Crisp3 (cysteine-rich secretory protein 3) - Rat Genome Database

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Gene: Crisp3 (cysteine-rich secretory protein 3) Rattus norvegicus
Analyze
Symbol: Crisp3
Name: cysteine-rich secretory protein 3
RGD ID: 619846
Description: Predicted to be located in extracellular region and specific granule. Predicted to be active in extracellular space. Orthologous to human CRISP3 (cysteine rich secretory protein 3); INTERACTS WITH bisphenol A; 17beta-estradiol (ortholog); 17beta-hydroxy-5alpha-androstan-3-one (ortholog).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 32 kDa epididymal protein; acidic epididymal glycoprotein D/E; Aeg; Crisp-1; Crisp1; cysteine-rich secretory protein 1; epididymal glycoprotein; protein D; protein E; protein IV; SCP; sialoprotein; sperm-coating glycoprotein
RGD Orthologs
Human
Mouse
Bonobo
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8927,928,591 - 27,969,205 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl927,895,536 - 27,969,198 (+)EnsemblGRCr8
mRatBN7.2920,432,051 - 20,472,663 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl920,450,908 - 20,472,658 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx928,962,775 - 29,003,213 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0934,065,231 - 34,105,840 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0932,376,050 - 32,416,659 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0924,047,405 - 24,088,066 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl924,066,303 - 24,088,064 (+)Ensemblrn6Rnor6.0
Rnor_5.0922,907,619 - 22,948,639 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4916,654,563 - 16,698,037 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera918,080,027 - 18,115,374 (+)NCBICelera
RGSC_v3.1916,651,884 - 16,695,359 (+)NCBI
Cytogenetic Map9q13NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Molecular cloning of the cDNA for androgen-dependent sperm-coating glycoproteins secreted by the rat epididymis. Brooks DE, etal., Eur J Biochem 1986 Nov 17;161(1):13-8.
2. Molecular cloning of complementary deoxyribonucleic acid for an androgen-regulated epididymal protein: sequence homology with metalloproteins. Charest NJ, etal., Mol Endocrinol 1988 Oct;2(10):999-1004.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8601434   PMID:12009203   PMID:12223513   PMID:12433721   PMID:14711787   PMID:16502470   PMID:16872593   PMID:17482178   PMID:17671267   PMID:18703418   PMID:21593480   PMID:23376485  
PMID:30520133  


Genomics

Comparative Map Data
Crisp3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8927,928,591 - 27,969,205 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl927,895,536 - 27,969,198 (+)EnsemblGRCr8
mRatBN7.2920,432,051 - 20,472,663 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl920,450,908 - 20,472,658 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx928,962,775 - 29,003,213 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0934,065,231 - 34,105,840 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0932,376,050 - 32,416,659 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0924,047,405 - 24,088,066 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl924,066,303 - 24,088,064 (+)Ensemblrn6Rnor6.0
Rnor_5.0922,907,619 - 22,948,639 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4916,654,563 - 16,698,037 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera918,080,027 - 18,115,374 (+)NCBICelera
RGSC_v3.1916,651,884 - 16,695,359 (+)NCBI
Cytogenetic Map9q13NCBI
CRISP3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38649,727,376 - 49,744,388 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl649,727,376 - 49,744,437 (-)Ensemblhg38GRCh38
GRCh37649,695,089 - 49,712,101 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36649,803,048 - 49,820,015 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34649,803,054 - 49,820,015NCBI
Celera651,251,171 - 51,268,255 (-)NCBICelera
Cytogenetic Map6p12.3NCBI
HuRef649,425,404 - 49,442,485 (-)NCBIHuRef
CHM1_1649,698,007 - 49,715,084 (-)NCBICHM1_1
T2T-CHM13v2.0649,569,352 - 49,586,363 (-)NCBIT2T-CHM13v2.0
Crisp3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391740,532,668 - 40,553,179 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1740,532,668 - 40,553,179 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381740,221,777 - 40,242,288 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1740,221,777 - 40,242,288 (-)Ensemblmm10GRCm38
MGSCv371740,358,726 - 40,379,207 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361739,685,254 - 39,705,741 (-)NCBIMGSCv36mm8
Celera1743,628,430 - 43,648,913 (-)NCBICelera
Cytogenetic Map17B2NCBI
cM Map1719.45NCBI
CRISP3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2564,211,609 - 64,228,607 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1660,077,260 - 60,094,258 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0649,297,914 - 49,314,978 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1650,558,388 - 50,575,431 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl650,559,742 - 50,568,518 (-)EnsemblpanPan2panpan1.1
CRISP3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl743,777,061 - 43,804,549 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1743,777,035 - 43,804,624 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2750,169,210 - 50,196,748 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CRISP3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11722,658,296 - 22,676,996 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1722,659,652 - 22,677,137 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604449,705,747 - 49,713,767 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Crisp3
379 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:70
Count of miRNA genes:59
Interacting mature miRNAs:65
Transcripts:ENSRNOT00000018163
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)9671488884474983Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9534647950346479Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9875049253750492Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)9131250552Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)949664545496645Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9621499551214995Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9875049253750492Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9141763315Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9534647950416711Rat
631643Bp120Blood pressure QTL 12030.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)9671488829567695Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)949664545496645Rat
1600365Mcs20Mammary carcinoma susceptibility QTL 203mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)92103143049025574Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)949664545496645Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9621499551214995Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
7 3 2 31 11 16 3 7 3 2 28 10 28 5 36 13 1 1

