Marf1 (meiosis regulator and mRNA stability factor 1) - Rat Genome Database

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Pathways
Gene: Marf1 (meiosis regulator and mRNA stability factor 1) Rattus norvegicus
Analyze
Symbol: Marf1
Name: meiosis regulator and mRNA stability factor 1
RGD ID: 619770
Description: Predicted to enable CCR4-NOT complex binding activity. Predicted to be involved in female meiotic nuclear division; oogenesis; and regulation of gene expression. Predicted to act upstream of or within double-strand break repair. Predicted to be located in peroxisome. Predicted to be active in cytoplasm. Orthologous to human MARF1 (meiosis regulator and mRNA stability factor 1); INTERACTS WITH 1,2,4-trimethylbenzene; 2,6-dinitrotoluene; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: limkain b1; limkain-b1; Lkap; LOC100910288; meiosis arrest female 1; meiosis arrest female protein 1; meiosis arrest female protein 1-like
RGD Orthologs
Human
Mouse
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8101,395,271 - 1,439,974 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl101,395,282 - 1,439,974 (+)EnsemblGRCr8
mRatBN7.210888,053 - 932,760 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10888,076 - 932,753 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx105,584,843 - 5,629,511 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01034,936,333 - 34,980,999 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010901,042 - 945,714 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.010908,806 - 953,481 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10908,806 - 953,474 (+)Ensemblrn6Rnor6.0
Rnor_5.01028,243 - 72,912 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.410826,803 - 872,214 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1011,477,637 - 11,521,007 (+)NCBICelera
RGSC_v3.110826,802 - 872,214 (+)NCBI
Cytogenetic Map10q11NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA)
peroxisome  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Information Derived from GenBank Report RGD, Sept. 2003
Additional References at PubMed
PMID:15932519   PMID:19389623   PMID:19946888   PMID:22442484   PMID:23090997  


Genomics

Comparative Map Data
Marf1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8101,395,271 - 1,439,974 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl101,395,282 - 1,439,974 (+)EnsemblGRCr8
mRatBN7.210888,053 - 932,760 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10888,076 - 932,753 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx105,584,843 - 5,629,511 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01034,936,333 - 34,980,999 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010901,042 - 945,714 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.010908,806 - 953,481 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10908,806 - 953,474 (+)Ensemblrn6Rnor6.0
Rnor_5.01028,243 - 72,912 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.410826,803 - 872,214 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1011,477,637 - 11,521,007 (+)NCBICelera
RGSC_v3.110826,802 - 872,214 (+)NCBI
Cytogenetic Map10q11NCBI
MARF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381615,594,387 - 15,643,154 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1615,594,302 - 15,643,209 (-)Ensemblhg38GRCh38
GRCh371615,688,244 - 15,737,011 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361615,595,745 - 15,644,510 (-)NCBIBuild 36Build 36hg18NCBI36
Celera1615,368,702 - 15,417,500 (-)NCBICelera
Cytogenetic Map16p13.11NCBI
HuRef1615,082,130 - 15,130,849 (-)NCBIHuRef
CHM1_11615,772,586 - 15,821,403 (-)NCBICHM1_1
T2T-CHM13v2.01615,599,246 - 15,648,059 (-)NCBIT2T-CHM13v2.0
Marf1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391613,927,030 - 13,977,157 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1613,927,037 - 13,981,215 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381614,109,166 - 14,159,278 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1614,109,173 - 14,163,351 (-)Ensemblmm10GRCm38
MGSCv371614,110,626 - 14,159,367 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361614,024,111 - 14,077,521 (-)NCBIMGSCv36mm8
Celera1614,717,048 - 14,765,808 (-)NCBICelera
Cytogenetic Map16A1NCBI
cM Map169.69NCBI
MARF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl37,180,740 - 7,228,413 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.137,180,762 - 7,228,229 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
