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Gene: Gmeb2 (glucocorticoid modulatory element binding protein 2) Rattus norvegicus

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Symbol:

Gmeb2

Name:

glucocorticoid modulatory element binding protein 2

RGD ID:

620481

Description:

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Orthologous to human GMEB2 (glucocorticoid modulatory element binding protein 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4-tert-Octylphenol; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

glucocorticoid modulatory element-binding protein 2; GMEB-2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	GMEB2 (glucocorticoid modulatory element binding protein 2)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Gmeb2 (glucocorticoid modulatory element binding protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Gmeb2 (glucocorticoid modulatory element binding protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	GMEB2 (glucocorticoid modulatory element binding protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	GMEB2 (glucocorticoid modulatory element binding protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Gmeb2 (glucocorticoid modulatory element binding protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	GMEB2 (glucocorticoid modulatory element binding protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	GMEB2 (glucocorticoid modulatory element binding protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Gmeb2 (glucocorticoid modulatory element binding protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Gmeb2 (glucocorticoid modulatory element binding protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	GMEB2 (glucocorticoid modulatory element binding protein 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	GMEB2 (glucocorticoid modulatory element binding protein 2)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Gmeb2 (glucocorticoid modulatory element binding protein 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Gmeb2 (glucocorticoid modulatory element binding protein 2)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	si:ch73-302a13.2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	si:ch73-302a13.2	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	gmeb-1	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	gmeb-2	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER)
Caenorhabditis elegans (roundworm):	gmeb-2	Alliance	DIOPT (OrthoFinder\|OrthoInspector\|PANTHER)
Caenorhabditis elegans (roundworm):	gmeb-3	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER)
Caenorhabditis elegans (roundworm):	gmeb-3	Alliance	DIOPT (Hieranoid\|OrthoFinder\|OrthoInspector\|PANTHER)
Caenorhabditis elegans (roundworm):	spe-44	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER)
Caenorhabditis elegans (roundworm):	spe-44	Alliance	DIOPT (Hieranoid\|OrthoFinder\|OrthoInspector\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	gmeb2	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	gmeb2	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	188,740,210 - 188,778,377 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	3	188,740,210 - 188,778,336 (-)	Ensembl				GRCr8
mRatBN7.2	3	168,362,650 - 168,400,788 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	168,362,650 - 168,400,788 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	3	172,743,290 - 172,781,413 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	181,702,391 - 181,740,513 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	178,363,600 - 178,401,733 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd	3	187,349,473 - 187,387,593 (-)	NCBI		Dahl_SR_JrHsd
Lyon_Normotensive	3	194,210,456 - 194,248,576 (-)	NCBI		Lyon_Normotensive
Lyon_Hypertensive	3	186,180,237 - 186,218,361 (-)	NCBI		Lyon_Hypertensive
F344_StmMcwi	3	167,121,070 - 167,159,190 (-)	NCBI		F344_StmMcwi
Rnor_6.0	3	176,756,006 - 176,791,960 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	176,753,860 - 176,791,960 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	3	180,463,794 - 180,501,893 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	3	170,394,799 - 170,430,752 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	3	164,185,677 - 164,221,207 (+)	NCBI		Celera
RGSC_v3.1	3	170,300,837 - 170,336,788 (-)	NCBI
Cytogenetic Map	3	q43	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

neuronal ceroid lipofuscinosis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-methylcholine (ISO)

4-tert-Octylphenol (EXP)

6-propyl-2-thiouracil (EXP)

acrylamide (EXP)

aflatoxin B1 (ISO)

amitrole (EXP)

ammonium chloride (EXP)

arsane (ISO)

arsenic atom (ISO)

benzene (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP)

bisphenol F (ISO)

carbamazepine (ISO)

CGP 52608 (ISO)

cisplatin (ISO)

coumarin (ISO)

cyclosporin A (ISO)

DDE (ISO)

Dibutyl phosphate (ISO)

diethylstilbestrol (EXP)

doxorubicin (ISO)

gentamycin (EXP)

GSK-J4 (ISO)

inulin (ISO)

methidathion (ISO)

methimazole (EXP)

methyl methanesulfonate (ISO)

monosodium L-glutamate (EXP)

N-nitrosomorpholine (EXP)

p-tert-Amylphenol (EXP)

perfluorooctane-1-sulfonic acid (ISO)

rotenone (EXP)

sodium arsenate (ISO)

Soman (EXP)

sulfadimethoxine (EXP)

tetrachloromethane (ISO)

thioacetamide (EXP)

thiram (ISO)

titanium dioxide (ISO)

trichostatin A (ISO)

triphenyl phosphate (ISO)

valproic acid (ISO)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

DNA-templated transcription (IEA)

positive regulation of transcription by RNA polymerase II (IDA)

regulation of transcription by RNA polymerase II (IBA,IDA)

Cellular Component

cytoplasm (IEA)

cytosol (IEA,ISO)

nucleoplasm (IEA,ISO)

nucleus (IBA,IEA)

Molecular Function

DNA binding (IEA)

DNA-binding transcription activator activity, RNA polymerase II-specific (IDA)

DNA-binding transcription factor activity, RNA polymerase II-specific (IC,IDA)

identical protein binding (IEA,ISO)

metal ion binding (IEA)

protein binding (IPI,ISO)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IBA)

sequence-specific DNA binding (IDA,IEA)

sequence-specific double-stranded DNA binding (IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Structure/activity relationships for GMEB-2: the second member of the glucocorticoid modulatory element-binding complex.	Chen J, etal., Biochemistry. 2004 Jan 13;43(1):245-55.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	Properties of the glucocorticoid modulatory element binding proteins GMEB-1 and -2: potential new modifiers of glucocorticoid receptor transactivation and members of the family of KDWK proteins.	Kaul S, etal., Mol Endocrinol. 2000 Jul;14(7):1010-27.
5.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
6.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
8.	Genomic organization of human GMEB-1 and rat GMEB-2: structural conservation of two multifunctional proteins.	Zeng H, etal., Nucleic Acids Res 2000 Apr 15;28(8):1819-29.

Additional References at PubMed

PMID:7665613	PMID:9651376

Genomics

Comparative Map Data

Gmeb2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	188,740,210 - 188,778,377 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	3	188,740,210 - 188,778,336 (-)	Ensembl				GRCr8
mRatBN7.2	3	168,362,650 - 168,400,788 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	168,362,650 - 168,400,788 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	3	172,743,290 - 172,781,413 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	181,702,391 - 181,740,513 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	178,363,600 - 178,401,733 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd	3	187,349,473 - 187,387,593 (-)	NCBI		Dahl_SR_JrHsd
Lyon_Normotensive	3	194,210,456 - 194,248,576 (-)	NCBI		Lyon_Normotensive
Lyon_Hypertensive	3	186,180,237 - 186,218,361 (-)	NCBI		Lyon_Hypertensive
F344_StmMcwi	3	167,121,070 - 167,159,190 (-)	NCBI		F344_StmMcwi
Rnor_6.0	3	176,756,006 - 176,791,960 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	176,753,860 - 176,791,960 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	3	180,463,794 - 180,501,893 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	3	170,394,799 - 170,430,752 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	3	164,185,677 - 164,221,207 (+)	NCBI		Celera
RGSC_v3.1	3	170,300,837 - 170,336,788 (-)	NCBI
Cytogenetic Map	3	q43	NCBI

GMEB2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	20	63,587,605 - 63,627,101 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	20	63,587,601 - 63,628,426 (-)	Ensembl			hg38	GRCh38
GRCh37	20	62,218,958 - 62,258,454 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	20	61,689,399 - 61,721,673 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	20	61,689,398 - 61,721,673	NCBI
Celera	20	58,899,645 - 58,938,975 (-)	NCBI		Celera
Cytogenetic Map	20	q13.33	NCBI
HuRef	20	58,949,205 - 58,988,662 (-)	NCBI		HuRef
CHM1_1	20	62,119,946 - 62,159,388 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	20	65,401,053 - 65,440,974 (-)	NCBI		T2T-CHM13v2.0

Gmeb2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	180,893,240 - 180,933,481 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	180,893,242 - 180,929,828 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	2	181,251,449 - 181,288,106 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	181,251,449 - 181,288,035 (-)	Ensembl			mm10	GRCm38
MGSCv37	2	180,986,156 - 181,022,671 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	2	181,180,858 - 181,217,373 (-)	NCBI		MGSCv36	mm8
Celera	2	185,334,258 - 185,370,656 (-)	NCBI		Celera
Cytogenetic Map	2	H4	NCBI
cM Map	2	103.63	NCBI

Gmeb2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955528	611,736 - 638,698 (+)	Ensembl
ChiLan1.0	NW_004955528	603,817 - 638,698 (+)	NCBI	ChiLan1.0	ChiLan1.0

GMEB2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	21	69,393,742 - 69,433,267 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	20	69,385,746 - 69,425,125 (-)	NCBI		NHGRI_mPanPan1
PanPan1.1	20	61,513,870 - 61,544,577 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	20	61,513,870 - 61,544,993 (-)	Ensembl			panPan2	panpan1.1

GMEB2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	24	47,173,914 - 47,198,461 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	24	47,175,957 - 47,196,847 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	24	46,372,542 - 46,398,257 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	24	48,142,959 - 48,171,305 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	24	48,144,999 - 48,336,418 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	24	47,157,878 - 47,186,158 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	24	47,283,374 - 47,311,121 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	24	48,021,124 - 48,049,104 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Gmeb2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	195,422,396 - 195,450,389 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936514	10,876,029 - 10,904,055 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936514	10,876,039 - 10,904,022 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GMEB2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	17	62,568,549 - 62,584,820 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	17	62,568,546 - 62,595,880 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

GMEB2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	2	598,340 - 628,370 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	2	604,429 - 628,373 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666050	48,153,467 - 48,186,276 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Gmeb2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624741	29,241,710 - 29,281,516 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624741	29,241,820 - 29,281,551 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Gmeb2
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	5	158,348,559 - 158,388,076 (-)	NCBI		Rrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	196
Count of miRNA genes:	120
Interacting mature miRNAs:	130
Transcripts:	ENSRNOT00000017986, ENSRNOT00000018237, ENSRNOT00000044026
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
9589106	Insul23	Insulin level QTL 23	13.86	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	3	152055202	189428310	Rat
1559282	Emca5	Estrogen-induced mammary cancer QTL 5	3.9		mammary gland integrity trait (VT:0010552)	percentage of study population developing mammary tumors during a period of time (CMO:0000948)	3	145335553	189428310	Rat
1578653	Vnigr3	Vascular neointimal growth QTL 3	3.1		artery morphology trait (VT:0002191)	artery neointimal hyperplastic lesion area (CMO:0001414)	3	151075912	189428310	Rat
1298068	Bp167	Blood pressure QTL 167		0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	161492708	189428310	Rat
1582256	Insul9	Insulin level QTL 9	4.4	0.0016	blood insulin amount (VT:0001560)	absolute change in serum insulin level (CMO:0002038)	3	155759447	189428310	Rat
1582248	Insul7	Insulin level QTL 7	3.9	0.0041	blood insulin amount (VT:0001560)	calculated serum insulin level (CMO:0000359)	3	155759447	189428310	Rat
1578666	Vnigr1	Vascular neointimal growth QTL 1	4.6		artery morphology trait (VT:0002191)	artery lumen area (CMO:0001409)	3	151075912	189428310	Rat
1300161	Rf10	Renal function QTL 10	3.57		renal blood flow trait (VT:2000006)	absolute change in renal vascular resistance (CMO:0001900)	3	181611379	189428310	Rat
8552791	Vie2	Viral induced encephalitis QTL 2	4.1		brain integrity trait (VT:0010579)	encephalitis incidence/prevalence measurement (CMO:0002361)	3	166376089	189428310	Rat
1578656	Vnigr2	Vascular neointimal growth QTL 2	4.2		artery morphology trait (VT:0002191)	lesioned artery residual lumen area (CMO:0001417)	3	151075912	189428310	Rat
631541	Bp81	Blood pressure QTL 81	4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	144575244	189428310	Rat
1582213	Insul6	Insulin level QTL 6	3.7	0.0009	blood insulin amount (VT:0001560)	calculated serum insulin level (CMO:0000359)	3	155759447	189428310	Rat
1598854	Memor10	Memory QTL 10	2		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	3	166376089	189428310	Rat

Markers in Region

D3Mco43

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	168,375,086 - 168,375,256 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	176,766,297 - 176,766,466	NCBI	Rnor6.0
Rnor_5.0	3	180,476,231 - 180,476,400	UniSTS	Rnor5.0
RGSC_v3.4	3	170,405,090 - 170,405,259	UniSTS	RGSC3.4
Celera	3	164,210,746 - 164,210,915	UniSTS
Cytogenetic Map	3	q43	UniSTS

PMC102812P1

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	168,364,857 - 168,365,388 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	176,756,068 - 176,756,598	NCBI	Rnor6.0
Rnor_5.0	3	180,466,002 - 180,466,532	UniSTS	Rnor5.0
RGSC_v3.4	3	170,394,861 - 170,395,391	UniSTS	RGSC3.4
Celera	3	164,220,615 - 164,221,145	UniSTS
Cytogenetic Map	3	q43	UniSTS

BF403392

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	168,402,495 - 168,402,647 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	176,793,698 - 176,793,849	NCBI	Rnor6.0
Rnor_5.0	3	180,503,631 - 180,503,782	UniSTS	Rnor5.0
RGSC_v3.4	3	170,432,490 - 170,432,641	UniSTS	RGSC3.4
Celera	3	164,183,788 - 164,183,939	UniSTS
RH 3.4 Map	3	1547.6	UniSTS
Cytogenetic Map	3	q43	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	160	91	90	59	92	59	6	356	192	11	139	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001389211	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_031803	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063284662	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063284663	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC117053	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF059273	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF203693	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF205778	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF205779	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF205780	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474066	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ211504	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000018237 ⟹ ENSRNOP00000018237

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	168,364,799 - 168,400,758 (-)	Ensembl
Rnor_6.0 Ensembl	3	176,756,009 - 176,791,960 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000044026 ⟹ ENSRNOP00000049928

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	3	188,740,210 - 188,764,226 (-)	Ensembl
mRatBN7.2 Ensembl	3	168,362,650 - 168,400,788 (-)	Ensembl
Rnor_6.0 Ensembl	3	176,753,860 - 176,781,040 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000101387 ⟹ ENSRNOP00000085762

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	3	188,740,210 - 188,778,336 (-)	Ensembl
mRatBN7.2 Ensembl	3	168,362,650 - 168,400,788 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000117366 ⟹ ENSRNOP00000086817

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	3	188,742,138 - 188,778,336 (-)	Ensembl
mRatBN7.2 Ensembl	3	168,364,582 - 168,400,788 (-)	Ensembl

RefSeq Acc Id:

NM_001389211 ⟹ NP_001376140

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	188,740,210 - 188,778,336 (-)	NCBI
mRatBN7.2	3	168,362,654 - 168,400,788 (-)	NCBI
Dahl_SR_JrHsd	3	187,349,473 - 187,387,593 (-)	NCBI
Lyon_Normotensive	3	194,210,456 - 194,248,576 (-)	NCBI
Lyon_Hypertensive	3	186,180,237 - 186,218,361 (-)	NCBI
F344_StmMcwi	3	167,121,070 - 167,159,190 (-)	NCBI

RefSeq Acc Id:

NM_031803 ⟹ NP_113991

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	188,740,210 - 188,778,336 (-)	NCBI
mRatBN7.2	3	168,362,654 - 168,400,788 (-)	NCBI
Dahl_SR_JrHsd	3	187,349,473 - 187,387,593 (-)	NCBI
Lyon_Normotensive	3	194,210,456 - 194,248,576 (-)	NCBI
Lyon_Hypertensive	3	186,180,237 - 186,218,361 (-)	NCBI
F344_StmMcwi	3	167,121,070 - 167,159,190 (-)	NCBI
Rnor_6.0	3	176,756,006 - 176,791,960 (-)	NCBI
Rnor_5.0	3	180,463,794 - 180,501,893 (-)	NCBI
RGSC_v3.4	3	170,394,799 - 170,430,752 (-)	RGD
Celera	3	164,185,677 - 164,221,207 (+)	RGD

Sequence:

show sequence

GCCACCACCACCAGCCGCCGCCGCACCCGTCACAGCCGGGCGCCGGAGCAGGCCCGTGTGGGCC
CAGGACTTCAGACTCTGGAGAAGTGACACTGTTGACCTCTGAGCCATGGCAACTCCAGATGTCA
GCGTCCACATGGAAGAAGTAGTGGTTGTGACAACTCCAGACACTGCAGTTGATGGCAGTGGTGT
AGAGGAGGTGAAGACAGTGCTTGTGACAACGAACCTAGCTCCTCATGGGGGTGATTTGACAGAA
GATAACATGGAAACAGAAAATGCAGCAGCTGCAGCCTGTGCCTTTACAGCCTCCTCACAGCTCA
AGGAAGCCGTGTTAGTGAAGATGGCTGAAGAGGGGGAGAACTTAGAGGCTGAAATTGTGTACCC
CATCACTTGTGGAGACAGCAGAGCTAACCTCATCTGGAGGAAGTTTGTGTGCCCTGGAATCAAT
GTGAAATGTGTTCAGTACGATGAACATGTGATCAGCCCAAAGGAGTTTGTGCATCTGGCAGGGA
AGTCTACCCTGAAGGACTGGAAGAGAGCCATCCGGATGAACGGCATCATGCTCAGGAAGATCAT
GGACTCTGGGGAGCTAGACTTCTACCAGCATGACAAGGTCTGCTCTAATACTTGCCGAAGCACC
AAGATTGACCTCTCAGGGGCCCGTGTGTCCCTGAGCAGTCCAACATCCACAGAGTACATCCCGC
TCACACCAGCTGCAGCTGATGTGAATGGCTCACCTGCCACCATCACCATAGAGACCTGTGAGGA
CCCTGGTGACTGGACCACAACCATTGGAGACGACACATTTGCATTCTGGCGGGGACTGAAGGAT
GCGGGCTTACTGGATGAAGTCATACAGGAATTTCAACAGGAGCTGGAGGAAACCATGAAAGGCC
TGCAGCAGCGAGTGCAGGACCCGCCCCTACAGCTCCGAGATGCTGTCCTCCTCAATAACATCGT
GCAAAACTTTGGCATGCTGGATCTGGTAAAGAAGGTACTGGCCAGCCACAAGTGCCAGATGGAT
CGTTCTCGAGAACAGTATGCACGGGACCTGGCAGCCCTGGAACAGCAGTGTGATGAACATCGCC
GCCGTGCCAAGGAACTGAAGCACAAGTCCCAGCACCTTAGCAATGTGCTCATGACGTTGACCCC
AGTTTCCCTGCCATCCCCTATGAAGCGGCCCCGTCTTGCACGGGCTACATCTGGACCAGCTGCT
ATGGCTTCCCAGGTGCTTACACAGTCTGCACAGATTGCACTTGGCCCAGGAATGCCTATGTCCC
AGTTGACCAGTGTGCCACTTGGCAAAGTAGTATCTACACTGCCCTCCACTGTCCTGGGCAAGGG
CTCTCCTCAAGCTGCCCCAGCCAGTTCACCGGCCTCCCCACTGCTTGGAGGCTACACAGTTTTG
GCCTCCTCTGGCTCTACCTTCCCCAGCACAGTAGAGATTCATCCGGACACATCCAGCCTCACAG
TTTTGAGCACAGCTGCCATGCAGGATGGCACGACAGTACTAAAGGTGGTCAGCCCCCTGCAGCT
GCTCACCCTGCCTGGCCTGGGACCCACACTACAGAATGTGGCTCAGGCATCACCTGCAGGCAGC
ACCATTGTGACAATGCCTACAGCAGCTGCTACTGGACCTGAGGAACACACAGCCACTATTGAGG
TGGCCGCTGTAGCAGAGGACCATGAGCAGAAGTAGCTGGCAGGGAGGCTAAAATCCTTCCAACA
TGGGCTGGCTGACTGCCTCTCCTCAGGCCGCTGCAGGCAGAGGCACTACAGACACAGGCCATAG
GGCTGGCTCAGCACAAGCAGGTCTGATGGGCTGAACCAAAGAGAGGATTGCCGGATGAATCAAG
AGAAGAAAAGGGGGCAGAATGTTGCCAGGAACCTGGAAAATCTGTCTTCAACTTATAAACTTCC
TCCCCTTTTTTTGTGGGAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_063284662 ⟹ XP_063140732

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	188,740,210 - 188,778,377 (-)	NCBI

RefSeq Acc Id:

XM_063284663 ⟹ XP_063140733

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	188,740,210 - 188,754,867 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001376140	(Get FASTA)	NCBI Sequence Viewer
	NP_113991	(Get FASTA)	NCBI Sequence Viewer
	XP_063140732	(Get FASTA)	NCBI Sequence Viewer
	XP_063140733	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAC64001	(Get FASTA)	NCBI Sequence Viewer
	AAF65537	(Get FASTA)	NCBI Sequence Viewer
	AAF65538	(Get FASTA)	NCBI Sequence Viewer
	AAF65539	(Get FASTA)	NCBI Sequence Viewer
	EDL88732	(Get FASTA)	NCBI Sequence Viewer
	EDL88733	(Get FASTA)	NCBI Sequence Viewer
	EDL88734	(Get FASTA)	NCBI Sequence Viewer
	EDL88735	(Get FASTA)	NCBI Sequence Viewer
	EDL88736	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000049928
	ENSRNOP00000085762
GenBank Protein	O88873	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_113991 ⟸ NM_031803
- Peptide Label:	isoform 1
- UniProtKB:	Q9QUZ7 (UniProtKB/Swiss-Prot), Q9JL88 (UniProtKB/Swiss-Prot), Q9JL87 (UniProtKB/Swiss-Prot), Q9JL86 (UniProtKB/Swiss-Prot), O88873 (UniProtKB/Swiss-Prot), G3V7R3 (UniProtKB/TrEMBL), A6KM27 (UniProtKB/TrEMBL)
- Sequence:	show sequence MATPDVSVHMEEVVVVTTPDTAVDGSGVEEVKTVLVTTNLAPHGGDLTEDNMETENAAAAACAF TASSQLKEAVLVKMAEEGENLEAEIVYPITCGDSRANLIWRKFVCPGINVKCVQYDEHVISPKE FVHLAGKSTLKDWKRAIRMNGIMLRKIMDSGELDFYQHDKVCSNTCRSTKIDLSGARVSLSSPT STEYIPLTPAAADVNGSPATITIETCEDPGDWTTTIGDDTFAFWRGLKDAGLLDEVIQEFQQEL EETMKGLQQRVQDPPLQLRDAVLLNNIVQNFGMLDLVKKVLASHKCQMDRSREQYARDLAALEQ QCDEHRRRAKELKHKSQHLSNVLMTLTPVSLPSPMKRPRLARATSGPAAMASQVLTQSAQIALG PGMPMSQLTSVPLGKVVSTLPSTVLGKGSPQAAPASSPASPLLGGYTVLASSGSTFPSTVEIHP DTSSLTVLSTAAMQDGTTVLKVVSPLQLLTLPGLGPTLQNVAQASPAGSTIVTMPTAAATGPEE HTATIEVAAVAEDHEQK hide sequence

Ensembl Acc Id:

ENSRNOP00000018237 ⟸ ENSRNOT00000018237

Ensembl Acc Id:

ENSRNOP00000049928 ⟸ ENSRNOT00000044026

RefSeq Acc Id:	NP_001376140 ⟸ NM_001389211
- Peptide Label:	isoform 2
- UniProtKB:	A6KM28 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000085762 ⟸ ENSRNOT00000101387

Ensembl Acc Id:

ENSRNOP00000086817 ⟸ ENSRNOT00000117366

RefSeq Acc Id:	XP_063140732 ⟸ XM_063284662
- Peptide Label:	isoform X1
- UniProtKB:	Q9QUZ7 (UniProtKB/Swiss-Prot), Q9JL88 (UniProtKB/Swiss-Prot), Q9JL87 (UniProtKB/Swiss-Prot), Q9JL86 (UniProtKB/Swiss-Prot), O88873 (UniProtKB/Swiss-Prot)

RefSeq Acc Id:	XP_063140733 ⟸ XM_063284663
- Peptide Label:	isoform X2
- UniProtKB:	A6KM28 (UniProtKB/TrEMBL)

Protein Domains

SAND

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-O88873-F1-model_v2	AlphaFold	O88873	1-529	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13692750

Promoter ID:

EPDNEW_R3275

Type:

multiple initiation site

Name:

Gmeb2_1

Description:

glucocorticoid modulatory element binding protein 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	3	176,791,982 - 176,792,042	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620481	AgrOrtholog
BioCyc Gene	G2FUF-46293	BioCyc
Ensembl Genes	ENSRNOG00000013339	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000044026	ENTREZGENE
	ENSRNOT00000101387	ENTREZGENE
Gene3D-CATH	3.10.390.10	UniProtKB/Swiss-Prot
InterPro	SAND-like_dom_sf	UniProtKB/Swiss-Prot
	SAND_dom	UniProtKB/Swiss-Prot
KEGG Report	rno:83635	UniProtKB/Swiss-Prot
NCBI Gene	83635	ENTREZGENE
PANTHER	GLUCOCORTICOID MODULATORY ELEMENT-BINDING PROTEIN 2	UniProtKB/Swiss-Prot
	PTHR10417	UniProtKB/Swiss-Prot
Pfam	SAND	UniProtKB/Swiss-Prot
PhenoGen	Gmeb2	PhenoGen
PROSITE	SAND	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000013339	RatGTEx
SMART	SAND	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF63763	UniProtKB/Swiss-Prot
UniProt	A0A8I5ZZY8_RAT	UniProtKB/TrEMBL
	A0A8I6A4G7_RAT	UniProtKB/TrEMBL
	A6KM24_RAT	UniProtKB/TrEMBL
	A6KM25_RAT	UniProtKB/TrEMBL
	A6KM26_RAT	UniProtKB/TrEMBL
	A6KM27	ENTREZGENE, UniProtKB/TrEMBL
	A6KM28	ENTREZGENE, UniProtKB/TrEMBL
	D3ZPD9_RAT	UniProtKB/TrEMBL
	G3V7R3	ENTREZGENE
	GMEB2_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
	Q9JL86	ENTREZGENE
	Q9JL87	ENTREZGENE
	Q9JL88	ENTREZGENE
	Q9QUZ7	ENTREZGENE
UniProt Secondary	Q9JL86	UniProtKB/Swiss-Prot
	Q9JL87	UniProtKB/Swiss-Prot
	Q9JL88	UniProtKB/Swiss-Prot
	Q9QUZ7	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2004-02-26	Gmeb2	glucocorticoid modulatory element binding protein 2			Symbol and Name status set to approved	625702	APPROVED
2002-08-07	Gmeb2	glucocorticoid modulatory element binding protein 2			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_product	member of KDWK protein family	727291

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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