Aplnr (apelin receptor) - Rat Genome Database

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Gene: Aplnr (apelin receptor) Rattus norvegicus
Analyze
Symbol: Aplnr
Name: apelin receptor
RGD ID: 621645
Description: Enables mechanoreceptor activity. Involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway and regulation of body fluid levels. Located in plasma membrane. Orthologous to human APLNR (apelin receptor); PARTICIPATES IN apelin signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Agtrl1; angiotensin receptor-like 1; Apj; B78; G-protein coupled receptor APJ; GPCR34
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8390,624,055 - 90,627,700 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl390,624,012 - 90,627,908 (+)EnsemblGRCr8
mRatBN7.2370,217,407 - 70,221,052 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl370,217,385 - 70,221,050 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx373,599,092 - 73,602,742 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0382,197,771 - 82,201,425 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0379,962,920 - 79,966,570 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd388,476,047 - 88,479,712 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive395,405,030 - 95,408,676 (+)NCBILyon_Normotensive
Lyon_Hypertensive387,320,764 - 87,324,421 (+)NCBILyon_Hypertensive
F344_StmMcwi368,634,905 - 68,638,571 (+)NCBIF344_StmMcwi
Rnor_6.0372,540,538 - 72,544,183 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl372,540,538 - 72,544,182 (+)Ensemblrn6Rnor6.0
Rnor_5.0379,052,120 - 79,055,765 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4368,365,637 - 68,369,282 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera369,568,426 - 69,572,071 (+)NCBICelera
RGSC_v3.1368,262,008 - 68,265,653 (+)NCBI
Cytogenetic Map3q24NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2-butoxyethanol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
acrylamide  (EXP)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[ghi]perylene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (EXP,ISO)
buta-1,3-diene  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP)
cantharidin  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
CGP 52608  (ISO)
chloroprene  (EXP,ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cocaine  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
cypermethrin  (ISO)
cytarabine  (ISO)
dioxygen  (ISO)
diquat  (ISO)
doxorubicin  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
fructose  (EXP)
gentamycin  (EXP)
hydrogen cyanide  (ISO)
hydrogen peroxide  (ISO)
methamphetamine  (EXP)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
nickel atom  (ISO)
niclosamide  (ISO)
nitrofen  (EXP)
Octicizer  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP)
phenformin  (EXP)
phenobarbital  (ISO)
phosgene  (ISO)
phosphane  (EXP)
pirinixic acid  (ISO)
potassium cyanide  (ISO)
rotenone  (EXP)
SCH 23390  (EXP)
silicon dioxide  (EXP)
sodium arsenate  (ISO)
tetrachloromethane  (EXP)
titanium dioxide  (ISO)
tributyl phosphate  (ISO)
trichloroethene  (EXP)
triclosan  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
tris(2-chloroethyl) phosphate  (ISO)
troglitazone  (ISO)
uranium atom  (EXP)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA)
plasma membrane  (IBA,IDA,IEA,ISO,ISS)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Molecular and functional characteristics of APJ. Tissue distribution of mRNA and interaction with the endogenous ligand apelin. Hosoya M, etal., J Biol Chem 2000 Jul 14;275(28):21061-7.
4. Regulatory roles for APJ, a seven-transmembrane receptor related to angiotensin-type 1 receptor in blood pressure in vivo. Ishida J, etal., J Biol Chem 2004 Jun 18;279(25):26274-9. Epub 2004 Apr 15.
5. Agonist-independent nuclear localization of the Apelin, angiotensin AT1, and bradykinin B2 receptors. Lee DK, etal., J Biol Chem 2004 Feb 27;279(9):7901-8. Epub 2003 Nov 26.
