Adam5 (ADAM metallopeptidase domain 5) - Rat Genome Database

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Gene: Adam5 (ADAM metallopeptidase domain 5) Rattus norvegicus
Analyze
Symbol: Adam5
Name: ADAM metallopeptidase domain 5
RGD ID: 621471
Description: Predicted to enable metalloendopeptidase activity. Involved in male gonad development. Predicted to be located in membrane. Predicted to be active in cell surface and plasma membrane. Orthologous to human ADAM5 (ADAM metallopeptidase domain 5 (pseudogene)); INTERACTS WITH acrylamide; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: a disintegrin and metallopeptidase domain 5; a disintegrin and metalloprotease domain (ADAM) 5; a disintegrin and metalloprotease domain 5; disintegrin and metalloproteinase domain-containing protein 5; MGC108772; tMDC II; tMDCII; transmembrane metalloproteinase-like, disintegrin-like, and cysteine-rich protein II
RGD Orthologs
Human
Mouse
Dog
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81673,925,345 - 74,001,354 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1673,925,734 - 74,001,346 (+)EnsemblGRCr8
mRatBN7.21667,223,095 - 67,298,733 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1667,223,143 - 67,298,737 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1672,500,298 - 72,568,132 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01675,905,967 - 75,973,807 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01671,149,564 - 71,223,095 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1673,839,365 - 73,907,209 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive1675,212,490 - 75,280,328 (+)NCBILyon_Normotensive
Lyon_Hypertensive1675,713,448 - 75,781,286 (+)NCBILyon_Hypertensive
F344_StmMcwi1671,874,731 - 71,948,464 (+)NCBIF344_StmMcwi
Rnor_6.01672,010,069 - 72,085,666 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1672,010,106 - 72,077,916 (+)Ensemblrn6Rnor6.0
Rnor_5.01671,658,527 - 71,732,482 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41671,652,550 - 71,720,886 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1665,125,575 - 65,192,645 (+)NCBICelera
RGSC_v3.11671,661,011 - 71,685,667 (+)NCBI
Cytogenetic Map16q12.4NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Chromosomal assignment of four testis-expressed mouse genes from a new family of transmembrane proteins (ADAMs) involved in cell-cell adhesion and fusion. Cho C, etal., Genomics 1996 Jun 15;34(3):413-7.
2. Rat MDC family of proteins: sequence analysis, tissue distribution, and expression in prepubertal and adult rat testis. Frayne J, etal., Mol Reprod Dev 1997 Oct;48(2):159-67.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Chronological gene expression of ADAMs during testicular development: prespermatogonia (gonocytes) express fertilin beta (ADAM2). Rosselot C, etal., Dev Dyn. 2003 Jul;227(3):458-67.
Additional References at PubMed
PMID:12477932  


Genomics

Comparative Map Data
Adam5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81673,925,345 - 74,001,354 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1673,925,734 - 74,001,346 (+)EnsemblGRCr8
mRatBN7.21667,223,095 - 67,298,733 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1667,223,143 - 67,298,737 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1672,500,298 - 72,568,132 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01675,905,967 - 75,973,807 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01671,149,564 - 71,223,095 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1673,839,365 - 73,907,209 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive1675,212,490 - 75,280,328 (+)NCBILyon_Normotensive
Lyon_Hypertensive1675,713,448 - 75,781,286 (+)NCBILyon_Hypertensive
F344_StmMcwi1671,874,731 - 71,948,464 (+)NCBIF344_StmMcwi
Rnor_6.01672,010,069 - 72,085,666 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1672,010,106 - 72,077,916 (+)Ensemblrn6Rnor6.0
Rnor_5.01671,658,527 - 71,732,482 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41671,652,550 - 71,720,886 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1665,125,575 - 65,192,645 (+)NCBICelera
RGSC_v3.11671,661,011 - 71,685,667 (+)NCBI
Cytogenetic Map16q12.4NCBI
ADAM5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38839,314,632 - 39,417,378 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl839,314,591 - 39,417,378 (+)Ensemblhg38GRCh38
GRCh37839,172,151 - 39,274,897 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36839,291,339 - 39,393,902 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34839,291,338 - 39,379,532NCBI
Celera838,123,987 - 38,226,669 (+)NCBICelera
Cytogenetic Map8p11.22NCBI
HuRef837,705,214 - 37,792,637 (+)NCBIHuRef
CHM1_1839,374,176 - 39,421,351 (+)NCBICHM1_1
T2T-CHM13v2.0839,591,725 - 39,694,643 (+)NCBIT2T-CHM13v2.0
Adam5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39825,217,109 - 25,314,385 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl825,217,109 - 25,314,385 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38824,727,093 - 24,824,369 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl824,727,093 - 24,824,369 (-)Ensemblmm10GRCm38
MGSCv37825,843,457 - 25,934,841 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36826,198,530 - 26,289,914 (-)NCBIMGSCv36mm8
Celera826,213,879 - 26,298,142 (-)NCBICelera
Cytogenetic Map8A2NCBI
cM Map813.26NCBI
LOC482849
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11626,042,746 - 26,177,358 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1626,564,402 - 26,698,986 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01627,872,686 - 28,007,310 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.11626,167,738 - 26,302,403 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01626,737,323 - 26,875,980 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01626,782,639 - 26,917,242 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0

