Scn7a (sodium voltage-gated channel alpha subunit 7) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Scn7a (sodium voltage-gated channel alpha subunit 7) Rattus norvegicus
Analyze
Symbol: Scn7a
Name: sodium voltage-gated channel alpha subunit 7
RGD ID: 61922
Description: Enables osmolarity-sensing monoatomic cation channel activity. Involved in sodium ion homeostasis. Predicted to be located in glial cell projection. Predicted to be active in plasma membrane. Biomarker of brain infarction. Orthologous to human SCN7A (sodium voltage-gated channel alpha subunit 7); INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: glial sodium channel alpha subunit; Na-G; nax channel; SCL-11; Scn6a; sodium channel protein type 7 subunit alpha; sodium channel voltage-gated type VI alpha polypeptide; sodium channel, voltage-gated, type 6, alpha polypeptide; sodium channel, voltage-gated, type VI, alpha polypeptide; sodium channel, voltage-gated, type VII, alpha; sodium channel, voltage-gated, type VII, alpha subunit
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8371,743,873 - 71,846,454 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl371,743,873 - 71,846,284 (-)EnsemblGRCr8
mRatBN7.2351,335,841 - 51,438,308 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl351,335,841 - 51,438,256 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx354,676,603 - 54,778,881 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0363,260,197 - 63,362,480 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0361,040,038 - 61,143,717 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0352,775,779 - 52,877,365 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl352,777,214 - 52,849,907 (-)Ensemblrn6Rnor6.0
Rnor_5.0359,395,313 - 59,496,997 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4348,633,302 - 48,710,734 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera350,919,278 - 50,994,687 (-)NCBICelera
RGSC_v3.1348,529,673 - 48,607,100 (-)NCBI
Cytogenetic Map3q21NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Structure and distribution of a broadly expressed atypical sodium channel. Akopian AN, etal., FEBS Lett 1997 Jan 3;400(2):183-7.
2. Identification of new therapeutic targets by genome-wide analysis of gene expression in the ipsilateral cortex of aged rats after stroke. Buga AM, etal., PLoS One. 2012;7(12):e50985. doi: 10.1371/journal.pone.0050985. Epub 2012 Dec 12.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. The glial voltage-gated sodium channel: cell- and tissue-specific mRNA expression. Gautron S, etal., Proc Natl Acad Sci U S A 1992 Aug 1;89(15):7272-6.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Neuronal sodium leak channel is responsible for the detection of sodium in the rat median preoptic nucleus. Tremblay C, etal., J Neurophysiol. 2011 Feb;105(2):650-60. doi: 10.1152/jn.00417.2010. Epub 2010 Nov 17.
Additional References at PubMed
PMID:15102913   PMID:16223844   PMID:19765660   PMID:23012479   PMID:23026072   PMID:32027092   PMID:37783507  


Genomics

Comparative Map Data
Scn7a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8371,743,873 - 71,846,454 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl371,743,873 - 71,846,284 (-)EnsemblGRCr8
mRatBN7.2351,335,841 - 51,438,308 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl351,335,841 - 51,438,256 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx354,676,603 - 54,778,881 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0363,260,197 - 63,362,480 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0361,040,038 - 61,143,717 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0352,775,779 - 52,877,365 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl352,777,214 - 52,849,907 (-)Ensemblrn6Rnor6.0
Rnor_5.0359,395,313 - 59,496,997 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4348,633,302 - 48,710,734 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera350,919,278 - 50,994,687 (-)NCBICelera
RGSC_v3.1348,529,673 - 48,607,100 (-)NCBI
Cytogenetic Map3q21NCBI
SCN7A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382166,403,573 - 166,494,249 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2166,403,472 - 166,611,482 (-)Ensemblhg38GRCh38
GRCh372167,260,083 - 167,350,759 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362166,969,785 - 167,051,724 (-)NCBIBuild 36Build 36hg18NCBI36
Celera2160,870,532 - 160,952,254 (-)NCBICelera
Cytogenetic Map2q24.3NCBI
HuRef2159,141,279 - 159,225,050 (-)NCBIHuRef
CHM1_12167,266,108 - 167,349,512 (-)NCBICHM1_1
