Sf3b1 (splicing factor 3b, subunit 1) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Sf3b1 (splicing factor 3b, subunit 1) Rattus norvegicus
Analyze
Symbol: Sf3b1
Name: splicing factor 3b, subunit 1
RGD ID: 620148
Description: Predicted to enable chromatin binding activity; mRNA binding activity; and splicing factor binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase III and spliceosomal complex assembly. Predicted to act upstream of or within anterior/posterior pattern specification; blastocyst formation; and mRNA splicing, via spliceosome. Predicted to be located in chromatin; nuclear matrix; and nuclear speck. Predicted to be part of nucleus. Human ortholog(s) of this gene implicated in hepatocellular carcinoma and myelodysplastic syndrome. Orthologous to human SF3B1 (splicing factor 3b subunit 1); PARTICIPATES IN spliceosome pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3H-1,2-dithiole-3-thione.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Sap155; splicing factor 3B subunit 1; splicing factor 3b, subunit 1, 155kD
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8963,986,829 - 64,026,723 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl963,986,829 - 64,026,719 (-)EnsemblGRCr8
mRatBN7.2956,492,403 - 56,532,300 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl956,492,403 - 56,532,300 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx965,002,980 - 65,042,759 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0970,118,880 - 70,158,654 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0968,417,802 - 68,457,524 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd967,740,122 - 67,779,888 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive963,515,561 - 63,555,336 (-)NCBILyon_Normotensive
Lyon_Hypertensive963,651,333 - 63,691,105 (-)NCBILyon_Hypertensive
F344_StmMcwi965,567,016 - 65,606,779 (-)NCBIF344_StmMcwi
Rnor_6.0961,594,620 - 61,634,510 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl961,594,620 - 61,634,510 (-)Ensemblrn6Rnor6.0
Rnor_5.0961,274,727 - 61,315,726 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4953,796,176 - 53,837,297 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera953,974,888 - 54,014,648 (-)NCBICelera
RGSC_v3.1953,814,990 - 53,838,594 (-)NCBI
Cytogenetic Map9q31NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dimethoxyphenol  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
acetazolamide  (ISO)
aflatoxin B1  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
Brodifacoum  (EXP)
Butylbenzyl phthalate  (ISO)
caffeine  (ISO)
calciol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroprene  (EXP)
chlorpyrifos  (EXP)
ciguatoxin CTX1B  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
coumarin  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (EXP)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dicrotophos  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
elemental selenium  (ISO)
ethanol  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
furfural  (ISO)
gentamycin  (EXP)
hinokiflavone  (ISO)
hydrogen peroxide  (ISO)
hydroquinone O-beta-D-glucopyranoside  (ISO)
ivermectin  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methidathion  (ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
miconazole  (ISO)
N,N-diethyl-m-toluamide  (EXP)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (EXP)
phenobarbital  (ISO)
quercitrin  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
Soman  (EXP)
testosterone enanthate  (ISO)
thapsigargin  (ISO)
thimerosal  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
troglitazone  (ISO)
ursodeoxycholic acid  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors. Chen YI, etal., Nucleic Acids Res. 2007;35(12):3928-44. Epub 2007 May 30.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Identification of anti-SF3B1 autoantibody as a diagnostic marker in patients with hepatocellular carcinoma. Hwang HM, etal., J Transl Med. 2018 Jun 28;16(1):177. doi: 10.1186/s12967-018-1546-z.
4. Molecular cloning, genetic mapping, and expression of the mouse Sf3b1 (SAP155) gene for the U2 snRNP component of spliceosome. Isono K, etal., Mamm Genome 2001 Mar;12(3):192-8.
5. Splicing factor SF3B1 is overexpressed and implicated in the aggressiveness and survival of hepatocellular carcinoma. López-Cánovas JL, etal., Cancer Lett. 2021 Jan 1;496:72-83. doi: 10.1016/j.canlet.2020.10.010. Epub 2020 Oct 8.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Comprehensive gene review and curation RGD comprehensive gene curation
14. Proteomic characterization of protein phosphatase complexes of the mammalian nucleus. Tran HT, etal., Mol Cell Proteomics. 2004 Mar;3(3):257-65. Epub 2004 Jan 14.