6. Pharmacological and immunohistochemical characterization of the APJ receptor and its endogenous ligand apelin. Medhurst AD, etal., J Neurochem 2003 Mar;84(5):1162-72.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. Regulation of rat APJ receptor messenger ribonucleic acid expression in magnocellular neurones of the paraventricular and supraopric nuclei by osmotic stimuli. O'Carroll AM and Lolait SJ, J Neuroendocrinol 2003 Jul;15(7):661-6.
10. Distribution of mRNA encoding B78/apj, the rat homologue of the human APJ receptor, and its endogenous ligand apelin in brain and peripheral tissues. O'Carroll AM, etal., Biochim Biophys Acta 2000 Jun 21;1492(1):72-80.
11. APJ receptor mRNA expression in the rat hypothalamic paraventricular nucleus: regulation by stress and glucocorticoids. O'Carroll AM, etal., J Neuroendocrinol 2003 Nov;15(11):1095-101.
12. Physiological role of a novel neuropeptide, apelin, and its receptor in the rat brain. Reaux A, etal., J Neurochem. 2001 May;77(4):1085-96.
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. APJ acts as a dual receptor in cardiac hypertrophy. Scimia MC, etal., Nature. 2012 Aug 16;488(7411):394-8. doi: 10.1038/nature11263.
17. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
18. The novel peptide apelin regulates intrarenal artery tone in diabetic mice. Zhong JC, etal., Regul Pept. 2007 Dec 4;144(1-3):109-14. Epub 2007 Jul 5.
Additional References at PubMed
PMID:11146423   PMID:15489334   PMID:16278022   PMID:17119870   PMID:18367654   PMID:18816630   PMID:19660504   PMID:20055692   PMID:20675385   PMID:22015267   PMID:22446510   PMID:22493882  
PMID:22796316   PMID:23086141   PMID:23668014   PMID:24770651   PMID:24966188   PMID:25639753   PMID:25708823   PMID:25995451   PMID:26631739   PMID:27378063   PMID:27632349   PMID:27994053  
PMID:28627589   PMID:28663440   PMID:28890073   PMID:28987634   PMID:30582943   PMID:32223946   PMID:36878020   PMID:37245722   PMID:38959295  


Genomics

Comparative Map Data
Aplnr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8390,624,055 - 90,627,700 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl390,624,012 - 90,627,908 (+)EnsemblGRCr8
mRatBN7.2370,217,407 - 70,221,052 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl370,217,385 - 70,221,050 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx373,599,092 - 73,602,742 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0382,197,771 - 82,201,425 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0379,962,920 - 79,966,570 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd388,476,047 - 88,479,712 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive395,405,030 - 95,408,676 (+)NCBILyon_Normotensive
Lyon_Hypertensive387,320,764 - 87,324,421 (+)NCBILyon_Hypertensive
F344_StmMcwi368,634,905 - 68,638,571 (+)NCBIF344_StmMcwi
Rnor_6.0372,540,538 - 72,544,183 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl372,540,538 - 72,544,182 (+)Ensemblrn6Rnor6.0
Rnor_5.0379,052,120 - 79,055,765 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4368,365,637 - 68,369,282 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera369,568,426 - 69,572,071 (+)NCBICelera
RGSC_v3.1368,262,008 - 68,265,653 (+)NCBI
Cytogenetic Map3q24NCBI
APLNR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381157,233,591 - 57,237,250 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1157,233,577 - 57,237,250 (-)Ensemblhg38GRCh38
GRCh371157,001,065 - 57,004,724 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361156,757,643 - 56,761,489 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341156,757,629 - 56,761,364NCBI
Celera1154,360,003 - 54,363,879 (-)NCBICelera
Cytogenetic Map11q12.1NCBI
HuRef1153,349,884 - 53,353,760 (-)NCBIHuRef
CHM1_11156,867,161 - 56,871,037 (-)NCBICHM1_1
T2T-CHM13v2.01157,183,042 - 57,186,701 (-)NCBIT2T-CHM13v2.0
Aplnr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39284,966,704 - 84,970,267 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl284,966,569 - 84,970,267 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38285,136,360 - 85,139,923 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl285,136,225 - 85,139,923 (+)Ensemblmm10GRCm38
MGSCv37284,976,517 - 84,980,080 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36284,937,239 - 84,940,762 (+)NCBIMGSCv36mm8
Celera286,724,848 - 86,728,415 (+)NCBICelera
Cytogenetic Map2DNCBI
cM Map249.45NCBI
