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Gene: Tmprss11d (transmembrane serine protease 11D) Rattus norvegicus

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Symbol:

Tmprss11d

Name:

transmembrane serine protease 11D

RGD ID:

620654

Description:

Enables serine-type peptidase activity. Involved in regulation of growth. Located in cell surface. Orthologous to human TMPRSS11D (transmembrane serine protease 11D); INTERACTS WITH acrylamide; ammonium chloride; bisphenol A.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

adrenal secretory serine protease; adrenal secretory serine protease precursor; AF198087; airway trypsin-like protease; Asp; AT; transmembrane protease serine 11D; transmembrane protease, serine 11d

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	TMPRSS11D (transmembrane serine protease 11D)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, Panther
Mus musculus (house mouse):	Tmprss11d (transmembrane protease, serine 11d)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	TMPRSS11D (transmembrane serine protease 11D)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	TMPRSS11D (transmembrane serine protease 11D)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	LOC100512911 (transmembrane protease serine 11D)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	TMPRSS11D (transmembrane serine protease 11D)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Tmprss11d (transmembrane serine protease 11D)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Tmprss11d (transmembrane protease, serine 11d)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	TMPRSS11D (transmembrane serine protease 11D)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG8172	Alliance	DIOPT (Hieranoid\|InParanoid)
Drosophila melanogaster (fruit fly):	CG9737	Alliance	DIOPT (Hieranoid\|OMA)
Xenopus tropicalis (tropical clawed frog):	tmprss11f	Alliance	DIOPT (InParanoid\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG17242	Alliance	DIOPT (Ensembl Compara\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	22,062,129 - 22,124,189 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	14	22,062,131 - 22,124,505 (+)	Ensembl				GRCr8
mRatBN7.2	14	21,707,336 - 21,769,398 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	21,707,336 - 21,769,396 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	14	22,059,965 - 22,119,374 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	23,378,886 - 23,438,289 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	21,909,971 - 21,969,391 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	23,330,933 - 23,392,993 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	23,330,933 - 23,392,991 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	14	23,218,327 - 23,289,174 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	14	23,474,013 - 23,536,005 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	14	21,179,225 - 21,240,035 (+)	NCBI		Celera
RGSC_v3.1	14	23,520,345 - 23,536,005 (+)	NCBI
Cytogenetic Map	14	p21	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Coronavirus infectious disease (ISO)

Human Influenza (ISO)

severe acute respiratory syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2-hydroxypropanoic acid (ISO)

acrylamide (EXP)

ammonium chloride (EXP)

antirheumatic drug (ISO)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP)

cadmium dichloride (EXP,ISO)

CGP 52608 (ISO)

crocidolite asbestos (ISO)

N-nitrosodiethylamine (EXP)

ozone (ISO)

pirinixic acid (ISO)

rac-lactic acid (ISO)

serpentine asbestos (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

zinc atom (EXP)

zinc(0) (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

protein processing (IBA)

proteolysis (IEA,ISO)

regulation of growth (IMP)

Cellular Component

cell surface (IDA)

extracellular region (IEA)

membrane (IEA)

plasma membrane (IBA,IEA)

Molecular Function

hydrolase activity (IEA)

peptidase activity (IEA)

protein binding (ISO)

serine-type endopeptidase activity (IEA)

serine-type peptidase activity (IBA,IDA,IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Identification of a serine protease involved with the regulation of adrenal growth.	Bicknell AB Ann N Y Acad Sci 2003 Jun;994:118-22.
2.	Characterization of a serine protease that cleaves pro-gamma-melanotropin at the adrenal to stimulate growth.	Bicknell AB, etal., Cell 2001 Jun 29;105(7):903-12.
3.	The adrenal secretory serine protease AsP is a short secretory isoform of the transmembrane airway trypsin-like protease.	Hansen IA, etal., Endocrinology 2004 Apr;145(4):1898-905. Epub 2003 Dec 22.
4.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:19056867	PMID:23376485	PMID:24227843