T2T-CHM13v2.02166,861,052 - 166,951,694 (-)NCBIT2T-CHM13v2.0
Scn7a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39266,503,770 - 66,615,254 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl266,503,769 - 66,615,258 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38266,673,426 - 66,784,910 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl266,673,425 - 66,784,914 (-)Ensemblmm10GRCm38
MGSCv37266,511,483 - 66,622,967 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36266,476,151 - 66,585,749 (-)NCBIMGSCv36mm8
Celera268,353,829 - 68,464,449 (-)NCBICelera
Cytogenetic Map2C1.3NCBI
cM Map239.21NCBI
Scn7a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554497,736,502 - 7,796,626 (+)Ensembl
ChiLan1.0NW_0049554497,714,424 - 7,798,383 (+)NCBIChiLan1.0ChiLan1.0
SCN7A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21369,060,845 - 69,153,034 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B69,075,898 - 69,167,988 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B53,676,298 - 53,768,289 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B171,151,969 - 171,243,717 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B171,151,969 - 171,243,717 (-)EnsemblpanPan2panpan1.1
SCN7A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13611,482,840 - 11,590,394 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3611,482,899 - 11,561,845 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3611,625,452 - 11,635,876 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03611,615,133 - 11,691,208 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3611,617,086 - 11,691,172 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13611,697,209 - 11,773,082 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03611,669,022 - 11,752,078 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03611,782,607 - 11,864,741 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Scn7a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303128,671,434 - 128,755,451 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646912,888,856 - 12,946,818 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493646912,862,314 - 12,946,784 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SCN7A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1572,945,288 - 73,026,656 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11572,946,147 - 73,026,656 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21581,526,958 - 81,626,378 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SCN7A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11051,929,727 - 52,024,734 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1051,927,523 - 52,004,720 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666040147,489,010 - 147,585,218 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Scn7a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247874,197,782 - 4,284,991 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247874,198,048 - 4,284,985 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Scn7a
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1544,102,237 - 44,198,091 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Scn7a
1267 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:18
Count of miRNA genes:17
Interacting mature miRNAs:17
Transcripts:ENSRNOT00000041096
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)351490129111359995Rat
634317Bw117Body weight QTL 1173.58abdominal fat pad mass (VT:1000711)abdominal fat pad weight to body weight ratio (CMO:0000095)35986366373704481Rat
1331795Rf30Renal function QTL 303.708urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)35986366387321459Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)35365182698651826Rat
2303593Gluco46Glucose level QTL 463blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)34887661993876619Rat
1354590Despr11Despair related QTL 110.000031locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)34887661993876619Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)33540319997383526Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)358601291153936591Rat
631832Sach1Saccharin preference QTL 12.70.02consumption behavior trait (VT:0002069)calculated saccharin drink intake volume (CMO:0001600)34790417292904172Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)349872657138829559Rat
1331777Bw24Body weight QTL 243.503body mass (VT:0001259)body weight (CMO:0000012)35986366387321459Rat
631647Bp122Blood pressure QTL 1226.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)35109256196092561Rat
