Ptprv (protein tyrosine phosphatase, receptor type, V) - Rat Genome Database

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Gene: Ptprv (protein tyrosine phosphatase, receptor type, V) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Ptprv
Name: protein tyrosine phosphatase, receptor type, V
RGD ID: 621123
Description: Enables protein tyrosine phosphatase activity. Involved in several processes, including cellular response to cAMP; cellular response to epidermal growth factor stimulus; and cellular response to parathyroid hormone stimulus. Predicted to be located in membrane; INTERACTS WITH 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one; 6-propyl-2-thiouracil; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: embryonic stem cell protein-tyrosine phosphatase; ES cell phosphatase; Esp; OST-PTP; Osteotesticular phosphatase; osteotesticular protein-tyrosine phosphatase; protein tyrosine phosphatase receptor type V; protein tyrosine phosphatase receptor type W; R-PTP-V; receptor-type tyrosine-protein phosphatase V
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Candidate Gene For: Bp396
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81349,099,922 - 49,120,247 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1349,099,925 - 49,120,121 (-)EnsemblGRCr8
mRatBN7.21346,548,125 - 46,569,148 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1346,548,128 - 46,568,329 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1349,154,881 - 49,175,084 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01350,442,953 - 50,463,157 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01347,709,077 - 47,729,254 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01351,935,239 - 51,956,262 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1351,935,243 - 51,955,735 (-)Ensemblrn6Rnor6.0
Rnor_5.01356,986,598 - 57,006,819 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41348,070,488 - 48,090,682 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1346,873,988 - 46,894,178 (-)NCBICelera
RGSC_v3.11348,084,530 - 48,104,725 (-)NCBI
Cytogenetic Map13q13NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Congenic mapping and sequence analysis of the Renin locus. Flister MJ, etal., Hypertension. 2013 Apr;61(4):850-6. doi: 10.1161/HYPERTENSIONAHA.111.01008. Epub 2013 Mar 4.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Parathyroid hormone regulates the expression of the receptor protein tyrosine phosphatase, OST-PTP, in rat osteoblast-like cells. Mauro LJ, etal., Endocrinology. 1996 Mar;137(3):925-33. doi: 10.1210/endo.137.3.8603605.
4. Identification of a hormonally regulated protein tyrosine phosphatase associated with bone and testicular differentiation. Mauro LJ, etal., J Biol Chem 1994 Dec 2;269(48):30659-67.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10087294  


Genomics

Variants

.
Variants in Ptprv
184 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:53
Count of miRNA genes:51
Interacting mature miRNAs:53
Transcripts:ENSRNOT00000007597
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134863963493639634Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133721624190057603Rat
9589141Insul28Insulin level QTL 2810.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)131186625456866254Rat
6893344Cm79Cardiac mass QTL 791.50.04heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)134627292251216694Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1338975045103588154Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133992469384924693Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134874981487285480Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132485392569853925Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133996821183286298Rat
2317040Aia21Adjuvant induced arthritis QTL 212.75joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)131238432057384320Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131746828262468282Rat
2317046Aia8Adjuvant induced arthritis QTL 83.9700000286102295joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)131238432057384320Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13742179187286911Rat
1331784Bp222Blood pressure QTL 2222.944arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)132433543255601132Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133708798382087983Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)134098358585983585Rat
724564Uae11Urinary albumin excretion QTL 115.7urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)134735425894285672Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1321120177109350286Rat
4145117Mcs27Mammary carcinoma susceptibility QTL 270.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)134599007750392939Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132624480871244808Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133379409678794096Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133992469384924693Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133483494779834947Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1311081740103588154Rat
2301962Cm72Cardiac mass QTL 724.12heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)133379409660914504Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133981472684814726Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133996821184968211Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132624480871244808Rat
12879472Bp399Blood pressure QTL 399arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134778041850392939Rat
11530006Niddm72Non-insulin dependent diabetes mellitus QTL 720.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)133828629883286298Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131103588154Rat
9589164Gluco66Glucose level QTL 666.670.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)131771133662711336Rat
7411662Foco29Food consumption QTL 2920.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)131186625456866254Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
14 12 66 155 86 85 54 78 54 6 329 177 11 133 76 92 31 13 13