MARF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1514,616,834 - 14,663,608 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl514,616,814 - 14,663,520 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366606815,377,055 - 15,423,836 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Marf1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624782186,813 - 231,136 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624782184,654 - 231,162 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Marf1
303 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:485
Count of miRNA genes:269
Interacting mature miRNAs:327
Transcripts:ENSRNOT00000003193
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135730538Rat
7387235Uae41Urinary albumin excretion QTL 415.260.1874urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)10130004247Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1092219745922197Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
1549898Neuinf3Neuroinflammation QTL 326.4nervous system integrity trait (VT:0010566)MHC Class II RT1A-positive spinal cord ventral horn area to total spinal cord ventral horn area ratio (CMO:0001980)1015893911Rat
631828Alc5Alcohol consumption QTL 52.4consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10117749933Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138832698Rat

Markers in Region
D10Mco48  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8101,399,112 - 1,399,267 (+)Marker Load Pipeline
mRatBN7.210891,891 - 892,046 (+)MAPPERmRatBN7.2
Rnor_6.010912,616 - 912,770NCBIRnor6.0
Rnor_6.01032,053 - 32,207NCBIRnor6.0
Rnor_5.01032,053 - 32,207UniSTSRnor5.0
Rnor_5.01011,592,869 - 11,593,023UniSTSRnor5.0
RGSC_v3.410830,613 - 830,767UniSTSRGSC3.4
RGSC_v3.410830,612 - 830,767RGDRGSC3.4
Celera1011,481,447 - 11,481,601UniSTS
RGSC_v3.110830,612 - 830,767RGD
Cytogenetic Map10q11UniSTS
C87306  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.210930,863 - 931,117 (+)MAPPERmRatBN7.2
Rnor_6.010951,585 - 951,838NCBIRnor6.0
Rnor_6.01071,016 - 71,269NCBIRnor6.0
Rnor_5.01071,016 - 71,269UniSTSRnor5.0
Rnor_5.01011,631,839 - 11,632,092UniSTSRnor5.0
RGSC_v3.410869,582 - 869,835UniSTSRGSC3.4
RGSC_v3.410870,327 - 870,580UniSTSRGSC3.4
Celera102,855 - 3,108UniSTS
Cytogenetic Map10q11UniSTS
RH129984  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.0102,452,538 - 2,452,729NCBIRnor5.0
Rnor_5.01072,675 - 72,866NCBIRnor5.0
Rnor_5.01011,633,498 - 11,633,689NCBIRnor5.0
RGSC_v3.410196,914 - 197,104UniSTSRGSC3.4
RGSC_v3.410871,987 - 872,177UniSTSRGSC3.4
Celera104,515 - 4,705UniSTS
Cytogenetic Map10q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
13 1 24 83 34 30 18 73 18 6 196 119 11 70 46 51 12 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000003193   ⟹   ENSRNOP00000003193
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl101,395,282 - 1,439,972 (+)Ensembl
mRatBN7.2 Ensembl10888,082 - 932,753 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000077828   ⟹   ENSRNOP00000071564
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl101,395,290 - 1,439,974 (+)Ensembl
mRatBN7.2 Ensembl10888,076 - 932,753 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000091520   ⟹   ENSRNOP00000073018
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl101,395,282 - 1,439,972 (+)Ensembl
mRatBN7.2 Ensembl10888,082 - 932,753 (+)Ensembl
Rnor_6.0 Ensembl10908,806 - 953,474 (+)Ensembl
RefSeq Acc Id: NM_133421   ⟹   NP_596912
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8101,395,303 - 1,439,972 (+)NCBI
mRatBN7.210888,082 - 932,752 (+)NCBI
Rnor_6.010908,806 - 953,472 (+)NCBI
Rnor_5.01028,243 - 72,912 (+)NCBI
RGSC_v3.410826,803 - 872,214 (+)RGD
Celera1011,477,637 - 11,521,007 (+)NCBI
Sequence:
RefSeq Acc Id: XM_003750779   ⟹   XP_003750827
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8101,395,438 - 1,439,974 (+)NCBI
mRatBN7.210888,213 - 930,528 (+)NCBI
Rnor_6.010908,943 - 953,481 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006245854   ⟹   XP_006245916
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8101,395,271 - 1,439,974 (+)NCBI
mRatBN7.210888,053 - 932,760 (+)NCBI
Rnor_6.010908,830 - 953,481 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006245855   ⟹   XP_006245917
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8101,399,887 - 1,439,974 (+)NCBI
mRatBN7.210892,664 - 930,528 (+)NCBI
Rnor_6.010913,439 - 953,481 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006245856   ⟹   XP_006245918
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8101,395,271 - 1,439,974 (+)NCBI
