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Gene: Pcsk4 (proprotein convertase subtilisin/kexin type 4) Rattus norvegicus

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Symbol:

Pcsk4

Name:

proprotein convertase subtilisin/kexin type 4

RGD ID:

620325

Description:

Predicted to enable serine-type endopeptidase activity. Predicted to be involved in several processes, including binding activity of sperm to zona pellucida; peptide hormone processing; and sperm capacitation. Predicted to be located in acrosomal membrane. Predicted to be active in Golgi membrane and trans-Golgi network. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma. Orthologous to human PCSK4 (proprotein convertase subtilisin/kexin type 4); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,2',5,5'-tetrachlorobiphenyl; 2,4-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

KEX2-like endoprotease 3; NEC 3; neuroendocrine convertase 3; PC4; prohormone convertase 3

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PCSK4 (proprotein convertase subtilisin/kexin type 4)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Mus musculus (house mouse):	Pcsk4 (proprotein convertase subtilisin/kexin type 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Pcsk4 (proprotein convertase subtilisin/kexin type 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PCSK4 (proprotein convertase subtilisin/kexin type 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PCSK4 (proprotein convertase subtilisin/kexin type 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Pcsk4 (proprotein convertase subtilisin/kexin type 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PCSK4 (proprotein convertase subtilisin/kexin type 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	PCSK4 (proprotein convertase subtilisin/kexin type 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Pcsk4 (proprotein convertase subtilisin/kexin type 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Pcsk4 (proprotein convertase subtilisin/kexin type 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Pcsk4 (proprotein convertase subtilisin/kexin type 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	PCSK4 (proprotein convertase subtilisin/kexin type 4)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	KEX2	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER)
Saccharomyces cerevisiae (baker's yeast):	KEX2	Alliance	DIOPT (Ensembl Compara\|OrthoInspector\|PANTHER)
Drosophila melanogaster (fruit fly):	Fur1	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Drosophila melanogaster (fruit fly):	Fur1	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	kpc-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	kpc-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	pcsk4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	pcsk4	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	10,032,040 - 10,040,263 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	7	10,031,988 - 10,040,255 (+)	Ensembl				GRCr8
mRatBN7.2	7	9,381,366 - 9,389,589 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	9,381,361 - 9,389,585 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	7	12,258,291 - 12,266,392 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	14,133,633 - 14,141,734 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	12,000,988 - 12,009,204 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	12,247,498 - 12,255,721 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	12,247,498 - 12,255,719 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	7	12,417,102 - 12,425,518 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	7	10,892,705 - 10,900,928 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	7	7,558,158 - 7,566,382 (+)	NCBI		Celera
RGSC_v3.1	7	10,892,704 - 10,900,926 (+)	NCBI
Cytogenetic Map	7	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

colorectal adenocarcinoma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (ISO)

17beta-estradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (EXP)

2,2',5,5'-tetrachlorobiphenyl (EXP)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4-dinitrotoluene (EXP)

3,3',4,4',5-pentachlorobiphenyl (EXP)

3,3',4,4'-tetrachlorobiphenyl (ISO)

4,4'-diaminodiphenylmethane (ISO)

6-propyl-2-thiouracil (EXP)

aflatoxin B1 (EXP,ISO)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

carbon nanotube (ISO)

clofibrate (ISO)

copper(II) sulfate (ISO)

Cuprizon (EXP)

cyclosporin A (ISO)

diazinon (ISO)

dibenz[a,h]anthracene (ISO)

Dibutyl phosphate (ISO)

dichloroacetic acid (ISO)

diquat (ISO)

endosulfan (EXP)

fipronil (EXP)

furan (ISO)

kojic acid (ISO)

methotrexate (ISO)

okadaic acid (ISO)

paracetamol (EXP,ISO)

