Gpr173 (G-protein coupled receptor 173) - Rat Genome Database

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Gene: Gpr173 (G-protein coupled receptor 173) Rattus norvegicus
Analyze
Symbol: Gpr173 (Ensembl: AABR07037489.1)
Name: G-protein coupled receptor 173
RGD ID: 620748
Description: Predicted to enable gonadotropin-releasing hormone receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and cellular response to gonadotropin-releasing hormone. Predicted to act upstream of or within negative regulation of neuron migration. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human GPR173 (G protein-coupled receptor 173); INTERACTS WITH ammonium chloride; bisphenol A; vinclozolin.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hypothetical protein LOC685576; LOC102555688; LOC685576; probable G-protein coupled receptor 173; probable G-protein coupled receptor 173-like; Sreb3; super conserved receptor expressed in brain 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X24,925,634 - 24,950,485 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX24,922,704 - 24,950,887 (-)EnsemblGRCr8
mRatBN7.2X21,446,261 - 21,471,119 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX21,447,361 - 21,471,498 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX18,914,539 - 18,915,660 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X21,207,908 - 21,209,029 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X22,014,735 - 22,015,856 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X22,417,753 - 22,418,873 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX22,417,753 - 22,418,873 (-)Ensemblrn6Rnor6.0
Rnor_5.0X64,162,930 - 64,164,050 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X41,846,307 - 41,847,429 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX21,710,846 - 21,711,967 (-)NCBICelera
RGSC_v3.1X41,899,775 - 41,900,898 (-)NCBI
Cytogenetic MapXq13NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA)
plasma membrane  (IBA,IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. An evolutionarily conserved G-protein coupled receptor family, SREB, expressed in the central nervous system. Matsumoto M, etal., Biochem Biophys Res Commun 2000 Jun 7;272(2):576-82.
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:23321696   PMID:27440717   PMID:32505354  


Genomics

Comparative Map Data
Gpr173
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X24,925,634 - 24,950,485 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX24,922,704 - 24,950,887 (-)EnsemblGRCr8
mRatBN7.2X21,446,261 - 21,471,119 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX21,447,361 - 21,471,498 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX18,914,539 - 18,915,660 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X21,207,908 - 21,209,029 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X22,014,735 - 22,015,856 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X22,417,753 - 22,418,873 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX22,417,753 - 22,418,873 (-)Ensemblrn6Rnor6.0
Rnor_5.0X64,162,930 - 64,164,050 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X41,846,307 - 41,847,429 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX21,710,846 - 21,711,967 (-)NCBICelera
RGSC_v3.1X41,899,775 - 41,900,898 (-)NCBI
Cytogenetic MapXq13NCBI
GPR173
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X53,048,789 - 53,080,615 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX53,048,789 - 53,080,615 (+)Ensemblhg38GRCh38
GRCh37X53,077,971 - 53,109,797 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X53,095,231 - 53,123,968 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34X52,961,526 - 52,990,263NCBI
CeleraX56,934,390 - 56,936,128 (+)NCBICelera
Cytogenetic MapXp11.22NCBI
HuRefX50,140,776 - 50,196,313 (+)NCBIHuRef
CHM1_1X53,068,643 - 53,099,921 (+)NCBICHM1_1
T2T-CHM13v2.0X52,333,387 - 52,366,851 (+)NCBIT2T-CHM13v2.0
Gpr173
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X151,126,594 - 151,151,763 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX151,126,594 - 151,151,700 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38X152,343,598 - 152,368,736 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX152,343,598 - 152,368,704 (-)Ensemblmm10GRCm38
MGSCv37X148,779,189 - 148,802,654 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36X147,685,362 - 147,708,827 (-)NCBIMGSCv36mm8
MGSCv36X129,353,131 - 129,376,480 (-)NCBIMGSCv36mm8
Cytogenetic MapXF3NCBI
cM MapX68.46NCBI
Gpr173
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955475137,239 - 158,670 (+)Ensembl
ChiLan1.0NW_004955475137,239 - 158,670 (+)NCBIChiLan1.0ChiLan1.0
GPR173
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X54,447,458 - 54,476,980 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X54,451,071 - 54,478,016 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X45,262,876 - 45,292,398 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X53,372,577 - 53,399,278 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX53,397,890 - 53,399,011 (+)EnsemblpanPan2panpan1.1
GPR173
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X45,009,157 - 45,033,188 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX45,012,005 - 45,013,126 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_TashaX36,397,385 - 36,421,386 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0X45,188,643 - 45,212,657 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX45,189,180 - 45,212,652 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X44,683,879 - 44,707,885 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X45,133,531 - 45,157,538 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X45,201,132 - 45,224,858 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Gpr173
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X37,721,834 - 37,741,529 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493675161,936 - 81,254 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493675161,770 - 82,769 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPR173
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX45,883,767 - 45,908,537 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1X45,883,738 - 45,908,197 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X51,383,702 - 51,408,183 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GPR173
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X49,185,372 - 49,217,506 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX49,213,513 - 49,214,631 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660863,137,575 - 3,169,537 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gpr173
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624909297,374 - 320,729 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624909297,324 - 320,731 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Gpr173
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1X13,489,911 - 13,494,016 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Gpr173
82 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598873Memor2Memory QTL 22.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)X2447036044931007Rat
70165Bp64Blood pressure QTL 645.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X400149344939387Rat
2290375Gluco34Glucose level QTL 342.75blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X2447036045082063Rat
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X197044046970440Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X811148653111486Rat

