Symbol:
Psd
Name:
pleckstrin and Sec7 domain containing
RGD ID:
620297
Description:
Predicted to enable guanyl-nucleotide exchange factor activity. Involved in maintenance of postsynaptic density structure; neuron differentiation; and regulation of postsynapse assembly. Is active in glutamatergic synapse. Orthologous to human PSD (pleckstrin and Sec7 domain containing); PARTICIPATES IN endocytosis pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type:
protein-coding
RefSeq Status:
VALIDATED
Previously known as:
EFA6; exchange factor for ADP-ribosylation factor guanine nucleotide factor 6; exchange factor for ARF6; exchange factor for ARF6 A; PH and SEC7 domain-containing protein 1; pleckstrin homology and SEC7 domain-containing protein 1
RGD Orthologs
Alliance Orthologs
More Info
more info ...
More Info
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
PSD (pleckstrin and Sec7 domain containing)
HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):
Psd (pleckstrin and Sec7 domain containing)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):
Psd (pleckstrin and Sec7 domain containing)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
PSD (pleckstrin and Sec7 domain containing)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
PSD (pleckstrin and Sec7 domain containing)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Psd (pleckstrin and Sec7 domain containing)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
PSD (pleckstrin and Sec7 domain containing)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):
PSD (pleckstrin and Sec7 domain containing)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Psd (pleckstrin and Sec7 domain containing)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Rattus rattus (black rat):
Psd (pleckstrin and Sec7 domain containing)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Homo sapiens (human):
PSD (pleckstrin and Sec7 domain containing)
Alliance
DIOPT (Ensembl Compara|HGNC|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Mus musculus (house mouse):
Psd (pleckstrin and Sec7 domain containing)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Caenorhabditis elegans (roundworm):
efa-6
Alliance
DIOPT (Ensembl Compara|InParanoid|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB)
Caenorhabditis elegans (roundworm):
efa-6
Alliance
DIOPT (Ensembl Compara|InParanoid|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Drosophila melanogaster (fruit fly):
Efa6
Alliance
DIOPT (Ensembl Compara|Hieranoid|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB)
Drosophila melanogaster (fruit fly):
Efa6
Alliance
DIOPT (Ensembl Compara|OrthoFinder|OrthoInspector|PANTHER)
Saccharomyces cerevisiae (baker's yeast):
SYT1
Alliance
DIOPT (Ensembl Compara|PANTHER)
Danio rerio (zebrafish):
psda
Alliance
DIOPT (Ensembl Compara|Hieranoid|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Danio rerio (zebrafish):
psda
Alliance
DIOPT (Ensembl Compara|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):
psd
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):
psd
Alliance
DIOPT (Ensembl Compara|OrthoFinder|PhylomeDB)
Latest Assembly:
GRCr8 - GRCr8 Assembly
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 1 255,114,703 - 255,130,151 (-) NCBI GRCr8 GRCr8 GRCr8 GRCr8 Ensembl 1 255,114,703 - 255,129,553 (-) Ensembl GRCr8 mRatBN7.2 1 245,173,279 - 245,188,681 (-) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 1 245,173,279 - 245,189,356 (-) Ensembl mRatBN7.2 UTH_Rnor_SHR_Utx 1 253,294,690 - 253,309,547 (-) NCBI UTH_Rnor_SHR_Utx UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 1 259,989,375 - 260,004,229 (-) NCBI UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 1 252,641,132 - 252,655,981 (-) NCBI UTH_Rnor_WKY_Bbb_1.0 UTH_Rnor_WKY_Bbb_1.0 Dahl_SR_JrHsd 1 254,442,145 - 254,457,002 (-) NCBI Dahl_SR_JrHsd Lyon_Normotensive 1 259,360,757 - 259,375,614 (-) NCBI Lyon_Normotensive Lyon_Hypertensive 1 256,126,033 - 256,140,888 (-) NCBI Lyon_Hypertensive F344_StmMcwi 1 252,687,683 - 252,702,540 (-) NCBI F344_StmMcwi Rnor_6.0 1 266,059,331 - 266,074,774 (-) NCBI Rnor_6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 1 266,059,331 - 266,074,181 (-) Ensembl rn6 Rnor6.0 Rnor_5.0 1 273,490,272 - 273,505,904 (-) NCBI Rnor_5.0 Rnor_5.0 rn5 RGSC_v3.4 1 251,527,890 - 251,542,740 (-) NCBI RGSC_v3.4 RGSC_v3.4 rn4 Celera 1 240,956,153 - 240,970,898 (-) NCBI Celera RGSC_v3.1 1 251,791,506 - 251,803,196 (-) NCBI Cytogenetic Map 1 q54 NCBI
JBrowse:
Only show annotations with direct experimental evidence (0 objects hidden)
