Megf6 (multiple EGF-like-domains 6) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Megf6 (multiple EGF-like-domains 6) Rattus norvegicus
Analyze
Symbol: Megf6
Name: multiple EGF-like-domains 6
RGD ID: 621188
Description: Predicted to enable calcium ion binding activity and scavenger receptor activity. Predicted to be involved in vesicle-mediated transport. Predicted to be located in extracellular region. Orthologous to human MEGF6 (multiple EGF like domains 6); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 7,12-dimethyltetraphene; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: EGF-like domain-containing protein 3; EGF-like protein 3; EGF-like-domain, multiple 3; Egfl3; epidermal growth factor-like protein 3; LOC100911486; multiple EGF-like domain protein 3; multiple EGF-like domains protein 6; multiple epidermal growth factor-like domains 6; multiple epidermal growth factor-like domains protein 6; multiple epidermal growth factor-like domains protein 6-like
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85170,020,699 - 170,121,557 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5170,020,778 - 170,121,554 (+)EnsemblGRCr8
mRatBN7.25164,738,272 - 164,839,142 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5164,738,352 - 164,839,139 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5167,442,460 - 167,543,339 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05169,263,873 - 169,364,753 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05169,226,389 - 169,327,272 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05171,588,901 - 171,620,947 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5171,472,273 - 171,620,947 (+)Ensemblrn6Rnor6.0
Rnor_5.05175,061,318 - 175,092,801 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45171,022,566 - 171,050,436 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5162,949,005 - 163,049,274 (+)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-azacytidine  (ISO)
7,12-dimethyltetraphene  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
Dibutyl phosphate  (ISO)
diethylstilbestrol  (EXP)
dorsomorphin  (ISO)
fenvalerate  (EXP)
ferric oxide  (EXP)
fulvestrant  (ISO)
genistein  (ISO)
gentamycin  (EXP)
GW 4064  (ISO)
indometacin  (ISO)
methapyrilene  (ISO)
nickel atom  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (EXP)
paraquat  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
propanal  (ISO)
quercetin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sunitinib  (ISO)
T-2 toxin  (ISO)
testosterone  (ISO)
tetraphene  (ISO)
thimerosal  (ISO)
titanium dioxide  (ISO)
Trapidil  (EXP)
triphenyl phosphate  (ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
2. Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening. Nakayama M, etal., Genomics 1998 Jul 1;51(1):27-34.
3. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Megf6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85170,020,699 - 170,121,557 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5170,020,778 - 170,121,554 (+)EnsemblGRCr8
mRatBN7.25164,738,272 - 164,839,142 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5164,738,352 - 164,839,139 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5167,442,460 - 167,543,339 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05169,263,873 - 169,364,753 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05169,226,389 - 169,327,272 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05171,588,901 - 171,620,947 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5171,472,273 - 171,620,947 (+)Ensemblrn6Rnor6.0
Rnor_5.05175,061,318 - 175,092,801 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45171,022,566 - 171,050,436 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5162,949,005 - 163,049,274 (+)NCBICelera
Cytogenetic Map5q36NCBI
MEGF6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3813,487,951 - 3,624,786 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl13,487,942 - 3,611,543 (-)Ensemblhg38GRCh38
GRCh3713,404,515 - 3,528,072 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3613,394,366 - 3,517,919 (-)NCBIBuild 36Build 36hg18NCBI36
Build 3413,429,640 - 3,471,169NCBI
Celera12,657,546 - 2,783,180 (-)NCBICelera
Cytogenetic Map1p36.32NCBI
HuRef12,699,245 - 2,824,471 (-)NCBIHuRef
CHM1_113,391,530 - 3,514,788 (-)NCBICHM1_1
T2T-CHM13v2.012,994,964 - 3,134,506 (-)NCBIT2T-CHM13v2.0
Megf6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394154,255,156 - 154,360,178 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4154,255,187 - 154,360,170 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm384154,170,704 - 154,275,721 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4154,170,730 - 154,275,713 (+)Ensemblmm10GRCm38
MGSCv374153,544,822 - 153,649,830 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv364153,014,513 - 153,119,521 (+)NCBIMGSCv36mm8
Celera4156,454,674 - 156,563,044 (+)NCBICelera
Cytogenetic Map4E2NCBI
cM Map483.89NCBI
Megf6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554868,029,200 - 8,102,876 (+)Ensembl
ChiLan1.0NW_0049554868,029,200 - 8,103,395 (+)NCBIChiLan1.0ChiLan1.0
LOC100975124