Markers in Region
GPR173_9777  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X21,449,637 - 21,449,749 (+)MAPPERmRatBN7.2
mRatBN7.2X21,448,866 - 21,449,749 (+)MAPPERmRatBN7.2
mRatBN7.2X21,448,866 - 21,450,366 (+)MAPPERmRatBN7.2
Rnor_6.0X22,417,503 - 22,418,384NCBIRnor6.0
Rnor_6.0X22,417,503 - 22,419,112NCBIRnor6.0
Rnor_5.0X64,162,690 - 64,164,300NCBIRnor5.0
RGSC_v3.4X41,846,057 - 41,846,940UniSTSRGSC3.4
CeleraX21,710,595 - 21,711,478UniSTS
Cytogenetic MapXq21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
10 1 24 68 27 23 11 16 11 6 122 60 11 55 41 45 12 12 12

Sequence


Ensembl Acc Id: ENSRNOT00000079982   ⟹   ENSRNOP00000096581
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX24,925,466 - 24,950,887 (-)Ensembl
mRatBN7.2 EnsemblX21,447,361 - 21,471,105 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000088630
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX24,925,202 - 24,950,887 (-)Ensembl
mRatBN7.2 EnsemblX21,449,227 - 21,471,498 (-)Ensembl
Rnor_6.0 EnsemblX22,417,753 - 22,418,873 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000151587   ⟹   ENSRNOP00000103741
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX24,925,505 - 24,931,064 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000171653   ⟹   ENSRNOP00000106457
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX24,922,704 - 24,929,706 (-)Ensembl
RefSeq Acc Id: NM_022255   ⟹   NP_071591
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X24,925,634 - 24,950,485 (-)NCBI
mRatBN7.2X21,446,261 - 21,471,119 (-)NCBI
Rnor_6.0X22,417,753 - 22,418,873 (-)NCBI
Rnor_5.0X64,162,930 - 64,164,050 (+)NCBI
RGSC_v3.4X41,846,307 - 41,847,429 (-)RGD
CeleraX21,710,846 - 21,711,967 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_071591 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAA96650 (Get FASTA)   NCBI Sequence Viewer  
  EDL86297 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000092248
  ENSRNOP00000096581.1
GenBank Protein Q9JJH2 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_071591   ⟸   NM_022255
- UniProtKB: Q9JJH2 (UniProtKB/Swiss-Prot),   A6KLC3 (UniProtKB/TrEMBL),   A0A8I6AH63 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000096581   ⟸   ENSRNOT00000079982
Ensembl Acc Id: ENSRNOP00000103741   ⟸   ENSRNOT00000151587
Ensembl Acc Id: ENSRNOP00000106457   ⟸   ENSRNOT00000171653
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K5Q7-F1-model_v2 AlphaFold A0A0G2K5Q7 1-117 view protein structure
AF-Q9JJH2-F1-model_v2 AlphaFold Q9JJH2 1-373 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620748 AgrOrtholog
BioCyc Gene G2FUF-2712 BioCyc
Ensembl Genes ENSRNOG00000057658 Ensembl
  ENSRNOG00000060137 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000079982.2 UniProtKB/Swiss-Prot
  ENSRNOT00000088630 ENTREZGENE
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
InterPro GPCR_Orphan/Phoenixin UniProtKB/Swiss-Prot
  GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
KEGG Report rno:64021 UniProtKB/Swiss-Prot
NCBI Gene 64021 ENTREZGENE
PANTHER G PROTEIN-COUPLED RECEPTOR UniProtKB/Swiss-Prot
  G-PROTEIN COUPLED RECEPTOR 173-RELATED UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PhenoGen Gpr173 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000057658 RatGTEx
  ENSRNOG00000060137 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
UniProt A0A8I6AH63 ENTREZGENE, UniProtKB/TrEMBL
  A6KLC3 ENTREZGENE, UniProtKB/TrEMBL
  GP173_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Gpr173  G-protein coupled receptor 173  LOC102555688  probable G-protein coupled receptor 173-like  Data merged from RGD:7675934 737654 PROVISIONAL
2015-07-29 LOC102555688  probable G-protein coupled receptor 173-like  LOC685576  hypothetical protein LOC685576  Data merged from RGD:1592572 737654 PROVISIONAL
2013-12-18 LOC102555688  probable G-protein coupled receptor 173-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-01-09 LOC685576  hypothetical protein LOC685576  LOC684078  hypothetical protein LOC684078  Data merged from RGD:1595169 1643240 APPROVED
2006-11-20 LOC685576  hypothetical protein LOC685576      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-20 LOC684078  hypothetical protein LOC684078      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-03-30 Gpr173  G-protein coupled receptor 173  Sreb3    Symbol updated 1299863 APPROVED
2005-01-20 Sreb3  G-protein coupled receptor 173    SREB3  Name updated 1299863 APPROVED
2002-08-07 Sreb3  SREB3      Symbol and Name status set to provisional 70820 PROVISIONAL