Psd Rat 1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene multiple interactions ISO Psd (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Psd Rat 1,2-dimethylhydrazine decreases expression ISO Psd (Mus musculus) 6480464 1,2-Dimethylhydrazine results in decreased expression of PSD mRNA CTD PMID:22206623 Psd Rat 1,2-dimethylhydrazine multiple interactions ISO Psd (Mus musculus) 6480464 [1,2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of PSD mRNA CTD PMID:22206623 Psd Rat 17beta-estradiol increases expression EXP 6480464 Estradiol results in increased expression of PSD mRNA CTD PMID:20068009 Psd Rat 17beta-estradiol multiple interactions ISO PSD (Homo sapiens) 6480464 [Estradiol co-treated with TGFB1 protein] results in increased expression of PSD mRNA CTD PMID:30165855 Psd Rat 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO Psd (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Psd Rat 2,2',5,5'-tetrachlorobiphenyl decreases expression ISO PSD (Homo sapiens) 6480464 2,5,2',5'-tetrachlorobiphenyl analog results in decreased expression of PSD mRNA CTD PMID:36804509 Psd Rat 2,2',5,5'-tetrachlorobiphenyl multiple interactions ISO Psd (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Psd Rat 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of PSD mRNA CTD PMID:33387578 Psd Rat 2,4,4'-trichlorobiphenyl multiple interactions ISO Psd (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Psd Rat 4,4'-sulfonyldiphenol decreases methylation ISO Psd (Mus musculus) 6480464 bisphenol S results in decreased methylation of PSD exon; bisphenol S results in decreased methylation more ... CTD PMID:33297965 Psd Rat 6-propyl-2-thiouracil increases expression EXP 6480464 Propylthiouracil results in increased expression of PSD mRNA CTD PMID:30047161 Psd Rat acetylsalicylic acid increases expression ISO PSD (Homo sapiens) 6480464 Aspirin results in increased expression of PSD mRNA CTD PMID:11906190 Psd Rat aflatoxin B1 increases methylation ISO PSD (Homo sapiens) 6480464 Aflatoxin B1 results in increased methylation of PSD intron CTD PMID:30157460 Psd Rat amitrole decreases expression EXP 6480464 Amitrole results in decreased expression of PSD mRNA CTD PMID:38685447 Psd Rat amitrole increases expression EXP 6480464 Amitrole results in increased expression of PSD mRNA CTD PMID:30047161 Psd Rat ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of PSD mRNA CTD PMID:16483693 Psd Rat benzo[a]pyrene decreases expression EXP 6480464 Benzo(a)pyrene results in decreased expression of PSD mRNA CTD PMID:21839799 Psd Rat benzo[a]pyrene decreases expression ISO PSD (Homo sapiens) 6480464 Benzo(a)pyrene results in decreased expression of PSD mRNA CTD PMID:32234424 Psd Rat benzo[a]pyrene increases methylation ISO PSD (Homo sapiens) 6480464 Benzo(a)pyrene results in increased methylation of PSD 3' UTR CTD PMID:27901495 Psd Rat benzo[a]pyrene affects methylation ISO PSD (Homo sapiens) 6480464 Benzo(a)pyrene affects the methylation of PSD 5' UTR; Benzo(a)pyrene affects the methylation of PSD intron CTD PMID:27901495|PMID:30157460 Psd Rat bis(2-ethylhexyl) phthalate increases methylation ISO Psd (Mus musculus) 6480464 Diethylhexyl Phthalate results in increased methylation of PSD exon; Diethylhexyl Phthalate results in increased methylation more ... CTD PMID:32864567 Psd Rat bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of PSD mRNA CTD PMID:25181051 Psd Rat bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of PSD mRNA CTD PMID:30816183 Psd Rat bisphenol F decreases expression ISO Psd (Mus musculus) 6480464 bisphenol F results in decreased expression of PSD mRNA CTD PMID:38685157 Psd Rat buta-1,3-diene decreases expression ISO Psd (Mus musculus) 6480464 1,3-butadiene results in decreased expression of PSD mRNA CTD PMID:29038090 Psd Rat chlorohydrocarbon multiple interactions EXP 6480464 [Hydrocarbons, Chlorinated co-treated with Polychlorinated Biphenyls co-treated with methylmercuric chloride] results in decreased expression of more ... CTD PMID:30744511 Psd Rat copper(II) sulfate increases expression ISO PSD (Homo sapiens) 6480464 Copper Sulfate results in increased expression of PSD mRNA CTD PMID:19549813 Psd Rat Cuprizon decreases expression EXP 6480464 Cuprizone results in decreased expression of PSD mRNA CTD PMID:26577399 Psd Rat diazinon increases methylation ISO PSD (Homo sapiens) 6480464 Diazinon results in increased methylation of PSD gene CTD PMID:22964155 Psd Rat doxorubicin increases expression ISO PSD (Homo sapiens) 6480464 Doxorubicin results in increased expression