Genomics

Comparative Map Data

Tmprss11d
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	22,062,129 - 22,124,189 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	14	22,062,131 - 22,124,505 (+)	Ensembl				GRCr8
mRatBN7.2	14	21,707,336 - 21,769,398 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	21,707,336 - 21,769,396 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	14	22,059,965 - 22,119,374 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	23,378,886 - 23,438,289 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	21,909,971 - 21,969,391 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	23,330,933 - 23,392,993 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	23,330,933 - 23,392,991 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	14	23,218,327 - 23,289,174 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	14	23,474,013 - 23,536,005 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	14	21,179,225 - 21,240,035 (+)	NCBI		Celera
RGSC_v3.1	14	23,520,345 - 23,536,005 (+)	NCBI
Cytogenetic Map	14	p21	NCBI

TMPRSS11D
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	67,820,876 - 67,884,002 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	4	67,820,876 - 67,884,002 (-)	Ensembl			hg38	GRCh38
GRCh37	4	68,686,594 - 68,749,720 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	68,369,189 - 68,432,311 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	4	66,148,993 - 66,212,123 (-)	NCBI		Celera
Cytogenetic Map	4	q13.2	NCBI
HuRef	4	64,599,718 - 64,662,811 (-)	NCBI		HuRef
CHM1_1	4	68,723,715 - 68,786,788 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	4	71,264,020 - 71,327,118 (-)	NCBI		T2T-CHM13v2.0

Tmprss11d
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	86,450,713 - 86,521,246 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	86,450,076 - 86,521,279 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	5	86,302,854 - 86,373,387 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	86,302,217 - 86,373,420 (-)	Ensembl			mm10	GRCm38
MGSCv37	5	86,731,879 - 86,802,412 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	5	87,377,415 - 87,447,948 (-)	NCBI		MGSCv36	mm8
Celera	5	83,534,942 - 83,599,327 (-)	NCBI		Celera
Cytogenetic Map	5	E1	NCBI
cM Map	5	43.56	NCBI

TMPRSS11D
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	3	62,009,950 - 62,073,071 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	4	62,219,965 - 62,283,079 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	4	56,164,300 - 56,227,415 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	4	62,558,360 - 62,621,487 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	62,558,360 - 62,621,480 (+)	Ensembl			panPan2	panpan1.1

TMPRSS11D
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	13	58,354,360 - 58,406,229 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	13	58,355,829 - 58,406,622 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	13	58,277,247 - 58,327,644 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	13	59,051,487 - 59,101,776 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	13	59,051,495 - 59,101,653 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	13	58,698,856 - 58,748,989 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	13	58,189,239 - 58,239,572 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	13	59,199,720 - 59,249,904 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

LOC100512911
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	65,570,946 - 65,623,801 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	8	65,570,433 - 65,623,785 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	8	69,994,402 - 70,046,430 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TMPRSS11D
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	7	1,076,592 - 1,146,080 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	7	1,106,307 - 1,145,673 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666066	1,170,690 - 1,233,491 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Tmprss11d
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624761	981,825 - 1,103,779 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Variants