PCB138 (EXP)

perfluorohexanesulfonic acid (ISO)

perfluorononanoic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (EXP,ISO)

phenobarbital (ISO)

pirinixic acid (ISO)

sodium arsenite (ISO)

sunitinib (ISO)

tetrachloromethane (ISO)

tetraphene (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

tributylstannane (ISO)

triptonide (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

acrosome reaction (ISO,ISS)

binding of sperm to zona pellucida (ISO,ISS)

fertilization (IEA,ISO,ISS)

peptide hormone processing (IBA)

protein processing (IEA,ISO,ISS)

proteolysis (IEA)

sperm capacitation (IEA,ISO,ISS)

Cellular Component

acrosomal membrane (IEA,ISO,ISS)

acrosomal vesicle (IEA,ISO,ISS)

cytoplasmic vesicle (IEA)

endoplasmic reticulum (IEA)

Golgi membrane (IBA)

trans-Golgi network (IBA)

Molecular Function

hydrolase activity (IEA)

peptidase activity (IEA)

protein binding (ISO)

serine-type endopeptidase activity (IBA,IEA)

serine-type peptidase activity (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Impact of Genetic Variation in MicroRNA-binding Site on Susceptibility to Colorectal Cancer.	Kang BW, etal., Anticancer Res. 2016 Jul;36(7):3353-61.
3.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
5.	Testicular expression of PC4 in the rat: molecular diversity of a novel germ cell-specific Kex2/subtilisin-like proprotein convertase.	Seidah NG, etal., Mol Endocrinol 1992 Oct;6(10):1559-70.

Additional References at PubMed

PMID:9192653	PMID:12477932	PMID:16040806	PMID:16371590	PMID:19342015	PMID:21080038	PMID:21302280

Genomics

Comparative Map Data

Pcsk4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	10,032,040 - 10,040,263 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	7	10,031,988 - 10,040,255 (+)	Ensembl				GRCr8
mRatBN7.2	7	9,381,366 - 9,389,589 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	9,381,361 - 9,389,585 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	7	12,258,291 - 12,266,392 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	14,133,633 - 14,141,734 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	12,000,988 - 12,009,204 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	12,247,498 - 12,255,721 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	12,247,498 - 12,255,719 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	7	12,417,102 - 12,425,518 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	7	10,892,705 - 10,900,928 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	7	7,558,158 - 7,566,382 (+)	NCBI		Celera
RGSC_v3.1	7	10,892,704 - 10,900,926 (+)	NCBI
Cytogenetic Map	7	q11	NCBI

PCSK4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	1,481,428 - 1,490,876 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	1,481,428 - 1,490,752 (-)	Ensembl			hg38	GRCh38
GRCh37	19	1,481,427 - 1,490,349 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	1,432,427 - 1,441,407 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	19	1,432,426 - 1,434,843	NCBI
Celera	19	1,415,419 - 1,424,399 (-)	NCBI		Celera
Cytogenetic Map	19	p13.3	NCBI
HuRef	19	1,255,223 - 1,264,091 (-)	NCBI		HuRef
CHM1_1	19	1,481,431 - 1,490,411 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	19	1,451,458 - 1,460,906 (-)	NCBI		T2T-CHM13v2.0

Pcsk4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	80,157,117 - 80,165,583 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	80,157,117 - 80,165,332 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	10	80,321,283 - 80,329,748 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	80,321,283 - 80,329,498 (-)	Ensembl			mm10	GRCm38
MGSCv37	10	79,784,028 - 79,792,218 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	10	79,724,431 - 79,732,602 (-)	NCBI		MGSCv36	mm8
Celera	10	81,336,155 - 81,344,348 (-)	NCBI		Celera
Cytogenetic Map	10	C1	NCBI
cM Map	10	39.72	NCBI

Pcsk4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955495	6,453,991 - 6,459,744 (+)	Ensembl
ChiLan1.0	NW_004955495	6,424,426 - 6,460,252 (+)	NCBI	ChiLan1.0	ChiLan1.0

PCSK4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	5,827,433 - 5,859,561 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	5,063,109 - 5,090,410 (-)	NCBI		NHGRI_mPanPan1
PanPan1.1 Ensembl	19	1,452,924 - 1,466,438 (-)	Ensembl			panPan2	panpan1.1

