTL 15	4.6		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	9	5346479	50416711	Rat
1600365	Mcs20	Mammary carcinoma susceptibility QTL 20	3		mammary gland integrity trait (VT:0010552)	mammary tumor growth rate (CMO:0000344)	9	21031430	49025574	Rat
1581517	Bp284	Blood pressure QTL 284			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	39220186	84220186	Rat
7411656	Foco26	Food consumption QTL 26	9.8	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	9	40029925	85029925	Rat
1298088	Edpm11	Estrogen-dependent pituitary mass QTL 11	2.5		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	9	6214995	51214995	Rat
1598823	Memor16	Memory QTL 16	1.9		exploratory behavior trait (VT:0010471)	difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)	9	31456061	57460683	Rat
1641894	Alcrsp12	Alcohol response QTL 12			response to alcohol trait (VT:0010489)	brain neurotensin receptor 1 density (CMO:0002068)	9	34960590	79960590	Rat

Markers in Region

RH142437

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	9	39,672,610 - 39,672,772 (+)	MAPPER	mRatBN7.2
Rnor_6.0	9	44,032,617 - 44,032,778	NCBI	Rnor6.0
Rnor_5.0	9	43,733,845 - 43,734,006	UniSTS	Rnor5.0
RGSC_v3.4	9	36,383,256 - 36,383,417	UniSTS	RGSC3.4
Celera	9	37,426,866 - 37,427,027	UniSTS
RH 3.4 Map	9	365.9	UniSTS
Cytogenetic Map	9	q21	UniSTS

BI274353

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	47,167,139 - 47,167,373 (+)	Marker Load Pipeline
RH 3.4 Map	9	363.59	UniSTS
Cytogenetic Map	9	q21	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_138919	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006244736	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006244737	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039083000	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063266625	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC133270	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY017209	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC061976	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473965	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ220352	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000009	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U96638	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000024582 ⟹ ENSRNOP00000024582

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	9	47,160,796 - 47,168,688 (+)	Ensembl
mRatBN7.2 Ensembl	9	39,664,971 - 39,672,890 (+)	Ensembl
Rnor_6.0 Ensembl	9	44,025,020 - 44,032,888 (+)	Ensembl

RefSeq Acc Id:

NM_138919 ⟹ NP_620274

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	47,160,818 - 47,168,692 (+)	NCBI
mRatBN7.2	9	39,665,016 - 39,672,890 (+)	NCBI
Rnor_6.0	9	44,025,022 - 44,032,896 (+)	NCBI
Rnor_5.0	9	43,726,196 - 43,734,124 (+)	NCBI
RGSC_v3.4	9	36,375,661 - 36,383,535 (+)	RGD
Celera	9	37,419,271 - 37,427,145 (+)	RGD

Sequence:

show sequence

CACGAGGCCCAGCGGCGACTGGGCTCCGTACCCGGCTAAGGTGGCGGTAGTCTTGGTCCCAAGG
CGAGGCCTCGTGGGCCTTCAGGTGCGGCCTGCTCTGTGTGCGCGGGGTGGCGTTCGTGCCGACG
GCCGTTTCCACGGTCAGTTCGCAACCTGGCATCTGAGCGGCTGGGGGTAGGACCAACCAGCGCC
CCGCAGCTCAAGTCCTAGGCCCGCCGTGAAGCTGCTGGGAAGATGCTACCAAGTACTTCTTTGA
ATTCTTCGATGTACGGGAATGGAGCTTTAAATTCCAGGGATGCAGCAAGACACACAGCTGGAGC
AAAACGCTACAAGTACCTCAGAAGGCTTTTTCGCTTTCGGCAGATGGACTTTGAGTTTGCGGCA
TGGCAGATGCTCTACCTGTTCACCTCCCCTCAGAGGGTTTATAGAAACTTTCACTACCGGAAGC
AAACGAAGGATCAGTGGGCCAGAGATGACCCTGCCTTCTTGGTCCTCCTAAGTATCTGGCTCTG
TGTGTCCACCATAGGATTTGGCTTTGTGCTGGACATGGGATTTTTTGAGACAATAAAGCTGCTC
CTGTGGGTTGTGTTCATAGATTGTGTAGGTGTTGGCCTTCTCATATCAACTTTAATGTGGTTCA
TCTCCAACAAGTACCTGGTGAAACGCCAGAGCAGAGATTACGATGTGGAGTGGGGCTACGCTTT
CGACGTGCACCTGAATGCTTTCTATCCGCTCCTCGTCATCCTGCATTTCATCCAGCTCTTCTTC
ATCAACCATGTTATTCTCACAGACACGTTTATTGGATATTTAGTTGGAAATACCTTATGGTTGA
TCGCGGTTGGCTATTATATCTATGTGACCTTCCTGGGATACAGTGCATTGCCATTTTTGAAAAA
TACAGTGGTCCTGCTCTATCCATTTGCACCTCTCATTGTGCTGTACGGACTATCACTGGCGCTG
GGATGGAACTTTACCCACACGTTGTGTTCCTTCTACAAGTACAGAGTGAAGTGACAGTGCCCTT
AGCTGTCCTGTCTGGTGTTGGGAAGGGATGAGTTCTTGTAAATCTGTAAATAGCTTCAAGATGT
AAAGTTTTACAAATTCGAGGTGATATTAACACTTGTCTAGACCATTCCTTAAAACGAATTAAAT
GTACATTTCTAATAAATATTTTTAAAGTAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_006244736 ⟹ XP_006244798