Aplnr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555112,322,920 - 2,324,068 (-)Ensembl
ChiLan1.0NW_0049555112,321,445 - 2,324,417 (-)NCBIChiLan1.0ChiLan1.0
APLNR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2958,390,693 - 58,394,694 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11159,409,548 - 59,411,613 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01152,475,088 - 52,479,102 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13159,965,089 - 159,968,944 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3159,967,360 - 159,968,502 (-)EnsemblpanPan2panpan1.1
APLNR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11838,878,621 - 38,882,280 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1838,878,947 - 38,886,206 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1838,423,440 - 38,427,189 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01839,559,840 - 39,563,591 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.11839,141,690 - 39,145,439 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01838,715,653 - 38,719,404 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01839,346,074 - 39,349,830 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Aplnr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494715,117,132 - 15,120,749 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365815,231,242 - 5,232,384 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365815,230,836 - 5,234,562 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
APLNR
(Sus scrofa - pig)		 No map positions available.
APLNR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1116,007,092 - 16,011,868 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl116,008,300 - 16,009,601 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666038113,347,578 - 113,351,438 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Aplnr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248643,308,794 - 3,309,939 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248643,308,548 - 3,311,431 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Aplnr
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1562,501,270 - 62,502,753 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Aplnr
23 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:302
Count of miRNA genes:186
Interacting mature miRNAs:234
Transcripts:ENSRNOT00000012379
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)351490129111359995Rat
1358293Bw38Body weight QTL 3860.0000031body mass (VT:0001259)body weight (CMO:0000012)374364268119364268Rat
61377Edpm3Estrogen-dependent pituitary mass QTL 37.050.038pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)373592611110333156Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)373592512136118980Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)35365182698651826Rat
2303593Gluco46Glucose level QTL 463blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)34887661993876619Rat
1354590Despr11Despair related QTL 110.000031locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)34887661993876619Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)33540319997383526Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)358601291153936591Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)349872657138829559Rat
631832Sach1Saccharin preference QTL 12.70.02consumption behavior trait (VT:0002069)calculated saccharin drink intake volume (CMO:0001600)34790417292904172Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)385062224136118980Rat
631647Bp122Blood pressure QTL 1226.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)35109256196092561Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)385062224136118980Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)381425008141509147Rat
9590286Uminl1Urine mineral level QTL 13.50.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)34865774493657744Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)370845569136091483Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)358925062103925062Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)370311536115311536Rat
631200Cm25Cardiac mass QTL 254.80.0001heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)381541464126563126Rat
9590136Scort3Serum corticosterone level QTL 323.370.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)34865774493657744Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)35076614595766145Rat
61356Bp37Blood pressure QTL 373blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)35109256196092561Rat
1558650Cm48Cardiac mass QTL 4840.0001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)35076614595766145Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)336721849110333156Rat
8694196Abfw2Abdominal fat weight QTL 216.580.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)34865774493657744Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)342158111124558371Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
8552950Pigfal12Plasma insulin-like growth factor 1 level QTL 127.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)34865774493657744Rat
8694386Bw159Body weight QTL 1594.520.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)34865774493657744Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)342158111124558371Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat

Markers in Region
RH137244  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2370,220,828 - 70,221,025 (+)MAPPERmRatBN7.2
Rnor_6.0372,543,960 - 72,544,156NCBIRnor6.0
Rnor_5.0379,055,542 - 79,055,738UniSTSRnor5.0
RGSC_v3.4368,369,059 - 68,369,255UniSTSRGSC3.4
Celera369,571,848 - 69,572,044UniSTS
Cytogenetic Map3q24UniSTS
UniSTS:234445  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2370,217,597 - 70,217,860 (+)MAPPERmRatBN7.2
Rnor_6.0372,540,729 - 72,540,991NCBIRnor6.0
Rnor_5.0379,052,311 - 79,052,573UniSTSRnor5.0
RGSC_v3.4368,365,828 - 68,366,090UniSTSRGSC3.4
Celera369,568,617 - 69,568,879UniSTS
Cytogenetic Map3q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 150 89 88 57 72 57 6 334 172 11 125 81 92 31 9 9

Sequence


Ensembl Acc Id: ENSRNOT00000012379   ⟹   ENSRNOP00000012379
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl390,624,012 - 90,627,908 (+)Ensembl
mRatBN7.2 Ensembl370,217,385 - 70,221,050 (+)Ensembl
Rnor_6.0 Ensembl372,540,538 - 72,544,182 (+)Ensembl
RefSeq Acc Id: NM_031349   ⟹   NP_112639
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8390,624,055 - 90,627,700 (+)NCBI
mRatBN7.2370,217,407 - 70,221,052 (+)NCBI
Dahl_SR_JrHsd388,476,047 - 88,479,712 (+)NCBI
Lyon_Normotensive395,405,030 - 95,408,676 (+)NCBI
Lyon_Hypertensive387,320,764 - 87,324,421 (+)NCBI
F344_StmMcwi368,634,905 - 68,638,571 (+)NCBI
Rnor_6.0372,540,538 - 72,544,183 (+)NCBI
Rnor_5.0379,052,120 - 79,055,765 (+)NCBI
RGSC_v3.4368,365,637 - 68,369,282 (+)RGD
Celera369,568,426 - 69,572,071 (+)RGD
Sequence:
RefSeq Acc Id: NP_112639   ⟸   NM_031349
- UniProtKB: Q9ESK2 (UniProtKB/Swiss-Prot),   Q9JHG3 (UniProtKB/Swiss-Prot),   A6HMT5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000012379   ⟸   ENSRNOT00000012379
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JHG3-F1-model_v2 AlphaFold Q9JHG3 1-377 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692191
Promoter ID:EPDNEW_R2716
Type:single initiation site
Name:Aplnr_1
Description:apelin receptor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0372,540,512 - 72,540,572EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621645 AgrOrtholog
BioCyc Gene G2FUF-49137 BioCyc
Ensembl Genes ENSRNOG00000009227 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000012379 ENTREZGENE
  ENSRNOT00000012379.5 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7097318 IMAGE-MGC_LOAD
InterPro APJ_rcpt UniProtKB/Swiss-Prot
  GPCR1 UniProtKB/Swiss-Prot
  GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
KEGG Report rno:83518 UniProtKB/Swiss-Prot
MGC_CLONE MGC:91642 IMAGE-MGC_LOAD
NCBI Gene 83518 ENTREZGENE
PANTHER APELIN RECEPTOR UniProtKB/Swiss-Prot
  CELL ADHESION MOLECULE UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PhenoGen Aplnr PhenoGen
PRINTS APJRECEPTOR UniProtKB/Swiss-Prot
  GPCRRHODOPSN UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000009227 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
UniProt A6HMT5 ENTREZGENE, UniProtKB/TrEMBL
  APJ_RAT UniProtKB/Swiss-Prot
  Q9ESK2 ENTREZGENE
  Q9JHG3 ENTREZGENE
UniProt Secondary Q9ESK2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-26 Aplnr  apelin receptor  Agtrl1  angiotensin receptor-like 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Agtrl1  angiotensin receptor-like 1      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Agtrl1  angiotensin receptor-like 1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_process involved in body fluid regulation 1304389
gene_process involved in the regulation of hypothalamic function 1304460