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21224,697,347 - 224,825,216 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11223,342,714 - 223,470,778 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012,155,295 - 2,283,034 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.113,283,100 - 3,405,920 (-)NCBIPanPan1.1PanPan1.1panPan2
MEGF6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1558,058,833 - 58,145,855 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl558,059,031 - 58,146,193 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha558,069,548 - 58,159,767 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0558,260,038 - 58,346,898 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl558,260,236 - 58,347,762 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1558,274,617 - 58,361,420 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0558,143,351 - 58,230,183 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0558,533,553 - 58,620,411 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Megf6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505829,101,134 - 29,196,271 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936737269,629 - 364,809 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MEGF6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl665,053,389 - 65,141,380 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1665,055,533 - 65,141,449 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2659,798,036 - 59,826,365 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103225737
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120128,075,329 - 128,195,618 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605432,339,756 - 32,476,481 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Megf6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248186,867,706 - 6,945,383 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Megf6
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v116,449,633 - 6,468,563 (-)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:40
Count of miRNA genes:37
Interacting mature miRNAs:39
Transcripts:ENSRNOT00000000169
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5130249266172190305Rat
1354583Despr3Despair related QTL34.980.0002locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)5132930505172190305Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5141212838172190305Rat
1300119Bp180Blood pressure QTL 1803.82arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5149642129171146538Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5131708216172190305Rat
1549904Neuinf1Neuroinflammation QTL 130nervous system integrity trait (VT:0010566)blood T lymphocyte count (CMO:0000110)5160111176171146538Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)599905133172190305Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5133789363172190305Rat
1331803Rf32Renal function QTL 322.798kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)5134369199172190305Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5136631198172190305Rat
1354631Swd2Spike wave discharge measurement QTL 23.640.0002brain electrophysiology trait (VT:0010557)brain total spike-and-wave discharge duration (CMO:0001740)5156396728172190305Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5133081618172190305Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5138002522170842766Rat
1581505Rf54Renal function QTL 54kidney physiology trait (VT:0002136)kidney 20-HETE level (CMO:0001854)5133270647172190305Rat
1298090Bp155Blood pressure QTL 1553.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)5156289283171137955Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5160071170172129029Rat
2317753Glom24Glomerulus QTL 243.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)5141764300172190305Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5133081618172190305Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5133789363172190305Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5148093485172129029Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5125969677172190305Rat

Markers in Region
BE096131  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25164,838,929 - 164,839,101 (+)MAPPERmRatBN7.2
Rnor_6.05171,620,738 - 171,620,909NCBIRnor6.0
Rnor_5.05175,092,592 - 175,092,763UniSTSRnor5.0
Celera5163,049,065 - 163,049,236UniSTS
RH 3.4 Map51159.6UniSTS
Cytogenetic Map5q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 3 67 150 88 89 58 29 58 6 274 124 11 130 74 92 31 9 9

Sequence


Ensembl Acc Id: ENSRNOT00000000169   ⟹   ENSRNOP00000000169
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5170,020,778 - 170,121,554 (+)Ensembl
mRatBN7.2 Ensembl5164,738,352 - 164,839,139 (+)Ensembl
Rnor_6.0 Ensembl5171,478,608 - 171,620,947 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000055386   ⟹   ENSRNOP00000052252
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5170,085,584 - 170,121,554 (+)Ensembl
mRatBN7.2 Ensembl5164,803,091 - 164,839,139 (+)Ensembl
Rnor_6.0 Ensembl5171,472,273 - 171,620,380 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000091417   ⟹   ENSRNOP00000074085
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5170,020,778 - 170,121,554 (+)Ensembl
mRatBN7.2 Ensembl5164,738,352 - 164,839,139 (+)Ensembl
Rnor_6.0 Ensembl5171,478,555 - 171,620,935 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000125770   ⟹   ENSRNOP00000108462