PCSK4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	57,370,035 - 57,376,207 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	57,369,328 - 57,375,590 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	57,162,069 - 57,168,223 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	58,101,329 - 58,107,483 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	58,101,344 - 58,107,490 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	57,157,552 - 57,163,690 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	57,637,009 - 57,643,163 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	57,839,018 - 57,845,172 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Pcsk4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	217,035,019 - 217,041,168 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936588	794,227 - 799,663 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936588	793,615 - 800,038 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PCSK4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	76,989,544 - 76,997,766 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	2	76,982,806 - 76,996,507 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	77,881,928 - 77,888,794 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PCSK4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	1,253,729 - 1,264,114 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	1,254,276 - 1,263,847 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666081	7,588,319 - 7,598,392 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Pcsk4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624828	7,208,995 - 7,216,188 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Pcsk4
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	1	154,552,363 - 154,560,389 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Pcsk4
19 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	179
Count of miRNA genes:	111
Interacting mature miRNAs:	128
Transcripts:	ENSRNOT00000022358
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
61410	Bw19	Body weight QTL 19	6.2	0.001	body mass (VT:0001259)	body weight (CMO:0000012)	7	1669658	46669658	Rat
1300176	Hrtrt10	Heart rate QTL 10	3.19		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	7	1	23748937	Rat
9590102	Sffal5	Serum free fatty acids level QTL 5	8.62	0.001	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	7	7216097	52216097	Rat
2290372	Gluco33	Glucose level QTL 33	2.71		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	7	1	31777942	Rat
1300149	Cm6	Cardiac mass QTL 6	4.09		heart mass (VT:0007028)	heart left ventricle weight to body weight ratio (CMO:0000530)	7	1	104117804	Rat
631503	Bp102	Blood pressure QTL 102	1.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	1709527	46709527	Rat
634336	Anxrr17	Anxiety related response QTL 17	3.66		locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	7	1509236	116977875	Rat
9590142	Scort5	Serum corticosterone level QTL 5	24.4	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	7	1	32612984	Rat
1582260	Bw72	Body weight QTL 72	3.2	0.0043	body mass (VT:0001259)	body weight (CMO:0000012)	7	1	39960528	Rat
1582261	Bw69	Body weight QTL 69	3.2	0.0048	body mass (VT:0001259)	body weight (CMO:0000012)	7	1	39960528	Rat
1582262	Bw75	Body weight QTL 75	3	0.0038	body mass (VT:0001259)	body weight (CMO:0000012)	7	1	39960528	Rat
10059592	Kidm45	Kidney mass QTL 45	3.95	0.025	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	7	9460877	54460877	Rat
2298550	Neuinf6	Neuroinflammation QTL 6	3.3		nervous system integrity trait (VT:0010566)	spinal cord RT1-B protein level (CMO:0002132)	7	1	29716167	Rat
724560	Plsm3	Polydactyly-luxate syndrome (PLS) morphotypes QTL 3		0.0003	tibia length (VT:0004357)	tibia length (CMO:0000450)	7	1	34650782	Rat
7411566	Bw136	Body weight QTL 136	10.4	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	7	1	32612984	Rat

Markers in Region

AI576245

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	9,384,203 - 9,384,306 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	12,250,336 - 12,250,438	NCBI	Rnor6.0
Rnor_5.0	7	12,420,131 - 12,420,233	UniSTS	Rnor5.0
RGSC_v3.4	7	10,895,543 - 10,895,645	UniSTS	RGSC3.4
Celera	7	7,560,997 - 7,561,099	UniSTS
RH 3.4 Map	7	25.3	UniSTS
Cytogenetic Map	7	q11	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
15	12	59	146	90	89	59	49	59	6	302	141	11	125	79	92	30	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_133559	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC120291	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC097288	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC107463	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474029	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	L14937	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000022358 ⟹ ENSRNOP00000022358

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	7	10,031,988 - 10,040,255 (+)	Ensembl
mRatBN7.2 Ensembl	7	9,381,361 - 9,389,585 (+)	Ensembl
Rnor_6.0 Ensembl	7	12,247,498 - 12,255,719 (+)	Ensembl