Variants

.
Variants in Adam5
348 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:105
Count of miRNA genes:91
Interacting mature miRNAs:96
Transcripts:ENSRNOT00000058330
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)164445512389455123Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)163692878281928782Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)164199206486992064Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164909919691442908Rat
631525Pia14Pristane induced arthritis QTL 144.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)166241446475736480Rat
1357403Slep4Serum leptin concentration QTL 43.91blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)163236104377361043Rat
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165942871491442908Rat
8694453Bw172Body weight QTL 1728.330.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)163105803976058039Rat
1298529Arunc1Aerobic running capacity QTL 14exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)163439829479398294Rat
6903294Stl30Serum triglyceride level QTL 302.60.0013blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)163188527176885271Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)164445512389455123Rat
8694364Abfw7Abdominal fat weight QTL 712.220.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)165942871491442908Rat
8694429Bw164Body weight QTL 16450.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)165942871491442908Rat

Markers in Region
D16Got64  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81673,941,190 - 73,941,374 (+)Marker Load Pipeline
mRatBN7.21667,238,574 - 67,238,760 (+)MAPPERmRatBN7.2
Rnor_6.01672,025,554 - 72,025,737NCBIRnor6.0
Rnor_5.01671,673,871 - 71,674,054UniSTSRnor5.0
RGSC_v3.41671,667,893 - 71,668,077RGDRGSC3.4
RGSC_v3.41671,667,894 - 71,668,077UniSTSRGSC3.4
Celera1665,140,919 - 65,141,102UniSTS
RGSC_v3.11671,668,159 - 71,668,342RGD
RH 3.4 Map16659.3RGD
RH 3.4 Map16659.3UniSTS
RH 2.0 Map16749.5RGD
Cytogenetic Map16q12.4UniSTS


Expression

RNA-SEQ Expression

appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
6 4 43 25 26 11 13 11 2 41 23 37 3 44 15 1 1

Sequence


Ensembl Acc Id: ENSRNOT00000058330   ⟹   ENSRNOP00000055132
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1673,925,748 - 73,993,590 (+)Ensembl
mRatBN7.2 Ensembl1667,223,143 - 67,290,973 (+)Ensembl
Rnor_6.0 Ensembl1672,010,106 - 72,077,916 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000092198   ⟹   ENSRNOP00000072681
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1673,928,786 - 73,982,418 (+)Ensembl
mRatBN7.2 Ensembl1667,226,166 - 67,279,801 (+)Ensembl
Rnor_6.0 Ensembl1672,011,870 - 72,068,048 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000102586   ⟹   ENSRNOP00000096900
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1673,925,777 - 74,001,346 (+)Ensembl
mRatBN7.2 Ensembl1667,223,143 - 67,298,737 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000156706   ⟹   ENSRNOP00000099898
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1673,925,734 - 73,974,933 (+)Ensembl
RefSeq Acc Id: NM_020303   ⟹   NP_064699
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81673,925,763 - 73,993,596 (+)NCBI
mRatBN7.21667,223,143 - 67,290,979 (+)NCBI
Dahl_SR_JrHsd1673,839,365 - 73,907,209 (+)NCBI
Lyon_Normotensive1675,212,490 - 75,280,328 (+)NCBI
Lyon_Hypertensive1675,713,448 - 75,781,286 (+)NCBI
F344_StmMcwi1671,874,731 - 71,948,464 (+)NCBI
Rnor_6.01672,010,126 - 72,077,908 (+)NCBI
Rnor_5.01671,658,527 - 71,732,482 (+)NCBI
RGSC_v3.41671,652,550 - 71,720,886 (+)RGD
Celera1665,125,575 - 65,192,645 (+)RGD
Sequence:
RefSeq Acc Id: XM_006253321   ⟹   XP_006253383
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81673,925,714 - 74,001,354 (+)NCBI
mRatBN7.21667,223,095 - 67,298,732 (+)NCBI
Rnor_6.01672,010,069 - 72,085,666 (+)NCBI
Rnor_5.01671,658,527 - 71,732,482 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006253322   ⟹   XP_006253384
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81673,925,714 - 73,993,596 (+)NCBI
mRatBN7.21667,223,095 - 67,290,979 (+)NCBI
Rnor_6.01672,010,071 - 72,077,912 (+)NCBI
Rnor_5.01671,658,527 - 71,732,482 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063275648   ⟹   XP_063131718
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81673,925,345 - 73,993,596 (+)NCBI
RefSeq Acc Id: NP_064699   ⟸   NM_020303
- UniProtKB: Q5BK84 (UniProtKB/Swiss-Prot),   A0A0G2K3K9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253383   ⟸   XM_006253321
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006253384   ⟸   XM_006253322
- Peptide Label: isoform X2
- Sequence:
Ensembl Acc Id: ENSRNOP00000072681   ⟸   ENSRNOT00000092198
Ensembl Acc Id: ENSRNOP00000055132   ⟸   ENSRNOT00000058330
Ensembl Acc Id: ENSRNOP00000096900   ⟸   ENSRNOT00000102586
RefSeq Acc Id: XP_063131718   ⟸   XM_063275648
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000099898   ⟸   ENSRNOT00000156706
Protein Domains
Disintegrin   EGF-like   Peptidase M12B

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5BK84-F1-model_v2 AlphaFold Q5BK84 1-709 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700177
Promoter ID:EPDNEW_R10699
Type:initiation region
Name:Adam5_1
Description:ADAM metallopeptidase domain 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01672,010,115 - 72,010,175EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621471 AgrOrtholog
BioCyc Gene G2FUF-10947 BioCyc
Ensembl Genes ENSRNOG00000017518 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000058330 ENTREZGENE
  ENSRNOT00000058330.5 UniProtKB/Swiss-Prot
  ENSRNOT00000102586 ENTREZGENE
  ENSRNOT00000156706 ENTREZGENE
Gene3D-CATH 3.40.390.10 UniProtKB/Swiss-Prot
  4.10.70.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7112347 IMAGE-MGC_LOAD
  IMAGE:7113658 IMAGE-MGC_LOAD
InterPro ADAM_Cys-rich UniProtKB/Swiss-Prot
  Disintegrin_CS UniProtKB/Swiss-Prot
  Disintegrin_dom UniProtKB/Swiss-Prot
  Disintegrin_dom_sf UniProtKB/Swiss-Prot
  EGF-like_dom UniProtKB/Swiss-Prot
  MetalloPept_cat_dom_sf UniProtKB/Swiss-Prot
  Peptidase_M12B UniProtKB/Swiss-Prot
  Reprolysin_adamalysin UniProtKB/Swiss-Prot
KEGG Report rno:498654 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108772 IMAGE-MGC_LOAD
  MGC:93940 IMAGE-MGC_LOAD
NCBI Gene Adam5 ENTREZGENE
PANTHER ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN UniProtKB/Swiss-Prot
  DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 5 UniProtKB/Swiss-Prot
Pfam ADAM_CR UniProtKB/Swiss-Prot
  Disintegrin UniProtKB/Swiss-Prot
  Reprolysin UniProtKB/Swiss-Prot
PhenoGen Adam5 PhenoGen
PROSITE ADAM_MEPRO UniProtKB/Swiss-Prot
  DISINTEGRIN_1 UniProtKB/Swiss-Prot
  DISINTEGRIN_2 UniProtKB/Swiss-Prot
  EGF_2 UniProtKB/Swiss-Prot
  EGF_3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000017518 RatGTEx
SMART ACR UniProtKB/Swiss-Prot
  DISIN UniProtKB/Swiss-Prot
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/Swiss-Prot
  SSF57552 UniProtKB/Swiss-Prot
UniProt A0A0G2K3K9 ENTREZGENE, UniProtKB/TrEMBL
  A0A140TAH8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AU58 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LDJ9_RAT UniProtKB/TrEMBL
  ADAM5_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-18 Adam5  ADAM metallopeptidase domain 5  Adam5  a disintegrin and metallopeptidase domain 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-18 Adam5  ADAM metallopeptidase domain 5  Adam5  a disintegrin and metallopeptidase domain 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-22 Adam5  a disintegrin and metallopeptidase domain 5  Adam5  a disintegrin and metalloprotease domain 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Adam5  a disintegrin and metalloprotease domain 5    a disintegrin and metalloprotease domain (ADAM) 5  Name updated 1299863 APPROVED
2002-08-07 Adam5  a disintegrin and metalloprotease domain (ADAM) 5      Symbol and Name status set to provisional 70820 PROVISIONAL