Sequence


Ensembl Acc Id: ENSRNOT00000018163   ⟹   ENSRNOP00000018162
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl927,935,234 - 27,968,624 (+)Ensembl
mRatBN7.2 Ensembl920,450,908 - 20,472,658 (+)Ensembl
Rnor_6.0 Ensembl924,066,303 - 24,088,064 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000112970   ⟹   ENSRNOP00000080951
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl927,955,666 - 27,969,198 (+)Ensembl
mRatBN7.2 Ensembl920,459,128 - 20,472,658 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000136801   ⟹   ENSRNOP00000103158
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl927,895,536 - 27,969,198 (+)Ensembl
RefSeq Acc Id: NM_022859   ⟹   NP_074050
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8927,928,591 - 27,969,203 (+)NCBI
mRatBN7.2920,432,051 - 20,472,663 (+)NCBI
Rnor_6.0924,047,454 - 24,088,064 (+)NCBI
Rnor_5.0922,907,619 - 22,948,639 (+)NCBI
RGSC_v3.4916,654,563 - 16,698,037 (+)RGD
Celera918,080,027 - 18,115,374 (+)RGD
Sequence:
RefSeq Acc Id: XM_063267694   ⟹   XP_063123764
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8927,947,413 - 27,969,205 (+)NCBI
Protein Sequences
Protein RefSeqs NP_074050 (Get FASTA)   NCBI Sequence Viewer  
  XP_063123764 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB59716 (Get FASTA)   NCBI Sequence Viewer  
  AAD41530 (Get FASTA)   NCBI Sequence Viewer  
  AAD41531 (Get FASTA)   NCBI Sequence Viewer  
  CAA28304 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000018162.4
  ENSRNOP00000103158
GenBank Protein P12020 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_074050   ⟸   NM_022859
- Peptide Label: precursor
- UniProtKB: P12020 (UniProtKB/Swiss-Prot),   A0A8I6G5B9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000018162   ⟸   ENSRNOT00000018163
Ensembl Acc Id: ENSRNOP00000080951   ⟸   ENSRNOT00000112970
RefSeq Acc Id: XP_063123764   ⟸   XM_063267694
- Peptide Label: isoform X1
- UniProtKB: A0A8I6G5B9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000103158   ⟸   ENSRNOT00000136801
Protein Domains
SCP   ShKT

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P12020-F1-model_v2 AlphaFold P12020 1-246 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696568
Promoter ID:EPDNEW_R7092
Type:single initiation site
Name:Crisp3_1
Description:cysteine-rich secretory protein 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0924,066,292 - 24,066,352EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619846 AgrOrtholog
BioCyc Gene G2FUF-28074 BioCyc
Ensembl Genes ENSRNOG00000013496 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000018163.6 UniProtKB/Swiss-Prot
  ENSRNOT00000136801 ENTREZGENE
Gene3D-CATH 1.10.10.740 UniProtKB/Swiss-Prot
  3.40.33.10 UniProtKB/Swiss-Prot
InterPro Allrgn_V5/Tpx1_CS UniProtKB/Swiss-Prot
  CAP_domain UniProtKB/Swiss-Prot
  CAP_sf UniProtKB/Swiss-Prot
  Crisp-like_dom UniProtKB/Swiss-Prot
  CRISP-related UniProtKB/Swiss-Prot
  Cysteine_rich_secretory UniProtKB/Swiss-Prot
  SCP_CRISP UniProtKB/Swiss-Prot
  ShKT_dom UniProtKB/Swiss-Prot
KEGG Report rno:64827 UniProtKB/Swiss-Prot
NCBI Gene 64827 ENTREZGENE
PANTHER PTHR10334 UniProtKB/Swiss-Prot
Pfam CAP UniProtKB/Swiss-Prot
  Crisp UniProtKB/Swiss-Prot
PhenoGen Crisp3 PhenoGen
PRINTS V5TPXLIKE UniProtKB/Swiss-Prot
PROSITE CRISP_1 UniProtKB/Swiss-Prot
  CRISP_2 UniProtKB/Swiss-Prot
  SHKT UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000013496 RatGTEx
SMART SCP UniProtKB/Swiss-Prot
Superfamily-SCOP Crisp domain-like UniProtKB/Swiss-Prot
  SSF55797 UniProtKB/Swiss-Prot
UniProt A0A8I6G5B9 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LPU9_RAT UniProtKB/TrEMBL
  CRIS1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-15 Crisp3  cysteine-rich secretory protein 3  Crisp1  cysteine-rich secretory protein 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Crisp1  cysteine-rich secretory protein 1  Aeg  epididymal glycoprotein  Symbol and Name updated 1299863 APPROVED
2002-08-07 Aeg  epididymal glycoprotein      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression secreted by the epididymis 632253
gene_homology has similarity to yeast carboxypeptidase Y 632252