RefSeq Acc Id:

NM_133559 ⟹ NP_598243

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	10,032,040 - 10,040,263 (+)	NCBI
mRatBN7.2	7	9,381,366 - 9,389,589 (+)	NCBI
Rnor_6.0	7	12,247,498 - 12,255,721 (+)	NCBI
Rnor_5.0	7	12,417,102 - 12,425,518 (+)	NCBI
RGSC_v3.4	7	10,892,705 - 10,900,928 (+)	RGD
Celera	7	7,558,158 - 7,566,382 (+)	RGD

Sequence:

show sequence

ATGCGGCCCTCCCAGACAGCGCTGTGGCTGGGTCTGGTTTTGTCTTTGGCCCTCCTGGCTGTGG
GGTGGGCCTCAGCCCGACCACCCATCTATGTCAGCAGCTGGGCAGTGCGGGTGACCAAAGGTTA
CCAGGAGGCTGAGCGCCTGGCACGTAAATTTGGCTTCGTCAACCTGGGACAGATCTTTCCTGAT
GACCAGTATTTCCATCTGAGGCACCGGGGTGTGGCCCAGCAGTCCCTGACTCCGCACTGGGGCC
ACCGTCTGCGCCTGAAGAAAGAGCCCAAGGTGCGGTGGTTTGAGCAGCAGACTTTGAGGCGGCG
GGTGAAGCGCTCCCTGGTGGTACCCACAGACCCCTGGTTTTCCAAGCAGTGGTACATGAACAAG
GAGATAGAACAAGATCTCAACATCCTAAAGGTTTGGAACCAGGGACTGACTGGCCGGGGAGTGG
TGGTCTCCATCTTGGATGATGGCATTGAGAAGGACCATCCGGACCTCTGGGCTAATTATGACCC
CCTGGCCAGCTATGACTTCAATGATTACGACCCAGATCCCCAGCCTCGATACACACCCAACGAT
GAGAACCGGCATGGAACACGCTGCGCTGGGGAGGTGTCTGCCACAGCAAACAACGGTTTCTGTG
GTGCCGGTGTGGCCTTCAATGCCAGAATTGGAGGCGTGCGCATGTTGGATGGAGCCATCACTGA
CATCGTGGAGGCTCAGTCCCTCAGCCTGCAGCCGCAACACATACACATCTATAGCGCCAGTTGG
GGCCCCGAGGATGATGGGCGCACAGTGGACGGACCCGGCCTCCTCACGCAGGAGGCCTTCAGGC
GTGGTGTAACCAAGGGCCGCCAAGGGCTGGGCACGCTGTTCATCTGGGCCTCGGGAAACGGTGG
CCTCCACTACGACAACTGCAATTGTGACGGCTACACCAACAGCATCCACACGCTGTCAGTGGGC
AGTACCACGCGGCAGGGCCGAGTGCCCTGGTACAGCGAGGCCTGCGCCTCCACGTTCACCACCA
CCTTCAGCAGCGGTGTGGTCACCGACCCACAGATCGTCACCACGGACCTACACCATCAATGCAC
CGACAAGCACACGGGCACCTCGGCCTCCGCCCCGCTGGCCGCTGGCATGATCGCCCTGGCGCTG
GAGGCCAACCCGCTGCTGACCTGGAGGGACCTGCAGCACCTGGTGGTCCGCGCGTCCAGGCCGG
CGCAGCTGCAGGCGGAGGACTGGAGGATCAACGGCGTGGGGCGCCAAGTGAGCCACCACTATGG
CTATGGGCTGCTGGACGCGGGGCTGCTGGTAGACCTGGCTCGCGTGTGGCTCCCTACTAAGCCT
CAGAAGAAATGCACCATTCGGGTGGTGCACACCCCAACCCCCATCCTGCCTCGGATGCTGGTGC
CAAAGAACGTGACTGTATGCTGCGATGGCTCGCGCCGCCGCCTCATCCGCTCGCTAGAGCATGT
TCAGGTCCAGCTGTCGCTCTCCTACAGCCGCCGCGGGGACCTGGAGATCTTCCTCACCAGCCCC
ATGGGCACGCGCTCCACGCTTGTGGCCATCAGACCCTTGGATATCAGCGGCCAAGGCTACAACA
ACTGGATCTTCATGTCTACTCACTACTGGGATGAGGACCCGCAGGGCCTGTGGACCCTGGGGCT
GGAGAATAAGGGCTACTATTATAACACAGGAACTCTGTACTACTGCACGCTGCTGCTGTATGGG
