Ackr3 (atypical chemokine receptor 3) - Rat Genome Database

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Gene: Ackr3 (atypical chemokine receptor 3) Rattus norvegicus
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Symbol: Ackr3
Name: atypical chemokine receptor 3
RGD ID: 620601
Description: Predicted to enable chemokine binding activity; chemokine receptor activity; and scavenger receptor activity. Involved in positive regulation of mesenchymal stem cell migration. Predicted to be located in several cellular components, including cell surface; clathrin-coated pit; and endosome. Predicted to be active in external side of plasma membrane. Orthologous to human ACKR3 (atypical chemokine receptor 3); PARTICIPATES IN cytokine mediated signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: C-X-C chemokine receptor type 7; chemokine (C-X-C motif) receptor 7; chemokine orphan receptor 1; Cmkor1; CXC-R7; CXCR-7; Cxcr7; G-protein coupled receptor RDC1 homolog; RDC-1; Rdc1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8998,247,300 - 98,258,877 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl998,246,605 - 98,260,214 (+)EnsemblGRCr8
mRatBN7.2990,799,682 - 90,811,246 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl990,799,686 - 90,811,237 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx999,226,229 - 99,237,752 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09104,362,114 - 104,373,635 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09102,727,673 - 102,739,194 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0997,355,881 - 97,367,455 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl997,355,924 - 97,367,445 (+)Ensemblrn6Rnor6.0
Rnor_5.0997,046,816 - 97,058,382 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4989,343,528 - 89,355,053 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera988,347,205 - 88,358,728 (+)NCBICelera
RGSC_v3.1989,548,296 - 89,559,818 (+)NCBI
Cytogenetic Map9q36NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-butoxyethanol  (ISO)
22-Hydroxycholesterol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
allethrin  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atrazine  (EXP)
azathioprine  (ISO)
Azoxymethane  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calciol  (ISO)
calcitriol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP)
dexamethasone  (ISO)
dextran sulfate  (ISO)
dibenz[a,h]anthracene  (ISO)
dibenzofuran  (EXP)
Dibutyl phosphate  (ISO)
diclofenac  (ISO)
dioxygen  (ISO)
diuron  (EXP,ISO)
dorsomorphin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
ethanol  (ISO)
fenvalerate  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
glycidol  (EXP)
GSK-J4  (ISO)
GW 4064  (ISO)
heparin  (EXP)
hexadecanoic acid  (EXP,ISO)
lipopolysaccharide  (EXP,ISO)
loliolide  (ISO)
melphalan  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
mifepristone  (ISO)
molibresib  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
paclitaxel  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
pevonedistat  (ISO)
phenformin  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
prednisolone  (ISO)
propiconazole  (ISO)
pyrethrins  (EXP)
raloxifene  (ISO)
ranitidine  (EXP)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium aurothiomalate  (ISO)
sodium dodecyl sulfate  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
ursolic acid  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cell surface  (IEA,ISO,ISS)
clathrin-coated pit  (IEA,ISO,ISS)
early endosome  (IEA)
endosome  (IEA,ISO,ISS)
external side of plasma membrane  (IBA)
membrane  (IEA)
plasma membrane  (IEA,ISO,ISS)
recycling endosome  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Identification and functional characterization of arginine vasopressin receptor 1A : atypical chemokine receptor 3 heteromers in vascular smooth muscle. Albee LJ, etal., Open Biol. 2018 Jan;8(1). pii: rsob.170207. doi: 10.1098/rsob.170207.
2. Increased myocardial expression of RAMP1 and RAMP3 in rats with chronic heart failure. Cueille C, etal., Biochem Biophys Res Commun 2002 Jun 7;294(2):340-6.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. GOA pipeline RGD automated data pipeline
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Evaluation of the role of downregulation of SNF5/INI1 core subunit of SWI/SNF complex in clear cell renal cell carcinoma development. Sarnowska E, etal., Am J Cancer Res. 2017 Nov 1;7(11):2275-2289. eCollection 2017.