Additional References at PubMed
PMID:11991638   PMID:12477932   PMID:15146077   PMID:15741318   PMID:18559850   PMID:20153721   PMID:22658674   PMID:22681889   PMID:23211737   PMID:24625528   PMID:27720643   PMID:27869233  
PMID:28541300   PMID:28781166   PMID:29360106   PMID:31904090   PMID:35039052  


Genomics

Comparative Map Data
Sf3b1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8963,986,829 - 64,026,723 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl963,986,829 - 64,026,719 (-)EnsemblGRCr8
mRatBN7.2956,492,403 - 56,532,300 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl956,492,403 - 56,532,300 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx965,002,980 - 65,042,759 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0970,118,880 - 70,158,654 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0968,417,802 - 68,457,524 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd967,740,122 - 67,779,888 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive963,515,561 - 63,555,336 (-)NCBILyon_Normotensive
Lyon_Hypertensive963,651,333 - 63,691,105 (-)NCBILyon_Hypertensive
F344_StmMcwi965,567,016 - 65,606,779 (-)NCBIF344_StmMcwi
Rnor_6.0961,594,620 - 61,634,510 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl961,594,620 - 61,634,510 (-)Ensemblrn6Rnor6.0
Rnor_5.0961,274,727 - 61,315,726 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4953,796,176 - 53,837,297 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera953,974,888 - 54,014,648 (-)NCBICelera
RGSC_v3.1953,814,990 - 53,838,594 (-)NCBI
Cytogenetic Map9q31NCBI
SF3B1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382197,389,784 - 197,435,093 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2197,388,515 - 197,435,079 (-)Ensemblhg38GRCh38
GRCh372198,254,508 - 198,299,817 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362197,964,943 - 198,008,016 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342198,082,205 - 198,125,277NCBI
Celera2192,012,574 - 192,055,648 (-)NCBICelera
Cytogenetic Map2q33.1NCBI
HuRef2190,109,104 - 190,152,365 (-)NCBIHuRef
CHM1_12198,262,509 - 198,305,605 (-)NCBICHM1_1
T2T-CHM13v2.02197,873,439 - 197,918,732 (-)NCBIT2T-CHM13v2.0
Sf3b1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39155,024,328 - 55,066,660 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl155,024,328 - 55,066,640 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38154,985,169 - 55,027,501 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl154,985,169 - 55,027,481 (-)Ensemblmm10GRCm38
MGSCv37155,042,013 - 55,084,322 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36154,929,714 - 54,988,277 (-)NCBIMGSCv36mm8
Celera155,504,913 - 55,547,551 (-)NCBICelera
Cytogenetic Map1C1.2NCBI
cM Map127.98NCBI
Sf3b1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554033,134,955 - 3,166,121 (+)Ensembl
ChiLan1.0NW_0049554033,134,960 - 3,163,395 (+)NCBIChiLan1.0ChiLan1.0
SF3B1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213100,006,148 - 100,049,332 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B100,020,997 - 100,065,215 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B84,633,272 - 84,678,602 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B202,530,200 - 202,573,346 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B202,530,200 - 202,573,346 (-)EnsemblpanPan2panpan1.1
SF3B1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1376,922,150 - 6,962,474 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl376,924,047 - 6,962,896 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha377,870,202 - 7,908,677 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0376,814,539 - 6,853,018 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl376,812,676 - 6,852,935 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1376,813,346 - 6,851,824 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0376,780,170 - 6,818,628 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0376,803,469 - 6,841,942 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Sf3b1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303155,048,266 - 155,088,514 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365061,749,563 - 1,791,739 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365061,749,591 - 1,790,860 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SF3B1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15101,276,851 - 101,299,105 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.115101,274,968 - 101,338,018 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215112,448,191 - 112,511,960 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SF3B1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11082,901,908 - 82,952,094 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1082,899,079 - 82,952,071 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666040116,491,563 - 116,541,710 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sf3b1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248892,796,351 - 2,835,592 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Sf3b1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v14129,447,082 - 129,490,250 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Sf3b1
183 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:128
Count of miRNA genes:94
Interacting mature miRNAs:107
Transcripts:ENSRNOT00000019126
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)9671488884474983Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)956047863101047863Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)94002992585029925Rat
1582203Gluco19Glucose level QTL 193.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)963376862108376862Rat
1300180Bw14Body weight QTL 143.776body mass (VT:0001259)body weight (CMO:0000012)93125043268875676Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)94445825699506504Rat
