Gzmm (granzyme M) - Rat Genome Database

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Gene: Gzmm (granzyme M) Rattus norvegicus
Analyze
Symbol: Gzmm
Name: granzyme M
RGD ID: 620022
Description: Enables serine-type peptidase activity. Predicted to be involved in apoptotic process and protein maturation. Predicted to act upstream of or within T cell mediated cytotoxicity. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human GZMM (granzyme M); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: granzyme M (lymphocyte met-ase 1); lymphoctye Met-ase 1; met-ase; natural killer cell granular protease; RNK-Met-1
RGD Orthologs
Human
Mouse
Bonobo
Pig
Green Monkey
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8710,661,683 - 10,667,448 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl710,661,684 - 10,667,504 (-)EnsemblGRCr8
mRatBN7.2710,011,065 - 10,016,841 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl710,011,066 - 10,016,665 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx712,891,888 - 12,897,490 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0714,769,969 - 14,775,570 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0712,629,438 - 12,634,985 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd713,409,653 - 13,415,200 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive713,573,100 - 13,578,647 (-)NCBILyon_Normotensive
Lyon_Hypertensive713,647,947 - 13,653,494 (-)NCBILyon_Hypertensive
F344_StmMcwi712,013,765 - 12,019,312 (-)NCBIF344_StmMcwi
Rnor_6.0712,893,431 - 12,899,004 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl712,893,432 - 12,899,004 (-)Ensemblrn6Rnor6.0
Rnor_5.0713,062,467 - 13,068,040 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4711,526,384 - 11,533,590 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera78,184,440 - 8,190,013 (-)NCBICelera
RGSC_v3.1711,526,394 - 11,533,533 (-)NCBI
Cytogenetic Map7q11NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
2. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Comprehensive gene review and curation RGD comprehensive gene curation
6. Purification and cloning of a novel serine protease, RNK-Met-1, from the granules of a rat natural killer cell leukemia. Smyth MJ, etal., J Biol Chem 1992 Dec 5;267(34):24418-25.
Additional References at PubMed
PMID:8889548   PMID:15326124   PMID:15454490   PMID:19946888   PMID:21857942   PMID:22206666  


Genomics

Comparative Map Data
Gzmm
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8710,661,683 - 10,667,448 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl710,661,684 - 10,667,504 (-)EnsemblGRCr8
mRatBN7.2710,011,065 - 10,016,841 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl710,011,066 - 10,016,665 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx712,891,888 - 12,897,490 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0714,769,969 - 14,775,570 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0712,629,438 - 12,634,985 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd713,409,653 - 13,415,200 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive713,573,100 - 13,578,647 (-)NCBILyon_Normotensive
Lyon_Hypertensive713,647,947 - 13,653,494 (-)NCBILyon_Hypertensive
F344_StmMcwi712,013,765 - 12,019,312 (-)NCBIF344_StmMcwi
Rnor_6.0712,893,431 - 12,899,004 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl712,893,432 - 12,899,004 (-)Ensemblrn6Rnor6.0
Rnor_5.0713,062,467 - 13,068,040 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4711,526,384 - 11,533,590 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera78,184,440 - 8,190,013 (-)NCBICelera
RGSC_v3.1711,526,394 - 11,533,533 (-)NCBI
Cytogenetic Map7q11NCBI
GZMM
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3819544,053 - 549,922 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl19544,034 - 549,924 (+)Ensemblhg38GRCh38
GRCh3719544,053 - 549,922 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3619495,027 - 500,919 (+)NCBIBuild 36Build 36hg18NCBI36
Build 3419495,026 - 500,919NCBI
Celera19268,078 - 273,971 (-)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef19314,019 - 320,234 (+)NCBIHuRef
CHM1_119543,125 - 549,515 (+)NCBICHM1_1
T2T-CHM13v2.019497,822 - 503,990 (+)NCBIT2T-CHM13v2.0
Gzmm
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391079,524,854 - 79,531,095 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1079,524,854 - 79,531,095 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381079,689,020 - 79,695,261 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1079,689,020 - 79,695,261 (+)Ensemblmm10GRCm38
MGSCv371079,151,765 - 79,158,005 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361079,092,149 - 79,098,389 (+)NCBIMGSCv36mm8
Celera1080,703,335 - 80,709,575 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
GZMM
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2204,870,103 - 4,877,454 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1194,108,179 - 4,116,170 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v019584,712 - 591,186 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.119514,047 - 521,578 (+)NCBIPanPan1.1PanPan1.1panPan2
GZMM
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl277,753,813 - 77,759,852 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1277,753,817 - 77,761,436 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
GZMM
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.16273,754 - 285,106 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl6273,798 - 284,965 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023668827282 - 4,292 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gzmm
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11155,179,043 - 155,184,759 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Gzmm
53 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:54
Count of miRNA genes:46
Interacting mature miRNAs:50
Transcripts:ENSRNOT00000011086
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7166965846669658Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)7123748937Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7721609752216097Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)71051708662346019Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)71011291699900612Rat
2290372Gluco33Glucose level QTL 332.71blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)7131777942Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7170952746709527Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7132612984Rat
1582260Bw72Body weight QTL 723.20.0043body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582261Bw69Body weight QTL 693.20.0048body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582262Bw75Body weight QTL 7530.0038body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)71011291660150541Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7946087754460877Rat
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7129716167Rat
1300138Hrtrt9Heart rate QTL 94.72heart pumping trait (VT:2000009)heart rate (CMO:0000002)71049882055498820Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134650782Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7132612984Rat

Markers in Region
AI327276  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2710,017,754 - 10,017,858 (+)MAPPERmRatBN7.2
Rnor_6.0712,900,124 - 12,900,227NCBIRnor6.0
Rnor_5.0713,069,160 - 13,069,263UniSTSRnor5.0
RGSC_v3.4711,534,710 - 11,534,813UniSTSRGSC3.4
Celera78,191,133 - 8,191,236UniSTS
Cytogenetic Map7q11UniSTS
RH143874  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8710,662,470 - 10,662,766 (+)Marker Load Pipeline
mRatBN7.2710,011,852 - 10,012,148 (+)MAPPERmRatBN7.2
Rnor_6.0712,894,219 - 12,894,514NCBIRnor6.0
Rnor_5.0713,063,255 - 13,063,550UniSTSRnor5.0
RGSC_v3.4711,527,172 - 11,527,467UniSTSRGSC3.4
Celera78,185,228 - 8,185,523UniSTS
RH 3.4 Map791.7UniSTS
Cytogenetic Map7q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 148 91 90 59 92 59 6 355 191 11 121 81 92 31 11 11

Sequence


Ensembl Acc Id: ENSRNOT00000011086   ⟹   ENSRNOP00000011086
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl710,661,684 - 10,667,416 (-)Ensembl
mRatBN7.2 Ensembl710,011,066 - 10,016,665 (-)Ensembl
Rnor_6.0 Ensembl712,893,432 - 12,899,004 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000095743   ⟹   ENSRNOP00000083530
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl710,661,684 - 10,664,150 (-)Ensembl
mRatBN7.2 Ensembl710,011,066 - 10,013,532 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000154313   ⟹   ENSRNOP00000103265
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl710,661,684 - 10,667,504 (-)Ensembl
RefSeq Acc Id: NM_057183   ⟹   NP_476531
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,661,683 - 10,667,256 (-)NCBI
mRatBN7.2710,011,065 - 10,016,638 (-)NCBI
Dahl_SR_JrHsd713,409,653 - 13,415,200 (-)NCBI
Lyon_Normotensive713,573,100 - 13,578,647 (-)NCBI
Lyon_Hypertensive713,647,947 - 13,653,494 (-)NCBI
F344_StmMcwi712,013,765 - 12,019,312 (-)NCBI
Rnor_6.0712,893,431 - 12,899,004 (-)NCBI
Rnor_5.0713,062,467 - 13,068,040 (-)NCBI
RGSC_v3.4711,526,384 - 11,533,590 (-)RGD
Celera78,184,440 - 8,190,013 (-)RGD
Sequence:
RefSeq Acc Id: XM_039078568   ⟹   XP_038934496
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,661,683 - 10,667,441 (-)NCBI
mRatBN7.2710,011,065 - 10,016,841 (-)NCBI
RefSeq Acc Id: XM_039078569   ⟹   XP_038934497
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,661,683 - 10,667,437 (-)NCBI
mRatBN7.2710,011,065 - 10,016,833 (-)NCBI
RefSeq Acc Id: XM_063263113   ⟹   XP_063119183
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,661,683 - 10,667,448 (-)NCBI
RefSeq Acc Id: NP_476531   ⟸   NM_057183
- Peptide Label: precursor
- UniProtKB: Q03238 (UniProtKB/Swiss-Prot),   G3V726 (UniProtKB/TrEMBL),   A6K8Y7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000011086   ⟸   ENSRNOT00000011086
RefSeq Acc Id: XP_038934496   ⟸   XM_039078568
- Peptide Label: isoform X2
- UniProtKB: Q03238 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038934497   ⟸   XM_039078569
- Peptide Label: isoform X3
- UniProtKB: A0A8I5ZVJ4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000083530   ⟸   ENSRNOT00000095743
RefSeq Acc Id: XP_063119183   ⟸   XM_063263113
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000103265   ⟸   ENSRNOT00000154313
Protein Domains
Peptidase S1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q03238-F1-model_v2 AlphaFold Q03238 1-258 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695056
Promoter ID:EPDNEW_R5580
Type:single initiation site
Name:Gzmm_1
Description:granzyme M
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0712,898,979 - 12,899,039EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620022 AgrOrtholog
BioCyc Gene G2FUF-34882 BioCyc
Ensembl Genes ENSRNOG00000030530 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000011086 ENTREZGENE
  ENSRNOT00000095743 ENTREZGENE
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot
InterPro Peptidase_S1_PA UniProtKB/Swiss-Prot
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot
  Peptidase_S1A UniProtKB/Swiss-Prot
  Trypsin_dom UniProtKB/Swiss-Prot
  TRYPSIN_HIS UniProtKB/Swiss-Prot
  TRYPSIN_SER UniProtKB/Swiss-Prot
NCBI Gene 29252 ENTREZGENE
PANTHER KALLIKREIN-RELATED UniProtKB/Swiss-Prot
  PTHR24271:SF51 UniProtKB/Swiss-Prot
Pfam Trypsin UniProtKB/Swiss-Prot
PharmGKB GZMM RGD
PhenoGen Gzmm PhenoGen
PRINTS CHYMOTRYPSIN UniProtKB/Swiss-Prot
PROSITE TRYPSIN_DOM UniProtKB/Swiss-Prot
  TRYPSIN_HIS UniProtKB/Swiss-Prot
  TRYPSIN_SER UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000030530 RatGTEx
SMART Tryp_SPc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50494 UniProtKB/Swiss-Prot
UniProt A0A8I5ZVJ4 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LQ33_RAT UniProtKB/TrEMBL
  A6K8Y7 ENTREZGENE, UniProtKB/TrEMBL
  G3V726 ENTREZGENE, UniProtKB/TrEMBL
  GRAM_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-19 Gzmm  granzyme M  Gzmm  granzyme M (lymphocyte met-ase 1)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Gzmm  granzyme M (lymphocyte met-ase 1)    lymphoctye Met-ase 1  Name updated 1299863 APPROVED
2002-08-07 Gzmm  lymphoctye Met-ase 1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_protein 238 amino acids; hydrolytically cleaves peptide substrates after methionine, leucine, and norleucine 728406