Oprpn (opiorphin prepropeptide) - Rat Genome Database

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Gene: Oprpn (opiorphin prepropeptide) Rattus norvegicus
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Symbol: Oprpn
Name: opiorphin prepropeptide
RGD ID: 620983
Description: Predicted to enable endopeptidase inhibitor activity. Predicted to be involved in regulation of sensory perception of pain. Predicted to be located in extracellular region. Orthologous to human OPRPN (opiorphin prepropeptide); INTERACTS WITH 2,2',5,5'-tetrachlorobiphenyl; acrylamide; C60 fullerene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Muc10; mucin 10; mucin 10, submandibular gland salivary mucin; Prol1; proline rich, lacrimal 1; RSM-1
RGD Orthologs
Human
Bonobo
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81419,986,575 - 20,001,589 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1419,986,575 - 20,001,589 (-)EnsemblGRCr8
mRatBN7.21419,702,535 - 19,717,550 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1419,702,535 - 19,717,550 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1419,671,787 - 19,685,837 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01420,990,666 - 21,004,716 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01419,713,368 - 19,728,701 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01421,338,464 - 21,353,533 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1421,338,601 - 21,352,491 (-)Ensemblrn6Rnor6.0
Rnor_5.01421,252,544 - 21,267,613 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41421,294,053 - 21,308,816 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1419,038,353 - 19,052,855 (-)NCBICelera
RGSC_v3.11421,294,394 - 21,294,762 (-)NCBI
Cytogenetic Map14p22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Molecular cloning of a rat submandibular gland apomucin. Albone EF, etal., J Biol Chem 1994 Jun 17;269(24):16845-52.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:17101991   PMID:22664934   PMID:23580065   PMID:24486428  


Genomics

Comparative Map Data
Oprpn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81419,986,575 - 20,001,589 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1419,986,575 - 20,001,589 (-)EnsemblGRCr8
mRatBN7.21419,702,535 - 19,717,550 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1419,702,535 - 19,717,550 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1419,671,787 - 19,685,837 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01420,990,666 - 21,004,716 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01419,713,368 - 19,728,701 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01421,338,464 - 21,353,533 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1421,338,601 - 21,352,491 (-)Ensemblrn6Rnor6.0
Rnor_5.01421,252,544 - 21,267,613 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41421,294,053 - 21,308,816 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1419,038,353 - 19,052,855 (-)NCBICelera
RGSC_v3.11421,294,394 - 21,294,762 (-)NCBI
Cytogenetic Map14p22NCBI
OPRPN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38470,397,940 - 70,410,195 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl470,397,931 - 70,410,195 (+)Ensemblhg38GRCh38
GRCh37471,263,657 - 71,275,912 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36471,298,188 - 71,310,503 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34471,444,452 - 71,456,671NCBI
Celera468,621,402 - 68,633,756 (+)NCBICelera
Cytogenetic Map4q13.3NCBI
HuRef467,065,908 - 67,078,224 (+)NCBIHuRef
CHM1_1471,299,691 - 71,312,010 (+)NCBICHM1_1
T2T-CHM13v2.0473,737,473 - 73,749,728 (+)NCBIT2T-CHM13v2.0
OPRPN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2359,680,693 - 59,693,006 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1459,875,811 - 59,889,597 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0453,820,177 - 53,833,961 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1460,165,212 - 60,177,582 (-)NCBIPanPan1.1PanPan1.1panPan2
OPRPN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1718,913,378 - 18,925,886 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl718,914,978 - 18,925,760 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660843,974,853 - 3,976,934 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Oprpn
24 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:13
Count of miRNA genes:13
Interacting mature miRNAs:13
Transcripts:ENSRNOT00000032459
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300114Srn2Serum renin concentration QTL 23.27blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)14395787821572472Rat
631528Scl11Serum cholesterol level QTL 114.9blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)141787564536079022Rat
7411573Bw139Body weight QTL 1394.70.001body mass (VT:0001259)body weight gain (CMO:0000420)14140068101Rat
9589814Gluco67Glucose level QTL 674.540.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14140068101Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)14939329839411170Rat
631212Bw5Body weight QTL55.43retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)141133490630674469Rat
2302277Gluco38Glucose level QTL 385.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141133471628389666Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14395787831121464Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14862139853621398Rat
61420Pia6Pristane induced arthritis QTL 64.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)141891545442433608Rat
70195Mcs8Mammary carcinoma susceptibility QTL 84.28mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)14395787824886169Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1411334716100078267Rat
2313397Coatc1Coat color QTL1coat/hair pigmentation trait (VT:0010463)coat/hair color measurement (CMO:0001808)141889519263895192Rat
631262Tcas4Tongue tumor susceptibility QTL 47.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)141790672654251504Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141415516Rat
70204Niddm20Non-insulin dependent diabetes mellitus QTL 205.10.000008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)14131893212Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14862139853621398Rat
1300140Srn3Serum renin concentration QTL 33.19blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)141513759431238250Rat