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	47,160,767 - 47,168,692 (+)	NCBI
mRatBN7.2	9	39,664,969 - 39,672,890 (+)	NCBI
Rnor_6.0	9	44,024,995 - 44,032,896 (+)	NCBI
Rnor_5.0	9	43,726,196 - 43,734,124 (+)	NCBI

Sequence:

show sequence

GGGCTACGTAGAGGCAAGGGAAGTGGCCCCAGCGGCGACTGGGCTCCGTACCCGGCTAAGGTGG
CGGTAGTCTTGGTCCCAAGGCGAGGCCTCGTGGGCCTTCAGGTGCGGCCTGCTCTGTGTGCGCG
GGGTGGCGTTCGTGCCGACGGCCGTTTCCACGGAAGATGCTACCAAGTACTTCTTTGAATTCTT
CGATGTACGGGAATGGAGCTTTAAATTCCAGGGATGCAGCAAGACACACAGCTGGAGCAAAACG
CTACAAGTACCTCAGAAGGCTTTTTCGCTTTCGGCAGATGGACTTTGAGTTTGCGGCATGGCAG
ATGCTCTACCTGTTCACCTCCCCTCAGAGGGTTTATAGAAACTTTCACTACCGGAAGCAAACGA
AGGATCAGTGGGCCAGAGATGACCCTGCCTTCTTGGTCCTCCTAAGTATCTGGCTCTGTGTGTC
CACCATAGGATTTGGCTTTGTGCTGGACATGGGATTTTTTGAGACAATAAAGCTGCTCCTGTGG
GTTGTGTTCATAGATTGTGTAGGTGTTGGCCTTCTCATATCAACTTTAATGTGGTTCATCTCCA
ACAAGTACCTGGTGAAACGCCAGAGCAGAGATTACGATGTGGAGTGGGGCTACGCCTTCGACGT
GCACCTGAATGCTTTCTATCCGCTCCTCGTCATCCTGCATTTCATCCAGCTCTTCTTCATCAAC
CATGTTATTCTCACAGACACGTTTATTGGATATTTAGTTGGAAATACCTTATGGTTGATCGCGG
TTGGCTATTATATCTATGTGACCTTCCTGGGATACAGTGCATTGCCATTTTTGAAAAATACAGT
GGTCCTGCTCTATCCATTTGCACCTCTCATTGTGCTGTACGGACTATCACTGGCGCTGGGATGG
AACTTTACCCACACGCTGTGTTCCTTCTACAAGTACAGAGTGAAGTGACAGTGCCCTTAGCTGT
CCTGTCTGGTGTTGGGAAGGGATGAGTTCTTGTAAATCTGTAAATAGCTTCAAGATGTAAAGTT
TTACAAATTCGAGGTGATATTAACACTTGTCTAGACCATTCCTTAAAACGAATTAAATGTACAT
TTCTAATAAATATTTTTAAAGTAAA

hide sequence

RefSeq Acc Id:

XM_006244737 ⟹ XP_006244799

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	47,160,723 - 47,168,692 (+)	NCBI
mRatBN7.2	9	39,664,944 - 39,672,890 (+)	NCBI
Rnor_6.0	9	44,024,994 - 44,032,896 (+)	NCBI
Rnor_5.0	9	43,726,196 - 43,734,124 (+)	NCBI

Sequence:

show sequence

CGGGCTACGTAGAGGCAAGGGAAGTGGCCCCAGCGGCGACTGGGCTCCGTACCCGGCTAAGGTG
GCGGTAGTCTTGGTCCCAAGGCGAGGCCTCGTGGGCCTTCAGGAAGATGCTACCAAGTACTTCT
TTGAATTCTTCGATGTACGGGAATGGAGCTTTAAATTCCAGGGATGCAGCAAGACACACAGCTG
GAGCAAAACGCTACAAGTACCTCAGAAGGCTTTTTCGCTTTCGGCAGATGGACTTTGAGTTTGC
GGCATGGCAGATGCTCTACCTGTTCACCTCCCCTCAGAGGGTTTATAGAAACTTTCACTACCGG
AAGCAAACGAAGGATCAGTGGGCCAGAGATGACCCTGCCTTCTTGGTCCTCCTAAGTATCTGGC
TCTGTGTGTCCACCATAGGATTTGGCTTTGTGCTGGACATGGGATTTTTTGAGACAATAAAGCT
GCTCCTGTGGGTTGTGTTCATAGATTGTGTAGGTGTTGGCCTTCTCATATCAACTTTAATGTGG
TTCATCTCCAACAAGTACCTGGTGAAACGCCAGAGCAGAGATTACGATGTGGAGTGGGGCTACG
CCTTCGACGTGCACCTGAATGCTTTCTATCCGCTCCTCGTCATCCTGCATTTCATCCAGCTCTT
CTTCATCAACCATGTTATTCTCACAGACACGTTTATTGGATATTTAGTTGGAAATACCTTATGG
TTGATCGCGGTTGGCTATTATATCTATGTGACCTTCCTGGGATACAGTGCATTGCCATTTTTGA
AAAATACAGTGGTCCTGCTCTATCCATTTGCACCTCTCATTGTGCTGTACGGACTATCACTGGC
GCTGGGATGGAACTTTACCCACACGCTGTGTTCCTTCTACAAGTACAGAGTGAAGTGACAGTGC
CCTTAGCTGTCCTGTCTGGTGTTGGGAAGGGATGAGTTCTTGTAAATCTGTAAATAGCTTCAAG
ATGTAAAGTTTTACAAATTCGAGGTGATATTAACACTTGTCTAGACCATTCCTTAAAACGAATT
AAATGTACATTTCTAATAAATATTTTTAAAGTAAA

hide sequence

RefSeq Acc Id:

XM_039083000 ⟹ XP_038938928

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	47,160,761 - 47,169,710 (+)	NCBI
mRatBN7.2	9	39,664,969 - 39,674,369 (+)	NCBI

RefSeq Acc Id:

XM_063266625 ⟹ XP_063122695

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	47,160,770 - 47,169,710 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_620274	(Get FASTA)	NCBI Sequence Viewer
	XP_006244798	(Get FASTA)	NCBI Sequence Viewer
	XP_006244799	(Get FASTA)	NCBI Sequence Viewer
	XP_038938928	(Get FASTA)	NCBI Sequence Viewer
	XP_063122695	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAB93932	(Get FASTA)	NCBI Sequence Viewer
	AAH61976	(Get FASTA)	NCBI Sequence Viewer
	AAK08985	(Get FASTA)	NCBI Sequence Viewer
	EDL99237	(Get FASTA)	NCBI Sequence Viewer
	EDL99238	(Get FASTA)	NCBI Sequence Viewer
	EDL99239	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000024582
	ENSRNOP00000024582.2
GenBank Protein	O55227	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_620274 ⟸ NM_138919

- UniProtKB:

O55227 (UniProtKB/Swiss-Prot), A6INH1 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MLPSTSLNSSMYGNGALNSRDAARHTAGAKRYKYLRRLFRFRQMDFEFAAWQMLYLFTSPQRVY
RNFHYRKQTKDQWARDDPAFLVLLSIWLCVSTIGFGFVLDMGFFETIKLLLWVVFIDCVGVGLL
ISTLMWFISNKYLVKRQSRDYDVEWGYAFDVHLNAFYPLLVILHFIQLFFINHVILTDTFIGYL
VGNTLWLIAVGYYIYVTFLGYSALPFLKNTVVLLYPFAPLIVLYGLSLALGWNFTHTLCSFYKY
RVK

hide sequence

RefSeq Acc Id:	XP_006244798 ⟸ XM_006244736
- Peptide Label:	isoform X1
- UniProtKB:	O55227 (UniProtKB/Swiss-Prot), A6INH1 (UniProtKB/TrEMBL)
- Sequence:	show sequence MLPSTSLNSSMYGNGALNSRDAARHTAGAKRYKYLRRLFRFRQMDFEFAAWQMLYLFTSPQRVY RNFHYRKQTKDQWARDDPAFLVLLSIWLCVSTIGFGFVLDMGFFETIKLLLWVVFIDCVGVGLL ISTLMWFISNKYLVKRQSRDYDVEWGYAFDVHLNAFYPLLVILHFIQLFFINHVILTDTFIGYL VGNTLWLIAVGYYIYVTFLGYSALPFLKNTVVLLYPFAPLIVLYGLSLALGWNFTHTLCSFYKY RVK hide sequence

RefSeq Acc Id:	XP_006244799 ⟸ XM_006244737
- Peptide Label:	isoform X1
- UniProtKB:	O55227 (UniProtKB/Swiss-Prot), A6INH1 (UniProtKB/TrEMBL)
- Sequence:	show sequence MLPSTSLNSSMYGNGALNSRDAARHTAGAKRYKYLRRLFRFRQMDFEFAAWQMLYLFTSPQRVY RNFHYRKQTKDQWARDDPAFLVLLSIWLCVSTIGFGFVLDMGFFETIKLLLWVVFIDCVGVGLL ISTLMWFISNKYLVKRQSRDYDVEWGYAFDVHLNAFYPLLVILHFIQLFFINHVILTDTFIGYL VGNTLWLIAVGYYIYVTFLGYSALPFLKNTVVLLYPFAPLIVLYGLSLALGWNFTHTLCSFYKY RVK hide sequence

Ensembl Acc Id:

ENSRNOP00000024582 ⟸ ENSRNOT00000024582

RefSeq Acc Id:	XP_038938928 ⟸ XM_039083000
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_063122695 ⟸ XM_063266625
- Peptide Label:	isoform X2

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-O55227-F1-model_v2	AlphaFold	O55227	1-259	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13696613

Promoter ID:

EPDNEW_R7138

Type:

initiation region

Name:

Unc50_1

Description:

unc-50 inner nuclear membrane RNA binding protein

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	9	44,025,025 - 44,025,085	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:621749	AgrOrtholog
BioCyc Gene	G2FUF-27788	BioCyc
Ensembl Genes	ENSRNOG00000018128	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000024582	ENTREZGENE
	ENSRNOT00000024582.5	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:5623807	IMAGE-MGC_LOAD
InterPro	UNC-50	UniProtKB/Swiss-Prot
KEGG Report	rno:192356	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:72256	IMAGE-MGC_LOAD
NCBI Gene	192356	ENTREZGENE
PANTHER	PROTEIN UNC-50 HOMOLOG	UniProtKB/Swiss-Prot
	PTHR12841	UniProtKB/Swiss-Prot
Pfam	UNC-50	UniProtKB/Swiss-Prot
PhenoGen	Unc50	PhenoGen
RatGTEx	ENSRNOG00000018128	RatGTEx
UniProt	A6INH1	ENTREZGENE, UniProtKB/TrEMBL
	O55227	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-05-05	Unc50	unc-50 inner nuclear membrane RNA binding protein	Unc50	unc-50 homolog (C. elegans)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2004-09-10	Unc50	unc-50 homolog (C. elegans)	Uncl	unc-50 related protein (UNCL)	Symbol and Name updated	1299863	APPROVED
2002-08-07	Uncl	unc-50 related protein (UNCL)			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_cellular_localization	localized to the inner nuclear membrane	634436
gene_domains	contains an amino-terminal RNA Recognition-like Motif	634436
gene_process	involved in the cell-surface expression of neuronal nicotinic receptors	634436

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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