1300169Bp177Blood pressure QTL 1772.96arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)33642511681425116Rat
9590286Uminl1Urine mineral level QTL 13.50.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)34865774493657744Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)370845569136091483Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)33779691982796919Rat
2302276Bw82Body weight QTL 824.32body mass (VT:0001259)body weight (CMO:0000012)35986366383358329Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)358925062103925062Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)370311536115311536Rat
9590136Scort3Serum corticosterone level QTL 323.370.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)34865774493657744Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)35076614595766145Rat
61356Bp37Blood pressure QTL 373blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)35109256196092561Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)336721849110333156Rat
1558650Cm48Cardiac mass QTL 4840.0001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)35076614595766145Rat
8694196Abfw2Abdominal fat weight QTL 216.580.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)34865774493657744Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)342158111124558371Rat
2325840Bp345Blood pressure QTL 3450.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)33870893183708931Rat
8552950Pigfal12Plasma insulin-like growth factor 1 level QTL 127.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)34865774493657744Rat
631676Cm8Cardiac mass QTL 87.030.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)33736373482363734Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)33610140381101403Rat
8694386Bw159Body weight QTL 1594.520.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)34865774493657744Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)342158111124558371Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat

Markers in Region
D3Wox31  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8371,744,009 - 71,744,113 (+)Marker Load Pipeline
mRatBN7.2351,335,977 - 51,336,081 (+)MAPPERmRatBN7.2
Rnor_6.0352,775,788 - 52,775,891NCBIRnor6.0
Rnor_5.0359,395,450 - 59,395,553UniSTSRnor5.0
RGSC_v3.4348,633,311 - 48,633,414UniSTSRGSC3.4
Celera350,919,287 - 50,919,390UniSTS
Cytogenetic Map3q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
13 12 65 137 82 81 50 27 50 6 257 125 11 116 61 87 31 8 8

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001388508 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_031686 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006234296 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105778 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105779 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105780 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105781 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284500 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284501 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284502 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC117350 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ277392 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M96578 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y09164 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000041096   ⟹   ENSRNOP00000044385
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl371,743,873 - 71,846,284 (-)Ensembl
mRatBN7.2 Ensembl351,335,841 - 51,438,256 (-)Ensembl
Rnor_6.0 Ensembl352,777,214 - 52,849,907 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000113647   ⟹   ENSRNOP00000089322
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl351,335,841 - 51,411,323 (-)Ensembl
RefSeq Acc Id: NM_001388508   ⟹   NP_001375437
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8371,743,873 - 71,846,284 (-)NCBI
mRatBN7.2351,335,841 - 51,438,256 (-)NCBI
RefSeq Acc Id: XM_039105778   ⟹   XP_038961706
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8371,743,873 - 71,845,960 (-)NCBI
mRatBN7.2351,336,048 - 51,437,932 (-)NCBI
RefSeq Acc Id: XM_039105779   ⟹   XP_038961707
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8371,743,873 - 71,845,917 (-)NCBI
mRatBN7.2351,336,048 - 51,437,886 (-)NCBI
RefSeq Acc Id: XM_039105780   ⟹   XP_038961708
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8371,743,873 - 71,846,454 (-)NCBI
mRatBN7.2351,335,841 - 51,438,308 (-)NCBI
RefSeq Acc Id: XM_039105781   ⟹   XP_038961709
