Gulo (gulonolactone (L-) oxidase) - Rat Genome Database

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Gene: Gulo (gulonolactone (L-) oxidase) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Gulo
Name: gulonolactone (L-) oxidase
RGD ID: 620701
Description: Enables L-gulonolactone oxidase activity. Predicted to be involved in L-ascorbic acid biosynthetic process. Predicted to be located in endoplasmic reticulum membrane; PARTICIPATES IN ascorbate and aldarate metabolic pathway; INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: GLO; L-gulono-gamma-lactone oxidase; L-gulonolactone oxidase; LGO
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Allele / Splice: Gulood
Is Marker For: Strains:   SHR.ODS-Gulood/Shi
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81544,381,226 - 44,403,314 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1544,381,214 - 44,403,422 (-)EnsemblGRCr8
mRatBN7.21540,205,677 - 40,227,766 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1540,205,665 - 40,227,874 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1542,070,707 - 42,092,904 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01543,220,905 - 43,243,102 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01541,665,982 - 41,688,069 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1542,925,642 - 42,947,839 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive1542,643,393 - 42,665,590 (-)NCBILyon_Normotensive
Lyon_Hypertensive1542,919,427 - 42,941,624 (-)NCBILyon_Hypertensive
F344_StmMcwi1541,932,268 - 41,954,355 (-)NCBIF344_StmMcwi
Rnor_6.01542,671,206 - 42,693,711 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1542,671,203 - 42,693,694 (-)Ensemblrn6Rnor6.0
Rnor_5.01548,898,664 - 48,921,163 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41545,410,685 - 45,434,014 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1539,877,272 - 39,899,657 (-)NCBICelera
RGSC_v3.11545,426,464 - 45,449,794 (-)NCBI
Cytogenetic Map15p12NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. A missense mutation of L-gulono-gamma-lactone oxidase causes the inability of scurvy-prone osteogenic disorder rats to synthesize L-ascorbic acid. Kawai T, etal., J Biol Chem. 1992 Oct 25;267(30):21973-6.
3. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
4. Isolation and sequence analysis of a complementary DNA encoding rat liver L-gulono-gamma-lactone oxidase, a key enzyme for L-ascorbic acid biosynthesis. Koshizaka T, etal., J Biol Chem 1988 Feb 5;263(4):1619-21.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. Guinea pigs possess a highly mutated gene for L-gulono-gamma-lactone oxidase, the key enzyme for L-ascorbic acid biosynthesis missing in this species. Nishikimi M, etal., J Biol Chem 1992 Oct 25;267(30):21967-72.
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. GOA pipeline RGD automated data pipeline
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1962571   PMID:3214183   PMID:8459881   PMID:12477932   PMID:15489334  


Genomics

Variants

.
Variants in Gulo
88 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:89
Count of miRNA genes:75
Interacting mature miRNAs:81
Transcripts:ENSRNOT00000022702
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)15231575947315759Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15144836456Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15231575953331089Rat
152025253Hrtrt24Heart rate QTL 243.82heart pumping trait (VT:2000009)153185580392671517Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)154367724488677244Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152852773273527732Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)154367724488677244Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1525285835104695021Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)152233635152597086Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)1525285835104695021Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151915576287086765Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)15278592347785923Rat
1598828Glom14Glomerulus QTL 142.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)154046315285463152Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151492659471614418Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)152233635167336351Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)154367724488677244Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)154367724488677244Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)1525285835104695021Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)154367724488677244Rat

Markers in Region
RH131451  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21540,205,709 - 40,205,911 (+)MAPPERmRatBN7.2
Rnor_6.01542,671,252 - 42,671,453NCBIRnor6.0
Rnor_5.01548,920,916 - 48,921,117UniSTSRnor5.0
RGSC_v3.41545,410,718 - 45,410,919UniSTSRGSC3.4
Celera1539,877,305 - 39,877,506UniSTS
Cytogenetic Map15p12UniSTS


Related Rat Strains
The following Strains have been annotated to Gulo
SHR.ODS-Gulood/Shi    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 11 41 110 91 88 59 26 59 6 230 90 90 57 91 29 5 5