of PSD mRNA CTD PMID:29803840 Psd Rat ethanol increases expression ISO Psd (Mus musculus) 6480464 Ethanol results in increased expression of PSD mRNA CTD PMID:30319688 Psd Rat ethanol multiple interactions ISO Psd (Mus musculus) 6480464 Ethanol affects the expression of and affects the splicing of PSD mRNA CTD PMID:30319688 Psd Rat folic acid multiple interactions ISO Psd (Mus musculus) 6480464 [1,2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of PSD mRNA CTD PMID:22206623 Psd Rat folic acid decreases expression ISO PSD (Homo sapiens) 6480464 Folic Acid results in decreased expression of PSD mRNA CTD PMID:21867686 Psd Rat FR900359 increases phosphorylation ISO PSD (Homo sapiens) 6480464 FR900359 results in increased phosphorylation of PSD protein CTD PMID:37730182 Psd Rat gentamycin increases expression EXP 6480464 Gentamicins results in increased expression of PSD mRNA CTD PMID:33387578 Psd Rat lead(0) affects expression ISO PSD (Homo sapiens) 6480464 Lead affects the expression of PSD mRNA CTD PMID:28903495 Psd Rat methimazole decreases expression EXP 6480464 Methimazole results in decreased expression of PSD mRNA CTD PMID:38685447 Psd Rat methimazole increases expression EXP 6480464 Methimazole results in increased expression of PSD mRNA CTD PMID:30047161 Psd Rat methylmercury chloride multiple interactions EXP 6480464 [Hydrocarbons, Chlorinated co-treated with Polychlorinated Biphenyls co-treated with methylmercuric chloride] results in decreased expression of more ... CTD PMID:30744511 Psd Rat N-methyl-4-phenylpyridinium increases expression ISO Psd (Mus musculus) 6480464 1-Methyl-4-phenylpyridinium results in increased expression of PSD mRNA CTD PMID:22776087 Psd Rat okadaic acid decreases expression ISO PSD (Homo sapiens) 6480464 Okadaic Acid results in decreased expression of PSD mRNA CTD PMID:38832940 Psd Rat paracetamol affects expression ISO Psd (Mus musculus) 6480464 Acetaminophen affects the expression of PSD mRNA CTD PMID:17562736 Psd Rat paracetamol increases expression EXP 6480464 Acetaminophen results in increased expression of PSD mRNA CTD PMID:33387578 Psd Rat PCB138 multiple interactions ISO Psd (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Psd Rat resveratrol multiple interactions ISO PSD (Homo sapiens) 6480464 [Plant Extracts co-treated with Resveratrol] results in decreased expression of PSD mRNA CTD PMID:23557933 Psd Rat S-nitrosoglutathione decreases expression ISO PSD (Homo sapiens) 6480464 S-Nitrosoglutathione results in decreased expression of PSD mRNA CTD PMID:38825487 Psd Rat sodium arsenite affects methylation ISO PSD (Homo sapiens) 6480464 sodium arsenite affects the methylation of PSD gene CTD PMID:28589171 Psd Rat sodium arsenite decreases expression ISO Psd (Mus musculus) 6480464 sodium arsenite results in decreased expression of PSD mRNA CTD PMID:37682722 Psd Rat sulfadimethoxine increases expression EXP 6480464 Sulfadimethoxine results in increased expression of PSD mRNA CTD PMID:30047161 Psd Rat Tesaglitazar decreases expression EXP 6480464 tesaglitazar results in decreased expression of PSD mRNA CTD PMID:21515302 Psd Rat thioacetamide increases expression EXP 6480464 Thioacetamide results in increased expression of PSD mRNA CTD PMID:34492290 Psd Rat titanium dioxide increases expression ISO Psd (Mus musculus) 6480464 titanium dioxide results in increased expression of PSD mRNA CTD PMID:23557971 Psd Rat titanium dioxide increases methylation ISO Psd (Mus musculus) 6480464 titanium dioxide results in increased methylation of PSD gene CTD PMID:35295148 Psd Rat trichloroethene increases expression EXP 6480464 Trichloroethylene results in increased expression of PSD mRNA CTD PMID:33387578 Psd Rat triclosan increases expression ISO PSD (Homo sapiens) 6480464 Triclosan results in increased expression of PSD mRNA CTD PMID:30510588 Psd Rat triphenyl phosphate affects expression ISO PSD (Homo sapiens) 6480464 triphenyl phosphate affects the expression of PSD mRNA CTD PMID:37042841 Psd Rat triptonide increases expression ISO Psd (Mus musculus) 6480464 triptonide results in increased expression of PSD mRNA CTD PMID:33045310 Psd Rat troglitazone decreases expression ISO Psd (Mus musculus) 6480464 troglitazone results in decreased expression of PSD mRNA CTD PMID:17569031 Psd Rat troglitazone decreases expression EXP 6480464 troglitazone results in decreased expression of PSD mRNA CTD PMID:21515302 Psd Rat trovafloxacin increases expression ISO Psd (Mus musculus) 6480464 trovafloxacin results in increased expression of PSD mRNA CTD PMID:35537566