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8371,743,873 - 71,846,454 (-)NCBI
mRatBN7.2351,335,841 - 51,438,308 (-)NCBI
RefSeq Acc Id: XM_063284500   ⟹   XP_063140570
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8371,743,873 - 71,845,666 (-)NCBI
RefSeq Acc Id: XM_063284501   ⟹   XP_063140571
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8371,743,873 - 71,784,319 (-)NCBI
RefSeq Acc Id: XM_063284502   ⟹   XP_063140572
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8371,756,417 - 71,846,454 (-)NCBI
Ensembl Acc Id: ENSRNOP00000044385   ⟸   ENSRNOT00000041096
RefSeq Acc Id: XP_038961709   ⟸   XM_039105781
- Peptide Label: isoform X3
- UniProtKB: A0A8I6GH51 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038961708   ⟸   XM_039105780
- Peptide Label: isoform X2
- UniProtKB: A0A8I6GH51 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001375437   ⟸   NM_001388508
- UniProtKB: Q64074 (UniProtKB/Swiss-Prot),   Q01340 (UniProtKB/Swiss-Prot),   F1LQQ7 (UniProtKB/TrEMBL),   P97706 (UniProtKB/TrEMBL),   A0A8I6GH51 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038961706   ⟸   XM_039105778
- Peptide Label: isoform X1
- UniProtKB: Q64074 (UniProtKB/Swiss-Prot),   Q01340 (UniProtKB/Swiss-Prot),   F1LQQ7 (UniProtKB/TrEMBL),   P97706 (UniProtKB/TrEMBL),   A0A8I6GH51 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038961707   ⟸   XM_039105779
- Peptide Label: isoform X1
- UniProtKB: Q64074 (UniProtKB/Swiss-Prot),   Q01340 (UniProtKB/Swiss-Prot),   F1LQQ7 (UniProtKB/TrEMBL),   P97706 (UniProtKB/TrEMBL),   A0A8I6GH51 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000089322   ⟸   ENSRNOT00000113647
RefSeq Acc Id: XP_063140570   ⟸   XM_063284500
- Peptide Label: isoform X1
- UniProtKB: Q64074 (UniProtKB/Swiss-Prot),   Q01340 (UniProtKB/Swiss-Prot),   P97706 (UniProtKB/Swiss-Prot),   F1LQQ7 (UniProtKB/Swiss-Prot),   A0A8I6GH51 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063140571   ⟸   XM_063284501
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063140572   ⟸   XM_063284502
- Peptide Label: isoform X5
- UniProtKB: A6HLY6 (UniProtKB/TrEMBL)
Protein Domains
Ion transport   Sodium ion transport-associated

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LQQ7-F1-model_v2 AlphaFold F1LQQ7 1-1704 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61922 AgrOrtholog
BioCyc Gene G2FUF-49537 BioCyc
Ensembl Genes ENSRNOG00000029342 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000041096 ENTREZGENE
  ENSRNOT00000041096.5 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot
  EF-hand UniProtKB/Swiss-Prot
  iswi atpase UniProtKB/Swiss-Prot
  Voltage-gated potassium channels. Chain C UniProtKB/Swiss-Prot
InterPro Ion_trans_dom UniProtKB/Swiss-Prot
  Na_channel_asu UniProtKB/Swiss-Prot
  Na_chnl_inactivation_gate UniProtKB/Swiss-Prot
  Na_trans_assoc_dom UniProtKB/Swiss-Prot
  VGCC_Ca_Na UniProtKB/Swiss-Prot
  Volt_channel_dom_sf UniProtKB/Swiss-Prot
NCBI Gene 64155 ENTREZGENE
PANTHER SODIUM CHANNEL PROTEIN UniProtKB/Swiss-Prot
  VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM UniProtKB/Swiss-Prot
Pfam Ion_trans UniProtKB/Swiss-Prot
  IQ_SCN5A_C UniProtKB/Swiss-Prot
  Na_trans_assoc UniProtKB/Swiss-Prot
PhenoGen Scn7a PhenoGen
PRINTS NACHANNEL UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000029342 RatGTEx
Superfamily-SCOP Voltage-gated potassium channels UniProtKB/Swiss-Prot
UniProt A0A8I6GH51 ENTREZGENE
  A6HLY6 ENTREZGENE, UniProtKB/TrEMBL
  A6HLY7_RAT UniProtKB/TrEMBL
  F1LQQ7 ENTREZGENE
  P97706 ENTREZGENE
  Q01340 ENTREZGENE
  Q64074 ENTREZGENE
  Q9ESV8_RAT UniProtKB/TrEMBL
  SCN7A_RAT UniProtKB/Swiss-Prot
UniProt Secondary P97706 UniProtKB/Swiss-Prot
  Q01340 UniProtKB/Swiss-Prot
  Q64074 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Scn7a  sodium voltage-gated channel alpha subunit 7  Scn7a  sodium channel, voltage-gated, type VII, alpha subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-03-13 Scn7a  sodium channel, voltage-gated, type VII, alpha subunit  Scn7a  sodium channel, voltage-gated, type VII, alpha  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Scn7a  sodium channel, voltage-gated, type VII, alpha  Scn6a  sodium channel, voltage-gated, type 6, alpha polypeptide   Symbol and Name updated 1299863 APPROVED
2002-06-10 Scn6a  sodium channel, voltage-gated, type 6, alpha polypeptide       Name updated 70585 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_homology shows 87% homology to mouse and 72% homology to human atypical Na+ channels 61747