Variants in Tmprss11d
357 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	90
Count of miRNA genes:	77
Interacting mature miRNAs:	81
Transcripts:	ENSRNOT00000002748
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
631528	Scl11	Serum cholesterol level QTL 11	4.9		blood cholesterol amount (VT:0000180)	blood total cholesterol level (CMO:0000051)	14	17875645	36079022	Rat
7411573	Bw139	Body weight QTL 139	4.7	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	14	1	40068101	Rat
9589814	Gluco67	Glucose level QTL 67	4.54	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	14	1	40068101	Rat
731183	Pia20	Pristane induced arthritis QTL 20	3.55		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	14	9393298	39411170	Rat
631212	Bw5	Body weight QTL5	5.43		retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	14	11334906	30674469	Rat
2302277	Gluco38	Glucose level QTL 38	5.8		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	14	11334716	28389666	Rat
1331740	Bw26	Body weight QTL 26	3.028		body mass (VT:0001259)	body weight (CMO:0000012)	14	3957878	31121464	Rat
1358296	Ael3	Aortic elastin QTL 3	3.7	0.00051	aorta elastin amount (VT:0003905)	aortic elastin	14	8621398	53621398	Rat
61420	Pia6	Pristane induced arthritis QTL 6	4.9		joint integrity trait (VT:0010548)	arthritic paw count (CMO:0001460)	14	18915454	42433608	Rat
70195	Mcs8	Mammary carcinoma susceptibility QTL 8	4.28		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	14	3957878	24886169	Rat
631839	Niddm37	Non-insulin dependent diabetes mellitus QTL 37	3.37		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	14	11334716	100078267	Rat
2313397	Coatc1	Coat color QTL1			coat/hair pigmentation trait (VT:0010463)	coat/hair color measurement (CMO:0001808)	14	18895192	63895192	Rat
631262	Tcas4	Tongue tumor susceptibility QTL 4	7.29		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	14	17906726	54251504	Rat
634352	Apr6	Acute phase response QTL 6	3.7		blood interleukin-6 amount (VT:0008595)	plasma interleukin-6 level (CMO:0001927)	14	1	41415516	Rat
70204	Niddm20	Non-insulin dependent diabetes mellitus QTL 20	5.1	0.000008	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	14	1	31893212	Rat
2302045	Pia39	Pristane induced arthritis QTL 39	4.9	0.001	blood immunoglobulin amount (VT:0002460)	serum immunoglobulin G2a level (CMO:0002116)	14	8621398	53621398	Rat
1300140	Srn3	Serum renin concentration QTL 3	3.19		blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	14	15137594	31238250	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
8	7	28	25	32	27	4	27	4	5	98	71	6	9	52	23	1	1

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001033652	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_022630	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC109073	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF198087	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF453776	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473981	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000014	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000088552 ⟹ ENSRNOP00000073795

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	14	22,062,131 - 22,124,505 (+)	Ensembl
mRatBN7.2 Ensembl	14	21,707,336 - 21,769,396 (+)	Ensembl
Rnor_6.0 Ensembl	14	23,330,933 - 23,392,991 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000116172 ⟹ ENSRNOP00000077187

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	14	22,094,045 - 22,124,505 (+)	Ensembl
mRatBN7.2 Ensembl	14	21,739,254 - 21,769,396 (+)	Ensembl

RefSeq Acc Id:

NM_001033652 ⟹ NP_001028824

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	22,062,129 - 22,124,189 (+)	NCBI
mRatBN7.2	14	21,707,336 - 21,769,398 (+)	NCBI
Rnor_6.0	14	23,330,933 - 23,392,993 (+)	NCBI
Rnor_5.0	14	23,218,327 - 23,289,174 (+)	NCBI
RGSC_v3.4	14	23,474,013 - 23,536,005 (+)	RGD
Celera	14	21,179,225 - 21,240,035 (+)	RGD

Sequence:

show sequence

ACGCGGGGAATGAATGGGATTGTTTCTGATTTGTAAGGTGTCTCCATCTCTGATTCTGGCCCAC
AAGTCACACCATTGGCTCAAGCTGATTCTTTCAGACTTGTTTTACAAGTTGGGTTTTAATTACA
CGGGATTTCCTCCTTTGGCTTCAGGTACACAGAACACGAAAGAGTCATTCAGTTGAGAGGGAAT
CTCAAAGCAGTAGGACGGACAGAACCAAGGACCTCTTCATTATTCAAGAGTAAAATGTATAGGC
CAAGATCAATGGTATCACCTTCAAGATTCTTCAATCCCTTTATGGTAGCTCTCATTGTCATAAT
AACAGTAGGGCTCCTGGCCATGACCGCAGGTCTACTTATTCACTTTTTAGCTTTTGACAAGAGA
GCTTACTTTTATCATAGCAACTTTCATATCCTAAATGTTGACTATACTGAAGCTTTAAACTCAC
CAGCTACGCATGAATACAGAACCTTGAGTGAAAGAATCGAGTCTATGATTACTGATGCATTTCG
AGAATCAAATCTACGAAGTGAGTTTATCAGGACACATGTTGTCAAACTGAGAAAAGAAGGGAGT
GGTGTGGTTGCGGATGTTGTCATGAAATTTCGATCTAGTAAGCGTAACAACAAAAAGGCAATCA
AAACCAGAATCCAATCTGTGCTACAAAGACTCAGCAGCTCTGGGAACTTGGAAATAGCCCCTTC
GAATGGGATAACATCACTCACTGACCAGGATACAGAAAATGTTTTGACTCAAGAATGTGGAGCA
CGTCCAGACCTTATAACACTGTCAGAAGAGAGAATCATTGGAGGCACTCAAGCTGAGACAGGTG
ACTGGCCCTGGCAAGTCAGTCTACAGCTCAACAATGTCCACCACTGTGGAGGTACCCTGATCAG
TAACTTGTGGGTCCTGACAGCCGCTCACTGCTTCAGAAGCTACTCGAATCCTCAACAATGGACA
GCCACCTTTGGTGTTTCTACAATAAGTCCTAGGTTAAGAGTGAGAGTAAGGGCTATTTTAGCCC
ATGCTGAGTACAACTCCATAACTCGTGATAATGATATTGCAGTTGTACAACTTGACAGACCTGT
CACCTTTACCAGAAATATCCATAGGGTATGTCTCCCAGCAGCAACCCAAAATATCATGCCTGAT
TCCGTCGCATATGTCACAGGATGGGGATCTCTCACTTATGGAGGCAACACGGTCACAAATCTAC
AGCAAGGAGAGGTCAGAATAGTAAGTTCGGAGGTGTGCAACGAGCCAGCTGGCTACGGTGGGAG
TGTCTTGCCAGGAATGCTCTGTGCTGGAGTCCGTTCAGGGGCCGTGGATGCATGCCAGGGTGAT
TCTGGTGGCCCACTAGTACAAGAAGACACAAGGCGGCTTTGGTTTGTCGTGGGGATTGTGAGCT
GGGGATATCAATGTGGCCTGCCAAATAAGCCAGGAGTGTATACGCGAGTGACAGCCTACCGCAA
CTGGATTAGGCAGCAGACTGGAATCTAGGGCGACCGAGGAAAACGCGCCGCCTCCCGTGAAGTC
TGTACCCAAGTGCCTGATTCAAATGCCGCAGCCTCGCTTTTCAACTGCCAAGGAAACTGGAAAC
GTCCCATTTCAACATCCCATTACAATAAATATGGTTTAACAGTTTAGCATTTCTTTGTCGATAT
AAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

NM_022630 ⟹ NP_072152

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	22,108,529 - 22,124,189 (+)	NCBI
mRatBN7.2	14	21,753,738 - 21,769,398 (+)	NCBI
Rnor_6.0	14	23,377,333 - 23,392,993 (+)	NCBI
Rnor_5.0	14	23,218,327 - 23,289,174 (+)	NCBI
RGSC_v3.4	14	23,474,013 - 23,536,005 (+)	RGD
Celera	14	21,224,369 - 21,240,035 (+)	NCBI