mRatBN7.210888,053 - 930,528 (+)NCBI
Rnor_6.010908,830 - 953,481 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063268362   ⟹   XP_063124432
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8101,395,297 - 1,439,974 (+)NCBI
RefSeq Acc Id: XM_063268363   ⟹   XP_063124433
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8101,395,271 - 1,439,974 (+)NCBI
RefSeq Acc Id: XM_063268364   ⟹   XP_063124434
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8101,395,271 - 1,422,192 (+)NCBI
RefSeq Acc Id: NP_596912   ⟸   NM_133421
- UniProtKB: Q8VIG2 (UniProtKB/Swiss-Prot),   F1LNE9 (UniProtKB/Swiss-Prot),   A6KU39 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006245916   ⟸   XM_006245854
- Peptide Label: isoform X2
- UniProtKB: A6KU39 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006245918   ⟸   XM_006245856
- Peptide Label: isoform X4
- UniProtKB: A6KU39 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_003750827   ⟸   XM_003750779
- Peptide Label: isoform X1
- UniProtKB: F1LNE9 (UniProtKB/Swiss-Prot),   Q8VIG2 (UniProtKB/Swiss-Prot),   A6KU39 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006245917   ⟸   XM_006245855
- Peptide Label: isoform X3
- UniProtKB: A0A0G2K0S5 (UniProtKB/TrEMBL),   A6KU39 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073018   ⟸   ENSRNOT00000091520
Ensembl Acc Id: ENSRNOP00000003193   ⟸   ENSRNOT00000003193
Ensembl Acc Id: ENSRNOP00000071564   ⟸   ENSRNOT00000077828
RefSeq Acc Id: XP_063124433   ⟸   XM_063268363
- Peptide Label: isoform X5
- UniProtKB: A6KU39 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063124434   ⟸   XM_063268364
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063124432   ⟸   XM_063268362
- Peptide Label: isoform X3
- UniProtKB: A0A0G2K0S5 (UniProtKB/TrEMBL),   A6KU39 (UniProtKB/TrEMBL)
Protein Domains
HTH OST-type   NYN   RRM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A096P6L2-F1-model_v2 AlphaFold A0A096P6L2 1-1735 view protein structure
AF-Q8VIG2-F1-model_v2 AlphaFold Q8VIG2 1-1735 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696922
Promoter ID:EPDNEW_R7447
Type:multiple initiation site
Name:Marf1_1
Description:meiosis regulator and mRNA stability factor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.010908,801 - 908,861EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619770 AgrOrtholog
BioCyc Gene G2FUF-26254 BioCyc
Ensembl Genes ENSRNOG00000056248 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000077828 ENTREZGENE
  ENSRNOT00000091520 ENTREZGENE
  ENSRNOT00000091520.2 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.420.610 UniProtKB/Swiss-Prot
  3.30.70.330 UniProtKB/Swiss-Prot
  5'-nuclease UniProtKB/Swiss-Prot
InterPro LOTUS-like UniProtKB/Swiss-Prot
  Marf1 UniProtKB/Swiss-Prot
  MARF1_LOTUS UniProtKB/Swiss-Prot
  Marf1_RRM1 UniProtKB/Swiss-Prot
  Marf1_RRM2 UniProtKB/Swiss-Prot
  Nucleotide-bd_a/b_plait_sf UniProtKB/Swiss-Prot
  NYN_limkain-b1 UniProtKB/Swiss-Prot
  OST-HTH/LOTUS_dom UniProtKB/Swiss-Prot
  RBD_domain_sf UniProtKB/Swiss-Prot
  RRM_dom UniProtKB/Swiss-Prot
KEGG Report rno:170946 UniProtKB/Swiss-Prot
NCBI Gene 170946 ENTREZGENE
PANTHER MEIOSIS REGULATOR AND MRNA STABILITY FACTOR 1 UniProtKB/Swiss-Prot
  PTHR14379 UniProtKB/Swiss-Prot
Pfam Limkain-b1 UniProtKB/Swiss-Prot
  MARF1_LOTUS UniProtKB/Swiss-Prot
  NYN UniProtKB/Swiss-Prot
  OST-HTH UniProtKB/Swiss-Prot
  RRM_1 UniProtKB/Swiss-Prot
PhenoGen Marf1 PhenoGen
PROSITE HTH_OST UniProtKB/Swiss-Prot
  RRM UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000056248 RatGTEx
SMART RRM UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54928 UniProtKB/Swiss-Prot
UniProt A0A096P6L2_RAT UniProtKB/TrEMBL
  A0A0G2K0S5 ENTREZGENE, UniProtKB/TrEMBL
  A6KU39 ENTREZGENE, UniProtKB/TrEMBL
  F1LNE9 ENTREZGENE
  MARF1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary F1LNE9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Marf1  meiosis regulator and mRNA stability factor 1  LOC100910288  meiosis arrest female protein 1-like  Data merged from RGD:6499221 737654 PROVISIONAL
2017-03-29 Marf1  meiosis regulator and mRNA stability factor 1  Marf1  meiosis arrest female 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-19 Marf1  meiosis arrest female 1  Lkap  limkain b1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-05 LOC100910288  meiosis arrest female protein 1-like      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_physical_interaction associates with LIM kinase-2 634611