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Gene: Rnf138 (ring finger protein 138) Rattus norvegicus

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Symbol:

Rnf138 (Ensembl: AABR07031480.1)

Name:

ring finger protein 138

RGD ID:

621485

Description:

Predicted to enable protein kinase binding activity; single-stranded DNA binding activity; and ubiquitin protein ligase activity. Predicted to be involved in DNA double-strand break processing involved in repair via single-strand annealing; double-strand break repair via homologous recombination; and protein ubiquitination. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Is active in glutamatergic synapse; postsynapse; and presynapse. Orthologous to human RNF138 (ring finger protein 138); INTERACTS WITH (+)-schisandrin B; 2,4-dinitrotoluene; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

E3 ubiquitin-protein ligase RNF138; MGC72355; ring finger protein 138, E3 ubiquitin protein ligase; RING-type E3 ubiquitin transferase RNF138; RSD-4; Rsd4; Trif; Trif gene; Trif-pending

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	RNF138 (ring finger protein 138)	HGNC	Ensembl, HomoloGene, NCBI, OMA, OrthoDB, Panther
Mus musculus (house mouse):	Rnf138 (ring finger protein 138)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Rnf138 (ring finger protein 138)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	RNF138 (ring finger protein 138)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	RNF138 (ring finger protein 138)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Rnf138 (ring finger protein 138)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	RNF138 (ring finger protein 138)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	RNF138 (ring finger protein 138)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Rnf138 (ring finger protein 138)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Rnf138 (ring finger protein 138)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	RNASE9 (ribonuclease A family member 9 (inactive))	HGNC	OMA
Alliance orthologs ³
Mus musculus (house mouse):	Rnf138 (ring finger protein 138)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Rnf138 (ring finger protein 138)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	RNF138 (ring finger protein 138)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	RNF138 (ring finger protein 138)	Alliance	DIOPT (HGNC\|Hieranoid\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	rnf138	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	rnf138	Alliance	DIOPT (OrthoFinder\|PANTHER)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	18	12,558,430 - 12,590,849 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	18	12,566,502 - 12,590,848 (+)	Ensembl				GRCr8
mRatBN7.2	18	12,291,557 - 12,315,931 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	18	12,291,590 - 12,315,930 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	18	12,482,547 - 12,506,187 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	18	13,270,197 - 13,293,835 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	18	12,541,843 - 12,565,479 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	18	15,146,925 - 15,167,361 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	18	14,930,044 - 14,947,566 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	18	12,764,220 - 12,788,635 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	18	12,291,209 - 12,314,858 (+)	NCBI		Celera
RGSC_v3.1	18	12,790,865 - 12,815,280 (+)	NCBI
Cytogenetic Map	18	p12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

COVID-19 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4-dinitrotoluene (EXP)

6-propyl-2-thiouracil (EXP)

aflatoxin B1 (ISO)

alachlor (EXP)

amitrole (EXP)

ammonium chloride (EXP)

antirheumatic drug (ISO)

atrazine (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bisphenol A (EXP)

bortezomib (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

calcitriol (ISO)

cisplatin (ISO)

cobalt dichloride (EXP)

cyclosporin A (ISO)

DDE (ISO)

decabromodiphenyl ether (EXP)

dexamethasone (EXP)

Dibutyl phosphate (ISO)

dibutyl phthalate (EXP)

ethanol (ISO)

flutamide (EXP)

genistein (EXP)

gold atom (ISO)

gold(0) (ISO)

indole-3-methanol (EXP)

ketamine (EXP)

lead diacetate (ISO)

mercury atom (ISO)

mercury(0) (ISO)

methapyrilene (EXP)

methimazole (EXP)

paracetamol (ISO)

phenobarbital (ISO)

phorone (EXP)

pirinixic acid (ISO)

propiconazole (EXP)

rotenone (EXP)

sodium arsenite (ISO)

sodium dichromate (EXP)

sunitinib (ISO)

tauroursodeoxycholic acid (EXP)

testosterone (EXP,ISO)

tetrachloromethane (EXP)

thalidomide (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

triphenyl phosphate (EXP,ISO)

ursodeoxycholic acid (EXP)

valproic acid (ISO)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to leukemia inhibitory factor (ISO)

DNA damage response (IEA)

DNA double-strand break processing involved in repair via single-strand annealing (IBA,IEA,ISO,ISS)

DNA repair (IEA)

double-strand break repair via homologous recombination (IBA,IEA,ISO,ISS)

protein ubiquitination (IEA,ISO,ISS)