11. Identification of three prolactin-related hormones as markers of invasive trophoblasts in the rat. Toft DJ and Linzer DI, Biol Reprod 2000 Aug;63(2):519-25.
12. Heteromerization of chemokine (C-X-C motif) receptor 4 with α1A/B-adrenergic receptors controls α1-adrenergic receptor function. Tripathi A, etal., Proc Natl Acad Sci U S A. 2015 Mar 31;112(13):E1659-68. doi: 10.1073/pnas.1417564112. Epub 2015 Mar 16.
13. CXCR-7 receptor promotes SDF-1alpha-induced migration of bone marrow mesenchymal stem cells in the transient cerebral ischemia/reperfusion rat hippocampus. Wang Y, etal., Brain Res. 2014 Aug 5;1575:78-86. doi: 10.1016/j.brainres.2014.05.035. Epub 2014 Jun 9.
14. [Expression of chemokine receptor CXCR4 and CCR7 in laryngeal carcinoma]. Zhang L, etal., Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2005 Nov;19(21):985-7, 991.
Additional References at PubMed
PMID:18513805   PMID:18615560   PMID:20388803   PMID:21418513   PMID:22300987   PMID:22457824   PMID:22940879   PMID:23289420   PMID:23383139   PMID:25032954   PMID:29146732   PMID:30551373  
PMID:33941256   PMID:34051857   PMID:36523152   PMID:37945645  


Genomics

Comparative Map Data
Ackr3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8998,247,300 - 98,258,877 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl998,246,605 - 98,260,214 (+)EnsemblGRCr8
mRatBN7.2990,799,682 - 90,811,246 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl990,799,686 - 90,811,237 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx999,226,229 - 99,237,752 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09104,362,114 - 104,373,635 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09102,727,673 - 102,739,194 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0997,355,881 - 97,367,455 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl997,355,924 - 97,367,445 (+)Ensemblrn6Rnor6.0
Rnor_5.0997,046,816 - 97,058,382 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4989,343,528 - 89,355,053 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera988,347,205 - 88,358,728 (+)NCBICelera
RGSC_v3.1989,548,296 - 89,559,818 (+)NCBI
Cytogenetic Map9q36NCBI
ACKR3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382236,537,122 - 236,582,354 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2236,567,692 - 236,582,358 (+)Ensemblhg38GRCh38
GRCh372237,478,468 - 237,490,997 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362237,143,119 - 237,155,736 (+)NCBIBuild 36Build 36hg18NCBI36
Build 342237,260,442 - 237,272,991NCBI
Celera2231,191,070 - 231,203,687 (+)NCBICelera
Cytogenetic Map2q37.3NCBI
HuRef2229,272,353 - 229,284,798 (+)NCBIHuRef
CHM1_12237,484,219 - 237,496,832 (+)NCBICHM1_1
T2T-CHM13v2.02237,027,450 - 237,072,880 (+)NCBIT2T-CHM13v2.0
Ackr3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39190,131,702 - 90,143,446 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl190,131,702 - 90,144,473 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38190,203,980 - 90,215,724 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl190,203,980 - 90,216,751 (+)Ensemblmm10GRCm38
MGSCv37192,100,578 - 92,112,863 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36192,035,174 - 92,047,459 (+)NCBIMGSCv36mm8
Celera193,147,393 - 93,159,682 (+)NCBICelera
Cytogenetic Map1DNCBI
cM Map145.28NCBI
Ackr3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955453195,346 - 218,034 (-)Ensembl
ChiLan1.0NW_004955453195,346 - 218,034 (-)NCBIChiLan1.0ChiLan1.0
ACKR3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213139,194,667 - 139,209,073 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B139,209,625 - 139,224,039 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B123,795,664 - 123,810,067 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B242,653,738 - 242,668,063 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B242,666,173 - 242,667,261 (+)EnsemblpanPan2panpan1.1