Sequence:

show sequence

TCGTCACTGAGCCTCATGAAATCAGGGTGAAATGAGTTTCAGCTTCTGTTTTGTTGATCTTCTT
CTCGTGCTTTCTTTCTTAACGCTAGCACTCACTGACCAGGATACAGAAAATGTTTTGACTCAAG
AATGTGGAGCACGTCCAGACCTTATAACACTGTCAGAAGAGAGAATCATTGGAGGCACTCAAGC
TGAGACAGGTGACTGGCCCTGGCAAGTCAGTCTACAGCTCAACAATGTCCACCACTGTGGAGGT
ACCCTGATCAGTAACTTGTGGGTCCTGACAGCCGCTCACTGCTTCAGAAGCTACTCGAATCCTC
AACAATGGACAGCCACCTTTGGTGTTTCTACAATAAGTCCTAGGTTAAGAGTGAGAGTAAGGGC
TATTTTAGCCCATGCTGAGTACAACTCCATAACTCGTGATAATGATATTGCAGTTGTACAACTT
GACAGACCTGTCACCTTTACCAGAAATATCCATAGGGTATGTCTCCCAGCAGCAACCCAAAATA
TCATACCTGATTCCGTCGCATATGCCACAGGATGGGGATCTCTCACTTATGGAGGCAACACGGT
CACAAATCTACAGCAAGGAGAGGTCAGAATAGTAAGTTCGGAGGTGTGCAACGAGCCAGCTGGC
TACGGTGGGAGTGTCTTGCCAGGAATGCTCTGTGCTGGAGTCCGTTCAGGGGCCGTGGATGCAT
GCCAGGGTGATTCTGGTGGCCCACTAGTACAAGAAGACACAAGGCGGCTTTGGTTTGTCGTGGG
GATTGTGAGCTGGGGATATCAATGTGGCCTGCCAAATAAGCCAGGAGTGTATACGCGAGTGACA
GCCTACCGCAACTGGATTAGGCAGCAGACTGGAATCTAGGGCGACCGAGGAAAACGCGCCGCCT
CCCGTGAAGTCTGTACCCAAGTGCCTGATTCAAATGCCGCAGCCTCGCTTTTCAACTGCCAAGG
AAACTGGAAACGTCCCATTTCAACATCCCATTACAATAAATATGGTTTAACAGTTTAGCATTTC
TTTGTCGATATAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001028824	(Get FASTA)	NCBI Sequence Viewer
	NP_072152	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAF13253	(Get FASTA)	NCBI Sequence Viewer
	AAL50817	(Get FASTA)	NCBI Sequence Viewer
	EDL89835	(Get FASTA)	NCBI Sequence Viewer
	EDL89836	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000073795
GenBank Protein	Q8VHJ4	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_001028824 ⟸ NM_001033652
- Peptide Label:	isoform a
- UniProtKB:	Q9QZ74 (UniProtKB/Swiss-Prot), Q8VHJ4 (UniProtKB/Swiss-Prot), G3V691 (UniProtKB/TrEMBL), A6JCR3 (UniProtKB/TrEMBL)
- Sequence:	show sequence MYRPRSMVSPSRFFNPFMVALIVIITVGLLAMTAGLLIHFLAFDKRAYFYHSNFHILNVDYTEA LNSPATHEYRTLSERIESMITDAFRESNLRSEFIRTHVVKLRKEGSGVVADVVMKFRSSKRNNK KAIKTRIQSVLQRLSSSGNLEIAPSNGITSLTDQDTENVLTQECGARPDLITLSEERIIGGTQA ETGDWPWQVSLQLNNVHHCGGTLISNLWVLTAAHCFRSYSNPQQWTATFGVSTISPRLRVRVRA ILAHAEYNSITRDNDIAVVQLDRPVTFTRNIHRVCLPAATQNIMPDSVAYVTGWGSLTYGGNTV TNLQQGEVRIVSSEVCNEPAGYGGSVLPGMLCAGVRSGAVDACQGDSGGPLVQEDTRRLWFVVG IVSWGYQCGLPNKPGVYTRVTAYRNWIRQQTGI hide sequence