61450Ciaa3CIA Autoantibody QTL 36.5blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)92956766474567664Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)94445825685262605Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92956766483835942Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)94172029586720295Rat
7207805Bmd88Bone mineral density QTL 884femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)93125043265651574Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
1581517Bp284Blood pressure QTL 284arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)93922018684220186Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)948718864108376862Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)94002992585029925Rat
1598849Memor17Memory QTL 172.2exploratory behavior trait (VT:0010471)difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)95746049778547958Rat
4889943Bss90Bone structure and strength QTL 904.1tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)95450650499506504Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)93496059079960590Rat

Markers in Region
D9Mco75  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8964,018,543 - 64,018,757 (+)Marker Load Pipeline
mRatBN7.2956,524,122 - 56,524,338 (+)MAPPERmRatBN7.2
Rnor_6.0961,626,336 - 61,626,551NCBIRnor6.0
Rnor_5.0961,307,552 - 61,307,767UniSTSRnor5.0
RGSC_v3.4953,829,120 - 53,829,335UniSTSRGSC3.4
Celera954,006,473 - 54,006,686UniSTS
Cytogenetic Map9q31UniSTS
AU049739  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2956,493,436 - 56,493,620 (+)MAPPERmRatBN7.2
Rnor_6.0961,595,654 - 61,595,837NCBIRnor6.0
Rnor_5.0961,276,870 - 61,277,053UniSTSRnor5.0
RGSC_v3.4953,797,210 - 53,797,393UniSTSRGSC3.4
Celera953,975,922 - 53,976,105UniSTS
Cytogenetic Map9q31UniSTS
SF3B1-1  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8964,000,347 - 64,001,038 (+)Marker Load Pipeline
mRatBN7.2956,505,924 - 56,506,615 (+)MAPPERmRatBN7.2
Rnor_6.0961,608,140 - 61,608,830NCBIRnor6.0
Rnor_5.0961,289,356 - 61,290,046UniSTSRnor5.0
RGSC_v3.4953,810,924 - 53,811,614UniSTSRGSC3.4
Celera953,988,283 - 53,988,967UniSTS
Cytogenetic Map9q31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000019126   ⟹   ENSRNOP00000019126
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl963,986,829 - 64,026,719 (-)Ensembl
mRatBN7.2 Ensembl956,492,403 - 56,532,300 (-)Ensembl
Rnor_6.0 Ensembl961,594,620 - 61,634,510 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000101949   ⟹   ENSRNOP00000095259
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl956,492,403 - 56,524,551 (-)Ensembl
RefSeq Acc Id: NM_053426   ⟹   NP_445878
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8963,986,829 - 64,026,719 (-)NCBI
mRatBN7.2956,492,403 - 56,532,300 (-)NCBI
Dahl_SR_JrHsd967,740,122 - 67,779,888 (-)NCBI
Lyon_Normotensive963,515,561 - 63,555,336 (-)NCBI
Lyon_Hypertensive963,651,333 - 63,691,105 (-)NCBI
F344_StmMcwi965,567,016 - 65,606,779 (-)NCBI
Rnor_6.0961,594,620 - 61,634,510 (-)NCBI
Rnor_5.0961,274,727 - 61,315,726 (-)NCBI
RGSC_v3.4953,796,176 - 53,837,297 (-)RGD
Celera953,974,888 - 54,014,648 (-)RGD
Sequence:
RefSeq Acc Id: XM_017596654   ⟹   XP_017452143
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8963,987,423 - 64,014,674 (-)NCBI
mRatBN7.2956,492,997 - 56,520,253 (-)NCBI
Rnor_6.0961,595,214 - 61,622,463 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063267777   ⟹   XP_063123847
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8964,012,863 - 64,026,723 (-)NCBI
RefSeq Acc Id: XM_063267778   ⟹   XP_063123848
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8964,012,863 - 64,026,723 (-)NCBI
RefSeq Acc Id: NP_445878   ⟸   NM_053426
- UniProtKB: G3V7T6 (UniProtKB/TrEMBL),   A6IP03 (UniProtKB/TrEMBL),   A0A8I6AP19 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017452143   ⟸   XM_017596654
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AP19 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000019126   ⟸   ENSRNOT00000019126
Ensembl Acc Id: ENSRNOP00000095259   ⟸   ENSRNOT00000101949
RefSeq Acc Id: XP_063123848   ⟸   XM_063267778
- Peptide Label: isoform X2
- UniProtKB: A6IP04 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063123847   ⟸   XM_063267777
- Peptide Label: isoform X2
- UniProtKB: A6IP04 (UniProtKB/TrEMBL)
Protein Domains
Phosphatase PP2A regulatory subunit A/Splicing   Splicing factor 3B subunit

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V7T6-F1-model_v2 AlphaFold G3V7T6 1-1304 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696669
Promoter ID:EPDNEW_R7193
Type:multiple initiation site
Name:Sf3b1_1
Description:splicing factor 3b, subunit 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0961,634,410 - 61,634,470EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620148 AgrOrtholog
BioCyc Gene G2FUF-27536 BioCyc
Ensembl Genes ENSRNOG00000013516 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000019126 ENTREZGENE
  ENSRNOT00000019126.7 UniProtKB/TrEMBL
Gene3D-CATH 1.25.10.10 UniProtKB/TrEMBL
InterPro ARM-like UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/TrEMBL
  PP2A/SF3B1-like_HEAT UniProtKB/TrEMBL
  SF3b_su1 UniProtKB/TrEMBL
  SF3b_su1-like UniProtKB/TrEMBL
KEGG Report rno:84486 UniProtKB/TrEMBL
NCBI Gene 84486 ENTREZGENE
PANTHER PTHR12097 UniProtKB/TrEMBL
Pfam PPP2R1A-like_HEAT UniProtKB/TrEMBL
  SF3b1 UniProtKB/TrEMBL
PhenoGen Sf3b1 PhenoGen
RatGTEx ENSRNOG00000013516 RatGTEx
Superfamily-SCOP ARM-type_fold UniProtKB/TrEMBL
UniProt A0A8I6AP19 ENTREZGENE
  A6IP03 ENTREZGENE, UniProtKB/TrEMBL
  A6IP04 ENTREZGENE, UniProtKB/TrEMBL
  G3V7T6 ENTREZGENE, UniProtKB/TrEMBL
  Q5FVK4_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Sf3b1  splicing factor 3b, subunit 1    splicing factor 3b, subunit 1, 155kD  Name updated 1299863 APPROVED
2002-08-07 Sf3b1  splicing factor 3b, subunit 1, 155kD      Symbol and Name status set to provisional 70820 PROVISIONAL