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5170,020,778 - 170,121,554 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000131670   ⟹   ENSRNOP00000110734
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5170,020,778 - 170,121,554 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000148002   ⟹   ENSRNOP00000108519
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5170,085,560 - 170,121,554 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000149353   ⟹   ENSRNOP00000108057
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5170,020,778 - 170,121,554 (+)Ensembl
RefSeq Acc Id: NM_022955   ⟹   NP_075244
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85170,020,778 - 170,121,554 (+)NCBI
mRatBN7.25164,738,352 - 164,839,139 (+)NCBI
Rnor_6.05171,588,901 - 171,620,947 (+)NCBI
Rnor_5.05175,061,318 - 175,092,801 (+)NCBI
RGSC_v3.45171,022,566 - 171,050,436 (+)RGD
Celera5162,949,005 - 163,049,274 (+)RGD
Sequence:
RefSeq Acc Id: XM_039110728   ⟹   XP_038966656
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85170,020,699 - 170,121,557 (+)NCBI
mRatBN7.25164,738,273 - 164,839,142 (+)NCBI
RefSeq Acc Id: XM_039110730   ⟹   XP_038966658
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85170,085,518 - 170,121,557 (+)NCBI
mRatBN7.25164,803,098 - 164,839,142 (+)NCBI
Protein Sequences
Protein RefSeqs NP_075244 (Get FASTA)   NCBI Sequence Viewer  
  XP_038966656 (Get FASTA)   NCBI Sequence Viewer  
  XP_038966658 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAA32462 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000000169
  ENSRNOP00000052252
  ENSRNOP00000108057
GenBank Protein O88281 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_075244   ⟸   NM_022955
- Peptide Label: precursor
- UniProtKB: O88281 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_038966656   ⟸   XM_039110728
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038966658   ⟸   XM_039110730
- Peptide Label: isoform X2
- UniProtKB: D4AA94 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000052252   ⟸   ENSRNOT00000055386
Ensembl Acc Id: ENSRNOP00000000169   ⟸   ENSRNOT00000000169
Ensembl Acc Id: ENSRNOP00000074085   ⟸   ENSRNOT00000091417
Ensembl Acc Id: ENSRNOP00000108057   ⟸   ENSRNOT00000149353
Ensembl Acc Id: ENSRNOP00000110734   ⟸   ENSRNOT00000131670
Ensembl Acc Id: ENSRNOP00000108462   ⟸   ENSRNOT00000125770
Ensembl Acc Id: ENSRNOP00000108519   ⟸   ENSRNOT00000148002
Protein Domains
EGF-like   EMI

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O88281-F1-model_v2 AlphaFold O88281 1-1574 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621188 AgrOrtholog
BioCyc Gene G2FUF-38961 BioCyc
Ensembl Genes ENSRNOG00000000156 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000000169 ENTREZGENE
  ENSRNOT00000055386 ENTREZGENE
  ENSRNOT00000149353 ENTREZGENE
Gene3D-CATH Laminin UniProtKB/Swiss-Prot
  Tie2 ligand-binding domain superfamily UniProtKB/Swiss-Prot
InterPro cEGF UniProtKB/Swiss-Prot
  EGF-like_Ca-bd_dom UniProtKB/Swiss-Prot
  EGF-like_dom UniProtKB/Swiss-Prot
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/Swiss-Prot
  EGF_Ca-bd_CS UniProtKB/Swiss-Prot
  EGF_extracell UniProtKB/Swiss-Prot
  EMI_domain UniProtKB/Swiss-Prot
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot
  Laminin_EGF UniProtKB/Swiss-Prot
  MEGF10/SREC1/2-like UniProtKB/Swiss-Prot
  NOTCH1_EGF-like UniProtKB/Swiss-Prot
KEGG Report rno:65049 UniProtKB/Swiss-Prot
NCBI Gene 65049 ENTREZGENE
PANTHER MULTIPLE EGF LIKE DOMAINS 6 UniProtKB/Swiss-Prot
  SCAVENGER RECEPTOR CLASS F UniProtKB/Swiss-Prot
Pfam cEGF UniProtKB/Swiss-Prot
  EGF_2 UniProtKB/Swiss-Prot
  EGF_CA UniProtKB/Swiss-Prot
  FXa_inhibition UniProtKB/Swiss-Prot
  Laminin_EGF UniProtKB/Swiss-Prot
PhenoGen Megf6 PhenoGen
PRINTS EGFLAMININ UniProtKB/Swiss-Prot
PROSITE ASX_HYDROXYL UniProtKB/Swiss-Prot
  EGF_1 UniProtKB/Swiss-Prot
  EGF_2 UniProtKB/Swiss-Prot
  EGF_3 UniProtKB/Swiss-Prot
  EGF_CA UniProtKB/Swiss-Prot
  EMI UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000000156 RatGTEx
SMART EGF UniProtKB/Swiss-Prot
  EGF_CA UniProtKB/Swiss-Prot
  EGF_Lam UniProtKB/Swiss-Prot
Superfamily-SCOP EGF/Laminin UniProtKB/Swiss-Prot
  SSF57184 UniProtKB/Swiss-Prot
UniProt A0A0G2K769_RAT UniProtKB/TrEMBL
  A0ABK0LCV4_RAT UniProtKB/TrEMBL
  A0ABK0M106_RAT UniProtKB/TrEMBL
  A0ABK0M218_RAT UniProtKB/TrEMBL
  A0ABK0M5M2_RAT UniProtKB/TrEMBL
  D4AA94 ENTREZGENE, UniProtKB/TrEMBL
  F1LLY1_RAT UniProtKB/TrEMBL
  MEGF6_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Megf6  multiple EGF-like-domains 6  LOC100911486  multiple epidermal growth factor-like domains protein 6-like  Data merged from RGD:6492904 737654 PROVISIONAL
2012-07-05 LOC100911486  multiple epidermal growth factor-like domains protein 6-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-02-19 Megf6  multiple EGF-like-domains 6  Egfl3  EGF-like-domain, multiple 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Egfl3  EGF-like-domain, multiple 3    MEGF6  Name updated 1299863 APPROVED
2002-08-07 Egfl3  MEGF6      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains seven-transmembrane protein containing multiple cadherin and EGF-like motifs, and two homologues of Drosophila slit protein 68762