ACGGCAGAGGACATGACAGCGCGGCCCCAGACCCCCCAGGTGACCAGCTGCGCGCACGCATGTG
CAGAGGGACACAGAGGGGCTGTGCCAGGAAAGTCATTGTCCCCTCTCCATTGTGGCAGAACTCT
GCCTCATCTCCAGCAAGCAGTGGTGGTGGCTCTACAGCCACACACAGCAGCCAGTGACCAAGGG
ACAGGACAGCTGTCACCCTCCTACCACACCTGCTCGGCAGCTTGACCAGCGACTACACTGCCTG
TTCCCTGCCCCTCATGCTGGGAGTGCTTCAGAGCCCCTCCAAGGCTTGTCACCTCTGGCAGCCA
TCCTGGCTATCAGTCTTGGGCCATGGTGCTGTCCCTGCTAACCAGGGCCTTTGGAAGGCCCCTC
ATCTTGAGGAAGGCCCACCTCTCCCCAGGCTGGATACCCCTGGGGAGCCAGAGATGCCCCACTC
TCAGGACAGAAGGCCGGTACCCCAAGGCCCTGCTCCCAGGCCGGGATAGGAATATGCCCCAGAA
GGCCACGGCAGAGAGCTGCATGGGTCACGTGACAGCCCGCAGCTCAGCCTCAGCTGCTCCCAGT
GGAAGAGACGTTTCCTCATTCTTTTTGGAGCAGGTATGGCAGACAAGAGGTCAGACCACAGCCA
CCAACCACCTGCCCCTTCCCTGTCTCCAAACCATCCCCATGTCTAACCTCATAGTTGGCAAATA
AAGTTAAACAGAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_598243	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA41814	(Get FASTA)	NCBI Sequence Viewer
	AAA41815	(Get FASTA)	NCBI Sequence Viewer
	AAA41816	(Get FASTA)	NCBI Sequence Viewer
	AAH97288	(Get FASTA)	NCBI Sequence Viewer
	EDL89295	(Get FASTA)	NCBI Sequence Viewer
	EDL89296	(Get FASTA)	NCBI Sequence Viewer
	EDL89297	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000022358
GenBank Protein	Q78EH2	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_598243 ⟸ NM_133559
- Peptide Label:	precursor
- UniProtKB:	A6K8M5 (UniProtKB/TrEMBL), D3ZKU8 (UniProtKB/TrEMBL)
- Sequence:	show sequence MRPSQTALWLGLVLSLALLAVGWASARPPIYVSSWAVRVTKGYQEAERLARKFGFVNLGQIFPD DQYFHLRHRGVAQQSLTPHWGHRLRLKKEPKVRWFEQQTLRRRVKRSLVVPTDPWFSKQWYMNK EIEQDLNILKVWNQGLTGRGVVVSILDDGIEKDHPDLWANYDPLASYDFNDYDPDPQPRYTPND ENRHGTRCAGEVSATANNGFCGAGVAFNARIGGVRMLDGAITDIVEAQSLSLQPQHIHIYSASW GPEDDGRTVDGPGLLTQEAFRRGVTKGRQGLGTLFIWASGNGGLHYDNCNCDGYTNSIHTLSVG STTRQGRVPWYSEACASTFTTTFSSGVVTDPQIVTTDLHHQCTDKHTGTSASAPLAAGMIALAL EANPLLTWRDLQHLVVRASRPAQLQAEDWRINGVGRQVSHHYGYGLLDAGLLVDLARVWLPTKP QKKCTIRVVHTPTPILPRMLVPKNVTVCCDGSRRRLIRSLEHVQVQLSLSYSRRGDLEIFLTSP MGTRSTLVAIRPLDISGQGYNNWIFMSTHYWDEDPQGLWTLGLENKGYYYNTGTLYYCTLLLYG TAEDMTARPQTPQVTSCAHACAEGHRGAVPGKSLSPLHCGRTLPHLQQAVVVALQPHTAASDQG TGQLSPSYHTCSAA hide sequence

Ensembl Acc Id:

ENSRNOP00000022358 ⟸ ENSRNOT00000022358

Protein Domains

P/Homo B Peptidase S8

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q78EH2-F1-model_v2	AlphaFold	Q78EH2	1-678	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13695023

Promoter ID:

EPDNEW_R5548

Type:

multiple initiation site

Name:

Pcsk4_1

Description:

proprotein convertase subtilisin/kexin type 4

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	7	12,247,478 - 12,247,538	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620325	AgrOrtholog
BioCyc Gene	G2FUF-34936	BioCyc
Ensembl Genes	ENSRNOG00000016405	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000022358	ENTREZGENE
Gene3D-CATH	3.30.70.850	UniProtKB/Swiss-Prot
	3.40.50.200	UniProtKB/Swiss-Prot
	Galactose-binding domain-like	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7456182	IMAGE-MGC_LOAD
InterPro	Galactose-bd-like_sf	UniProtKB/Swiss-Prot
	Kexin/furin	UniProtKB/Swiss-Prot
	P_dom	UniProtKB/Swiss-Prot
	Peptidase_S8/S53_dom	UniProtKB/Swiss-Prot
	Peptidase_S8/S53_dom_sf	UniProtKB/Swiss-Prot
	Peptidase_S8_Asp-AS	UniProtKB/Swiss-Prot
	Peptidase_S8_His-AS	UniProtKB/Swiss-Prot
	Peptidase_S8_Ser-AS	UniProtKB/Swiss-Prot
	Peptidase_S8_subtilisin-rel	UniProtKB/Swiss-Prot
	S8_pro-domain	UniProtKB/Swiss-Prot
	S8_pro-domain_sf	UniProtKB/Swiss-Prot
KEGG Report	rno:171085	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:114269	IMAGE-MGC_LOAD
NCBI Gene	171085	ENTREZGENE
PANTHER	PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 4	UniProtKB/Swiss-Prot
	PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED	UniProtKB/Swiss-Prot
Pfam	P_proprotein	UniProtKB/Swiss-Prot
	Peptidase_S8	UniProtKB/Swiss-Prot
	S8_pro-domain	UniProtKB/Swiss-Prot
PhenoGen	Pcsk4	PhenoGen
PRINTS	SUBTILISIN	UniProtKB/Swiss-Prot
PROSITE	P_HOMO_B	UniProtKB/Swiss-Prot
	SUBTILASE	UniProtKB/Swiss-Prot
	SUBTILASE_ASP	UniProtKB/Swiss-Prot
	SUBTILASE_HIS	UniProtKB/Swiss-Prot
	SUBTILASE_SER	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000016405	RatGTEx
Superfamily-SCOP	Protease propeptides/inhibitors	UniProtKB/Swiss-Prot
	SSF49785	UniProtKB/Swiss-Prot
	SSF52743	UniProtKB/Swiss-Prot
UniProt	A6K8M5	ENTREZGENE, UniProtKB/TrEMBL
	A6K8M6_RAT	UniProtKB/TrEMBL
	A6K8M7_RAT	UniProtKB/TrEMBL
	D3ZKU8	ENTREZGENE, UniProtKB/TrEMBL
	PCSK4_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary	A1A4C9	UniProtKB/Swiss-Prot
	Q07213	UniProtKB/Swiss-Prot
	Q07214	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2004-09-10	Pcsk4	proprotein convertase subtilisin/kexin type 4			Symbol and Name status set to approved	1299863	APPROVED
2002-08-07	Pcsk4	proprotein convertase subtilisin/kexin type 4			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_expression	enriched in testis; expressed in pachytene spermatocytes and the round spermatids	633734

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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