ACKR3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12547,327,921 - 47,339,632 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2547,327,963 - 47,339,622 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2547,833,792 - 47,835,768 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02547,675,583 - 47,687,325 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2547,675,593 - 47,687,321 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12547,593,385 - 47,595,361 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02547,386,571 - 47,388,546 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02547,617,367 - 47,619,344 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ackr3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303189,351,726 - 189,380,121 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365251,559,575 - 1,565,641 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365251,559,575 - 1,570,679 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACKR3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15136,370,530 - 136,382,553 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.115136,370,457 - 136,382,559 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215150,847,155 - 150,859,228 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ACKR3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110122,558,998 - 122,573,747 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10122,571,853 - 122,572,941 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604076,827,681 - 76,842,164 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ackr3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248472,189,257 - 2,200,352 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248472,189,167 - 2,200,355 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Ackr3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v14162,212,965 - 162,224,536 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ackr3
105 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:279
Count of miRNA genes:174
Interacting mature miRNAs:201
Transcripts:ENSRNOT00000026558
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)956047863101047863Rat
1582203Gluco19Glucose level QTL 193.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)963376862108376862Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)965657365108376720Rat
724547Cm21Cardiac mass QTL 212.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)986720043110356905Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)94445825699506504Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)986720043121768150Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)964220169109220169Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)964220169109220169Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)964220169109220169Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)968875497121768150Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)983161999118999486Rat
4889852Pur26Proteinuria QTL 26150.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)985262459109044727Rat
7794784Mcs31Mammary carcinoma susceptibility QTL 312.98mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)985262459118999486Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)948718864108376862Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)964220169109220169Rat
4889943Bss90Bone structure and strength QTL 904.1tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)95450650499506504Rat

Markers in Region
AA997721  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2990,810,888 - 90,811,085 (+)MAPPERmRatBN7.2
Rnor_6.0997,367,098 - 97,367,294NCBIRnor6.0
Rnor_5.0997,058,025 - 97,058,221UniSTSRnor5.0
RGSC_v3.4989,354,702 - 89,354,898UniSTSRGSC3.4
Celera988,358,377 - 88,358,573UniSTS
RH 3.4 Map9783.99UniSTS
Cytogenetic Map9q35UniSTS
UniSTS:240533  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2990,809,700 - 90,810,054 (+)MAPPERmRatBN7.2
Rnor_6.0997,365,910 - 97,366,263NCBIRnor6.0
Rnor_5.0997,056,837 - 97,057,190UniSTSRnor5.0
RGSC_v3.4989,353,514 - 89,353,867UniSTSRGSC3.4
Celera988,357,189 - 88,357,542UniSTS
Cytogenetic Map9q35UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 74 59 6 338 174 11 142 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000026558   ⟹   ENSRNOP00000026558
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl990,808,766 - 90,811,223 (+)Ensembl
Rnor_6.0 Ensembl997,355,924 - 97,367,445 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000098919   ⟹   ENSRNOP00000091223
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl990,799,686 - 90,811,234 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000108608   ⟹   ENSRNOP00000094961
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl998,247,244 - 98,258,883 (+)Ensembl