Markers in Region
BI279147  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map14291.1UniSTS
Cytogenetic Map14p21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
4 1 3 20 15 20 1 44 1 2 70 57 7 9 7 26 19

Sequence


Ensembl Acc Id: ENSRNOT00000032459   ⟹   ENSRNOP00000038702
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1419,986,575 - 20,001,589 (-)Ensembl
mRatBN7.2 Ensembl1419,702,535 - 19,717,550 (-)Ensembl
Rnor_6.0 Ensembl1421,338,601 - 21,352,491 (-)Ensembl
RefSeq Acc Id: NM_133513   ⟹   NP_598197
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81419,986,575 - 20,001,589 (-)NCBI
mRatBN7.21419,702,535 - 19,717,550 (-)NCBI
Rnor_6.01421,338,464 - 21,353,533 (-)NCBI
Rnor_5.01421,252,544 - 21,267,613 (-)NCBI
RGSC_v3.41421,294,053 - 21,308,816 (-)RGD
Celera1419,038,353 - 19,052,855 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_598197 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA20966 (Get FASTA)   NCBI Sequence Viewer  
  AAA75589 (Get FASTA)   NCBI Sequence Viewer  
  EDL88508 (Get FASTA)   NCBI Sequence Viewer  
  EDL88509 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000038702
  ENSRNOP00000038702.3
RefSeq Acc Id: NP_598197   ⟸   NM_133513
- Peptide Label: precursor
- UniProtKB: E9PTY1 (UniProtKB/TrEMBL),   Q63549 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000038702   ⟸   ENSRNOT00000032459

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-E9PTY1-F1-model_v2 AlphaFold E9PTY1 1-309 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620983 AgrOrtholog
BioCyc Gene G2FUF-16153 BioCyc
Ensembl Genes ENSRNOG00000023578 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000032459 ENTREZGENE
  ENSRNOT00000032459.7 UniProtKB/TrEMBL
KEGG Report rno:65182 UniProtKB/TrEMBL
NCBI Gene 65182 ENTREZGENE
PANTHER PROLINE RICH, LACRIMAL 1 UniProtKB/TrEMBL
  PROLINE-RICH, LACRIMAL 1 UniProtKB/TrEMBL
PhenoGen Oprpn PhenoGen
RatGTEx ENSRNOG00000023578 RatGTEx
UniProt E9PTY1 ENTREZGENE, UniProtKB/TrEMBL
  Q62605_RAT UniProtKB/TrEMBL
  Q63549 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-07-25 Oprpn  opiorphin prepropeptide  Prol1  proline rich, lacrimal 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-04-23 Prol1  proline rich, lacrimal 1  Muc10  mucin 10, submandibular gland salivary mucin  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Muc10  mucin 10, submandibular gland salivary mucin      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Muc10  mucin 10, submandibular gland salivary mucin      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains an N-terminal domain which is enriched in glutamine,proline ,tyrosine and a central region which consisted of eleven, 39-base pair tandem repeats with the consensus sequence PTTDSTTPAPTTK, and a C-terminal domain which is enriched in threonine and serine residues 633373
gene_protein 322 amino acid residues 633373