RefSeq Acc Id:	NP_072152 ⟸ NM_022630
- Peptide Label:	isoform b precursor
- UniProtKB:	A6JCR4 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSFSFCFVDLLLVLSFLTLALTDQDTENVLTQECGARPDLITLSEERIIGGTQAETGDWPWQVS LQLNNVHHCGGTLISNLWVLTAAHCFRSYSNPQQWTATFGVSTISPRLRVRVRAILAHAEYNSI TRDNDIAVVQLDRPVTFTRNIHRVCLPAATQNIIPDSVAYATGWGSLTYGGNTVTNLQQGEVRI VSSEVCNEPAGYGGSVLPGMLCAGVRSGAVDACQGDSGGPLVQEDTRRLWFVVGIVSWGYQCGL PNKPGVYTRVTAYRNWIRQQTGI hide sequence

Ensembl Acc Id:

ENSRNOP00000073795 ⟸ ENSRNOT00000088552

Ensembl Acc Id:

ENSRNOP00000077187 ⟸ ENSRNOT00000116172

Protein Domains

Peptidase S1 SEA

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q8VHJ4-F1-model_v2	AlphaFold	Q8VHJ4	1-417	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620654	AgrOrtholog
BioCyc Gene	G2FUF-16071	BioCyc
Ensembl Genes	ENSRNOG00000055991	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000088552	ENTREZGENE
Gene3D-CATH	2.40.10.10	UniProtKB/Swiss-Prot
	3.30.70.960	UniProtKB/Swiss-Prot
InterPro	Pept_S1A_HAT/DESC1	UniProtKB/Swiss-Prot
	Peptidase_S1_PA	UniProtKB/Swiss-Prot
	Peptidase_S1_PA_chymotrypsin	UniProtKB/Swiss-Prot
	Peptidase_S1A	UniProtKB/Swiss-Prot
	SEA_dom	UniProtKB/Swiss-Prot
	SEA_dom_sf	UniProtKB/Swiss-Prot
	Trypsin_dom	UniProtKB/Swiss-Prot
	TRYPSIN_HIS	UniProtKB/Swiss-Prot
	TRYPSIN_SER	UniProtKB/Swiss-Prot
KEGG Report	rno:64565	UniProtKB/Swiss-Prot
NCBI Gene	64565	ENTREZGENE
PANTHER	ACROSIN-RELATED	UniProtKB/Swiss-Prot
	HYALIN	UniProtKB/Swiss-Prot
Pfam	SEA	UniProtKB/Swiss-Prot
	Trypsin	UniProtKB/Swiss-Prot
PhenoGen	Tmprss11d	PhenoGen
PIRSF	TMPRSS11ABCDE	UniProtKB/Swiss-Prot
PRINTS	CHYMOTRYPSIN	UniProtKB/Swiss-Prot
PROSITE	SEA	UniProtKB/Swiss-Prot
	TRYPSIN_DOM	UniProtKB/Swiss-Prot
	TRYPSIN_HIS	UniProtKB/Swiss-Prot
	TRYPSIN_SER	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000055991	RatGTEx
SMART	Tryp_SPc	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF50494	UniProtKB/Swiss-Prot
	SSF82671	UniProtKB/Swiss-Prot
UniProt	A0A8I5YC90_RAT	UniProtKB/TrEMBL
	A6JCR3	ENTREZGENE, UniProtKB/TrEMBL
	A6JCR4	ENTREZGENE, UniProtKB/TrEMBL
	G3V691	ENTREZGENE, UniProtKB/TrEMBL
	Q8VHJ4	ENTREZGENE
	Q9QZ74	ENTREZGENE
	TM11D_RAT	UniProtKB/Swiss-Prot
UniProt Secondary	Q9QZ74	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2018-01-26	Tmprss11d	transmembrane serine protease 11D	Tmprss11d	transmembrane protease, serine 11d	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-30	Tmprss11d	transmembrane protease, serine 11d	AF198087	adrenal secretory serine protease precursor	Symbol and Name updated	1299863	APPROVED
2002-08-07	AF198087	adrenal secretory serine protease precursor			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_expression	increased expression occurs during growth of the adrenal cortex	631871
gene_protein	precursor encodes two isoforms, adrenal secretory serine protease AsP and a transmembrane airway trypsin-like protease	1304278

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD