Nln (neurolysin) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Nln (neurolysin) Rattus norvegicus
Analyze
Symbol: Nln
Name: neurolysin
RGD ID: 621518
Description: Enables metalloendopeptidase activity and oligopeptidase activity. Involved in peptide catabolic process and protein catabolic process. Is active in mitochondrial intermembrane space. Orthologous to human NLN (neurolysin); PARTICIPATES IN renin-angiotensin cascade pathway; INTERACTS WITH 1,10-phenanthroline; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: MEP; microsomal endopeptidase; mitochondrial oligopeptidase M; neurolysin (metallopeptidase M3 family); neurolysin, mitochondrial; neurotensin endopeptidase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8236,867,436 - 36,966,749 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl236,853,551 - 36,966,680 (-)EnsemblGRCr8
mRatBN7.2235,133,634 - 35,232,927 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl235,134,145 - 35,232,914 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx242,248,083 - 42,345,656 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0240,306,773 - 40,404,352 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0235,163,341 - 35,261,069 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd237,058,820 - 37,156,549 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive237,087,541 - 37,185,268 (-)NCBILyon_Normotensive
Lyon_Hypertensive236,991,841 - 37,089,566 (-)NCBILyon_Hypertensive
F344_StmMcwi236,820,003 - 36,917,588 (-)NCBIF344_StmMcwi
Rnor_6.0234,086,970 - 34,185,835 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl234,087,880 - 34,185,812 (-)Ensemblrn6Rnor6.0
Rnor_5.0253,215,233 - 53,314,136 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4234,915,111 - 35,031,566 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera231,110,866 - 31,209,296 (-)NCBICelera
RGSC_v3.1234,835,479 - 34,951,935 (-)NCBI
Cytogenetic Map2q13NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
COVID-19  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,10-phenanthroline  (EXP)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-phenylbutyric acid  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buspirone  (EXP)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
chromium(6+)  (ISO)
cobalt dichloride  (ISO)
cyclosporin A  (ISO)
deoxynivalenol  (ISO)
dextran sulfate  (ISO)
dibutyl phthalate  (EXP)
dimethyl sulfoxide  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
EDTA(2-)  (EXP)
entinostat  (ISO)
erianin  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fipronil  (EXP)
formaldehyde  (ISO)
genistein  (ISO)
inulin  (ISO)
ivermectin  (ISO)
ketamine  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mercury dibromide  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
nickel atom  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
succimer  (ISO)
sunitinib  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Molecular cloning and expression of rat brain endopeptidase 3.4.24.16. Dauch P, etal., J Biol Chem 1995 Nov 10;270(45):27266-71.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. Metalloendopeptidases EC 3.4.24.15/16 regulate bradykinin activity in the cerebral microvasculature. Norman MU, etal., Am J Physiol Heart Circ Physiol 2003 Jun;284(6):H1942-8. Epub 2003 Feb 13.
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. Mapping sequence differences between thimet oligopeptidase and neurolysin implicates key residues in substrate recognition. Ray K, etal., Protein Sci 2002 Sep;11(9):2237-46.
8. GOA pipeline RGD automated data pipeline
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Novel natural peptide substrates for endopeptidase 24.15, neurolysin, and angiotensin-converting enzyme. Rioli V, etal., J Biol Chem. 2003 Mar 7;278(10):8547-55. doi: 10.1074/jbc.M212030200. Epub 2002 Dec 24.
11. Characterization of a mitochondrial metallopeptidase reveals neurolysin as a homologue of thimet oligopeptidase. Serizawa A, etal., J Biol Chem. 1995 Feb 3;270(5):2092-8.
12. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:9182559   PMID:11248043   PMID:12609826   PMID:16515556   PMID:17882707   PMID:18614015   PMID:22039052   PMID:23412923   PMID:24719317   PMID:24719333   PMID:25378390  


Genomics

Comparative Map Data
Nln
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8236,867,436 - 36,966,749 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl236,853,551 - 36,966,680 (-)EnsemblGRCr8
mRatBN7.2235,133,634 - 35,232,927 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl235,134,145 - 35,232,914 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx242,248,083 - 42,345,656 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0240,306,773 - 40,404,352 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0235,163,341 - 35,261,069 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd237,058,820 - 37,156,549 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive237,087,541 - 37,185,268 (-)NCBILyon_Normotensive
Lyon_Hypertensive236,991,841 - 37,089,566 (-)NCBILyon_Hypertensive
F344_StmMcwi236,820,003 - 36,917,588 (-)NCBIF344_StmMcwi
Rnor_6.0234,086,970 - 34,185,835 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl234,087,880 - 34,185,812 (-)Ensemblrn6Rnor6.0
Rnor_5.0253,215,233 - 53,314,136 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4234,915,111 - 35,031,566 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera231,110,866 - 31,209,296 (-)NCBICelera
RGSC_v3.1234,835,479 - 34,951,935 (-)NCBI
Cytogenetic Map2q13NCBI
NLN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38565,722,205 - 65,829,283 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl565,722,205 - 65,871,725 (+)Ensemblhg38GRCh38
GRCh37565,018,032 - 65,125,111 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36565,053,841 - 65,155,149 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34565,053,840 - 65,155,143NCBI
Celera562,016,491 - 62,123,591 (+)NCBICelera
Cytogenetic Map5q12.3NCBI
HuRef561,976,109 - 62,083,226 (+)NCBIHuRef
CHM1_1565,017,717 - 65,124,844 (+)NCBICHM1_1
T2T-CHM13v2.0566,543,992 - 66,651,091 (+)NCBIT2T-CHM13v2.0
Nln
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913104,159,558 - 104,246,170 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl13104,159,565 - 104,246,122 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3813104,023,050 - 104,109,673 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl13104,023,057 - 104,109,614 (-)Ensemblmm10GRCm38
MGSCv3713104,813,519 - 104,899,694 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3613105,143,604 - 105,229,957 (-)NCBIMGSCv36mm8
Celera13108,414,173 - 108,500,684 (-)NCBICelera
Cytogenetic Map13D1NCBI
cM Map1356.16NCBI
Nln
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554463,256,078 - 3,374,462 (-)Ensembl
ChiLan1.0NW_0049554463,258,278 - 3,374,337 (-)NCBIChiLan1.0ChiLan1.0
NLN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2448,098,743 - 48,198,296 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1546,242,006 - 46,351,916 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0548,180,768 - 48,283,281 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1549,834,121 - 49,938,192 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl549,840,482 - 49,938,192 (-)EnsemblpanPan2panpan1.1
NLN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1251,445,941 - 51,551,425 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl251,444,566 - 51,538,028 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha248,400,415 - 48,494,439 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0251,935,923 - 52,030,529 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl251,935,938 - 52,041,328 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1248,995,440 - 49,095,747 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0249,784,767 - 49,878,766 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0250,676,985 - 50,771,434 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Nln
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213194,447,083 - 194,544,535 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364803,383,540 - 3,481,009 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364803,383,514 - 3,480,991 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NLN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1644,225,677 - 44,334,610 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11644,225,706 - 44,333,623 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21647,574,962 - 47,681,332 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NLN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1461,918,079 - 62,022,517 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl461,918,137 - 62,016,144 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604910,561,550 - 10,666,098 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nln
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248154,017,514 - 4,162,237 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248154,020,212 - 4,162,233 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Nln
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v13193,258,751 - 193,350,025 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Nln
935 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:86
Count of miRNA genes:65
Interacting mature miRNAs:78
Transcripts:ENSRNOT00000066925
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10755430Coatc6Coat color QTL 60.02576coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)21332504158325041Rat
7387318Stl32Serum triglyceride level QTL 323.20.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)22411781369117813Rat
10755436Coatc8Coat color QTL 80.02431coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23675034481750344Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
738010Lnnr3Liver neoplastic nodule remodeling QTL 32.94liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)2142977529Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
9590080Insglur4Insulin/glucose ratio QTL 428.70.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)2615276751152767Rat
1300160Hrtrt3Heart rate QTL 33.62heart pumping trait (VT:2000009)absolute change in heart rate (CMO:0000534)23561408353462005Rat
1579916Bp270Blood pressure QTL 2700.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)21605188361051883Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22203804467038044Rat
731166Mamtr2Mammary tumor resistance QTL 20.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2962358154623581Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)227148328145807373Rat
9590095Sffal3Serum free fatty acids level QTL 36.780.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)22888999173889991Rat
1331764Bp205Blood pressure QTL 2053.476arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)21436870759368707Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1600379Mcs18Mammary carcinoma susceptibility QTL 182.6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2962358144538110Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)27605533104774005Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22865266683465677Rat
1578664Bmd9Bone mineral QTL density 95femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)2573632550736325Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)228652666139067443Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)230219200171802126Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21822713763227137Rat
61371Edpm1Estrogen-dependent pituitary mass QTL 140.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)23686864381868643Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)230219200171802126Rat
1582246Cm60Cardiac mass QTL 605.8heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)23326999678269996Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22865266673652666Rat

Markers in Region
D2Mgh1  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8236,868,643 - 36,868,772 (+)Marker Load Pipeline
mRatBN7.2235,134,841 - 35,134,970 (+)MAPPERmRatBN7.2
Rnor_6.0234,088,175 - 34,088,303NCBIRnor6.0
Rnor_5.0253,216,438 - 53,216,566UniSTSRnor5.0
RGSC_v3.4234,914,943 - 34,915,072RGDRGSC3.4
RGSC_v3.4234,914,944 - 34,915,072UniSTSRGSC3.4
Celera231,110,695 - 31,110,827UniSTS
RGSC_v3.1234,835,312 - 34,835,441RGD
RH 3.4 Map2126.7UniSTS
RH 3.4 Map2126.7RGD
RH 2.0 Map2189.6RGD
SHRSP x BN Map215.0498RGD
FHH x ACI Map223.0699RGD
Cytogenetic Map2q13UniSTS
RH132947  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2235,231,684 - 35,232,738 (+)MAPPERmRatBN7.2
Rnor_6.0234,184,591 - 34,185,644NCBIRnor6.0
Rnor_5.0253,312,891 - 53,313,944UniSTSRnor5.0
RGSC_v3.4235,030,475 - 35,031,528UniSTSRGSC3.4
Celera231,208,205 - 31,209,258UniSTS
RH 3.4 Map2139.8UniSTS
Cytogenetic Map2q13UniSTS
BM382907  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2235,135,013 - 35,135,165 (+)MAPPERmRatBN7.2
Rnor_6.0234,088,347 - 34,088,498NCBIRnor6.0
Rnor_5.0253,216,610 - 53,216,761UniSTSRnor5.0
RGSC_v3.4234,915,116 - 34,915,267UniSTSRGSC3.4
Celera231,110,871 - 31,111,022UniSTS
RH 3.4 Map2123.4UniSTS
Cytogenetic Map2q13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_053970 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006231880 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006231881 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017590591 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101583 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101584 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101585 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281171 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005500227 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC129167 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC072687 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473955 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228111 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230641 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X87157 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000066925   ⟹   ENSRNOP00000059652
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl236,868,811 - 36,931,537 (-)Ensembl
mRatBN7.2 Ensembl235,135,300 - 35,232,914 (-)Ensembl
Rnor_6.0 Ensembl234,088,342 - 34,185,682 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000082755   ⟹   ENSRNOP00000069520
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl236,868,389 - 36,966,680 (-)Ensembl
mRatBN7.2 Ensembl235,134,145 - 35,197,739 (-)Ensembl
Rnor_6.0 Ensembl234,087,880 - 34,185,812 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000136255   ⟹   ENSRNOP00000110362
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl236,867,130 - 36,966,680 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000136305   ⟹   ENSRNOP00000109293
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl236,853,551 - 36,966,680 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000151101   ⟹   ENSRNOP00000108426
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl236,854,504 - 36,966,680 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000165562   ⟹   ENSRNOP00000108124
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl236,873,270 - 36,966,680 (-)Ensembl
RefSeq Acc Id: NM_053970   ⟹   NP_446422
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8236,868,811 - 36,966,572 (-)NCBI
mRatBN7.2235,135,009 - 35,232,776 (-)NCBI
Dahl_SR_JrHsd237,058,820 - 37,156,549 (-)NCBI
Lyon_Normotensive237,087,541 - 37,185,268 (-)NCBI
Lyon_Hypertensive236,991,841 - 37,089,566 (-)NCBI
F344_StmMcwi236,820,003 - 36,917,588 (-)NCBI
Rnor_6.0234,088,342 - 34,185,682 (-)NCBI
Rnor_5.0253,215,233 - 53,314,136 (-)NCBI
RGSC_v3.4234,915,111 - 35,031,566 (-)RGD
Celera231,110,866 - 31,209,296 (-)RGD
Sequence:
RefSeq Acc Id: XM_006231880   ⟹   XP_006231942
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8236,869,341 - 36,966,729 (-)NCBI
mRatBN7.2235,135,539 - 35,232,925 (-)NCBI
Rnor_6.0234,097,165 - 34,185,835 (-)NCBI
Rnor_5.0253,215,233 - 53,314,136 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039101583   ⟹   XP_038957511
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8236,867,436 - 36,966,749 (-)NCBI
mRatBN7.2235,133,634 - 35,232,925 (-)NCBI
RefSeq Acc Id: XM_039101584   ⟹   XP_038957512
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8236,867,436 - 36,966,717 (-)NCBI
mRatBN7.2235,133,637 - 35,232,926 (-)NCBI
RefSeq Acc Id: XM_039101585   ⟹   XP_038957513
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8236,885,894 - 36,966,729 (-)NCBI
mRatBN7.2235,153,414 - 35,232,927 (-)NCBI
RefSeq Acc Id: XM_063281171   ⟹   XP_063137241
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8236,884,537 - 36,966,729 (-)NCBI
RefSeq Acc Id: XR_005500227
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8236,869,338 - 36,966,729 (-)NCBI
mRatBN7.2235,135,536 - 35,232,925 (-)NCBI
RefSeq Acc Id: NP_446422   ⟸   NM_053970
- Peptide Label: precursor
- UniProtKB: Q6GQQ4 (UniProtKB/Swiss-Prot),   P42676 (UniProtKB/Swiss-Prot),   A0A0G2JSY3 (UniProtKB/TrEMBL),   A6I5E6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006231942   ⟸   XM_006231880
- Peptide Label: isoform X3
- UniProtKB: Q6GQQ4 (UniProtKB/Swiss-Prot),   P42676 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000069520   ⟸   ENSRNOT00000082755
Ensembl Acc Id: ENSRNOP00000059652   ⟸   ENSRNOT00000066925
RefSeq Acc Id: XP_038957511   ⟸   XM_039101583
- Peptide Label: isoform X1
- UniProtKB: Q6GQQ4 (UniProtKB/Swiss-Prot),   P42676 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038957512   ⟸   XM_039101584
- Peptide Label: isoform X2
- UniProtKB: A0A0G2JVK4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038957513   ⟸   XM_039101585
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063137241   ⟸   XM_063281171
- Peptide Label: isoform X5
Ensembl Acc Id: ENSRNOP00000109293   ⟸   ENSRNOT00000136305
Ensembl Acc Id: ENSRNOP00000108426   ⟸   ENSRNOT00000151101
Ensembl Acc Id: ENSRNOP00000108124   ⟸   ENSRNOT00000165562
Ensembl Acc Id: ENSRNOP00000110362   ⟸   ENSRNOT00000136255
Protein Domains
Peptidase M3A/M3B catalytic

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P42676-F1-model_v2 AlphaFold P42676 1-704 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691119
Promoter ID:EPDNEW_R1644
Type:initiation region
Name:Nln_1
Description:neurolysin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0234,185,744 - 34,185,804EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621518 AgrOrtholog
BioCyc Gene G2FUF-54558 BioCyc
Ensembl Genes ENSRNOG00000011561 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000066925 ENTREZGENE
  ENSRNOT00000082755 ENTREZGENE
  ENSRNOT00000165562 ENTREZGENE
Gene3D-CATH 1.10.1370.10 UniProtKB/Swiss-Prot
  3.40.390.10 UniProtKB/Swiss-Prot
  Endopeptidase. Chain P, domain 1 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7099208 IMAGE-MGC_LOAD
InterPro MetalloPept_cat_dom_sf UniProtKB/Swiss-Prot
  Neurolysin/TOP_dom2 UniProtKB/Swiss-Prot
  Neurolysin/TOP_N UniProtKB/Swiss-Prot
  Pept_M3A_M3B UniProtKB/Swiss-Prot
  Pept_M3A_M3B UniProtKB/Swiss-Prot
KEGG Report rno:117041 UniProtKB/Swiss-Prot
MGC_CLONE MGC:91547 IMAGE-MGC_LOAD
NCBI Gene 117041 ENTREZGENE
PANTHER NEUROLYSIN, MITOCHONDRIAL UniProtKB/Swiss-Prot
  PTHR11804 UniProtKB/Swiss-Prot
Pfam Peptidase_M3 UniProtKB/Swiss-Prot
PhenoGen Nln PhenoGen
PROSITE ZINC_PROTEASE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000011561 RatGTEx
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/Swiss-Prot
UniProt A0A0G2JSY3 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2JVK4 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LC09_RAT UniProtKB/TrEMBL
  A0ABK0LR62_RAT UniProtKB/TrEMBL
  A0ABK0LT20_RAT UniProtKB/TrEMBL
  A0ABK0M0F5_RAT UniProtKB/TrEMBL
  A6I5E6 ENTREZGENE, UniProtKB/TrEMBL
  A6I5E7_RAT UniProtKB/TrEMBL
  NEUL_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q6GQQ4 ENTREZGENE
UniProt Secondary Q6GQQ4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-03 Nln  neurolysin  Nln  neurolysin (metallopeptidase M3 family)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Nln  neurolysin (metallopeptidase M3 family)      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Nln  neurolysin (metallopeptidase M3 family)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in brain, ileum, kidney, and testis 729279
gene_protein 704-amino acid protein 729279