Sequence


Ensembl Acc Id: ENSRNOT00000007597   ⟹   ENSRNOP00000007597
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1349,099,925 - 49,120,121 (-)Ensembl
mRatBN7.2 Ensembl1346,548,132 - 46,568,329 (-)Ensembl
Rnor_6.0 Ensembl1351,935,243 - 51,955,735 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000110943   ⟹   ENSRNOP00000095225
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1349,099,925 - 49,118,025 (-)Ensembl
mRatBN7.2 Ensembl1346,548,128 - 46,566,234 (-)Ensembl
RefSeq Acc Id: NM_033099   ⟹   NP_149090
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81349,099,925 - 49,120,121 (-)NCBI
mRatBN7.21346,548,132 - 46,568,329 (-)NCBI
Rnor_6.01351,935,246 - 51,955,440 (-)NCBI
Rnor_5.01356,986,598 - 57,006,819 (-)NCBI
RGSC_v3.41348,070,488 - 48,090,682 (-)RGD
Celera1346,873,988 - 46,894,178 (-)RGD
Sequence:
RefSeq Acc Id: XM_039091068   ⟹   XP_038946996
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81349,099,922 - 49,120,239 (-)NCBI
mRatBN7.21346,548,125 - 46,569,128 (-)NCBI
RefSeq Acc Id: XM_039091069   ⟹   XP_038946997
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81349,099,922 - 49,120,239 (-)NCBI
mRatBN7.21346,548,125 - 46,569,128 (-)NCBI
RefSeq Acc Id: XM_039091070   ⟹   XP_038946998
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81349,099,922 - 49,120,241 (-)NCBI
mRatBN7.21346,548,125 - 46,569,129 (-)NCBI
RefSeq Acc Id: XM_039091071   ⟹   XP_038946999
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81349,102,466 - 49,120,247 (-)NCBI
mRatBN7.21346,550,670 - 46,569,131 (-)NCBI
RefSeq Acc Id: NP_149090   ⟸   NM_033099
- Peptide Label: precursor
- UniProtKB: Q64612 (UniProtKB/Swiss-Prot),   A0A8I6AM78 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000007597   ⟸   ENSRNOT00000007597
RefSeq Acc Id: XP_038946998   ⟸   XM_039091070
- Peptide Label: isoform X3
- UniProtKB: A0A8I6AM78 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946996   ⟸   XM_039091068
- Peptide Label: isoform X1
- UniProtKB: F1M8J3 (UniProtKB/TrEMBL),   A0A8I6AM78 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946997   ⟸   XM_039091069
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AM78 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946999   ⟸   XM_039091071
- Peptide Label: isoform X4
- UniProtKB: A6ICD7 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000095225   ⟸   ENSRNOT00000110943
Protein Domains
Fibronectin type-III   Tyrosine specific protein phosphatases   Tyrosine-protein phosphatase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q64612-F1-model_v2 AlphaFold Q64612 1-1711 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698837
Promoter ID:EPDNEW_R9361
Type:single initiation site
Name:Ptprv_1
Description:protein tyrosine phosphatase, receptor type, V
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01351,955,399 - 51,955,459EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621123 AgrOrtholog
BioCyc Gene G2FUF-18219 BioCyc
Ensembl Genes ENSRNOG00000005277 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000007597 ENTREZGENE
  ENSRNOT00000110943 ENTREZGENE
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot
  3.90.190.10 UniProtKB/Swiss-Prot
InterPro FN3_dom UniProtKB/Swiss-Prot
  FN3_sf UniProtKB/Swiss-Prot
  Ig-like_fold UniProtKB/Swiss-Prot
  Prot-tyrosine_phosphatase-like UniProtKB/Swiss-Prot
  PTPase_domain UniProtKB/Swiss-Prot
  PTPRJ_TM UniProtKB/Swiss-Prot
  RTP_Phos/Ushers UniProtKB/Swiss-Prot
  Tyr_Pase_AS UniProtKB/Swiss-Prot
  Tyr_Pase_cat UniProtKB/Swiss-Prot
  TYR_PHOSPHATASE_dom UniProtKB/Swiss-Prot
KEGG Report rno:64576 UniProtKB/Swiss-Prot
NCBI Gene 64576 ENTREZGENE
PANTHER CYTOKINE RECEPTOR UniProtKB/Swiss-Prot
  PROTEIN TYROSINE PHOSPHATASE, RECEPTOR TYPE, H UniProtKB/Swiss-Prot
Pfam fn3 UniProtKB/Swiss-Prot
  PTP_tm UniProtKB/Swiss-Prot
  Y_phosphatase UniProtKB/Swiss-Prot
PhenoGen Ptprv PhenoGen
PRINTS PRTYPHPHTASE UniProtKB/Swiss-Prot
PROSITE FN3 UniProtKB/Swiss-Prot
  TYR_PHOSPHATASE_1 UniProtKB/Swiss-Prot
  TYR_PHOSPHATASE_2 UniProtKB/Swiss-Prot
  TYR_PHOSPHATASE_PTP UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000005277 RatGTEx
SMART FN3 UniProtKB/Swiss-Prot
  PTPc UniProtKB/Swiss-Prot
  PTPc_motif UniProtKB/Swiss-Prot
Superfamily-SCOP SSF49265 UniProtKB/Swiss-Prot
  SSF52799 UniProtKB/Swiss-Prot
UniProt A0A8I6AM78 ENTREZGENE, UniProtKB/TrEMBL
  A6ICD7 ENTREZGENE, UniProtKB/TrEMBL
  F1M8J3 ENTREZGENE, UniProtKB/TrEMBL
  PTPRV_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Ptprv  protein tyrosine phosphatase, receptor type, V  Esp  Osteotesticular phosphatase  Symbol and Name updated 1299863 APPROVED
2002-08-07 Esp        Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains an extracellular domain with 10 fibronectin type III repeats and a cytoplasmic region with two catalytic domains 632779
gene_protein 1711 amino acids 632779
gene_regulation induced by parathyroid hormone and cyclic AMP analogues 632779