mRatBN7.2 Ensembl990,799,694 - 90,811,204 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000113813   ⟹   ENSRNOP00000088201
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl998,246,605 - 98,260,214 (+)Ensembl
mRatBN7.2 Ensembl990,801,452 - 90,811,223 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000115723   ⟹   ENSRNOP00000086994
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl990,803,254 - 90,811,234 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000116518   ⟹   ENSRNOP00000083985
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl990,800,545 - 90,811,237 (+)Ensembl
RefSeq Acc Id: NM_053352   ⟹   NP_445804
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8998,247,354 - 98,258,877 (+)NCBI
mRatBN7.2990,799,717 - 90,811,240 (+)NCBI
Rnor_6.0997,355,924 - 97,367,449 (+)NCBI
Rnor_5.0997,046,816 - 97,058,382 (+)NCBI
RGSC_v3.4989,343,528 - 89,355,053 (+)RGD
Celera988,347,205 - 88,358,728 (+)RGD
Sequence:
RefSeq Acc Id: XM_006245479   ⟹   XP_006245541
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8998,247,300 - 98,258,877 (+)NCBI
mRatBN7.2990,799,682 - 90,811,246 (+)NCBI
Rnor_6.0997,355,881 - 97,367,455 (+)NCBI
Rnor_5.0997,046,816 - 97,058,382 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039084258   ⟹   XP_038940186
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8998,247,333 - 98,258,877 (+)NCBI
mRatBN7.2990,799,694 - 90,811,246 (+)NCBI
RefSeq Acc Id: NP_445804   ⟸   NM_053352
- UniProtKB: Q9JLZ0 (UniProtKB/Swiss-Prot),   O89039 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006245541   ⟸   XM_006245479
- Peptide Label: isoform X1
- UniProtKB: Q9JLZ0 (UniProtKB/Swiss-Prot),   O89039 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000026558   ⟸   ENSRNOT00000026558
RefSeq Acc Id: XP_038940186   ⟸   XM_039084258
- Peptide Label: isoform X1
- UniProtKB: O89039 (UniProtKB/Swiss-Prot),   Q9JLZ0 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSRNOP00000091223   ⟸   ENSRNOT00000098919
Ensembl Acc Id: ENSRNOP00000088201   ⟸   ENSRNOT00000113813
Ensembl Acc Id: ENSRNOP00000086994   ⟸   ENSRNOT00000115723
Ensembl Acc Id: ENSRNOP00000094961   ⟸   ENSRNOT00000108608
Ensembl Acc Id: ENSRNOP00000083985   ⟸   ENSRNOT00000116518

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O89039-F1-model_v2 AlphaFold O89039 1-362 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696849
Promoter ID:EPDNEW_R7373
Type:single initiation site
Name:Ackr3_1
Description:atypical chemokine receptor 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0997,355,904 - 97,355,964EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620601 AgrOrtholog
BioCyc Gene G2FUF-26755 BioCyc
Ensembl Genes ENSRNOG00000019622 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000026558.4 UniProtKB/Swiss-Prot
  ENSRNOT00000098919.1 UniProtKB/Swiss-Prot
  ENSRNOT00000108608 ENTREZGENE
  ENSRNOT00000108608.1 UniProtKB/Swiss-Prot
  ENSRNOT00000113813 ENTREZGENE
  ENSRNOT00000113813.1 UniProtKB/Swiss-Prot
  ENSRNOT00000115723.1 UniProtKB/Swiss-Prot
  ENSRNOT00000116518.1 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
InterPro ACKR3 UniProtKB/Swiss-Prot
  GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
  GPER1-like UniProtKB/Swiss-Prot
KEGG Report rno:84348 UniProtKB/Swiss-Prot
NCBI Gene 84348 ENTREZGENE
PANTHER CHEMOKINE (C-X-C MOTIF) RECEPTOR 7 UniProtKB/Swiss-Prot
  G-PROTEIN COUPLED RECEPTOR 182 AND ESTROGEN RECEPTOR 1 UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PhenoGen Ackr3 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot
  RDC1ORPHANR UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000019622 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
UniProt ACKR3_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q9JLZ0 ENTREZGENE
UniProt Secondary Q9JLZ0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-08-04 Ackr3  atypical chemokine receptor 3  Cxcr7  chemokine (C-X-C motif) receptor 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-22 Cxcr7  chemokine (C-X-C motif) receptor 7  Cmkor1  chemokine orphan receptor 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Cmkor1  chemokine orphan receptor 1  Rdc1    Symbol updated 1299863 APPROVED
2002-08-07 Rdc1  chemokine orphan receptor 1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in atria and ventricles of the heart 625420
gene_product member of the CGRP (calcitonin gene-related peptide) family 625420