Wnt signaling pathway (IEA)

Cellular Component

chromosome (IEA)

glutamatergic synapse (IDA,IEP)

postsynapse (IDA,IEP)

presynapse (IDA,IEP)

site of double-strand break (IBA,IEA,ISO,ISS)

Molecular Function

DNA binding (IEA)

metal ion binding (IEA)

protein binding (ISO)

protein kinase binding (IEA,ISO)

single-stranded DNA binding (IBA,IEA,ISO,ISS)

transferase activity (IEA)

ubiquitin protein ligase activity (IBA,IEA,ISO,ISS)

zinc ion binding (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Ubiquitin Ligase RNF138 Promotes Episodic Ataxia Type 2-Associated Aberrant Degradation of Human Cav2.1 (P/Q-Type) Calcium Channels.	Fu SJ, etal., J Neurosci. 2017 Mar 1;37(9):2485-2503. doi: 10.1523/JNEUROSCI.3070-16.2017. Epub 2017 Feb 6.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
4.	GOA pipeline	RGD automated data pipeline
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:15489334	PMID:16714285	PMID:20439489	PMID:21630459	PMID:26502055	PMID:26502057	PMID:32084554

Genomics

Comparative Map Data

Rnf138
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	18	12,558,430 - 12,590,849 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	18	12,566,502 - 12,590,848 (+)	Ensembl				GRCr8
mRatBN7.2	18	12,291,557 - 12,315,931 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	18	12,291,590 - 12,315,930 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	18	12,482,547 - 12,506,187 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	18	13,270,197 - 13,293,835 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	18	12,541,843 - 12,565,479 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	18	15,146,925 - 15,167,361 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	18	14,930,044 - 14,947,566 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	18	12,764,220 - 12,788,635 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	18	12,291,209 - 12,314,858 (+)	NCBI		Celera
RGSC_v3.1	18	12,790,865 - 12,815,280 (+)	NCBI
Cytogenetic Map	18	p12	NCBI

RNF138
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	18	32,091,874 - 32,131,561 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	18	32,091,871 - 32,131,561 (+)	Ensembl			hg38	GRCh38
GRCh37	18	29,671,837 - 29,711,524 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	18	27,925,835 - 27,965,522 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	18	26,478,784 - 26,518,455 (+)	NCBI		Celera
Cytogenetic Map	18	q12.1	NCBI
HuRef	18	26,528,248 - 26,568,009 (+)	NCBI		HuRef
CHM1_1	18	29,599,353 - 29,639,057 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	18	32,282,268 - 32,321,925 (+)	NCBI		T2T-CHM13v2.0

Rnf138
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	18	21,134,202 - 21,161,281 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	18	21,134,398 - 21,161,281 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	18	21,001,245 - 21,028,224 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	18	21,001,341 - 21,028,224 (+)	Ensembl			mm10	GRCm38
MGSCv37	18	21,159,842 - 21,186,724 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	18	21,144,351 - 21,171,233 (+)	NCBI		MGSCv36	mm8
Celera	18	21,496,957 - 21,523,998 (+)	NCBI		Celera
Cytogenetic Map	18	A2	NCBI
cM Map	18	11.73	NCBI

Rnf138
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955402	19,330,961 - 19,358,799 (+)	Ensembl
ChiLan1.0	NW_004955402	19,344,480 - 19,358,799 (+)	NCBI	ChiLan1.0	ChiLan1.0

RNF138
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	17	49,468,799 - 49,508,777 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	18	35,161,399 - 35,201,374 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	18	25,300,480 - 25,340,010 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	18	28,896,127 - 28,934,935 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2

RNF138
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	7	57,521,416 - 57,554,793 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	7	57,523,595 - 57,556,005 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	7	56,955,081 - 56,990,132 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	7	57,502,811 - 57,538,001 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	7	57,485,272 - 57,537,434 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	7	57,179,830 - 57,214,993 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	7	57,199,179 - 57,234,266 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	7	57,495,078 - 57,530,149 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Rnf138
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404944	53,172,154 - 53,204,341 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936682	1,173,797 - 1,205,870 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936682	1,173,734 - 1,206,417 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

RNF138
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	115,926,774 - 115,978,724 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	6	115,927,021 - 115,975,754 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	108,584,385 - 108,632,318 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

RNF138
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	18	48,604,241 - 48,643,834 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	18	48,603,965 - 48,642,720 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666050	23,157,057 - 23,195,283 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Rnf138
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624770	860,391 - 895,039 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624770	858,081 - 895,361 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Rnf138
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	15	22,313,904 - 22,338,205 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Rnf138
319 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	312
Count of miRNA genes:	196
Interacting mature miRNAs:	247
Transcripts:	ENSRNOT00000021061
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2301410	Bp317	Blood pressure QTL 317		0.004	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	12219237	26822399	Rat
2301409	Cm70	Cardiac mass QTL 70		0.001	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	18	7065728	52065728	Rat
61382	Bp46	Blood pressure QTL 46	18.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	12216684	31644508	Rat
12904716	Am21	Aortic mass QTL 21		0.005	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	18	7065728	52065728	Rat
8552968	Pigfal19	Plasma insulin-like growth factor 1 level QTL 19	11.4		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	18	1	26032889	Rat
12904714	Cm131	Cardiac mass QTL 131		0.002	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	18	7065728	52065728	Rat
12904715	Cm132	Cardiac mass QTL 132		0.001	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	18	7065728	52065728	Rat
1331781	Scl28	Serum cholesterol level QTL 28	3.995		blood HDL cholesterol amount (VT:0000184)	serum high density lipoprotein cholesterol level (CMO:0000361)	18	1	25071266	Rat
6903356	Bp354	Blood pressure QTL 354	4.6		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	1	15642423	Rat
6903345	Bp349	Blood pressure QTL 349	3.9		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	3917226	48917226	Rat
6903347	Bp350	Blood pressure QTL 350	4.4		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	1	31610627	Rat
2312568	Glom21	Glomerulus QTL 21	2	0.005	kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	18	5460455	42690191	Rat
6903349	Bp351	Blood pressure QTL 351	3.5		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	3917226	48917226	Rat
6903351	Bp352	Blood pressure QTL 352	3.3		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	3917226	48917226	Rat
1331766	Bp236	Blood pressure QTL 236	3.022		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	1	31610627	Rat
631264	Scl22	Serum cholesterol level QTL 22	6.2		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	18	12216684	31644508	Rat
2325839	Bp348	Blood pressure QTL 348		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	1	44930869	Rat
12904680	Bw189	Body weight QTL 189		0.019	body mass (VT:0001259)	body weight (CMO:0000012)	18	12219237	26822399	Rat
2293708	Bss46	Bone structure and strength QTL 46	8.8	0.0001	lumbar vertebra morphology trait (VT:0010494)	lumbar vertebra cortical cross-sectional area (CMO:0001690)	18	12066482	57066482	Rat
1641910	Colcr3	Colorectal carcinoma resistance QTL 3	5.02	0.000007	intestine integrity trait (VT:0010554)	poorly differentiated malignant colorectal tumor number (CMO:0002076)	18	1	25022372	Rat
12904693	Am20	Aortic mass QTL 20		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	18	12219237	26822399	Rat
1578667	Bss21	Bone structure and strength QTL 21	3.5		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	18	12066482	85493247	Rat
12904695	Kidm73	Kidney mass QTL 73		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	18	12219237	26822399	Rat
2312598	Bp340	Blood pressure QTL 340		0.05	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	3811902	30809809	Rat
12904689	Cm128	Cardiac mass QTL 128		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	18	12219237	26822399	Rat
12904690	Cm129	Cardiac mass QTL 129		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	18	12219237	26822399	Rat
2300180	Bmd67	Bone mineral density QTL 67	4.8	0.0001	femur mineral mass (VT:0010011)	bone mineral density (CMO:0001226)	18	1	34566578	Rat
12904691	Cm130	Cardiac mass QTL 130		0.001	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	18	12219237	26822399	Rat
9590248	Scort10	Serum corticosterone level QTL 10	19.71	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	18	1	26032889	Rat
2299160	Iddm35	Insulin dependent diabetes mellitus QTL 35	2.79		blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	18	4482648	49482648	Rat
1331753	Bp231	Blood pressure QTL 231	3.643		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	1	54490981	Rat
1578661	Bss20	Bone structure and strength QTL 20	3.7		femur morphology trait (VT:0000559)	femoral neck cross-sectional area (CMO:0001697)	18	12066482	85493247	Rat
11565454	Kidm59	Kidney mass QTL 59		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	18	7065728	52065728	Rat
2293661	Bss50	Bone structure and strength QTL 50	4.64	0.0003	lumbar vertebra size trait (VT:0010518)	lumbar vertebra trabecular cross-sectional area (CMO:0001692)	18	1	34566578	Rat
61375	Bp41	Blood pressure QTL 41	2.4		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	18	4307354	49307354	Rat

Markers in Region

RH137198

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_5.0	3	9,492,778 - 9,493,079	NCBI	Rnor5.0
RGSC_v3.4	3	4,859,269 - 4,859,569	UniSTS	RGSC3.4
Celera	11	63,200,736 - 63,200,942	UniSTS
Celera	3	4,325,822 - 4,326,122	UniSTS
Cytogenetic Map	11	q22	UniSTS
Cytogenetic Map	18	p12	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	hemolymphoid system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	sensory system	visual system
7	1	18	52	67	138	95	11	51	36	32	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_053588	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039097200	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039097201	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF315468	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC061821	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473974	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ220857	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000018	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000021061 ⟹ ENSRNOP00000021061

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	18	12,291,590 - 12,309,732 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000100953 ⟹ ENSRNOP00000091039

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	18	12,292,218 - 12,315,238 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000102423 ⟹ ENSRNOP00000084639

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	18	12,292,302 - 12,315,930 (+)	Ensembl

RefSeq Acc Id:

NM_053588 ⟹ NP_446040

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	12,567,224 - 12,590,849 (+)	NCBI
mRatBN7.2	18	12,292,302 - 12,315,931 (+)	NCBI
Rnor_6.0	18	15,146,925 - 15,167,361 (-)	NCBI
Rnor_5.0	18	14,930,044 - 14,947,566 (-)	NCBI
RGSC_v3.4	18	12,764,220 - 12,788,635 (+)	RGD
Celera	18	12,291,209 - 12,314,858 (+)	RGD

Sequence:

show sequence

GCCACCTCGGCTCCTGCGGGCGCTGTCGCCTCTCCCGCCCACCCCTCGCCATGTCCGAGGAGCT
TTCGGCGGACACGTCCTACACGGAAGATGATTTCTACTGCCCAGTCTGTCAGGAGGTGCTCAAG
ACGCCGGTGCGGACCGCGGCCTGTCAGCACGTTTTCTGTAGAAAATGTTTCCTGACTGCAATGA
GAGAGAGTGGAATACATTGTCCCCTATGTCGCGGAAGTGTGACTAGAAGAGAAAGAGCATGTCC
GGAACGGGCCATAGATCTTGAAAATATCATGAGGAGGGTTTCTGGTAGCTGCAGATGCTGTTCA
AAAAAGATTAAATTTTATCGCATGAGACATCATTACAAATCTTGTAAGAAGTATCAGGATGAAT
ATGGTGTCTCTTCTGTCATTCCAAATGTTAAGATTTCTCAAGATTCAGTAAGGAGCAGTAATAG
GAGTGAAACATCTGCATCTGATAACACAGAAACTTATCAAGAGGATACAAGTTCTTCTGGGCAT
CCCACCTTTAAGTGTCCCTTATGTCAAGAGTCAAATTTCACCAGACAACGTTTATTGGATCACT
GTAATAGTAACCACCTGTTTCAGATAGTTCCTGTGAATCTTCAGCTAGATGAGGAAACCCAATA
TCAAACTGCTGTGGAAGAGTCTTTCCAAGTTAACATGTGATGTGTGTAGACATCTCTGCCTCCT
TGCTACCTACAAGTGCCATCTTTAAGGAGAAGACATGAAGTCACCGTTTTCAGTAATTTGCTGT
GCATATTAATAAAAATAATAATTCAGTCTACTGTATTAGGTTTTTAATTGAAAATAAAGGTGGG
CCACCCTAATTCCATTCTCTAGACAGTTACTTTAACAGCATGGAAAGGGTCGTATTTCACTTGT
ATGGTGAAAAGGGAATCTGTTGTCTTTTTCTTTCTTGTATTACATATTCTGAATGTTTAAGTTG
TTTTTGATAATTTGGTACAGTTCCTTCTATTTAGTACAGAGATAACTGCAAATTCTGAACGATG
TGATTCCTATAAAACTAATAAACCTGAGCCATTTGTCAGAGCTGCAGAGTGGAAACTTGAAGTG
CAAAGGGGAGGGGGGTCCAAAGGGGTTTTTCAAAAGAATAGATCCTAGCTGAGGATACAATAAG
AAAATTGTATTTATATAATGTTTAGTATTTTTGAAGACTAGTGAGATTTCTTTAATAATTTTGA
CTCTGAAAGTGTATTGTACAAATGTTTCTTCTTTTGTGGTTAGAAGAAACAAGAGAAAAAGTTT
TCGTTGGTGGTGTTTGTTATTTCAATCTAGGTTGAGTAATTTGTAAGCCCAAATATGTTATATG
ACAGTTCTTTGTAGTCAGTGTTTCTCACTTGCTGATGAAACTTTTTAGTCAGTGAATGATACAT
TACACTTAAATTAGTTTTTTAAAAATCCAAAGTTGCAGATGTATGTGGATATGTACATAGACTT
TTGCATGTATATATACACATATATATCCTTGCCTAGAGTTTGTCAGGTTATGTATAGAATTTCT
ATTAAAGAGTTTTAATAATGGACAGCAATATAGGATTGAAGTATTTATCTCATTTGTTTAAAAC
TTTGTATGTTACCACGTTTTTAAAACAGTAAACCAAATACTACGTGGTACAGTTGGCTGTTATT
ACACCTGAAAAAATGTGTTAAATGGTGCTCATTTGTTCTTTTTGAAAATGATTCATAGCTGATG
TGTGGTGAGATTTTACCAGCCTCTGTTTCACTACATTTTAGTCAAAACCGAGTTCTTAATCTTT
GGTATAAGGTAATGTAGAGAAGTCACAGAGCGCAGGGTGAAGAGGGAATTCTGACATTCCACAC
TAACATAACACTGTTACGCTTTCTTTAAAATAACTAAACGCAAAAGAAAATCTCTGAAGTAGTT
TGCTGCTAATATATACATATATTGTAAAAAAGGTATATTTTGATTTTCTTAATACCCTTGTTGA
CTTTTCTACAATGAACATTTTTTTTAACTTGATTTAATAAAAATGTTAATTTTGGATGTGCAGT
TTTGTAAAAACCTTTTTCAGTTAAACAGTAATGACTTTATTTATGTTTAGTAATGTAGACTCAC
AACAAGCCATACATCTTAATACCTTTTTATTCCCTGTCATTTCTTGAGCGTGACGTTTACTGTG
TTCTCTAGCACTTTGAGTTGACATACAAGAGTGTAATCCTAGGAACATCTATATAATGAACTCT
TTAAAGGGAGACTTCTCTCCACAGAAGCAATAACCTGGATGCTTTTAAAGTTAAATTTAGCCAG
TGCGTTGCTAAATCTCCCTGGGATGTACAAACTTAAAGGGAAACTTGTACTAGAGATCATTTTG
GAATCCTGTTTGAAGTCTTGTGGATGAGTTAAATATTAATATATTTATAGCTTTTTCATGAGAA
TTATCTCTTTTGCATTAGTAACTTATTAAAAATGGAAAAAAGTTTTAAATTCTTTTTTGTCAGT
AGATTAAGAACAAGGGTTGACTTTACAGTTTAATTCATGGGGAAGAAGCCTCAGTGGTGGTGGT
TAGTAGCCGCCAGCATGAAGGAGGAAGCTGTAGCAGTGTGCTGACGCATCGCTTTCACGGTACC
ACTTAGGAAAGCCATTTCTCCTTCAACTTAGTTTAGTCTTTGTCCTTCAATACAGTGTTCATTG
AGATGTATTGCTTTATTTTTCAATTAAAAATGGTTTTCTCCTAAAAAAAAAAAAAAAAAAAAAA
A

hide sequence

RefSeq Acc Id:

XM_039097200 ⟹ XP_038953128

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	12,558,430 - 12,588,910 (+)	NCBI
mRatBN7.2	18	12,291,557 - 12,315,931 (+)	NCBI

RefSeq Acc Id:

XM_039097201 ⟹ XP_038953129

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	12,558,430 - 12,588,910 (+)	NCBI
mRatBN7.2	18	12,291,576 - 12,315,931 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_446040	(Get FASTA)	NCBI Sequence Viewer
	XP_038953128	(Get FASTA)	NCBI Sequence Viewer
	XP_038953129	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH61821	(Get FASTA)	NCBI Sequence Viewer
	AAK11282	(Get FASTA)	NCBI Sequence Viewer
	EDL76101	(Get FASTA)	NCBI Sequence Viewer
	EDL76102	(Get FASTA)	NCBI Sequence Viewer
	EDL76103	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000021061
	ENSRNOP00000084639
	ENSRNOP00000084639.1
	ENSRNOP00000091039
GenBank Protein	Q99PD2	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_446040 ⟸ NM_053588

- UniProtKB:

Q99PD2 (UniProtKB/Swiss-Prot), A6J2H0 (UniProtKB/TrEMBL), A6J2H1 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSEELSADTSYTEDDFYCPVCQEVLKTPVRTAACQHVFCRKCFLTAMRESGIHCPLCRGSVTRR
ERACPERAIDLENIMRRVSGSCRCCSKKIKFYRMRHHYKSCKKYQDEYGVSSVIPNVKISQDSV
RSSNRSETSASDNTETYQEDTSSSGHPTFKCPLCQESNFTRQRLLDHCNSNHLFQIVPVNLQLD
EETQYQTAVEESFQVNM

hide sequence

RefSeq Acc Id:	XP_038953128 ⟸ XM_039097200
- Peptide Label:	isoform X1
- UniProtKB:	A6J2G9 (UniProtKB/TrEMBL), A0A8I6ABB7 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038953129 ⟸ XM_039097201
- Peptide Label:	isoform X2
- UniProtKB:	Q99PD2 (UniProtKB/Swiss-Prot), A6J2H0 (UniProtKB/TrEMBL), A6J2H1 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000091039 ⟸ ENSRNOT00000100953

Ensembl Acc Id:

ENSRNOP00000021061 ⟸ ENSRNOT00000021061

Ensembl Acc Id:

ENSRNOP00000084639 ⟸ ENSRNOT00000102423

Protein Domains

C2HC RNF-type RING-type UIM

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D4ABZ6-F1-model_v2	AlphaFold	D4ABZ6	1-209	view protein structure
AF-Q99PD2-F1-model_v2	AlphaFold	Q99PD2	1-209	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:621485	AgrOrtholog
BioCyc Gene	G2FUF-8205	BioCyc
Ensembl Genes	ENSRNOG00000015645	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000021061	ENTREZGENE
	ENSRNOT00000100953	ENTREZGENE
	ENSRNOT00000102423	ENTREZGENE
	ENSRNOT00000102423.1	UniProtKB/Swiss-Prot
Gene3D-CATH	3.30.40.10	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:5599087	IMAGE-MGC_LOAD
InterPro	E3_ubiq-protein_ligase_RNF138	UniProtKB/Swiss-Prot
	ZF_C2HC_RNF	UniProtKB/Swiss-Prot
	Znf_RING	UniProtKB/Swiss-Prot
	Znf_RING/FYVE/PHD	UniProtKB/Swiss-Prot
KEGG Report	rno:94196	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:72355	IMAGE-MGC_LOAD
NCBI Gene	94196	ENTREZGENE
PANTHER	E3 UBIQUITIN-PROTEIN LIGASE RNF138	UniProtKB/Swiss-Prot
	E3 UBIQUITIN-PROTEIN LIGASE RNF138	UniProtKB/Swiss-Prot
Pfam	zf-C3HC4_2	UniProtKB/Swiss-Prot
	zf_C2HC_14	UniProtKB/Swiss-Prot
PhenoGen	Rnf138	PhenoGen
PROSITE	ZF_C2HC_RNF	UniProtKB/Swiss-Prot
	ZF_RING_2	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000015645	RatGTEx
SMART	RING	UniProtKB/Swiss-Prot
Superfamily-SCOP	RING/U-box	UniProtKB/Swiss-Prot
UniProt	A0A8I6ABB7	ENTREZGENE, UniProtKB/TrEMBL
	A6J2G9	ENTREZGENE, UniProtKB/TrEMBL
	A6J2H0	ENTREZGENE, UniProtKB/TrEMBL
	A6J2H1	ENTREZGENE, UniProtKB/TrEMBL
	D4ABZ6_RAT	UniProtKB/TrEMBL
	Q99PD2	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-04-13	Rnf138	ring finger protein 138	Rnf138	ring finger protein 138, E3 ubiquitin protein ligase	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2012-10-15	Rnf138	ring finger protein 138, E3 ubiquitin protein ligase	Rnf138	ring finger protein 138	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2004-02-11	Rnf138	ring finger protein 138	Trif-pending	Trif gene	Symbol and Name updated to reflect Human and Mouse nomenclature	625702	APPROVED
2002-08-07	Trif-pending	Trif gene			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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