Sequence


Ensembl Acc Id: ENSRNOT00000022702   ⟹   ENSRNOP00000022703
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1544,381,214 - 44,403,422 (-)Ensembl
mRatBN7.2 Ensembl1540,205,665 - 40,227,874 (-)Ensembl
Rnor_6.0 Ensembl1542,671,203 - 42,693,694 (-)Ensembl
RefSeq Acc Id: NM_022220   ⟹   NP_071556
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81544,381,226 - 44,403,314 (-)NCBI
mRatBN7.21540,205,677 - 40,227,766 (-)NCBI
Dahl_SR_JrHsd1542,925,642 - 42,947,839 (-)NCBI
Lyon_Normotensive1542,643,393 - 42,665,590 (-)NCBI
Lyon_Hypertensive1542,919,427 - 42,941,624 (-)NCBI
F344_StmMcwi1541,932,268 - 41,954,355 (-)NCBI
Rnor_6.01542,671,219 - 42,693,570 (-)NCBI
Rnor_5.01548,898,664 - 48,921,163 (+)NCBI
RGSC_v3.41545,410,685 - 45,434,014 (-)RGD
Celera1539,877,272 - 39,899,657 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_071556 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41164 (Get FASTA)   NCBI Sequence Viewer  
  AAH89803 (Get FASTA)   NCBI Sequence Viewer  
  BAA02232 (Get FASTA)   NCBI Sequence Viewer  
  BAA33497 (Get FASTA)   NCBI Sequence Viewer  
  EDL85374 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000022703
GenBank Protein P10867 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_071556   ⟸   NM_022220
- UniProtKB: Q9QWR6 (UniProtKB/Swiss-Prot),   Q64597 (UniProtKB/Swiss-Prot),   Q5EBC1 (UniProtKB/Swiss-Prot),   P10867 (UniProtKB/Swiss-Prot),   A0A140TAC7 (UniProtKB/TrEMBL),   A6K6L4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000022703   ⟸   ENSRNOT00000022702
Protein Domains
FAD-binding PCMH-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P10867-F1-model_v2 AlphaFold P10867 1-440 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699753
Promoter ID:EPDNEW_R10276
Type:initiation region
Name:Gulo_1
Description:gulonolactone (L-) oxidase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01542,693,681 - 42,693,741EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620701 AgrOrtholog
BioCyc Gene G2FUF-13338 BioCyc
BioCyc Pathway PWY3DJ-35471 [L-ascorbate biosynthesis IV (animals, D-glucuronate pathway)] BioCyc
BioCyc Pathway Image PWY3DJ-35471 BioCyc
Ensembl Genes ENSRNOG00000016648 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000022702 ENTREZGENE
Gene3D-CATH 3.30.43.10 UniProtKB/Swiss-Prot
  3.30.465.10 UniProtKB/Swiss-Prot
  3.30.70.2520 UniProtKB/Swiss-Prot
  Vanillyl-alcohol Oxidase, Chain A, domain 4 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7324344 IMAGE-MGC_LOAD
InterPro ALO UniProtKB/Swiss-Prot
  FAD-bd_PCMH UniProtKB/Swiss-Prot
  FAD-bd_PCMH-like_sf UniProtKB/Swiss-Prot
  FAD-bd_PCMH_sub1 UniProtKB/Swiss-Prot
  FAD-bd_PCMH_sub2 UniProtKB/Swiss-Prot
  FAD_lactone_oxidase UniProtKB/Swiss-Prot
  Oxid_FAD_bind_N UniProtKB/Swiss-Prot
  Oxy_OxRdtase_FAD_BS UniProtKB/Swiss-Prot
  Sugar_lactone_oxidase UniProtKB/Swiss-Prot
  Vanillyl_alc_oxidase_C-sub2 UniProtKB/Swiss-Prot
KEGG Report rno:60671 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108695 IMAGE-MGC_LOAD
NCBI Gene 60671 ENTREZGENE
PANTHER L-GULONOLACTONE OXIDASE UniProtKB/Swiss-Prot
  PTHR43762 UniProtKB/Swiss-Prot
Pfam ALO UniProtKB/Swiss-Prot
  FAD_binding_4 UniProtKB/Swiss-Prot
PhenoGen Gulo PhenoGen
PIRSF LGO_GLO UniProtKB/Swiss-Prot
PROSITE FAD_PCMH UniProtKB/Swiss-Prot
  OX2_COVAL_FAD UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000016648 RatGTEx
Superfamily-SCOP SSF56176 UniProtKB/Swiss-Prot
UniProt A0A140TAC7 ENTREZGENE, UniProtKB/TrEMBL
  A6K6L4 ENTREZGENE, UniProtKB/TrEMBL
  GGLO_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q5EBC1 ENTREZGENE
  Q64597 ENTREZGENE
  Q9QWR6 ENTREZGENE
UniProt Secondary Q5EBC1 UniProtKB/Swiss-Prot
  Q64597 UniProtKB/Swiss-Prot
  Q9QWR6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-22 Gulo  gulonolactone (L-) oxidase  Gulo  L-gulonolactone oxidase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Gulo  L-gulonolactone oxidase    L-gulono-gamma-lactone oxidase  Name updated 1299863 APPROVED
2002-08-07 Gulo  L-gulono-gamma-lactone oxidase      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized in the microsomes of the liver and kidney 728524
gene_protein 440 amino acids; 50.6 kDa 728524